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CK Life Sciences Presenting Preclinical Data for Its Investigational Dual-Antigen Cancer Vaccines, Co-targeting PRAME and PD-L1, at the 2023 Society for Immunotherapy of Cancer (SITC) Annual Meeting

CK Life Sciences Int'l., (Holdings) Inc.

HONG KONG SAR - Media OutReach - 1 November 2023 - CK Life Sciences Int'l., (Holdings) Inc. is presenting preclinical data for its investigational dual-antigen cancer vaccines, co-targeting PRAME (preferentially expressed antigen in melanoma) and PD-L1 (programmed death-ligand 1), on November 4 at the 2023 Society for Immunotherapy of Cancer (SITC) Annual Meeting in San Diego, California, USA. The investigational cancer vaccines evaluated in the preclinical study contain antigenic sequences of PRAME and PD-L1 intended to induce anti-cancer immune responses. PRAME is a cancer antigen highly expressed in many different types of cancers and has been associated with different oncogenic processes. PD-L1 represents one of the most important immune checkpoint antigens highly expressed on cancer cells to limit T-cell activation in the tumour microenvironment. "CK Life Sciences has a growing pipeline of cancer vaccines in various stages of development. The preclinical efficacy results of our dual-targeting PRAME/ PD-L1 cancer vaccines in liver cancer are promising and we hope to start clinical trials in the coming years," said Melvin Toh, Vice President & Chief Scientific Officer at CK Life Sciences. "Liver cancer is the second most common cause of cancer death in Asia and remains a major unmet medical need. We plan to investigate the PRAME/ PD-L1 dual-targeting cancer vaccines further in liver cancer and other cancer types known to over-express PRAME and PD-L1." DETAILS ON POSTER PRESENTATION: Abstract 1336: Authors: Session Date and Time In this preclinical study, we investigated whether dual-antigen cancer vaccines co-targeting PRAME and PD-L1 could suppress tumour growth in both prophylactic and therapeutic syngeneic mouse hepatocellular carcinoma (HCC) models. Two recombinant fusion protein vaccines comprised of PD-L1 and PRAME with or without GM-CSF were synthesised and formulated with a Toll-like receptor 9 agonist CpG oligodeoxynucleotide and aluminum hydroxide for vaccination. In the prophylactic tumour model study, the vaccines were administrated subcutaneously twice at a two-week interval before implantation of mouse HCC cells expressing PRAME, followed by weekly vaccination. In the therapeutic model study, the vaccines were administrated weekly into the animals after tumour cell implantation. Body weight and tumour volume were measured three times a week. All mice experienced a recoverable body weight loss without any abnormal behavior or reduction of activity after vaccination. In the prophylactic model (n=10 mice), both fusion protein vaccines significantly inhibited tumour growth, with 76.4% ( P<0.01 ) and 59.5% ( P<0.05 ) tumour growth inhibition (TGI) compared to control group, respectively. Importantly, there were some vaccinated mice without palpable tumour mass at the end of the study. These results were consistent with that found in the therapeutic model study (n = 10 mice), in which both vaccines significantly inhibited tumour growth, with 43.4% ( P<0.01 ) and 40.7% ( P<0.05 ) TGI, respectively, and prolonged animal survival compared to the control group (P<0.01). The results of this preclinical study clearly highlight the potential of simultaneously targeting PRAME and PD-L1 by fusion protein vaccination in cancer immunotherapy. DISCLAIMER This press release may contain forward-looking statements regarding the Group's research and development projects which may involve risks and uncertainties. Actual results may differ materially from expectations discussed in such forward-looking statements. All information in this press release is for general reference only and is not intended as investment advice or medical advice. CK Life Sciences Int'l., (Holdings) Inc. does not warrant or represent, express or implied, as to the accuracy, completeness or updated status of such information. No liability will be accepted for any loss or damage howsoever arising from or in reliance upon such information. REFERENCES [1] Gradecki S, Slingluff C, Gru A. J Cutan Pathol. PRAME expression in 155 cases of metastatic melanoma. Accessed at https://onlinelibrary.wiley.com/doi/10.1111/cup.13876. [2] Oyama K, Kanki K, Shimizu H, Kono Y, Azumi J, Toriguchi K, Hatano E, Shiota G. Gastrointest Tumors. Impact of preferentially expressed antigen of melanoma on the prognosis of hepatocellular carcinoma. Accessed at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465675/. [3] Thongprasert S, Yang PC, Lee J, Soo R, Gruselle O, Myo A, Louahed J, Lehmann F, Brichard V, Coche T. Lung Cancer. The prevalence of expression of MAGE-A3 and PRAME tumor antigens in East and South East Asian non-small cell lung cancer patients. Accessed at https://pubmed.ncbi.nlm.nih.gov/27794402/. [4] Epping M, Hart A, Glas A, Krijgsman O, Bernards R. Br J Cancer. PRAME expression and clinical outcome of breast cancer. Accessed at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527791/. [5] Ahmad S, Borch T, Hansen M, Andersen M. Cancer Immunol Immunother. PD-L1-specific T cells. Accessed at https://pubmed.ncbi.nlm.nih.gov/26724936/. CK Life Sciences Int'l., (Holdings) Inc. CK Life Sciences Int'l., (Holdings) Inc. (stock code: 0775) is listed on the Stock Exchange of Hong Kong. Bearing the mission of improving the quality of life, CK Life Sciences is engaged in the business of research and development, manufacturing, commercialisation, marketing, sale of, and investment in, products and assets which fall into three core categories - nutraceuticals, pharmaceuticals and agriculture-related. CK Life Sciences is a member of the CK Hutchison Group. For additional information, please visit www.ck-lifesciences.com. About PRAME PRAME is a protein commonly expressed by cancer cells, including melanoma (1), liver cancer (2), lung cancer (3) and breast cancer (4). PRAME contributes to the development and spread of cancer cells, and studies have shown that high levels of PRAME are associated with poor outcomes in cancer patients (2,4). In recent years, researchers have been exploring ways to target PRAME using immunotherapy, such as T-cell therapy and cancer vaccines, as a potential treatment for cancer. About PD-L1 PD-L1 is a protein expressed by certain immune cells and cancer cells. It plays a role in suppressing anti-cancer immune responses by binding to a receptor called programmed death-1 (PD-1) on T-cells, limiting the activation of T-cells, thereby helping cancer cells evade the immune system. Antibodies that can block the interaction of PD-L1 and PD-1 have been approved for the treatment of certain types of cancer. Recent studies have shown the presence of PD-L1-specific T-cells in both healthy individuals and cancer patients, which suggests that targeting PD-L1 with T-cell therapy or cancer vaccines could be a promising approach for cancer treatment (5). Contact Details CK Life Sciences Int'l., (Holdings) Inc. Wendy Tong Barnes +852 2122 2150 wendytb@ckah.com

November 01, 2023 09:06 PM Eastern Daylight Time

MGC Pharmaceuticals secures funding through to the end of 2024

MGC Pharmaceuticals Ltd

MGC Pharmaceuticals Ltd (LSE:MXC, OTC:MGCLF, ASX:MXC) CEO and Managing Director Roby Zomer speaks to Thomas Warner from Proactive London about the recent securing of the single largest injection of funding in the company's history. Following a difficult period of restructuring for the business, the investment provides the company with financial stability through to the end of 2024. MGC aims to progress its leading drugs, CannEpil and CimetrA, toward FDA approval and expand its medicinal footprint via early patient access schemes in the UK, Ireland, and other regions. Crucially, the recent funding influx originated primarily from Israel and the United States, indicating a shift in MGC's financial grounding. While historically reliant on Australian and UK capital, the company now sees American investors recognizing its potential, especially in FDA registrations in the lucrative US pharmaceutical market. Furthermore, MGC's European operations continue to strengthen, with production facilities in Slovenia and Malta and headquarters in Slovenia and the UK. For existing shareholders, Zomer assures that the restructuring and new investment ensure that the company remains on track to meet its goals. Reflecting on the company's challenging journey, Zomer emphasises the importance of persistence and belief in the company's mission. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

November 01, 2023 11:08 AM Eastern Daylight Time

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Living with Acromegaly: Spreading Awareness and Highlighting Treatment Options on Acromegaly Awareness Day

YourUpdateTV

A video accompanying this announcement is available at: https://youtu.be/y696riLIIKs For more information, visit MYCAPSSA.COM Acromegaly is a rare condition that affects about 25,000 people living in the U.S. It is caused by a benign tumor in the pituitary gland which is located just beneath the brain. This benign tumor makes too much growth hormone, and this can cause various issues such as fatigue, headaches, and increased growth of hands and feet and pretty much every part of the body. If not treated, acromegaly can cause high blood sugar as in Diabetes and high blood pressure, and sometimes cause serious damage to the heart which can be life-threatening. The good news is that there are some very good treatments available to help control the problem. A nationwide media tour was conducted on October 23rd to discuss the drug MYCAPSSA as well as to hear about the experiences of someone living with acromegaly. The media tour featured Dr. Anthony P. Heaney, Professor at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA) and Becky Bierman, a person living with acromegaly. Mycapssa, is a twice-daily oral medication that reduces the production of growth hormone and is designed for people who have previously been on an injectable version of octreotide therapy for the long-term maintenance of acromegaly. During the media tour Dr. Heaney and Becky discussed: · What acromegaly is and how many people it affects. · What it is like living with acromegaly. · Treatment options available for someone living with this disease. People diagnosed with acromegaly considering a new treatment option should talk to their doctors first. For more information, you can visit www.Mycapssa.com Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

November 01, 2023 09:57 AM Eastern Daylight Time

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Elsevier Partners with the Korean Society for Molecular and Cellular Biology to Publish Molecules and Cells

Elsevier

The Korean Society for Molecular and Cellular Biology (KSMCB), one of the largest and most prominent academic societies in the field of life sciences in Korea, and Elsevier, a leader in information and analytics for customers across the global research and health ecosystems, are pleased to announce a new partnership to publish Molecules and Cells, the flagship journal of KSMCB. This English-language publication will be hosted on Elsevier’s industry-leading online platform of peer-reviewed literature, ScienceDirect, beginning January 1, 2024. Continuing as a Gold Open Access, online-only publication, all articles will be immediately and permanently free to read and download. Junho Lee, PhD, Professor, Department of Biological Sciences, Seoul National University and President of KSMCB, commented, “It is with great pleasure that I would like to announce that KSMCB has entered into a co-publishing agreement with Elsevier. The rationale behind this decision is to meet the challenges of an ever-changing publishing environment and the growing needs of society members and scientific colleagues. We will be able to take advantage of the global network and professionalism that Elsevier brings, which will result in the recognition that our journal strives to achieve on the global stage. We envision that Molecules and Cells will make a giant leap forward in the near future to becoming a premier international scientific journal of which we can all be proud.” Launched in 1990 and now in its 46th volume, Molecules and Cells has continually solidified its position as a leading journal in the fields of molecular and cellular biology. It has published articles in English from more than 30 countries on its way to becoming a globally recognized journal. Since 1995, the journal has been indexed in Web of Science/Science Citation Index-Expanded, the first Korean journal in the biological sciences to be accepted for inclusion in this service. Molecules and Cells continues its tradition of publishing excellence under the expert leadership of Editor-in-Chief Jae Bum Kim, PhD, supported by an eminent editorial board. After earning his doctoral degree in the Department of Microbiology & Molecular Genetics, Harvard University, Prof. Kim has held a number of prestigious academic appointments in Korea and the United States. He is currently Professor in the Department of Biological Sciences and serves as the Director of the Center for Adipose Tissue Remodeling, Creative Research Initiatives, Center for Studies on Structure-Function in Adipocyte at Seoul National University. Prof. Kim noted, “The editorial team, editorial board, KSMCB leadership, and I remain passionate and committed to timely publication of the highest quality scholarly work. We anticipate that Elsevier’s exceptional level of publishing expertise and professionalism will help bring the journal to a wider worldwide audience of authors and readers more efficiently and effectively, providing greater opportunities for collaboration and knowledge sharing.” The journal will expand its impact and outreach through availability via ScienceDirect, which will host 33 years of Molecules and Cells back volumes (from 1990 onwards). ScienceDirect has 1 billion annual visits and over 17,000 licenses worldwide. Manuscripts may be submitted via Editorial Manager. Accepted manuscripts, on average, will be available online within 48 hours in a pre-release format. Molecules and Cells is covered in important abstracting and indexing services including Science Citation Index-Expanded (current Journal Impact Factor 3.8), Scopus (current CiteScore 6.9), PubMed, Current Contents®/Life Sciences, and Chemical Abstract Service. Louise Curtis, Elsevier Senior Vice President, Life Sciences, Social Sciences, Economics, remarked, “We are delighted that KSMCB has selected Elsevier as its partner, and we are proud to publish this well-established, well-run open access journal. It is an excellent complement to the Elsevier molecular and cell biology journal portfolio, expanding our author base into the Korean scientific community. We are committed to providing the best possible support for KSMCB’s mission and community and fostering an international exchange of cutting-edge research.” Notes for editors About Molecules and Cells Molecules and Cells is an international online open access journal devoted to the advancement and dissemination of fundamental knowledge and ground-breaking research in all areas of cellular and molecular biology. Publications cover a broad range of topics of general interest but should be within relevant fields of biology. It is the official journal of the Korean Society for Molecular and Cellular Biology. www.sciencedirect.com/journal/molecules-and-cells About the Korean Society for Molecular and Cellular Biology (KSMCB) The Korean Society of Molecular and Cellular Biology (KSMCB) was founded in 1989. During the last 30 years, KSMCB has grown into one of the largest and most prominent academic societies in the life sciences in Korea. KSMCB serves as a platform for molecular and cellular biologists outside Korea as well, providing them with the opportunity of collaboration and knowledge of cutting-edge research trends. The Society publishes Molecules and Cells, a molecular biology journal with a broad subject coverage and readership, and hosts an annual international conference, a forum for cutting-edge research in all areas of molecular and cellular biology. www.ksmcb.or.kr/eng About Elsevier and society partnerships Elsevier has long-standing partnerships with over 600 learned societies worldwide, helping them to realize their missions and inspire and support their communities. We pride ourselves on consistently delivering outstanding publishing outcomes through strategic insight, reliable finances, global dissemination, embracing open science and open access, and championing the needs of the communities we jointly serve. www.elsevier.com/societies About Elsevier As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems. In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, academic leaders, funders, R&D-intensive corporations, doctors, and nurses. Elsevier employs 9,000 people worldwide, including over 2,500 technologists. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on over 2,800 journals, including The Lancet and Cell; 46,000+ eBook titles; and iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. Contact Details Carolien van der Zanden Senior Marketing Communications Manager, Elsevier c.zanden@elsevier.com Jae Bum Kim Editor-in-Chief, Molecules and Cells jaebkim@snu.ac.kr Company Website https://www.elsevier.com/

November 01, 2023 09:00 AM Eastern Daylight Time

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DPH Biologicals, University of Illinois Team Up to Improve Crop Residue Management

DPH Biologicals

• Trials focus on benefits of biologicals for post-harvest stubble control • First-year results unveiled October 30 at international agronomy sciences meeting DPH Biologicals and the University of Illinois Urbana-Champaign (UIUC) announced today a research collaboration validating the impact biologicals make to accelerate decomposition of crop residue, thereby unlocking the adoption of more sustainable and profitable farming practices for United States high-yield, broadacre growers. Starting in spring of 2023, the UIUC Crop Physiology Lab run by Fred Below, Ph.D. and Connor Sible, Ph.D., began researching the impact of microbial solutions in crop residue management including the use of TerraTrove® Residuce®, technology developed by DPH Bio. Residuce is a biodigester, a biological specifically formulated to accelerate the process of plant tissue degradation. “Supporting Dr. Below’s lab is an opportunity to ground-truth the benefits of biodigesters, understand how technologies like Residuce can enable more sustainable and profitable cropping practices and to develop best practice use recommendations supporting our retail and channel partners with high-value, science-verified cropping solutions,” said Alex Cochran, Ph.D., DPH Bio’s Chief Technology Officer. A subset of biofertilizers, biodigester sales are exploding as part of the expanding global biofertility market, projected to reach $3.75 billion USD in sales by 2030, a CAGR of 12.80%, underpinned by market demand for more sustainably-grown food with farmers’ need to offset increasing costs and shrinking profit margins. Residuce, available in a liquid and dry formulation, is currently used on 1.5 million North American acres, a 50% growth rate in the past year. Already, early UIUC trial results indicate improved yields when biodigesters were used with cover crop plantings. Cover crops are typically associated with lower yields, a correlation that has discouraged grower adoption despite the well-known soil health benefits of cover cropping. Using Residuce on an unmanaged cereal rye cover crop partially eliminated the nearly nine-bushel yield penalty average experienced when a cover crop is planted between no-till corn and soybean rotations, according to research presented Monday by UIUC graduate student Darby Danzl at the 2023 ASA, CSSA, SSSA International Annual Meeting, held jointly by the American Society of Agronomy, the Crop Science Society of America and the Soil Science Society of America. The yield penalty was nearly fully eliminated when a fertilizer source was combined with Residuce. Research Focuses on Value-Creation of Biodigesters for Corn, Soybean and Wheat Production With UIUC already a research leader in residue management strategies in broadacre cropping systems, the ongoing field trial collaborations with DPH Bio will focus on further defining the value biodigesters bring to unlocking the value of residue for sustainable agriculture. DPH Bio recently published “ Rethinking Crop Residue Management with Biodigesters,” an analysis of research into crop residue management, includes work already completed by the UIUC crop physiology lab as well as DPH Bio’s field trial results. The UIUC-DPH partnership will expand upon the research and benefits of biodigesters presented in the white paper. Large volumes of crop residue create problems, Sible said, with high-yielding cultivars and practices like no-till, double-cropping and cover cropping generating more residue than growers’ have ever experienced. Today’s average 180-bushel corn crop yields 3.9 tons per acre of corn stover and every additional bushel in yield contributes another 43.7 pounds of stover, according to UIUC research. Growers complain of delayed germination, poor plant stands, nutrients locked up in the decomposing process, increased disease and pest outbreaks from pathogens that overwinter in thick residue layers and yield penalties associated with residue accumulation. Yet, once broken down, residue is an untapped source of nutrients and better soil and crop health. Strategies for accelerating residue degradation are key, Below said. “Residue is nature’s biological. It’s so good for the soil and the plant, and there's a lot of nutrition there. But residue can be your best friend or your worst nightmare,” Below said. “The quicker you can degrade residue, the easier you can plant, the more uniform your crop is going to emerge and the more likely you’re going to get the benefits of that residue.” The next round of joint UIUC-DPH Bio trials will focus on: ● The benefits of biodigesters for cover crop management in no-till corn and soybean. ● Fall versus spring residue management with biodigesters to benefit continuous corn yield. ● Biodigesters value to residue management in a wheat-soybean double crop rotation. Studies conducted in 2023 will be available this winter. The second round of trial results will be available before the 2025 planting season. About DPH Biologicals DPH Biologicals aims to be the industry’s most trusted biologicals provider. We attract, develop and scale technologies improving broad market access and simplifying the grower experience with biologicals. With more than three decades invested into scientific research, field-testing, partner relationships and product development, we’ve built three proven product platforms – BellaTrove® for biocontrols; TerraTrove® for biofertility and biodigesters; and RegenAphex™, a regenerative, plant-based humus extract that serves as a foundation for our flagship biofertilizer SP-1 Classic and a platform for third-party technological development. For more information, visit www.dphbio.com. Contact Details AgTech PR for DPH Bio Georgie Smith georgie@agtechpr.com Company Website http://www.dphbio.com

November 01, 2023 08:30 AM Eastern Daylight Time

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News Release

Perimeter Medical Imaging AI initiates new clinical trial site in Seattle, WA

Perimeter Medical Imaging AI

Adrian Mendes, the CEO of Perimeter Medical Imaging, joined Steve Darling from Proactive with news that the company has initiated an additional clinical trial site at the University of Washington in the Fred Hutch Cancer Center. Perimeter's clinical trial is a multi-center, randomized, two-arm pivotal study that evaluates the investigational Perimeter B-Series Optical Coherence Tomography (OCT) technology. This technology is combined with Perimeter's proprietary ImgAssist AI software and is used during breast conservation surgeries. The core of this innovative approach is the use of ultra-high-resolution, real-time, advanced imaging tools to examine excised tissues at the cellular level, providing crucial insights to surgeons. Mendes emphasized the significance of this additional clinical trial site, as it plays a vital role in gathering valuable data generated during the study. This data will be instrumental in supporting the commercialization of Perimeter's B-Series technology. The company's ultimate goal is to transform cancer surgery by providing advanced technology that not only improves patient outcomes but also helps reduce healthcare costs. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

October 31, 2023 03:22 PM Eastern Daylight Time

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News Release

1606 Corp announces cutting-edge AI-driven CHATCBDW is live and in operation

1606 Corp.

1606 Corp CEO Greg Lambrecht joined Steve Darling from Proactive to share news the company has officially unveiled its cutting-edge AI chatbot, ChatCBDW, which represents a significant advancement in the world of CBD products and customer engagement. Lambrecht explained that ChatCBDW has undergone key designs and rigorous testing before being launched and is now live and operational. This innovative chatbot offers a wide range of user-centric features that go beyond the ordinary. One of its standout attributes is its capability to respond to user inquiries and provide comprehensive education on all aspects of CBD. However, ChatCBDW doesn't stop there. It takes personalization to the next level by offering tailored product recommendations to users and engaging in conversations that closely mimic human interaction. This level of innovation empowers customers to make well-informed choices, explore a diverse array of CBD products, and promises an unparalleled shopping experience within the CBD industry. The seamless integration of ChatCBDW with Microsoft Azure is a key component of its capabilities. Microsoft Azure is renowned for its scalability, unwavering reliability, and cutting-edge AI functionalities. This integration ensures that ChatCBDW can operate impeccably, even during periods of peak demand, delivering users a consistently responsive and seamless experience throughout their interaction with the chatbot. The company has also announced that Cool Blue Distribution is now a North American licensed reseller of ChatCBDW and is set to engage its network of over 800 CBD retailers immediately. The first direct-to-merchant marketing campaign is scheduled to begin by mid-November 2023, with the goal of generating notable revenue before January 1, 2024. Contact Details Proactive Canada +1 604-688-8158 na-editorial@proactiveinvestors.com

October 31, 2023 03:16 PM Eastern Daylight Time

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Stay Ahead of Cough, Cold and Flu Season

YourUpdateTV

As the colder months approach, millions of people across the nation are gearing up for the inevitable cough, cold and flu season. Recently, Emergency Room Physician, Dr. Darria Long, conducted a satellite media tour to share tips and advice on how to stay healthy and prepared. A video accompanying this announcement is available at: https://youtu.be/5yVw5AWHbXw As the colder months approach, millions of people across the nation are gearing up for the inevitable cold and flu season. The cough, cold and flu season is marked by a significant increase in the spread of respiratory viruses, which can lead to a surge in illnesses and medical visits. Advanced preparation provides an opportunity to ensure that necessary supplies, medications, and remedies are readily available. Having essential items, like Mucinex 12H, on hand before symptoms strike can make a significant difference. Mucinex 12-Hour relieves chest congestion and thins and loosens mucus. It is clinically proven to last up to 12 hours and provide relief for your chest congestion and make coughs more productive. One dose of Mucinex 12-Hour lasts 3 times longer than other 4-HR medicines helping individuals manage discomfort effectively and get back to their daily activities sooner. Always use over-the-counter products as directed. If symptoms persist, you should contact your healthcare professional and get checked out if deemed necessary. Taking better care of ourselves during the cough, cold and flu season is paramount to staying healthy and minimizing the risk of falling ill. Key preventative measures like washing your hands often, covering your nose and mouth with a tissue when you cough or sneeze, and sneezing into your elbow if you don’t have a tissue are extremely effective at preventing the spread of germs. Additionally, maintaining a healthy lifestyle is crucial. Adequate sleep, a balanced diet rich in fruits and vegetables, regular physical activity, and managing stress contribute to a strong immune system. Staying hydrated by drinking plenty of fluids, particularly water and herbal teas, can also help keep our respiratory tract moist and better able to fend off viruses. For more information on how to take care of yourself this cold and flu season, visit Mucinex.com. You can stop by Walmart, Target, your local pharmacy or food retailer to buy Mucinex now ahead of this cough and cold season. BIO: Dr. Darria Long, MD Dr. Darria Long leverages the best of science, to make our lives healthier, better… and easier. By combining her life’s work as an Emergency Room physician and being a mom of two – Dr. Darria has become the nation’s ‘making life better for women’ doctor by helping individuals pave ways to stay present and remain healthy during times of constant distractions and high stress. With a website devoted to distilling health headlines and creating a thriving lifestyle, Dr. Darria shares simple, evidence-based (from western, eastern, and integrative medicine) advice on physical and mental wellness, and the health guidance you’d expect and trust from a close friend. A favored national TV contributor and national bestselling author of Mom Hacks, Dr. Darria is also a TED speaker “How to triage your life like an ER doctor,” and Clinical Assistant Professor at the University of Tennessee. She received her training in emergency medicine at Yale School of Medicine and her MBA from Harvard Business School. A featured regular on CNN, Headline News, NBC, Interview Healthline, Hallmark, Lifetime, Dr. Oz, Thrive Global, Atlanta Small Business Network, Parenting for the future, and many others. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

October 31, 2023 01:04 PM Eastern Daylight Time

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PathAI Announces Research Presentations at the Society for Immunotherapy of Cancer’s 38th Annual Meeting

PathAI

PathAI, a leading technology company which combines AI-powered pathology solutions with end-to-end central pathology and histology services, today announced it will present research underscoring the efficacy of PathExplore’s human interpretable features (HIFs) through three poster presentations at the Society for Immunotherapy of Cancer’s 38 th Annual Meeting on November 1-5 in San Diego, CA. The posters showcase how PathExplore provides high-resolution characterization of the tumor microenvironment (TME) through a standardized panel of HIFs derived from H&E whole slide images across multiple cancer types. Additionally, Incendia Therapeutics will present two posters reporting results that were generated utilizing PathExplore. “Building upon past publications and presentations, we continue to see the utility for histological features of the tumor microenvironment to further our understanding of disease biology, patient prognosis, and therapeutic response, which ultimately may lead to the discovery and implementation of novel biomarkers to advance precision medicine,” explained Mike Montalto, Ph.D., Chief Scientific Officer, PathAI. All three posters demonstrate the correlation between specific HIFs and established molecular measurements of the TME (e.g., gene expression profiles of specific cell populations), as well as specific HIFs and complex molecular signatures (e.g., immune phenotypes) which could better aid in the identification of patients eligible for targeted therapies, or result in the identification of new histology-based biomarkers. Quantifying the effect of microsatellite instability and mismatch repair deficiency on the tumor microenvironment (Poster 73) In this research, PathAI investigated the potential to predict and compare microsatellite stability and mismatch repair subtypes in colorectal and endometrial cancers utilizing PathExplore HIFs. The findings suggest MSS/dMMR tumors may warrant consideration for immunotherapy due to their TME’s similarity to microsatellite instability-high (MSI-H) and tumor mutation burden-high (TMB-H) solid tumors and AI-powered analysis of H&E WSI presents a more accessible and scalable method than current dMMR testing options. This poster will be presented by Judy Chen and Shima Nofallah on Friday, November 3 rd. Poster hall hours are 9 a.m. to 7 p.m. PT. Quantification of tumor infiltrating lymphocytes (TILs) from pathology slides reflects molecular immune phenotypes (Poster 122) In this research, PathAI deployed its PathExplore products on H&E WSI across eight cancer indications to extract HIFs quantifying the TME, including features that represent TIL fractions, densities, and distributions. Analysis revealed statistically significant correlations between TIL-associated HIFs with gene expression of known lymphocyte markers, as well as immune signature scores such as lymphocyte infiltration. These results show the predictive power that TIL-associated HIFs have for identifying immune phenotypes, as well as a promising direction for the discovery of histology-based immune biomarkers. This poster will be presented by Judy Shen on Saturday, November 4 th. Poster hall hours are 9 a.m. to 8:30 p.m. PT. Deep learning models identify key tumor microenvironment features associated with genetic signatures of UV metagenesis and alkylating agent treatment in melanoma (Poster 110) In this research, PathAI used PathExplore HIFs to investigate the association between TME features and mutational signatures indicative of UV mutagenesis, as well as alkylating agents-induced mutations. The results suggest that quantifying a tumor’s tissue and cellular composition can reveal meaningful information regarding the underlying mutation-driven or treatment-induced changes in the TME, which may have implications for therapy selection. This poster will be presented by Shima Nofallah on Saturday, November 4 th. Poster hall hours are 9 a.m. to 8:30 p.m. PT. Incendia Therapeutics (formerly known as Parthenon Therapeutics) posters In addition to the posters above, Incendia Therapeutics will present two posters on Friday, November 3 rd reporting results that were generated utilizing PathExplore. One poster (Poster 1287) compares PathExplore HIFs to mIF features and concluded that "TME models are a robust tool to distinguish tissue and cell features from H&E slides, comparable to mlF image analysis, but requiring less effort, time, and expense." In the second (Poster 1497), Incendia Therapeutics leveraged HIFs quantifying lymphocyte densities across cancer epithelium, cancer stroma, and the epithelial-stromal interface (ESI) to characterize barriers to lymphocyte entry into the cancer epithelium across immune phenotypes. More information on these posters can be found at https://www.incendiatx.com Please visit the PathAI booth, 615, to learn more and meet the team, or email us at bd@pathai.com. About PathAI PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

October 31, 2023 10:00 AM Eastern Daylight Time

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