Kratom and Hydrocodone – Is It Safe To Combine?

Kratom and Hydrocodone

When the body is experiencing chronic pain, it can be difficult and stressful. For some people who are in severe conditions that cause this type of suffering on a daily basis such as surgeries or sick health conditions like arthritis; they turn towards Kratom and Hydrocodone for temporary relief until their next scheduled visit with medical professionals.

These substances will help get you out there quicker than your average prescription medications would do which may have unwanted side effects due to their strength compared to other drugs. That notwithstanding, both Kratom and Hydrocodone have their similarities. Most notably both acts on the central nervous system (CNS) to relieve pain. As such, they provide similar effects but with varying long-term consequences.

However, before you incorporate Kratom and Hydrocodone into your wellness program, it’s vital to understand the types of interactions they might have. This is because while some drug interactions are useful, others can be damaging since they negate each other’s benefits. This might result in harmful effects or significant damage to your health at its worst.

In this post, we’ll compare Kratom vs Hydrocodone. We’ll discuss their interactions and learn about the fundamentals of these substances as well as examine the benefits and drawbacks of each option.

Is there Interaction between Kratom and Hydrocodone?

Kratom and hydrocodone are thought to work in tandem to achieve the same goal. As a result, both substances affect the opioid receptors and boost each other’s effects (agonistic interaction).

And because sedatives interact with hydrocodone, combining certain strains of Kratom with this drug may can lead to respiratory depression and profound sedation and should therefore be avoided.

To be on the safe side, therefore you might want to avoid taking any red vein Kratom strains with hydrocodone. This is because red veined Kratom strains are known to produce sedative effects.

Is it Safe to Take Kratom with Hydrocodone?

This is still a debatable issue from a medical perspective as it has not been fully studied given that there is very little research about Kratom so far. However, from the little available documentation, it’s clear that Kratom and hydrocodone have had some interactions.

However, it’s important to note that Hydrocodone – a semi-synthetic opioid painkiller – and Kratom – a natural opioid-like herbal supplement has the potential to have a negative interaction with each other.

So, if you’re thinking about combining Kratom and Hydrocodone, talk to your doctor first. They’ll have the best knowledge of your situation since they’ll take all of the variables into account. Furthermore, they’ll be able to assist you in monitoring for interactions if you plan on taking both drugs.

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What Are the Combined Effects of Kratom and Hydrocodone

Hydrocodone is classified as an opioid, whereas Kratom has opioid-like effects and activities. As a result, both Kratom and Hydrocodone interact with your head’s opioid receptors.

As such, users sometimes combine them which is not particularly shocking. The neurological processes are nearly identical, resulting in mirrored outcomes.

With that in mind, the majority of Kratom and hydrocodone users report experiencing similar effects. Here are some of the effects.

  • Euphoria
  • Pain relief
  • Relaxation
  • Stimulation
  • Soothing
  • Booted moods
  • Overall sense of wellbeing

Kratom and hydrocodone are two painkillers that many people use to ease their physical discomfort. However, these drugs also have a tendency of producing feelings such as happiness or euphoria when taken in certain doses by those who take them for therapeutic purposes.

And with the world being really stressful at the moment, it isn’t surprising if we can easily abuse the hydrocodone Kratom combo. As a result, you develop tolerance for both, especially if taken on a daily basis. This causes the Kratom and hydrocodone effects to begin to dissipate at the usual dose, necessitating more of the drug to achieve the same pleasurable sensations.

What Exactly Is Kratom and How Does It Work?

Kratom (Mitragyna speciosa) is a tropical evergreen tree in the coffee family native to Southeast Asia. The leaves of Kratom are used as a stimulant and an opioid substitute. Kratom has been used as an herbal remedy in Thailand and other countries for centuries.

Kratom is not currently approved for medical use in the United States, but it is being used as an herbal supplement and a recreational drug.

How Does Kratom Work?

The active ingredients in Kratom, mitragynine and 7-hydroxymitragynine, bind to the opioid receptors in the brain, producing sedative, analgesic (pain relief), and euphoric effects. At low doses, Kratom produces stimulant effects, while at high doses it can produce sedative effects.

What Exactly Is Hydrocodone and How Does It Work?

Hydrocodone is an opioid agonist. Opioid drugs (like hydrocodone and oxycodone) contain opium compounds and produce effects like those of morphine, such as pain relief, drowsiness and feelings of euphoria (a “high”).

How Does Hydrocodone Work?

As an opioid receptor agonist located primarily within the central nervous system (CNS), Hydrocodone produces analgesic effects by activating mu-opioid receptors. This triggers a chemical reaction in the brain that reduces pain and boosts dopamine which provides a physical and emotional release.

Kratom vs. Hydrocodone – The Differences


As you already Know Kratom is a natural product that comes in various forms which are Kratom powder, Kratom capsules, Kratom pill, and Kratom resin/extracts. Some people also chew the raw leaves or brew the dried, powdered tea and consume it as tea while others may consume it in their food or smoke the leaves.

Hydrocodone, on the other hand, is a pharmaceutical drug available as an oral medication that comes in various forms which are capsules, pill, syrup, or elixir. Pill/Tablets and capsules containing Hydrocodone should not be crushed, chewed, or dissolved since this might result in uncontrolled rapid medication delivery and overdose.

How long does Hydrocodone and Kratom Last

Hydrocodone takes 20 to 30 minutes to work, with peak effects occurring 30 to 60 minutes after ingestion. Its pain-relieving abilities wear off after four to six hours. However, the drug may still be found urine for up to four days, in saliva for up to 36 hours, and hair for 90 days following the final pill.

Kratom, on the other hand, can cause effects that last for two hours depending on dosage. For instance, when Kratom is consumed in higher doses, its effects can last for up to eight hours. In a urinalysis, Kratom metabolites can be detected even after a week since taking Kratom for a heavy Kratom user. In blood tests, Kratom can be detected just a few hours or days after consumption, while in in hair tests it can be detected up to 90 days after ingestion.

Short and Long-Term Side Effects

Unfortunately, opioid addictions do exist and so do Kratom addictions. In the United States, opioid addiction is a serious problem. That said, there have been reports of hydrocodone overdose as well as those of Kratom overdose.

Kratom and Hydrocodone have both been shown to be addictive for humans. Short-term adverse effects may not be as serious, but long-term excessive usage of Kratom or Hydrocodone can produce serious and potentially deadly side effects. Here’s a brief rundown of the side effects of Kratom and hydrocodone.

Kratom Hydrocodone
Short-term effects



  • Lack of appetite
  • Constipation
  • Increased social behavior
  • Nausea
  • Dry mouth
  • Talkativeness
  • Sweating


Short-term effects




  • Insomnia
  • Nausea
  • Lightheadedness
  • Low blood pressure
  • Dry mouth
  • Fatigue
  • Uncontrolled  shaking
  • Back pain and muscle tightening
Adverse effects
  • Discoloration of the cheeks
  • Itching
  • Psychotic symptoms
  • Sensitivity to sunburns
  • ·Significant weight loss
Adverse effects
  • Respiratory problems
  • Liver damage
  • Sensorineural hearing loss
  • Gastroenteritis
  • Skin rush

Kratom and Hydrocodone Legality

Hydrocodone is a Prescription Opioid Painkiller. It’s against the law to purchase this medicine unless you have a prescription. After major surgical procedures, this might frequently be given by a doctor to a patient. Vicodin is one form of hydrocodone.

Kratom, on the other hand, federally legal in the U.S. Unfortunately, it’s illegal to use, possess, buy, or sell Kratom in the states of Arkansas, Alabama, Rhode Island ,Vermont, Indiana, and Wisconsin so be sure to check Kratom’s legality in your current state before you decide to order. Kratom, unlike hydrocodone, may be purchased over the internet without a prescription! It’s considerably more accessible.

Can Kratom Assist Treat Hydrocodone Addiction?

There is some anecdotal evidence that Kratom can assist in the management of opioid addiction by reducing withdrawal symptoms. Kratom has analgesic, anti-inflammatory, anxiolytic, and euphoric properties. It also relieves pain and anxiety.

These effects make it an appealing option for people addicted to opioids. And because it binds to the same brain receptors as opioids, and it can help with symptoms of opioid withdrawal.

However, unlike painkillers like Hydrocodone or opiates, Kratom activates a different class of opioid receptors. As a result, it does not produce the same euphoric high as many of these other medications.

Despite the fact that there is a lot of anecdotal evidence to suggest that Kratom might help people dealing with opioid use disorders, there is little research on the topic.

Reddit User Comments on Combining Hydrocodone and Kratom

In one subreddit a user reported that 15 mg Hydrocodone made them euphoric, while others didn’t experience any serious side effects from the drug at all when they took both together.

A discussion on another subreddit suggested using both Hydrocodone and Kratom simultaneously in safe doses helped them relieve pain faster without any noticeable side effects. Note however that this does not apply to everybody because if you have more medications into your routine this may not work- so don’t go overboard with these ideas just yet.

From the discussions on the subreddit’s, we can conclusively say that Hydrocodone and Kratom are an effective combination but only if the perfect dosage as per your body requires are used.

So, is Kratom and Hydrocodone Combination Safe?

Hydrocodone and Kratom are great for helping those in severe pain, but it’s important to be mindful of the drugs you take for your pain. Opioid medications such as Hydrocodone should only incorporated into your Kratom regimen under the recommendations of your physician and should only be used for a short period of time.

For those who are attempting to manage their chronic pain, Kratom compared to Hydrocodone, seems like a great option as it works equally as effectively while being far less addicting and hazardous. It’s also available in various forms and can be easily obtained from online stores such as Nova Kratom without a prescription. You can also mix it with other substances. Keep in mind that hydrocodone is highly advised when recovering from a medical problem such as surgery or when prescribed by your doctor.

When choosing between the two, however, remember to choose what works for you and not what we recommend. Always listen to your doctor and most importantly your body as it will tell you what it needs. You can also join a support group if you are fighting addiction to make sure you have all the help you need.