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Kuros Biosciences "doing extremely well" in innovative spinal fusion treatments

Kuros Biosciences

Kuros Biosciences (SIX:KURN) CEO Joost de Bruijn speaks to Thomas Warner from Proactive about the innovative work the spinal fusion biologics-focused company has been focused on recently and looks ahead to what investors can expect from it in the future. Kuros Biosciences is headquartered in Switzerland with locations across the Netherlands and the USA, and specialises in autologous biologics aimed at regenerating bone tissue, with a specific focus on spinal fusions. Its flagship and first commercial product MagnetOs, is a unique synthetic bone graft that de Bruijn explains stands out for its unique surface topography that stimulates bone formation post-implantation, thereby setting it apart from other synthetic alternatives. De Bruijn also a product still in development called Fibrin PTH, a pharma-derived treatment designed to stimulate bone formation through gradual release of parathyroid hormone, offering a novel approach to addressing spinal issues and potential opening up a lucrative new market. He goes on to give a summary of the company's half-year results highlighting strong revenue growth in the US and reveals an ambitious five-year growth target. Contact Details Proactive UK Ltd Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

August 11, 2023 11:34 AM Eastern Daylight Time

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Xeris Biopharma CEO unveils record quarterly revenue, underpinned by unique business model

Xeris Biopharma Holdings

Xeris Biopharma chairman and CEO Paul Edick joined Proactive's Stephen Gunnion with details of the company's second-quarter performance, which saw record revenue driven by the success of their products, including Gvoke, Keveyis, and Recorlev. For the quarter, which ended on June 30, 2023, the company achieved sales of $38 million, up 50% year-over-year and 14% sequentially. Edick noted that Xeris' unique business model includes three pillars: a thriving commercial business, technology for in-house product development, and partnerships to enhance others' drugs. This diversified approach provides the company with strategic flexibility and options for growth. He also expressed confidence in achieving cash flow breakeven by the fourth quarter and emphasized the company's sustainability without the need for additional public equity sales. Regarding the pipeline program for Xerisol levothyroxine, Edick said Xeris is enrolling in the phase two study. The data collected will shape the phase three trial and regulatory negotiations with the US Food and Drug Administration (FDA). Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

August 10, 2023 11:59 AM Eastern Daylight Time

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Premium Amanita Muscaria Mushroom Gummies Launched by Exhale Wellness

Blue Ribbon Media

Exhale Wellness, a premiere-rated, all-natural hemp brand, becomes the newest addition to the thriving US psychedelics market with its proud range of mystical mushroom gummies. These spellbinding Amanita Muscaria Mushroom Gummies redefine the landscape for psychoactive gummies with 500mg of pure potency, creating a new benchmark for individuals seeking an escape to their happy place. Crafted using pure Amanita mushrooms without any additives or artificial flavoring, these gummies embody a potent, mystical experience with cruelty-free lab certification testifying to its safety. If you're a gummy connoisseur looking to try trend-breaking new launches, this is your sign to get to know Amanita Muscaria Mushroom gummies well. Understanding The Mystical Amanita Gummies & Its Effects Amanita Muscaria Mushrooms are the easiest to recognize. If you've ever encountered soft, white mushrooms with red polka-dotted tops, know these mushrooms can take you on a mind-expanding, marvelous journey. This mushroom's blend of psychoactive alkaloids is particularly responsible for the mystical experience. Among these, the two alkaloid blends that stand out for their prominent psychoactive personalities are muscarine & ibotenic acid. What makes these psychoactive mushrooms different than other psychedelics is their interaction with various receptors, encouraging mild hallucinogenic properties when taken in a high quantity. Unlocking the wonders with Exhale Wellness Amanita Mushroom Gummies If you're looking for a calming, elevating escape in the form of a wholesome treat, the Amanita mushroom gummies could be your go-to munchie destination. These gummies are crafted using all-natural ingredients along with 5mg of Muscimol and 500mg of Amanita muscaria mushroom fruiting body extract. Amanita mushrooms are less powerful than psilocybin, better known as 'magic' mushrooms, and won't cause a steep feeling of intoxication if used responsibly. However, the effects majorly depend on the quantity and compatibility of the user. For new users, 1/2 a gummy would be the best way to start their mushroom gummy journey. If the craving for a better, more elevated experience persists, users can use the other half of the gummy after 2-3 hours to continue their mystical adventure. Where Do Amanita Mushroom Gummies Stand Legally? Amanita Muscaria Mushroom gummies lack the crude potency 'magic' mushrooms or psilocybin contains, and hence, do not fall under the Controlled Substances list. In the US, Louisiana is currently the only state that has imposed limitations on the distribution and sales of Amanita extract and related products. Safety and Thrills Rolled Into One With Exhale Wellness Amanita Mushroom Gummies The market for psychoactive on-the-go treats is ballooning with each passing day, and mushroom gummies are at the top of the trend list, which means newer variations and more refined experiences are on the horizon. New launches like Exhale Wellness' Amanita Muscaria Mushroom gummies are further propelling the expansion and popularity of these fun-sized treats. However, stringent protocols for quality and safety testing are one of the driving factors that distinguish prominent brands like these from others. About Exhale Wellness Exhale Wellness is an all-natural hemp brand highly regarded for its premium-quality hemp. Sustainably sourced from the finest farms in Colorado, Exhale Wellness is known for its extensive line of Delta-8, Delta-9, Delta-10, THC, HHC, and CBD products, with their newest introduction being Amanita Muscaria Mushroom gummies. All products sourced, manufactured, and advertised are USA-made and safety certified through stringent third-party lab tests to ensure the purity and potency of all products. Contact Details Exhale Wellness Support at Exhale Wellness +1 323-448-3810 support@exhalewell.com Company Website https://www.exhalewell.com/

August 10, 2023 07:14 AM Eastern Daylight Time

Roquefort Therapeutics making headway with siRNA

Roquefort Therapeutics PLC

Roquefort Therapeutics PLC (LSE:ROQ, OTCQB:ROQAF) chief executive Ajan Reginald speaks to Thomas Warner from Proactive after announcing the successful development of new small interfering RNA (siRNA) sequences. Reginald says that siRNA holds immense potential as a cancer treatment, explaining that SiRNA binds to and blocks specific RNA, stopping the production of cancer-fueling substances and ultimately killing cancer cells. He suggests that the technology has been gaining traction since it received the Nobel Prize in 2006, and that Big Pharma is now actively seeking partnerships in the siRNA field. Reginald goes on to say that for Roquefort Therapeutics, the significance of their recent developments lies in their early innovation and focus on STAT6, a key target in their research. The company acquired R&D company Oncogeni last year before STAT6 gained widespread recognition, giving them what he considers a competitive edge in intellectual property and development. He goes on to give a brief overview of the projects Roquefort is currently focused on, concluding by saying that "we're always trying to find new targets... if we can be first to find a new target, that's when shareholders will see very large deals." Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

August 09, 2023 07:48 AM Eastern Daylight Time

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Navis Clinical Laboratories Joins Nashville Area Health Services Community With Grand Opening of New Headquarters

Navis Clinical Laboratories

Navis Clinical Laboratories ( navisclinical.com ), a leading provider of laboratory services that is making groundbreaking strides in health care solutions for substance use disorder and other disease states, celebrated its official grand opening with a ribbon cutting ceremony at its new corporate headquarters located in the Greater Nashville area city of Franklin, Tenn. Focused on innovative, cutting-edge research and development, Navis provides laboratory drug testing solutions and molecular and clinical blood testing for healthcare providers to aid in the diagnosis, treatment, management and prevention of substance use disorder, mental health conditions, chronic pain, and common comorbid acute and chronic diseases, including HIV/AIDS, hepatitis, sexually transmitted infections (STIs), urinary tract infections (UTIs), respiratory infections and antibiotic resistant infections. President and CEO Richard Stripp, Ph.D., who was joined by Navis leadership, employees, friends and family, shared his excitement about Navis’ future. “We’re delighted to be in Nashville, the health services capital of the U.S., and to have the opportunity to bring business and jobs to the area. We have a very aggressive growth strategy, and this is just the beginning for us. We have a national footprint serving clients nationwide, and this move will help facilitate our evolution into a one-stop shop for our clients and allow us to deliver services to patients who really need our help.” Lori Odom, Senior Vice President of Economic Development, Nashville Area Chamber of Commerce, opened the ceremony with a warm welcome to Navis, which joins the area’s robust and diverse health care community of more than 500 health care companies, making it the largest industry in the region. “Nashville is known as Music City, but it is also Healthcare City. Our mission is to create economic prosperity by facilitating leadership and partnership with companies, and Navis is a great example of what that can accomplish,” said Odom. “At Navis, we understand that behind everything we do is a human being whose life is directly impacted by the services we provide,” said Dr. Stripp. “Many patients we serve have complex health conditions. Navigating the healthcare system to find care that treats the whole patient rather than just a single illness is often a challenge. We advocate for those patients by developing solutions that empower healthcare providers to provide exceptional care, improve outcomes and save lives.” Navis launched in February of this year and currently owns three state-of-the-art laboratories located in New York, Washington and Massachusetts, allowing it to provide services nationally to healthcare practices. Dr. Stripp originally founded the New York laboratory location as American Forensic Toxicology Services. About Navis Clinical Laboratories Navis Clinical Laboratories ( navisclinical.com ) believes in advocating for those who can’t advocate for themselves, helping them navigate through challenging times. Focused on innovative, cutting-edge research and development to aid in the diagnosis, treatment, management and prevention of disease, Navis provides toxicology, clinical blood and molecular testing for healthcare providers to help reduce suffering and save the lives of people with substance use disorder, mental health conditions, chronic pain and other acute and chronic diseases. Contact Details Kim Kudasik kkudasik@navisclinical.com

August 08, 2023 06:00 AM Central Daylight Time

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Therma Bright CEO says permanent insurance codes for Venowave could be a game changer

Therma Bright Inc

Therma Bright Inc CEO Rob Fia discusses the imminent decision on permanent codes for Venowave, its compact, lightweight deep vein thrombosis (DVT) prevention device, with Proactive's Stephen Gunnion. Fia said the importance of securing these codes from the Centers for Medicare and Medicaid Services (CMS) lies in easier reimbursement processes, streamlining billing, and facilitating distribution. Venowave is a groundbreaking compression device that actively moves blood from the calf to the heart, FDA-approved for preventing blood clots and addressing issues like deep vein thrombosis, chronic venous insufficiency, and varicose veins. Unlike pneumatic devices in the market, Venowave employs waveform technology, setting it apart. Fia highlighted the potential market size, estimated at over a billion dollars, and the significant advantage of holding the first permanent code for a compression device. The CEO also elaborated on the expanding US distribution network, including partnerships with a Medicare Advantage healthcare provider and Texas-based doctors' groups. These partnerships offer direct engagement with payers, facilitating billing and reimbursement. Moreover, Therma Bright is also finalizing agreements with a distributor in Connecticut. The anticipated outcome of securing permanent codes for Venowave could revolutionize the industry, simplifying processes and enhancing market reach, Fia said. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

August 07, 2023 01:54 PM Eastern Daylight Time

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Avricore Health's HealthTab expands globally with UK feasibility study

Avricore Health

Avricore Health CEO Hector Bremner tells Proactive's Stephen Gunnion that HealthTab has been selected for a UK-based feasibility study, marking an important international expansion. Avricore Health has achieved success in Canada with HealthTab, the company's leading pharmacy-based platform for testing and health data management. Now, in partnership with Barts Hart Centre and HEART UK, the platform will be used to support NHS England's efforts to enhance community pharmacy-driven care for cardiovascular disease. The success of the NHS's Health Check program, which conducted over a million opportunistic blood pressure checks, revealed the need for advanced screening methods. Bremner emphasized the increasing role of community pharmacies in global healthcare systems, offering on-demand care beyond emergency rooms. The feasibility study will initially focus on five locations in London, with plans to rapidly scale up to 50 and beyond. Avricore Health envisions HealthTab as a global solution, with consistent demand across markets, and the UK's supportive pharmacy infrastructure and population size make it an ideal starting point. Bremner expressed optimism about HealthTab's potential to revolutionize healthcare delivery internationally. Contact Details Proactive Studio +1 347-449-0879 na-editorial@proactiveinvestors.com

August 07, 2023 01:37 PM Eastern Daylight Time

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Immunic CEO says Q2 results "couldn't be better"

Immunic Inc

Immunic Inc (NASDAQ:IMUX) president and CEO Dr Daniel Vitt speaks to Thomas Warner from Proactive following the release of the Munich-based biotechnology company's second-quarter financial results and a corporate update. Dr. Vitt says that the performance of the business during Q2 "couldn't have been better", highlighting what he calls "scientifically a very good quarter and uneventful on the more general financial side." He goes on to give more detail about the progress achieved with Immunic's prospective multiple sclerosis (MS) and celiac disease treatments during the quarter, noting the preclinical data for its most advanced molecule IMU-838 that was published in the Journal of Medicinal Chemistry and positive results From Phase 1b Clinical Trial of IMU-856 in celiac disease. Looking to the future, Dr. Vitt expects more trial data to be released in the fall of this year, and reiterates that the company is fully funded into Q4 of 2024. Contact Details Proactive United States +1 347-449-0879 action@proactiveinvestors.com

August 07, 2023 09:50 AM Eastern Daylight Time

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HKBU unveils treatment potential of herbal extract compound isoliquiritigenin for pancreatic cancer

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 7 August 2023 - A research led by scientists of Hong Kong Baptist University (HKBU) found that isoliquiritigenin (ISL), a flavonoid isolated from the Chinese herbal medicine licorice, can inhibit pancreatic cancer progression. It may also enhance the efficacy of conventional chemotherapeutic drugs in treating pancreatic cancer. It is the first time that a research group reported the anticancer potential of ISL in treating pancreatic cancer. The research findings have been published in the international academic journal Phytomedicine and recently presented in the Annual Congress of the European Association for Cancer Research 2023 in Torino, Italy. Pancreatic cancer as the "silent killer" Pancreatic cancer is often called the "silent killer" as most patients experience little or no symptoms until it has advanced and spread. According to the Global Cancer Statistics 2020 released by the International Agency for Research on Cancer, the mortality-to-incidence ratio of pancreatic cancer is greater than 93%. It is the fourth leading cause of cancer deaths in Hong Kong. Whipple (pancreaticoduodenectomy) operation is the only available curative treatment of pancreatic cancer. However, only 20% of patients are suitable for resection and the recurrence rate is high. In non-resectable cases and metastatic pancreatic cancer patients, the chemotherapeutic drug gemcitabine (GEM) remains the mainstream treatment. Nevertheless, GEM-based combination therapy exhibits profound chemoresistance with serious systemic toxicity. Gancao extract identified as anticancer agent In the search for alternative treatments for pancreatic cancer, a research team led by Dr Joshua Ko Ka-Shun, Associate Professor, Teaching and Research Division of the School of Chinese Medicine at HKBU, screened all the potential pancreatic cancer disease markers and the biological therapeutic activities of phytochemicals from the medicinal plant Glycyrrhiza glabra (licorice, or Gancao in Chinese) using network pharmacology. Network pharmacology is an emerging discipline which systematically catalogue the molecular interactions of a drug molecule in a living cell using complex computations, and has become an important tool in botanical drug discovery. Using this approach, the team identified ISL as a potential anticancer agent for the treatment of pancreatic cancer. With a series of cell experiments, the team demonstrated that ISL suppressed the growth and induced apoptosis (programmed cell death) of pancreatic cancer cells. In two human pancreatic cancer cell lines applied with 12.5 μM and 25 μM concentrations of ISL respectively, their cell survival rates were about 50% and 80% lower than the control cells with no ISL applied. The percentage of late stage apoptosis in the two cell lines was 11% and 13% respectively, compared to less than 5% in the control cells. Inhibits cancer progression with fewer side effects "ISL possesses a unique property of inhibiting pancreatic cancer progression through the blockade of autophagy, which is a natural process where the body's cells clean out damaged or unnecessary components. The blockade of late-stage autophagy in our experiments results in cancer cell death," said Dr Ko. The research team further employed a mice tumor model to investigate the efficacy of ISL in inhibiting pancreatic cancer cell growth in vivo. The mice were divided into three groups with GEM (GEM group), ISL (ISL group) and no treatment agent (control group) applied. The ISL group was further divided into two sub-groups treated with 30mg/kg and 60mg/kg of ISL. On the 21st day of the experiment, the tumor volumes of the control group and the GEM group were1000 mm3 and 400 mm3 respectively. The tumor volumes of the two ISL sub-groups treated with 30mg/kg and 60mg/kg of ISL were about 500 mm3 and 300 mm3 respectively. The results showed that ISL demonstrated treatment effects comparable to that of GEM. Meanwhile, compared with GEM, ISL showed fewer side effects in mice including neutropenia (drop in white blood cell count), anemia and body weight loss. Enhances effects of chemotherapies Current first-line chemotherapeutic drugs for pancreatic cancer, such as GEM and 5-fluorouracil (5-FU), are frequently associated with chemoresistance. It is because these drugs induce autophagy which favours the growth of cancer cells, and thus jeopardises their treatment effects. To explore ISL's potential in counteracting the chemoresistance of GEM and 5-FU, the research team set up experiments with pancreatic cancer cells treated with GEM or 5-FU alone, and GEM or 5-FU together with ISL. The growth inhibition rate of pancreatic cancer cells applied with GEM and ISL together is 18% higher than using GEM only, while the growth inhibition rate using 5-FU and ISL together is 30% higher than 5-FU only. The results showed that ISL can enhance the treatment effects of chemotherapeutic drugs by blocking autophagy, which is conducive to the death of cancer cells. "The findings in this study open a new avenue for developing ISL as a novel autophagy inhibitor in the treatment of pancreatic cancer. We hope to collaborate with other research partners to further evaluate the effectiveness and potential clinical application of ISL in treating pancreatic cancer," said Dr Ko. Contact Details Communication and Public Relations Office Christina Wu christinawu@hkbu.edu.hk

August 07, 2023 09:00 AM Eastern Daylight Time

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