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CURE ALZHEIMER’S FUND RECEIVES $50,000 GRANT FROM GREATER TOLEDO COMMUNITY FOUNDATION

Alzheimer’s Disease Research Foundation

Cure Alzheimer’s Fund (CureAlz), a non-profit dedicated to funding the most promising research to end Alzheimer’s disease, received a $50,000 grant from the Robert A. Stranahan, Jr. Charitable Advised Fund of the Greater Toledo Community Foundation. This grant represents their largest gift to Cure Alzheimer’s Fund since the Robert A. Stranahan, Jr. Charitable Advised Fund made its first grant to the non-profit in 2016. Through eight years of consecutive giving, the fund has provided $235,000 to CureAlz scientists working to find a cure. “Year after year, we are more encouraged by the progress Cure Alzheimer’s Fund is making to understand Alzheimer’s disease,” said Keith Burwell, President of Greater Toledo Community Foundation. “Our continued philanthropic support provides necessary funding for research that accelerates the discoveries that will eventually tackle Alzheimer’s disease and find a cure.” “The Greater Toledo Community Foundation recognizes the physical, emotional and financial impact this disease has on so many families in its community and around the world and has been a wonderful partner to CureAlz in our mission to find a cure,” said Meg Smith, CEO of Cure Alzheimer’s Fund. “Alzheimer’s devastates not just individual patients but their family and community as well. Developing effective, accessible therapies requires deep understanding of the complex causes and pathologies of Alzheimer’s. The scientists CureAlz supports are pursuing vital high-risk, high-reward research to accelerate progress. We are deeply grateful to the Greater Toledo Community Foundation for sharing our goal to end the burden of Alzheimer’s.” It is estimated that more than 6.5 million Americans are currently living with Alzheimer’s disease, a number that is expected to increase rapidly as the Baby Boomer generation continues to age. It is projected that the share of adults 65 and older in the US population will rise to 22 percent by 2050. With age as the biggest risk factor, Alzheimer’s disease is poised to place an unmanageable financial burden on the US healthcare system, caregivers, and loved ones. With the philanthropic support of the Robert A. Stranahan, Jr. Charitable Advised Fund of the Greater Toledo Community Foundation and tens of thousands of other donors, CureAlz has been able to direct more than $180 million to Alzheimer’s disease research since its inception in 2004 and has delivered critical breakthroughs for the research community. About Greater Toledo Community Foundation Greater Toledo Community Foundation is a public charitable organization created by citizens of our community to enrich the quality of life for individuals and families in our area. In existence since 1973, the Foundation has more than 970 individual current funds with assets of approximately $406 million. The Foundation provides philanthropic services for individuals, families, businesses and corporations to meet their charitable giving needs. For more information on the Foundation, visit the organization’s website at www.toledocf.org or follow them on Facebook or LinkedIn. About Cure Alzheimer’s Fund Cure Alzheimer’s Fund is a non-profit dedicated to funding the most promising research to prevent, slow, or reverse Alzheimer’s disease. Since its founding in 2004, Cure Alzheimer’s Fund has provided grants to the world’s leading researchers and contributed more than $180 million to research. Its funded initiatives have been responsible for many key breakthroughs in understanding the causes and pathology of Alzheimer’s disease. Cure Alzheimer’s Fund has received a 4-star rating for more than 12 consecutive years from Charity Navigator. With 100 percent of funds raised going to support research, Cure Alzheimer’s Fund has been able to provide grants to many of the best scientific minds in the field of Alzheimer’s research. For more information, please visit https://www.curealz.org/. Contact Details Barbara Chambers +1 978-417-9890 bchambers@curealz.org

November 01, 2023 05:51 AM Eastern Daylight Time

News Release

Perimeter Medical Imaging AI initiates new clinical trial site in Seattle, WA

Perimeter Medical Imaging AI

Adrian Mendes, the CEO of Perimeter Medical Imaging, joined Steve Darling from Proactive with news that the company has initiated an additional clinical trial site at the University of Washington in the Fred Hutch Cancer Center. Perimeter's clinical trial is a multi-center, randomized, two-arm pivotal study that evaluates the investigational Perimeter B-Series Optical Coherence Tomography (OCT) technology. This technology is combined with Perimeter's proprietary ImgAssist AI software and is used during breast conservation surgeries. The core of this innovative approach is the use of ultra-high-resolution, real-time, advanced imaging tools to examine excised tissues at the cellular level, providing crucial insights to surgeons. Mendes emphasized the significance of this additional clinical trial site, as it plays a vital role in gathering valuable data generated during the study. This data will be instrumental in supporting the commercialization of Perimeter's B-Series technology. The company's ultimate goal is to transform cancer surgery by providing advanced technology that not only improves patient outcomes but also helps reduce healthcare costs. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

October 31, 2023 03:22 PM Eastern Daylight Time

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News Release

1606 Corp announces cutting-edge AI-driven CHATCBDW is live and in operation

1606 Corp.

1606 Corp CEO Greg Lambrecht joined Steve Darling from Proactive to share news the company has officially unveiled its cutting-edge AI chatbot, ChatCBDW, which represents a significant advancement in the world of CBD products and customer engagement. Lambrecht explained that ChatCBDW has undergone key designs and rigorous testing before being launched and is now live and operational. This innovative chatbot offers a wide range of user-centric features that go beyond the ordinary. One of its standout attributes is its capability to respond to user inquiries and provide comprehensive education on all aspects of CBD. However, ChatCBDW doesn't stop there. It takes personalization to the next level by offering tailored product recommendations to users and engaging in conversations that closely mimic human interaction. This level of innovation empowers customers to make well-informed choices, explore a diverse array of CBD products, and promises an unparalleled shopping experience within the CBD industry. The seamless integration of ChatCBDW with Microsoft Azure is a key component of its capabilities. Microsoft Azure is renowned for its scalability, unwavering reliability, and cutting-edge AI functionalities. This integration ensures that ChatCBDW can operate impeccably, even during periods of peak demand, delivering users a consistently responsive and seamless experience throughout their interaction with the chatbot. The company has also announced that Cool Blue Distribution is now a North American licensed reseller of ChatCBDW and is set to engage its network of over 800 CBD retailers immediately. The first direct-to-merchant marketing campaign is scheduled to begin by mid-November 2023, with the goal of generating notable revenue before January 1, 2024. Contact Details Proactive Canada +1 604-688-8158 na-editorial@proactiveinvestors.com

October 31, 2023 03:16 PM Eastern Daylight Time

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Stay Ahead of Cough, Cold and Flu Season

YourUpdateTV

As the colder months approach, millions of people across the nation are gearing up for the inevitable cough, cold and flu season. Recently, Emergency Room Physician, Dr. Darria Long, conducted a satellite media tour to share tips and advice on how to stay healthy and prepared. A video accompanying this announcement is available at: https://youtu.be/5yVw5AWHbXw As the colder months approach, millions of people across the nation are gearing up for the inevitable cold and flu season. The cough, cold and flu season is marked by a significant increase in the spread of respiratory viruses, which can lead to a surge in illnesses and medical visits. Advanced preparation provides an opportunity to ensure that necessary supplies, medications, and remedies are readily available. Having essential items, like Mucinex 12H, on hand before symptoms strike can make a significant difference. Mucinex 12-Hour relieves chest congestion and thins and loosens mucus. It is clinically proven to last up to 12 hours and provide relief for your chest congestion and make coughs more productive. One dose of Mucinex 12-Hour lasts 3 times longer than other 4-HR medicines helping individuals manage discomfort effectively and get back to their daily activities sooner. Always use over-the-counter products as directed. If symptoms persist, you should contact your healthcare professional and get checked out if deemed necessary. Taking better care of ourselves during the cough, cold and flu season is paramount to staying healthy and minimizing the risk of falling ill. Key preventative measures like washing your hands often, covering your nose and mouth with a tissue when you cough or sneeze, and sneezing into your elbow if you don’t have a tissue are extremely effective at preventing the spread of germs. Additionally, maintaining a healthy lifestyle is crucial. Adequate sleep, a balanced diet rich in fruits and vegetables, regular physical activity, and managing stress contribute to a strong immune system. Staying hydrated by drinking plenty of fluids, particularly water and herbal teas, can also help keep our respiratory tract moist and better able to fend off viruses. For more information on how to take care of yourself this cold and flu season, visit Mucinex.com. You can stop by Walmart, Target, your local pharmacy or food retailer to buy Mucinex now ahead of this cough and cold season. BIO: Dr. Darria Long, MD Dr. Darria Long leverages the best of science, to make our lives healthier, better… and easier. By combining her life’s work as an Emergency Room physician and being a mom of two – Dr. Darria has become the nation’s ‘making life better for women’ doctor by helping individuals pave ways to stay present and remain healthy during times of constant distractions and high stress. With a website devoted to distilling health headlines and creating a thriving lifestyle, Dr. Darria shares simple, evidence-based (from western, eastern, and integrative medicine) advice on physical and mental wellness, and the health guidance you’d expect and trust from a close friend. A favored national TV contributor and national bestselling author of Mom Hacks, Dr. Darria is also a TED speaker “How to triage your life like an ER doctor,” and Clinical Assistant Professor at the University of Tennessee. She received her training in emergency medicine at Yale School of Medicine and her MBA from Harvard Business School. A featured regular on CNN, Headline News, NBC, Interview Healthline, Hallmark, Lifetime, Dr. Oz, Thrive Global, Atlanta Small Business Network, Parenting for the future, and many others. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

October 31, 2023 01:04 PM Eastern Daylight Time

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PathAI Announces Research Presentations at the Society for Immunotherapy of Cancer’s 38th Annual Meeting

PathAI

PathAI, a leading technology company which combines AI-powered pathology solutions with end-to-end central pathology and histology services, today announced it will present research underscoring the efficacy of PathExplore’s human interpretable features (HIFs) through three poster presentations at the Society for Immunotherapy of Cancer’s 38 th Annual Meeting on November 1-5 in San Diego, CA. The posters showcase how PathExplore provides high-resolution characterization of the tumor microenvironment (TME) through a standardized panel of HIFs derived from H&E whole slide images across multiple cancer types. Additionally, Incendia Therapeutics will present two posters reporting results that were generated utilizing PathExplore. “Building upon past publications and presentations, we continue to see the utility for histological features of the tumor microenvironment to further our understanding of disease biology, patient prognosis, and therapeutic response, which ultimately may lead to the discovery and implementation of novel biomarkers to advance precision medicine,” explained Mike Montalto, Ph.D., Chief Scientific Officer, PathAI. All three posters demonstrate the correlation between specific HIFs and established molecular measurements of the TME (e.g., gene expression profiles of specific cell populations), as well as specific HIFs and complex molecular signatures (e.g., immune phenotypes) which could better aid in the identification of patients eligible for targeted therapies, or result in the identification of new histology-based biomarkers. Quantifying the effect of microsatellite instability and mismatch repair deficiency on the tumor microenvironment (Poster 73) In this research, PathAI investigated the potential to predict and compare microsatellite stability and mismatch repair subtypes in colorectal and endometrial cancers utilizing PathExplore HIFs. The findings suggest MSS/dMMR tumors may warrant consideration for immunotherapy due to their TME’s similarity to microsatellite instability-high (MSI-H) and tumor mutation burden-high (TMB-H) solid tumors and AI-powered analysis of H&E WSI presents a more accessible and scalable method than current dMMR testing options. This poster will be presented by Judy Chen and Shima Nofallah on Friday, November 3 rd. Poster hall hours are 9 a.m. to 7 p.m. PT. Quantification of tumor infiltrating lymphocytes (TILs) from pathology slides reflects molecular immune phenotypes (Poster 122) In this research, PathAI deployed its PathExplore products on H&E WSI across eight cancer indications to extract HIFs quantifying the TME, including features that represent TIL fractions, densities, and distributions. Analysis revealed statistically significant correlations between TIL-associated HIFs with gene expression of known lymphocyte markers, as well as immune signature scores such as lymphocyte infiltration. These results show the predictive power that TIL-associated HIFs have for identifying immune phenotypes, as well as a promising direction for the discovery of histology-based immune biomarkers. This poster will be presented by Judy Shen on Saturday, November 4 th. Poster hall hours are 9 a.m. to 8:30 p.m. PT. Deep learning models identify key tumor microenvironment features associated with genetic signatures of UV metagenesis and alkylating agent treatment in melanoma (Poster 110) In this research, PathAI used PathExplore HIFs to investigate the association between TME features and mutational signatures indicative of UV mutagenesis, as well as alkylating agents-induced mutations. The results suggest that quantifying a tumor’s tissue and cellular composition can reveal meaningful information regarding the underlying mutation-driven or treatment-induced changes in the TME, which may have implications for therapy selection. This poster will be presented by Shima Nofallah on Saturday, November 4 th. Poster hall hours are 9 a.m. to 8:30 p.m. PT. Incendia Therapeutics (formerly known as Parthenon Therapeutics) posters In addition to the posters above, Incendia Therapeutics will present two posters on Friday, November 3 rd reporting results that were generated utilizing PathExplore. One poster (Poster 1287) compares PathExplore HIFs to mIF features and concluded that "TME models are a robust tool to distinguish tissue and cell features from H&E slides, comparable to mlF image analysis, but requiring less effort, time, and expense." In the second (Poster 1497), Incendia Therapeutics leveraged HIFs quantifying lymphocyte densities across cancer epithelium, cancer stroma, and the epithelial-stromal interface (ESI) to characterize barriers to lymphocyte entry into the cancer epithelium across immune phenotypes. More information on these posters can be found at https://www.incendiatx.com Please visit the PathAI booth, 615, to learn more and meet the team, or email us at bd@pathai.com. About PathAI PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

October 31, 2023 10:00 AM Eastern Daylight Time

Groundwork BioAg Supercharges Agricultural Carbon Sequestration

Groundwork BioAg

Groundwork BioAg ® announced today the global launch of the Rootella Carbon ™ program, based on mycorrhizal carbon - a frontier technology that leverages mycorrhizal fungi as a nature-based solution for carbon dioxide removal. Rootella Carbon harnesses the power of Rootella® – highly effective mycorrhizal inoculants that are proven to sequester significant amounts of carbon in cropland (1-4 tCO2eq/acre annually). This innovative, Verra-certified program represents a transformative approach to carbon sequestration for conventional and regenerative farmers alike. “Since our inception, we have known that mycorrhiza – the Queen of Biologicals™ – offers a compelling agricultural solution to mitigate climate change,” said Dr. Yossi Koffman, co-founder and CEO of Groundwork BioAg. “Rootella Carbon delivers on that vision by paving the way to a gigaton of CO2 sequestration in the next decade.” Rootella has been applied on over 4.5 million acres in 17 countries. Rootella Carbon Enrollment Unlocks New Value Carbon credit programs have been touted as a new revenue source for farmers, but adoption has been slow thus far due to high costs and practice change requirements. In a recent survey of top producers in the United States, 63% of respondents said they would enroll in a carbon program if a product like Rootella unlocks additional revenue and fits easily into existing farming practices. Simultaneously, carbon buyers are fueling demand for premium, verifiable credits to meet net-zero pledges responsibly and sustainably. This year, a select group of corn, soybean, alfalfa, and cotton farmers across eight states enrolled acres in Rootella Carbon, the first mycorrhizal carbon project in the world. “Clearly soil biology is the new frontier and will be for the next 10 years,” said Sledge Taylor, who farms corn, soybean and cotton on a multi-generational farm in Mississippi and enrolled in Rootella Carbon. "I invest in my soil; it is a true asset." Rootella Carbon Program Ushers in a New Asset Class • Enables Adoption by Conventional and Regenerative Farmers: Rootella Carbon provides growers the additionality, or practice change, needed for carbon credit eligibility, regardless of current cultivation practices. • Delivers Carbon Permanence: Mycorrhizal fungi are carbon’s main pathway into the soil. Up to 20% of plant photosynthate is passed to mycorrhizae, creating a positive net flux of carbon into the soil. Mycorrhizae aggregate soil particles to form stable and recalcitrant carbon-based molecules that persist in the soil for millennia. • Boasts Impressive Co-Benefits: Groundwork BioAg was the first to crack the code on mass production of mycorrhiza for mainstream agriculture. By joining the Rootella Carbon program, farmers can leverage the co-benefits of Rootella products, including increased yields, fertilizer savings, and stress tolerance, while earning carbon credits. • Generates Premium Carbon Credits: Rootella Carbon farmers expect to sequester 1-4 tCO2eq per acre per year—an unprecedented carbon sequestration rate. Carbon buyers gain access to high-integrity, high-volume, Verra-certified carbon credits. Enrollment in Rootella Carbon is currently open to farms with a minimum of 250 acres, at https://www.groundworkbioag.com/rootella-carbon About Groundwork BioAg Groundwork BioAg, a global bioagriculture company, leverages the natural power of mycorrhizal fungi to improve the productivity, sustainability and profitability of commercial agriculture and expand regenerative agriculture practices. Groundwork BioAg’s unique and proprietary manufacturing process was the first to solve challenges inherent in high-volume, supremely concentrated mycorrhizal inoculant production. We will not rest until every hectare of arable land is protected by mycorrhizae and every farmer benefits from higher crop yields while preserving our soils. For more information, visit www.groundworkbioag.com. Contact Details AgTech PR for Groundwork BioAg Jennifer Goldston +1 816-260-0040 jennifer@agtechpr.com Company Website https://www.groundworkbioag.com

October 31, 2023 08:30 AM Eastern Daylight Time

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Evgen Pharma "delighted" with cash position after promising first half

Evgen Pharma PLC

Evgen Pharma PLC (AIM:EVG) CEO Dr Huw Jones and new CFO Toni Hanninen speak to Thomas Warner from Proactive after the clinical stage drug development company announced its interim results for the six months to 31 September 2023. Dr Jones gives an overview of how Evgen has been performing on the operational side, highlighting clinical progress, the successful receipt of some new grant funding as well as changes to the board and to the executive team with the hiring of Toni Hanninen in late summer. Hanninen gives an overview of how Evgen performed financial during the reporting period, noting that there were no nasty surprises during the six months and that the company's cash runway of £3.7mln currently runs to the end of 2024. He goes on to say that he is "very very delighted" with the length of the runway given the financial challenges many of Evgen's peers are currently facing. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 31, 2023 06:43 AM Eastern Daylight Time

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News Release

Marizyme Inc CEO releases corporate update including details of key progress on DuraGraft

Marizyme Inc

Marizyme Inc CEO David Barthel joined Steve Darling from Proactive to provide an exciting update on the remarkable progress that the company has achieved in recent months. Among the standout developments is the approval received from the US Food and Drug Administration for its groundbreaking product, DuraGraft. DuraGraft is a first-in-class vascular conduit solution that has received FDA clearance, marking a significant milestone for Marizyme. This innovative product is specifically indicated for use in adult patients undergoing Coronary Artery Bypass Grafting (CABG) surgeries. Its primary purpose is to facilitate the flushing and storage of saphenous vein grafts employed in CABG procedures, offering a cutting-edge solution to enhance patient outcomes in cardiac surgery. One notable aspect of Marizyme's progress is the growing acceptance of DuraGraft in both Europe and Asia. The company has achieved impressive sales figures, with a total of 1,131 DuraGraft kits shipped so far this year. This is a remarkable increase compared to the 485 DuraGraft kits shipped in the previous year, underscoring the product's traction and demand in the international market. In summary, Marizyme, under the leadership of CEO David Barthel, is making significant strides in the medical industry. The FDA approval of DuraGraft and its increasing adoption in international markets signify the company's commitment to advancing medical technologies that improve patient outcomes. As Marizyme continues to expand its reach and forge new partnerships, it is poised for continued growth and success in the years ahead. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

October 30, 2023 03:23 PM Eastern Daylight Time

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News Release

BioHarvest Sciences closes first tranche of financing bringing in C$11.78M to Treasury

BioHarvest Sciences Inc.

BioHarvest Sciences CEO Ilan Sobel joined Steve Darling from Proactive to share some exciting developments. The company has achieved a major milestone by successfully closing the first tranche of its financing, raising nearly C$12 million, even in the face of challenging market conditions. This accomplishment underscores the significant investor confidence in BioHarvest's strategic vision and the strength of its management team. The capital raised through this financing round will play a pivotal role in advancing several key initiatives within BioHarvest Sciences. One of the notable areas of focus is new product development and expansion. BioHarvest has ambitious plans to expand its product range, moving from a single SKU to ten SKUs spanning five different categories. Leveraging its advanced scientific capabilities, proven efficacy, and exceptional taste, the company is poised to make a significant impact in these markets. The eagerly awaited flagship product, a revolutionary coffee offering, is slated to disrupt the market starting in December. Geographical expansion is another crucial aspect of BioHarvest's growth strategy. With recent approval from Health Canada, the company is gearing up to enter the Canadian market, further extending its global footprint. Additionally, BioHarvest is accelerating clinical trials across various domains, positioning itself for substantial growth over the next 12 to 24 months. These clinical trials will not only underscore the efficacy of their products but also enhance their credibility and market presence. Despite the challenges posed by the current market conditions, BioHarvest remains unwavering in its commitment to the safety of its employees and the consistent delivery of high-quality products. The company's focus for the remainder of 2023 includes robust marketing initiatives and the highly anticipated launch of its innovative coffee product, aimed at revitalizing the stagnant decaffeinated coffee market. Contact Details Proactive Investors Canada +1 604-688-8158 na-editorial@proactiveinvestors.com

October 30, 2023 03:18 PM Eastern Daylight Time

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