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Living With Narcolepsy: Symptoms and Misconceptions

YourUpdateTV

Confusion, stereotypes, and stigma about the sleep disorder narcolepsy persist to this day. This can lead to a long time to diagnosis and prevent people who think they have narcolepsy from reaching out to a healthcare professional to learn more. So, what is narcolepsy? Narcolepsy is a rare, chronic, debilitating neurological disorder that affects the way the brain controls sleep-wake cycles. 1,2 Narcolepsy affects approximately 165,000 Americans, with one of its main symptoms being excessive daytime sleepiness, or the inability to stay awake and alert during the day. 1 Other symptoms may include cataplexy, which is the sudden and brief loss of muscle strength or tone brought on by certain emotions or situations, sleep paralysis, vivid hallucinations when falling asleep or waking up, and disturbed nighttime sleep. 3,4 Narcolepsy is estimated to be severely underdiagnosed. 5,6 It can take an average of 10 years for people living with narcolepsy to be diagnosed after experiencing their first symptoms. 5 Narcolepsy can disrupt everyday life, 1 but the symptoms of narcolepsy aren’t always obvious, and may be inaccurately attributed to other medical conditions. 3,7 Getting to know narcolepsy means recognizing the symptoms, understanding their impact, and finding resources and support to help manage the disorder. Dr. Michael J. Thorpy, a world-renowned sleep specialist and narcolepsy expert based in New York, New York, and Jessica, a person living with narcolepsy, conducted a nationwide media tour in conjunction with Your Update TV and Harmony Biosciences to help address misconceptions, learn more about the signs and symptoms, find out what it is like to live with narcolepsy, and discover resources to help those impacted. For more information visit: WWW.KNOWNARCOLEPSY.COM and WWW.KNOWNARCOLEPSY.COM/STORIES References: 1 National Institutes of Health. Narcolepsy. U.S. Department of Health and Human Services. May 2017. 2 Narcolepsy Fact Sheet. NIH Publication No. 17-1637. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Narcolepsy-Fact-Sheet. 3 American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed.; 2014. 4 Silber MH, Krahn LE, Olson EJ, Pankratz VS. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep. 2002;25(2):197-202. 5 Overeem, Sebastiaan & Reading, Paul & Bassetti, Claudio. (2012). Narcolepsy. Sleep Medicine Clinics. 7. 263–281. 10.1016/j.jsmc.2012.03.013. 6 Carter LP, Acebo C, Kim A. Patients' journeys to a narcolepsy diagnosis: a physician survey and retrospective chart review. Postgrad Med. 2014;126(3):216-224. 7 Thorpy M, Morse AM. Reducing the clinical and socioeconomic burden of narcolepsy by earlier diagnosis and effective treatment. Sleep Med Clin. 2017;12(1):61-71. About YourUpdateTV: YourUpdateTV i s a social media video portal for organizations to share their content. It includes separate channels for Health and Wellness, Lifestyle, Media and Entertainment, Money and Finance, Social Responsibility, Sports and Technology. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

October 15, 2021 03:00 PM Eastern Daylight Time

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MCR Labs Announces First Annual “Cannabis Science Fair,” Begins Accepting Submissions

MCR Labs

Massachusetts-based cannabis testing company MCR Labs will host its inaugural “Cannabis Science Fair” at The BUild Lab IDG Capital Student Innovation Center on December 11. MCR Labs is partnering with The Cannabis Center of Excellence (CCoE) and Innovate@BU to organize the event, which is billed as “an exhibition of research and progress from the institutions working to expand our cannabis knowledge.” Groups interested in showcasing their cannabis-focused work at the science fair are invited to submit abstracts and other materials to MCR Labs via https://ma.mcrlabs.com/event/the-cannabis-science-fair. “We’re extremely excited about the potential for this event,” said Melissa Kenton, MCR Labs event and outreach coordinator. “It’s been on our radar for over a year, and we cannot wait to see what our fellow cannabis scientists and innovators are ready to share with us and the community.” Submissions for the Cannabis Science Fair will be assessed by MCR Labs and their event partners and selected for inclusion based on the soundness of methodologies, their potential scientific or industry impact and how thoroughly their findings are presented. A limited number of submissions will be selected for full presentations, poster presentations and demonstrations of any devices or prototypes. Projects chosen to be exhibited at the Cannabis Science Fair and other details about the event will be announced in November. Sponsorship opportunities are available and the event will be free to the public. Please contact MCR Labs for additional information about the event and how to join. About MCR Labs: MCR Labs is one of the longest operational cannabis testing laboratories on the East coast with facilities operating in several legal cannabis markets. We are ISO/IEC 17025:2017 accredited providers of analytical cannabis product testing and R&D services committed to assisting licensed marijuana establishments, patients, researchers, entrepreneurs, and advocates. Our team of chemists and pharmaceutical scientists are dedicated to advancing public health and safety through leading-edge chemical analysis of cannabis products and offering unparalleled guidance and support for partners, regulators, and the communities we serve. For more information visit http://mcrlabs.com. Contact Details MCR Labs Joe Crinkley +1 857-230-0839 joe@mcrlabs.com Company Website http://mcrlabs.com

October 14, 2021 02:17 PM Eastern Daylight Time

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GRYT Health and Bristol Myers Squibb Team Up to Launch Diversity in Oncology Initiative

GRYT Health

In light of the health disparities in oncology, GRYT Health (“grit”), an oncology solutions company that was started and run by cancer survivors, and Bristol Myers Squibb, have partnered to launch Diversity in Oncology, a virtual platform available at www.diversityinoncology.com to highlight and raise awareness of the health disparities in oncology facing diverse patients in the U.S. As one example of a racial disparity that exists in oncology, according to the National Institute of Health, “The invasive breast cancer age-adjusted mortality rate for black women age <40 was twice that for white women.” The Diversity in Oncology initiative will co-create a series of live, interactive sessions that bring together a multi-stakeholder audience of local and national organizations, patients and caregivers, healthcare providers, clinical trial teams and principal investigators, schools of public health and others. The goal of the initiative is to have courageous conversations about what’s currently inequitable, so that this cross-stakeholder, cross-cultural initiative can work towards structural changes in clinical trials. By bringing together diverse patients who have experienced inequities, alongside those who run trials, we will highlight current inequities and identify ways to adapt the system. The first of four live sessions will be October 27, 2021, from 4:00 – 5:30pm ET and is titled “Experience of Diverse Patients and Families in Clinical Trials.” It will feature an opening keynote from Wendy Short Bartie, senior vice president, U.S. Oncology at Bristol Myers Squibb, followed by a panel conversation moderated by Megan-Claire Chase, partnership director at GRYT Health and equity advocate. The session will include “break-out” rooms where attendees will be able to interact with the speakers to ask questions and to share their own stories and experiences in cancer clinical trials. “This initiative is about acknowledgment of the real and current issues in cancer clinical trials that need to be fixed,” said Megan-Claire Chase, partnership director at GRYT Health and moderator of the first session on the Diversity in Oncology platform. “This initiative is being developed with the voices of the underrepresented communities living these experiences, so that resources and structural change can be co-designed together.” The panel speakers in the first session will share their own personal experiences - as patients participating in clinical trials, as well as those who chose not to participate in a clinical trial. “When I participated in a clinical trial for breast cancer, the research team never showed any care or concern to my questions,” said Venus Ginés, president and founder, Día de la Mujer Latina® Inc. and speaker on the Oct. 27 session of Diversity in Oncology. “When I shared about the side effects that I was struggling with - they would say ‘I will document it on your file,’ but there was no support or follow-up care. After three months, I left the trial and upon not getting a call-back, I felt it had been a waste of my time.” Venus founded Día de la Mujer Latina® Inc. not only to educate Latinas about breast and cervical cancer, but as a result of her experience. In her work, she teaches promotores/community health workers to be more patient-centered and respectful to their constituents and patients, providing timely responses, resources, and support. Upcoming sessions, all available on the same virtual platform, will focus on topics relevant to bringing awareness to and developing solutions for healthcare inequities, including the experience of diverse physicians, principal investigators in clinical research, improving representation of diversity in clinical trials, and new models of academia and community collaboration in terms of clinical research. The virtual platform will provide resources and access to organizations and individuals advancing health equity, as well as the opportunity to participate in the live, interactive sessions to foster discussion and collaboration. To register for free access to the platform and the series, visit www.DiversityinOncology.com. All sessions will be recorded and also available on demand. Source: Breast cancer epidemiology in blacks and whites: disparities in incidence, mortality, survival rates and histology (nih.gov) GRYT Health is a digital oncology company that empowers people to be in charge of their own health through education, engagement and support. We offer a community free from judgment that focuses on humanity and the value each person brings. Our mission is to improve quality of life and increase survival for people facing cancer through the relentless focus on patient experience. We put patients first and work with healthcare organizations that do the same. We use the patient voice to enhance drug development and access; and together, we are helping to move healthcare forward. Visit www.grythealth.com or www.solutions.grythealth.com to learn more. Contact Details Lindsay Barnes +1 215-410-9982 Lindsay.Barnes@evokegroup.com Company Website https://www.grythealth.com

October 14, 2021 11:52 AM Eastern Daylight Time

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Premier Rugby Sevens Hosts Landmark Inaugural Event – Sets Sights on 2022

Premier Rugby Sevens

Premier Rugby Sevens (PR7s) officially launched their new league on Oct. 9, marking several firsts within the sports industry and rugby community. As the first U.S. sports league to launch with men and women earning equal pay, PR7s also broke gender barriers in the rugby community as the first professional women’s rugby league in North America. Supported by six league sponsors, 18 games were broadcast live in a single day via Fox Sports in the United States, TSN in Canada, and Facebook Watch around the world. “This is only the beginning,” said Owen Scannell, CEO of Premier Rugby Sevens. “What started as an idea early in the pandemic became a reality on Saturday thanks to a team of incredibly talented staff, athletes, coaches, broadcast partners, sponsors, and fans. We will reveal our 2022 plans soon and look forward to growing PR7s into a league that offers both women and men an opportunity to compete at the highest level. Thousands of fans experienced the excitement live in the stadium and thousands more consumed it live on televisions, tablets, and cell phones thanks to our partners at Fox Sports and TSN. An incredible foundation is in place and we’re ready to grow our league with more cities and events next year.” Fifteen Olympians from the 2020 Olympic Games competed in the inaugural event. With 120 total players, six men’s teams and four women’s teams debuted in Memphis. Led by rugby legend Perry Baker, the Experts won the first PR7s men’s championship. And as one of the most dominant players in the world, Alev Kelter led the Loonies to the first women’s championship. Competing in games that last 14 minutes, the two champions played four times each en route to their titles on Saturday. Full game results can be view at PRSevens.com/results. Samurai Sportswear, Kane Innovations, Inc., Sperry Rail, Inc., Campbell Clinic, Ghost River Brewing Co., and Memphis Tourism sponsored the inaugural event. The partnerships included jersey logos for Kane Innovations and Sperry Rail. Ghost River Brewing sponsored the daylong festival. PR7s features six men’s teams and four women’s teams that play multiple games in one location on a single day. Team brands include the Loonies (men and women), the Loggerheads (men and women), the Experts (men and women), the Headliners (men and women), the Locals (men), and the Team (men). The league’s first captains featured stars from both the Men’s and Women’s U.S. Olympic Rugby Sevens teams, including Perry Baker (Experts men), Danny Barrett (Team men), Abby Gustaitis, (Loggerheads women), Alev Kelter (Loonies women), Matai Leuta (Locals men), Folau Niua (Headliners men), Naya Tapper, (Headliners women), Stephen Tomasin, (Loonies men) and Kevon Williams (Loggerheads men). About Premier Rugby Sevens Premier Rugby Sevens (PR7s) is a groundbreaking professional sports league in North America that debuted on Oct. 9, 2021, on Fox Sports and TSN. PR7s is the first league of its kind with both women’s teams and men’s teams under one umbrella with equal pay. With a focus on accessibility and entertaining content for fans, the league showcases the electrifying sport of rugby sevens through a single-day touring format in cities across the United States and Canada. To learn more about Premier Rugby Sevens, go to PRSevens.com and follow the league on Twitter, Instagram, Facebook, and LinkedIn. Contact Details Eric Nemeth eric.nemeth@prsevens.com Company Website https://prsevens.com/

October 14, 2021 09:03 AM Eastern Daylight Time

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South Florida Real Estate Trends for Fall 2021

Miami Luxury Waterfront Homes

Since the start of the COVID-19 pandemic and work-from-home orders, buyers have been flocking to Miami and nearby areas in South Florida. And it's not just homeowners — companies including Microsoft, JetBlue Airways and Goldman Sachs have recently moved their headquarters to Florida. The city is also luring in Tech crowds thanks heavily to the Mayor, Francis Suarez, who has been targeting Silicon Valley. These trends have seen billionaire businesspeople make the move to Miami while the local economy has seen a boom as of late. Although it's hard to say if this particular trend will continue as COVID-19 carries on, it's not unbelievable to think that workers and businesses alike may continue to take up permanent residence in the area. When it comes to real estate, luxury homes and condos continue to be in high demand through the fall months and with listings moving fast and limited availability, average home prices have risen exceptionally in the last year. Miami recently surpassed L.A. as the most expensive housing market, coming in second only to New York City. Florida has seen a massive trend of transplants from big cities, including New York & California, where homeowners are used to paying top-dollar for real estate and higher taxes. As such, luxury properties have been flipping for record profits with some garnering nearly three times the original investment within a short span. Last month, a waterfront estate in Miami Beach was flipped for nearly a 50% gain in just 4 months. It sold for $19 million in May of 2021 and for $28.1 million in September. Flips for luxury single-family homes are becoming more common due to the low inventory of houses available for sale in South Florida. "This market is truly unique," says Samantha Joelle Elenson, a realtor with ONE Sotheby's International Realty for nearly a decade. Miami is thriving with its growing population. The local entertainment and culture scenes are expanding to accommodate the city's newest residents. "Miami is at the forefront for the place to be," Elenson says. The city saw a surge of restaurants open and supper clubs are gaining momentum. Last season, New Yorkers notoriously booked reservations in Miami's top restaurants months in advance so locals planning a night out would be wise to book ahead — something Miami locals may need to adjust to. "Our city is attracting various industries and people for different reasons," Samantha explains. "I was getting calls from out-of-state clients looking to escape to Miami for their freedom as they put it. There was also a tech wave and all of a sudden Silicon Valley was looking at Miami. After the Presidential election and proposed tax adjustments, we began seeing a migration of billion-dollar businesses relocate headquarters here along with their employees. The surge of new residents caught the attention of top hospitality groups like Major Food Group from New York, which opened the almost impossible to get into Carbone and ZZ's. The city is evolving quickly and as a result new opportunities are emerging." When it comes to real estate pricing, it's clear to see this trend continuing well into the fall of 2021 according to the data presented by Samantha's Brokerage, ONE Sotheby's International Realty, which is a leading luxury firm in South Florida. The Trends report can be viewed at https://www.onesothebysrealty.com/trends. It presents the only market report focused on Florida’s East Coast. Data is presented from a macro perspective down to a city level from Miami to Cocoa Beach. October is now well underway and although the market in neighborhoods throughout South Florida shows signs of a shift toward seasonal trends, buyer competition, particularly among domestic newcomers, is expected to continue. Pricing for single-family homes and condominiums should hold steady or see a slight decrease through the remainder of 2021. Thanks to buyer competition, in August 2021, more than 27% of homes were sold above the asking price. By comparison, February 2021 saw just 13% of the area's homes sold above asking. In August 2021, Miami-Dade County saw the highest average sales price. Single-family homes sold for an average of $995,538 — a 32% increase over the August 2020 average, while condos sold for an average of $556,225 — also a 32% increase over August 2020 numbers. "Buyers are struggling to get properties at asking with phenomenal terms," Samantha shares. The county saw more than 1,247 transactions close in August after an average of 41 days on the market. Homes in neighborhoods such as South Miami, Miami Beach, Surfside, Golden Beach and Bay Harbor had average sales prices exceeding $1 million with luxury homes Bay Harbor Islands boasting the highest average sales price at $8.625 million and homes in South Miami selling for an average of $1,184,063 — 26% more than in August 2020. Throughout Miami-Dade County, available listings have increased slightly over the past few months, with 3% more available listings in August than in July 2021, when available listings hit a record low. As the availability of homes for sale increases in South Miami and other neighborhoods throughout Miami-Dade, average sales prices are seeing a slight downward trend. However, the Miami housing market remains hot and competition among buyers is at an all-time high, meaning homes are selling fast and sellers are seeing full-price offers and bidding wars over properties. As fall progresses, it's expected that competition for luxury homes in South Miami and other sought-after communities in the area will continue. "Clients traveled this summer as countries reopened but the housing demand remained high even without their presence," she says. "I expect as the season approaches those who were unsure of an address in Miami, will return to the sunshine state where they happily found refuge last season with all of their friends." Overall, the South Florida real estate market continues to thrive in the fall of 2021. Competition is at all-time highs while average sale prices remain among the highest in the country. About Miami Luxury Waterfront Homes One of ‘America’s Best Real Estate Agents’ as ranked by REAL Trends WSJ, native Floridian Samantha Joelle Elenson specializes in waterfront luxury properties, beachfront condominiums, and upscale property developments in and around Miami and Broward County. Raised in Golden Beach, Florida, Samantha is a third-generation real estate professional who draws on more than 40 years of family real estate development and investment experience. Since joining ONE Sotheby’s International Realty in 2012, Samantha has achieved residential real estate sales totaling more than $75 million. Her goal is to connect clients with the finest real estate properties in South Florida and provide each buyer or seller with personalized customer service complemented by her exclusive network, shrewd negotiating skills, and professional expertise. Her concierge approach to her clients and unrelenting passion for real estate are hallmarks of her service. Visit https://www.miamiluxurywaterfronthomes.com/. Contact Details Miami Luxury Waterfront Homes Samantha Joelle Elenson +1 786-393-4793 selenson@onesothebysrealty.com Company Website https://www.miamiluxurywaterfronthomes.com/

October 14, 2021 08:03 AM Eastern Daylight Time

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Lensbaby Announces “Shoot Extraordinary” Photography Conference

Lensbaby

Lensbaby, the leader in award-winning creative effect camera lenses, is excited to announce its 2021 virtual photography conference taking place Dec. 7-9. Join us for the Lensbaby “Shoot Extraordinary” Photography Conference 2021 on December 7th! Click here to register and claim your free spot today. Registered conference attendees will be automatically entered to win prizes including a grand prize worth over $2500. For 16 years, Lensbaby has been an ally of the unusual, and an advocate for the unique — this three day conference will be a testament to our passion for blazing your own trail. With 16 speakers and top Lensbaby educators from around the globe, there is something for everyone. Conference attendees can expect to learn the ethos of the Lensbaby “Shoot Extraordinary” motto, while learning the nuances and uncommon qualities of its photo and video lenses. For a full list of course topics, visit our 2021 virtual photography conference page. How Do You #SHOOT EXTRAORDINARY with Lensbaby? Register for your FREE ticket to our virtual photography event where you'll have access to three days of Lensbaby and creative photography education. About Lensbaby // Lensbaby creates tools that enable photographers and videographers to find their unique visual voice. For over 16 years, they have been manufacturing high-quality creative effects lenses, optics and accessories out of their Portland, Oregon headquarters. Lensbaby sells its products on its website as well as through a worldwide network of retailers and distributors. For more information, visit www.lensbaby.com Lensbaby, “Shoot Extraordinary” ### Learn more and register for free here. For a look into what to expect, you can check out the Lensbaby 2020 Photography Conference here. Contact Details VP Sales and Marketing, Lensbaby Michael Anthony Michael@lensbaby.com PR & Marketing, M&P Digital Creative Agency Andrea Larson andrea@mcmillanphillips.com Company Website https://lensbaby.com/

October 13, 2021 11:49 AM Eastern Daylight Time

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KOAN CORDIALS ARE NOW AVAILABLE FOR DELIVERY THROUGHOUT CALIFORNIA

Resonate Blends, Inc

Koan, a Resonate Blends brand, is leading a new area of plant-based wellness with the direct-to-consumer launch of the world’s first cannabis cordials - non-alcoholic, single-dose, plant-derived liquids designed to help mindful consumers to find inspiration, restore balance, and improve the quality of their lives. By combining the wisdom of traditional, holistic wellness practices with cutting-edge science and technology, Koan has developed a brand-new way to harness the wide-ranging benefits of cannabis, utilizing various ratios of THC and CBD, along with botanical terpenes, adaptogens, and other plant extracts to deliver precise and consistent life-enhancing experiences. The six cordials - Calm, Balance, Play, Create, Delight, and Wonder – have the fast on-set of a tincture, the long duration of an edible, and the ease and social benefits of a beverage all in one single-dose bottle. Calm, for example, has a large concentration of CBD with low levels of THC ensuring a profoundly calming experience without getting you high. The low level of THC amplifies the benefits of natural plant extracts including Linalool—known to help treat anxiety, depression, and insomnia—Beta-Caryophyllene, an anti-inflammatory, and Limonene—a naturally-derived anti-depressive—to help ease stress and return to a comfortable and functional mind/body state. On the other extreme is Koan's Wonder formulation carefully crafted to support consumers in every way when their goal is to ponder the infinite. Wonder has higher levels of THC with low levels to CBD designed to help refine the powerful experience. Koan's other blends of Cordials enhance creativity, bring a feeling of enchantment, or unleash a feeling of energy, joy, and more. The full range of products is designed to help those using cannabis in an intentional way to find what they are looking for with precision, consistency, and refinement. “At Koan we’re mastering the art of experience. It’s more than science, it’s our passion - refining, amplifying, and calibrating cannabis so you can always find what you are looking for. We are deeply enmeshed in the science, we have two patents pending supporting our formulations, processes, and bioavailability to ensure that consumers get exactly what they expect, every time, from our products,” said Geoff Selzer, CEO and Founder. “We are delighted to partner with Grassdoor for our direct to home delivery ensuring that all of our customers can get our products whenever they choose in the most convenient, safe, discrete, and reliable fashion possible.” Koan is committed to demystifying cannabis and harnessing its impactful ingredients to create products that support intentional and mindful use as a core part of daily wellness—physical, spiritual, and most importantly, emotional. Through precision crafting, Koan invites a general sense of well-being, lean-in awareness and presence rather than the “check-out high” normally associated with most cannabis-based products. The single-dose cordials are artfully designed to be both portable and discrete, with fast-acting ingredients that allow a quick onset for a long-lasting experience of up to four hours. The delightful citrus and botanical notes of the cordials can be enjoyed directly out of the bottle or poured into any beverage or one of Koan’s signature cannabis cocktail recipes. Koan Cordials are now available for purchase directly at https://koan.life. Koan provides the option to order individual cordial three packs, or in themed bundles such as the Serenity Bundle, Engage Bundle, or the Experience Bundle. Koan has proudly partnered with Grassdoor, the premier direct-to-consumer e-commerce solution for cannabis brands in California, to allow consumers to shop Koan’s portfolio of Cordials with same-day delivery across Southern California (including Los Angeles and San Diego) and Northern California (including San Francisco, San Jose, and Oakland). Grassdoor is one of the largest end-to-end delivery solutions in cannabis, providing same-day delivery to 75% of the population of California. ABOUT RESONATE BLENDS, INC. Resonate Blends, Inc. (OTCQB:KOAN) develops Koan Cordials, meticulously formulated blends of THC, CBD, Terpenes, and Botanicals that provide a refined cannabis experience. Unlike strain-based or full-spectrum products, Koan Cordials are scientifically crafted to highlight specific cannabis characteristics, with predictable experiences and intensity allowing people to tap into specific feelings in a new, better way. ABOUT GRASSDOOR Grassdoor is the premier delivery marketplace and direct-to-consumer ecommerce platform in cannabis, providing customers same-day delivery of top brands in 45 minutes or less throughout California, including Los Angeles, Orange County, San Diego, Ventura, San Francisco, San Jose, Oakland, and more. In addition to being the fastest licensed delivery service in the state, Grassdoor aims to be the safest, friendliest, and most reliable cannabis delivery solution worldwide. This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended. Examples of forward-looking statements include, among others, statements we make regarding guidance relating to net income; anticipated customer onboardings; and expected operating results, such as revenue growth and earnings. All forward-looking statements are inherently uncertain as they are based on current expectations and assumptions concerning future events or future performance of the Company. Readers are cautioned not to place undue reliance on these forward-looking statements, which are only predictions and speak only as of the date hereof. In evaluating such statements, prospective investors should review carefully various risks and uncertainties identified in this release and matters set out in the Company's SEC filings. These risks and uncertainties could cause the Company's actual results to differ materially from those indicated in the forward-looking statements. Contact Details BPCM Katie Bell +1 323-655-5541 koancordials@bpcm.com Company Website https://www.resonateblends.com

October 13, 2021 08:03 AM Pacific Daylight Time

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Global Energy Leader Chevron Shipping joins NAMEPA, Demonstrating its Dedication to Save Our Seas.

North American Marine Environment Protection Association

Carleen Lyden Walker, Co-Founder and Executive Director of the North American Marine Environment Protection Association (NAMEPA), announced that Chevron Shipping has joined NAMEPA as its newest corporate member. NAMEPA is proud to be partnering with Chevron Shipping in making strides to Save Our Seas and towards a cleaner future. “We are delighted that our discussions with Chevron Shipping have resulted in their decision to join NAMEPA’s efforts towards sustainability,” stated Ms. Walker. NAMEPA’s mission of preserving the marine environment and promoting sustainable marine industry best practices is aligned with Chevron Shipping’s goals. “Protecting people and the environment has always been a core value of Chevron Shipping. We are pleased to join NAMEPA and its likeminded members striving for a safer, ever-cleaner environment and marine industry,” said Mark Ross, President of Chevron Shipping. NAMEPA proudly welcomes Chevron Shipping to its global and diverse network of individuals and companies in a new partnership that will help progress towards a greener future. About Chevron Shipping: Chevron Shipping Company LLC is a wholly owned subsidiary of Chevron U.S.A. Inc. (NYSE: CVX). Chevron’s fleet has provided a vital link between our operations and the marketplace for more than 125 years. Today, Chevron Shipping Company is an industry leader in safely and reliably transporting crude oil, liquefied natural gas (LNG) and refined products that power the world. Learn more. The North American Marine Environment Protection Association (NAMEPA) is a marine industry-led organization of environmental stewards preserving the marine environment by promoting sustainable marine industry best practices and educating seafarers, students and the public about the need and strategies for protecting global ocean, lake and river resources. Visit us at: www.namepa.net Contact Details NAMEPA Carleen Lyden Walker +1 203-255-4686 executivedirector@namepa.net Company Website https://namepa.net/

October 13, 2021 10:26 AM Eastern Daylight Time

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Holland & Barrett backs Floe Oral Care to tackle gum disease via salivary biomarkers

Floe Oral Care

Floe Oral Care, the oral healthcare business dedicated to improving oral and systemic health by means of a direct-to-consumer subscription, has secured £350k from a group of high profile investors including Holland & Barrett, Lord Mervyn Davies, Tim Farazmand, Professor John Deanfield CBE, Sir Nigel Rudd, and Julio Bruno. Existing shareholders Stephen Welton, Dr. Jose Navarro, and Charles Southey are also following on. Founded by Anglo-Spanish duo Will Welton and Javier Navarro, Floe is an online subscription service on a mission to address the UK’s ‘dental care timebomb’ by building a preventative routine for consumers and providing vital insights into undetected gum disease. Will Welton, Co-founder at Floe Oral Care said: “If your mouth is the gateway to your body, then protecting it requires not only using the right products but also visibility of what condition your gums are in. The impact of gum disease is significant, and the prevalence of periodontitis has barely changed over the last 20 years. Our mission is to build a service that both tracks and improves oral and systemic health. We want to encourage a pro-active relationship with dental care by capturing and contextualising oral health data, and are thrilled to be bringing on board a fantastic group of investors from business and healthcare as well as an excellent and highly relevant corporate partner. This is a great platform for the next stage of our development” Periodontitis is now the sixth most prevalent disease in the world, and according to research led by The Economist Intelligence Unit (IEU), costs the UK £6.4bn a year in treatment. Nearly half the adults in the UK have some form of periodontal disease, which has increasingly been shown to raise the risk of serious health conditions including cardiovascular disease and diabetes. Its awareness has remained low however amongst the general public and other health professionals - it’s often referred to as a silent killer - with the study showing that three out of four adults with periodontitis do not know they have the condition at all. Tamara Rajah MBE, Chief Business & Science Officer, Holland and Barrett: “H&B are committed to making health and wellness a way of life for everyone, and to supporting early-stage innovation in wellness as part of our strategy. Recognising that effective oral health management can disproportionately impact an individual’s overall health and wellness, coupled with our interest about the potential of diagnostics, makes Floe very exciting for us. We look forward to working with Will, Javier and the team at Floe to optimise the way we manage our oral health and improve lives.” Floe is building a data driven approach, designed to cast light on untreated periodontitis and put the right measures in place to improve it. The service will track gum health via proprietary at home saliva testing whilst delivering essential products to support your oral health. Floe launched their core dental kit in August 2020, delivering their own unique toothpaste formulations (Dusk and Dawn), an ultra-soft toothbrush, and charcoal dental floss, delivered every three months to improve preventative habits in a more sustainable way. The products are all built with the environment in mind, including a free-returns service collecting used products for specialist recycling when subscribers' new boxes arrive. Julio Bruno, CEO of Time Out Group plc, will be joining the board as a Non-Executive Director whilst Stephen Welton, founder and Executive Chairman of BGF, the UK’s largest growth capital investor, will remain as the Chairman. Professor John Deanfield CBE joins Floe as Chief Medical Officer, to put together a world leading Advisory Board to inform the strategy of the saliva testing and future healthcare products. Professor Deanfield is one of the leading cardiologists in the UK and has published several papers on the linkage between oral and systemic health. Professor John Deanfield CBE commented: “We now understand the big impact oral health can have on important diseases in the rest of the body. This underpins a new opportunity to benefit from a change in approach to oral health – I am excited to be joining Floe to help address this.” About Floe Oral Care Floe Oral Care is a subscription service providing core dental products/ services on a quarterly basis with a closed loop recycling process to ensure that plastic doesn’t end up in the ocean. It was co-founded by William Welton and Javier Navarro to deliver technology enabled dental healthcare solutions whilst protecting the planet’s environment. Javier comes from a family of dentists and spent the first part of his career in banking. Will’s background is in consumer goods with commercial roles within the drinks industry and e-commerce. For careers please get in touch via CV and covering letter to hello@getfloe.com. About Holland & Barrett Holland & Barrett is the UK’s leading wellness retailer* and one of the largest in Europe. We make health and wellness and way of life for everyone, with a leading range of own brand, innovative vitamins, supplements, specialist food, sports nutrition and ethical beauty brands. Established in 1870, Holland & Barrett has been trusted for wellness for over 150 years and is owned by the Letter One Retail Group (L1 Retail). Holland & Barrett has a retail presence of more than 1000 stores across 16 countries worldwide, including over 800 in the UK and Ireland**, as well as a rapidly expanding e-commerce business. Holland & Barrett’s colleagues are “qualified to advise” with in depth training in nutrition and supplements to give accessible personalised advice to customers on their individual needs. *Kantar Brand Tracking – health and wellness retailers March 2021 ** up to 30 September 2020. Contact Details Floe Oral Care Bilal Mahmood +44 7714 007257 bilal@getfloe.com Company Website https://getfloe.com/

October 13, 2021 08:00 AM Eastern Daylight Time

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