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Willow Bioscience eyes another use for BioOxi platform with R&D of ursodeoxycholic acid

Willow Biosciences Inc.

Willow Bioscience CEO Dr Chris Savile joined Steve Darling from Proactive to announce some significant developments within the company. Willow Bioscience specializes in the production of ursodeoxycholic acid (UDCA), a vital pharmaceutical ingredient with extensive applications in nutraceutical and pharmaceutical products. UDCA is notably used in the management and treatment of cholestatic liver diseases and gallstone conditions. Moreover, it serves as a crucial intermediate compound for tauroursodeoxycholic acid (TUDCA), an essential active pharmaceutical ingredient in a recently approved combination therapy for the treatment of ALS in Canada and the United States. In partnership with Sandhill One, LLC, Willow has successfully completed research and development on its UDCA program. This collaborative initiative enabled Willow to optimize a proprietary enzyme necessary for UDCA development. Of particular significance is the achievement of selective C-H hydroxylation at an industrial scale, often regarded as a challenging feat in the field of chemistry. Dr Savile's announcement also extended to the financial front. Willow Bioscience is initiating an offering of convertible debenture units in a non-brokered private placement to raise approximately $1.2 million. Notably, insiders, including members of the Board of Directors and senior management, are expected to subscribe to approximately 50% of the total funds raised. This underscores the strong commitment and confidence that the company's leadership has in Willow's vision and future prospects. These developments indicate that Willow Bioscience is making significant strides in its mission to advance pharmaceutical research and contribute to the development of innovative therapies and treatment options. With a focus on expanding its product portfolio and securing essential funding, the company is poised to play a pivotal role in the pharmaceutical and nutraceutical industries. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

September 12, 2023 01:39 PM Eastern Daylight Time

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Itaconix targeting "very aggressive growth" during remainder of 2023

Itaconix PLC

Itaconix PLC (LSE:ITX, OTCQB:ITXXF) CEO John Shaw speaks to Thomas Warner from Proactive London after the sustainable plant-based polymer company announced its unaudited interim results for the six months ended 30 June 2023. Shaw gives an overview of the interims, highlighting the achievement of $4 million in revenues, marking their fifth consecutive record. Gross profit margins also increased, and he says the company boasts ample cash reserves for future growth initiatives. Shaw emphasises the significance of growth within their existing customer base, underscoring their commitment to providing a competitive edge through specialty ingredients. Board changes during the reporting period include the addition of seasoned CFO Paul LeBlanc and the appointment of Dr. Peter Nieuwenhuizen as permanent chair. Looking ahead, he says Itaconix aims to secure more consumer brands, with a focus on smaller accounts for sustained revenue growth. Recent fundraising efforts position the company to pursue larger ventures, particularly in the Velafresh and plant-based super absorbent sectors. Shaw anticipates aggressive growth for the remainder of the calendar year, emphasising increased profitability and resources for major new initiatives. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

September 12, 2023 09:51 AM Eastern Daylight Time

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Doceree launches The NEXT Marketing Lab – a data innovation opportunity for pharma marketers – at Digital Pharma East 2023

Doceree Inc

Doceree, a global platform building unprecedented solutions for HCP programmatic marketing with proprietary data tools, today announced yet another pathbreaking measure for the life sciences industry, The NEXT Marketing Lab. The innovation lab dedicates itself to addressing one of the most pressing challenges in the pharmaceutical sector: data intricacies, especially rigid data silos, that hinder commercial team collaboration, informed decision-making, next-gen research and clinical transformation. Curated for Doceree clients, who will gain exclusive access to the solution, The NEXT Marketing Lab will use proprietary cross-functional collaboration methodologies to identify tailored, next generation data strategies and solutions that maximize outcomes. As a well-known global pharma tech company built around proprietary technology and data tools, Doceree aims to revolutionize data solutions that marketing, sales and access teams can use to plan, deliver, and scale HCP communications backed by timely actionable insights. “The pharma landscape has evolved drastically with the industry waking up to the new reality of digital and incorporating the same into its fold to target HCPs across online platforms. The new scenario is a lot different from how data was traditionally collected in a controlled manner. The digital push has led to innumerable, vast and unstructured HCP datasets that are difficult to exploit for valuable insights that can drive key business decisions to make HCP communications more effective in terms of precision, timing and relevancy,” said Harshit Jain MD, Founder & Global CEO, Doceree. “We are guided by the vision of transforming the pharma messaging landscape. It is with this intent we have launched our latest initiative to break big data silos and bring value to pharma marketing by structuring scattered datapoints. As opposed to how unreal big data in the pharma sector may have looked, it is now a reality the industry can’t escape, and its potential can’t be ignored. The lab will greatly facilitate marketers to use and share data with ease and work with HCP datasets holistically to enhance internal and external collaborations to support innovation. This is the kind of value creation we aim to make for our partners as we assist them in their business growth.” Backed by a team of experts with extensive experience in pharmaceutical marketing, medical, consulting, data science, and technology, Doceree will engage with life sciences companies to explore and customize data strategies and solutions that align to their unique needs. The NEXT Marketing Lab collaborations can be tailored to tackle diverse challenges, such as cross-functional insight sharing, reliable HCP behavior modeling, physician-level personalization and compliant RWD integration. Cross-functional collaboration executed within a well-designed process is key to unlocking change. The NEXT Marketing Lab will use Doceree’s proprietary 4D™ methodology to: Decipher the most pressing commercial challenges impacted by data limitations. Decode relevant and viable data solutions. Decide what to prioritize based on impact and feasibility. Deliver a phased roadmap to achieve goals. “Doceree’s The NEXT Marketing Lab is designed to help marketers not only explore transformational data opportunities, but also to cross the chasm between innovative ideas and impactful market solutions,” said Kate Miller, Executive Vice President of Strategy at Doceree. “At Doceree, our mission is to push how data and technology can enhance the digital experience for the benefit of healthcare providers and their patients. The NEXT Marketing Lab is a significant milestone in fulfilling this vision.” For inquiries about Doceree’s The NEXT Marketing Lab, please contact partner@doceree.com Doceree is a global platform building unprecedented solutions for healthcare professional (HCP) programmatic messaging with proprietary data tools. It facilitates messaging between life sciences brands and HCPs through an extensive global network of digital endemic and point-of-care platforms to programmatically deliver personalized communications to HCPs and transparent marketing campaign metrics at scale. To learn more, visit doceree.com. Contact Details Priyanka Bhasin +91 78387 03702 priyanka.bhasin@doceree.com Company Website https://doceree.com/us/

September 12, 2023 07:42 AM Eastern Daylight Time

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Unleashing Pet Industry Trends to Keep Your Furry Friend Healthy, Happy & Pampered

YourUpdateTV

A video accompanying this announcement is available at: https://youtu.be/Z2YHiW3ehKw Pets are undeniably cherished members of our families and ensuring their happiness, health and comfort is a top priority. In today's world, our furry, feathered, and scaly companions live the good life alongside us, and we strive to provide them with the very best—from their favorite treats to specialized diets, stylish collars, interactive toys and even high-tech gadgets. But what's the next big thing for your beloved pet? That's where SUPERZOO comes in, the pet industry's premier retail event that sets the stage for the latest trends and groundbreaking new products ready to elevate your pet's lifestyle to new heights! With pet spending on the rise, the range of trending products is ever-expanding—from pet health solutions and grooming tools to groundbreaking advancements featuring automation and artificial intelligence, the possibilities to enhance your pet's life are endless. A nationwide media tour was conducted to discuss these topics and more live from the Mandalay Bay Convention Center in Las Vegas, where SUPERZOO took center stage. Organized by the World Pet Association, SUPERZOO is the pet industry’s largest and most comprehensive pet retail event in North America. Topics that were discussed during the media tour included: The latest pet product news and industry insights live from SUPERZOO Pet products that will be hitting retail shelves later this year How technology is taking pet care to the next level What’s next in pet health and wellness trends, including unique foods and diets, specialized supplements, creative habitats and more For more information, visit www.SUPERZOO.org Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

September 11, 2023 02:15 PM Eastern Daylight Time

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Tissue Regenix Group says "disciplined approach" paying off at half-year stage

Tissue Regenix Group PLC

Tissue Regenix Group PLC (AIM:TRX) chief executive Danny Lee and chief financial officer David Cocke speak to Thomas Warner from Proactive London after the regenerative medicine company released its interim results for the first six months of 2023. Cocke reports that the company reported a remarkable 19% growth, marking the sixth consecutive period of growth since the pandemic's onset. Their BioRinse and T-cell segments demonstrated substantial growth, with the former up by 20% and the latter by 29%. Gross profit increased to 49%, owing to efficiency gains from their Phase One expansion. He suggests that the company's growth strategy, driven by a "disciplined approach" to supply, sales revenue, sustainability, and scale, has been fundamental to their success. Lee also discusses the launch of a new product under the BioRinse brand, focused on producing safe, sterile tissue for sports medicine applications in the lucrative US market, estimated at approximately $300 million. The new product will primarily be used for tendon and ligament repairs in joints like the knee, ankle and elbow. Looking ahead, the company remains committed to continued growth, both in their core business and expansion into new markets, such as the United States. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

September 05, 2023 08:37 AM Eastern Daylight Time

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Avricore Health CEO feels company is set up for success with new partnerships and emerging markets

Avricore Health

Avricore Health CEO Hector Bremner discussed the company's significant growth, partnerships, and expansion into new markets during an interview with Steve Darling from Proactive. Bremner shared how these developments position Avricore Health for future success, with a strong focus on the company's flagship product, HealthTab. Bremner emphasized that the core of Avricore Health's operations centers around HealthTab, an innovative health monitoring solution. The company is working on expanding the reach of HealthTab by partnering with more pharmacies not only across Canada but also on a global scale. This expansion strategy aims to bring HealthTab's benefits to a wider audience and increase the company's market presence. Regarding financial performance, Bremner highlighted the impressive growth achieved by Avricore Health. Revenues for the first half of 2023 reached $1,177,290, representing a remarkable 437% increase compared to the same period in the previous year. This growth was attributed to the deployment of more HealthTab systems and increased tests sold. Additionally, the company's gross profit surged by 511% to $440,152, with a gross margin of 37.39% — outperforming the company's target margin of 30%. This performance underscores the solid fundamentals of the company and its ability to increase scale while simultaneously improving profitability. Avricore Health's success story also includes its recent selection by a collaborative effort involving the renowned Barts Heart Centre and the national cardiovascular charity HEART UK. The company was chosen to assess the feasibility of integrating cholesterol testing into community pharmacies in the UK. This initiative aims to complement opportunistic blood pressure checks, assess cardiovascular risk, and expand clinical services offered to patients. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

August 31, 2023 01:28 PM Eastern Daylight Time

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hVIVO announces move to "good facility at a very good price"

hVIVO PLC

hVIVO PLC (AIM:HVO) chief executive Mo Khan speaks to Thomas Warner from Proactive after the specialist contract research organisation announced plans for a new state-of-the-art consolidated challenge trial facility at the life sciences hub in Canary Wharf, London. The expansion, largely funded by hVIVO clients, reflects a growing order book and increasing demand for its human challenge trial services, the company said in a statement. The move involves bringing together quarantine beds, laboratories, and corporate offices into one facility. Notably, the new space will accommodate up to 70 quarantine beds, a significant increase from the previous capacity. The enhanced laboratory space will enable more concurrent studies, fostering revenue growth. He notes that hVIVO's "hugely successful screening facilities in Plumbers Row in East London and in Manchester will remain at their current locations, but the rest of the company will be consolidating into one facility." The phased move is expected to be completed in Q2 of the coming year and promises expanded capabilities, operational efficiency, and sustained growth for hVIVO. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

August 31, 2023 05:48 AM Eastern Daylight Time

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Reprise Biomedical’s Miro3D® Wound Matrix Granted Level II HCPCS Code by CMS

Reprise Biomedical

Reprise Biomedical, Inc., a leading innovator in medical biotechnology for wound care, is pleased to announce that the Centers for Medicare and Medicaid Services (CMS) has assigned a Level II Healthcare Common Procedure Coding System (HCPCS) code to its revolutionary Miro3D wound matrix, effective October 1, 2023. Miro3D is a three-dimensional porcine-derived acellular graft designed to create a protective environment for wounds, specifically for use in cases requiring coverage of and conformance to intricate, tunneling, and irregular wound beds. Available in four sizes, Miro3D features a consistent two-centimeter-thick porous sheet scaffolding structure. When hydrated, Miro3D softens slightly, adapting well to various wound bed shapes and can be fixated to surrounding tissue using preferred methods such as sutures or staples. CMS has assigned HCPCS Level II code A2025, ‘Miro3d, per cubic centimeter,’ to Miro3D. This new Level II HCPCS code permits healthcare providers to bill Medicare and other insurance carriers for Miro3D, thereby making Miro3D more accessible to patients across the country. CMS’s acceptance of Reprise Biomedical’s HCPCS application and coding assignment reinforces the company’s commitment to becoming a leading provider of innovative medical technologies devoted to enhancing patient outcomes and quality of life. “At the core of Reprise Biomedical’s product portfolio lies Miro3D—a completely unique three-dimensional wound care solution,” commented Carrie Powers, CEO of Reprise Biomedical. “The three-dimensional sheet scaffolding structure of Miro3D, which can be tailored to fit wound sizes through trimming or cutting, is transforming the treatment landscape for deep and tunneling wounds, diabetic foot ulcers, and other advanced wound conditions,” Ms. Powers added. About Reprise Biomedical, Inc.: Reprise Biomedical, Inc. is focused on creating and delivering innovative solutions for wound care management through its proprietary perfusion decellularization technology. With a dedication to advancing healthcare, Reprise Biomedical aims to reshape the wound care landscape by offering next-generation technologies that significantly elevate patient outcomes. As the company continues to grow its product portfolio, patients and healthcare providers alike can look forward to the positive impact of Reprise Biomedical’s wound healing solutions. To learn more about Reprise Biomedical and its innovative Miro3D product, please visit https://reprisebio.com. Contact Details Contact Carrie Powers, CEO +1 763-284-6780 cpowers@reprisebio.com Company Website https://reprisebio.com

August 28, 2023 08:00 AM Central Daylight Time

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G-Medical Innovations Holdings Ltd

G Medical Innovations Holdings Ltd. (OTC: GMVDF) (“G Medical Innovations”), an industry innovator in comprehensive remote patient monitoring solutions, announced yesterday that on August 22, 2023, it received a letter from the staff of The Nasdaq Stock Market (the “Exchange” or “Nasdaq”) notifying the Company that the Nasdaq Hearings Panel has determined to delist the Company’s ordinary shares from the Exchange, based on the Company’s failure to comply with the minimum $2,500,000 stockholders’ equity requirement under Nasdaq Listing Rule 5550(b). The Company’s ordinary shares are expected to be traded on the over-the-counter (OTC) Pink. The Company’s receipt of the letter from Nasdaq does not affect the Company’s business, operations, or reporting requirements with the Securities and Exchange Commission (“SEC”). Dr. Yacov Geva, Chief Executive Officer of G Medical Innovations commented “while we regret the delisting of our shares from Nasdaq, we remain confident in the long term growth and success of the Company. We will work relentlessly to get our shares listed back on a national securities exchange as soon as practicable”, Dr Geva concluded. About G Medical Innovations G Medical Innovations is a health care company engaged in the development of next generation mHealth and telemedicine solutions and monitoring service platforms. The Company’s solutions and services can empower consumers, patients, and providers to better monitor, manage and improve clinical and personal health outcomes, especially for those who suffer from cardiovascular disease, pulmonary disease, and diabetes. The Company’s current product lines consist of its Prizma medical device, a clinical-grade device that can transform almost any smartphone into a medical monitoring device, enabling both health care providers and individuals to monitor, manage and share a wide range of vital signs and biometric indicators; its Extended Holter and Monitoring Cardiac Telemetry Patch services, utilizing multi-channel patient-worn biosensors with algorithms, to generate real time analysis and transmission that captures electrocardiography data continuously, including QT syndrome prolongation detection. In addition, the Company is developing its wireless vital signs monitoring system, which is expected to provide full, continuous, and real-time monitoring of a wide range of vital signs and biometrics. Its monitoring services include provision of independent diagnostic testing facility monitoring services and private monitoring services. For more information about G Medical innovations, visit https://gmedinnovations.com/. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates,” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, G Medical Innovations is using forward-looking statements when it discusses its intention to quote its shares and warrants on the OTCQB or OTCQX, when it discusses the Company’s long term growth and success, when it discusses working to get the Company’s shares listed back on a national securities exchange as soon as practicable, or when the Company discusses the potential benefits of G Medical Innovations’ technology and products. Because such statements deal with future events and are based on the Company’s current expectations, they are subject to various risks and uncertainties, and actual results, performance, or achievements of G Medical Innovations could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties, including those discussed under the heading “Risk Factors” in G Medical’s Innovations Annual Report on Form 20-F for the year ended December 31, 2022, filed with the SEC on May 16, 2023, and our other filings with the SEC, which are available on the SEC’s website, www.sec.gov. Except as otherwise required by law, G Medical Innovations undertakes no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. Investor Relations Contact G Medical Innovations service@gmedinnovations.com G Medical Innovations Holdings Ltd. is a health care company engaged in the development of next generation mHealth and telemedicine solutions and monitoring service platforms. The Company’s solutions and services can empower consumers, patients, and providers to better monitor, manage and improve clinical and personal health outcomes, especially for those who suffer from cardiovascular disease, pulmonary disease, and diabetes. The Company’s current product lines consist of its Prizma medical device, a clinical-grade device that can transform almost any smartphone into a medical monitoring device, enabling both health care providers and individuals to monitor, manage and share a wide range of vital signs and biometric indicators; its Extended Holter and Monitoring Cardiac Telemetry Patch services, utilizing multi-channel patient-worn biosensors with algorithms, to generate real time analysis and transmission that captures electrocardiography data continuously, including QT syndrome prolongation detection. In addition, the Company is developing its wireless vital signs monitoring system, which is expected to provide full, continuous, and real-time monitoring of a wide range of vital signs and biometrics. Its monitoring services include provision of independent diagnostic testing facility monitoring services and private monitoring services. This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates,” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, G Medical Innovations is using forward-looking statements when it discusses: revenue growth and profitability in future periods; the launch of the Company’s CLIA lab in Austin, TX, the Company’s online store for its Prizma Monitoring Devices on Amazon Marketplace and the Company’s HTKs business and online stores; potential announcements with large homecare service companies and large distributors for devices and At Home Test Kits; and the Company’s plans to expand its line of monitoring products and services offered to patients, hospitals and clinics. Because such statements deal with future events and are based on the Company’s current expectations, they are subject to various risks and uncertainties, and actual results, performance, or achievements of G Medical Innovations could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties,, including those discussed under the heading “Risk Factors” in G Medical’s Innovations Annual Report on Form 20-F for the year ended December 31, 2022, filed with the Securities and Exchange Commission (“SEC”) on May 16, 2023, and our other filings with the SEC, which are available on the SEC’s website, www.sec.gov. Except as otherwise required by law, G Medical Innovations undertakes no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. Contact Details G Medical Innovations Investor Relation +972 8-958-4777 service@gmedinnovations.com Company Website https://gmedinnovations.com

August 24, 2023 11:30 AM Eastern Daylight Time

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