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Osteopore "chasing the holy grail of tissue regeneration”

Osteopore Ltd

Osteopore Ltd (ASX:OSX) Chairman Mark Leong speaks to Thomas Warner from Proactive London about the Australian-Singaporean medical technology company's pursuit of what he calls the "holy grail of tissue regeneration." Leong explains that aiming to commercialise products designed to enable natural bone healing across multiple therapeutic areas, including both hard and soft tissue. Initially focused on bone regeneration, Osteopore has received major regulatory approvals for their implants. However, their technology also holds promise for soft tissue regeneration, including shoulder rotator cuff tendon repair and cartilage regeneration. Looking ahead, the company aims to enter the "huge" Chinese market and is actively researching ways to accelerate tissue regeneration, potentially reducing healing time significantly. He says "In the next half a year or so you'll see us breaking some new ground into entering the Chinese market... and on the technology front we will be putting more effort into developing the soft tissue part because that's a whole new area of therapeutic treatment... we are chasing the holy grail of tissue regeneration which is to speed up tissue regeneration." Contact Details Proactive Australia Pty Ltd Proactive Australia Pty Ltd +61 431 597 771 action.australia@proactiveinvestors.com

July 27, 2023 06:00 PM Eastern Daylight Time

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4GLOBAL "very pleased" with final results and looking to the future

4GLOBAL PLC

4GLOBAL PLC (AIM:4GBL) CEO Eloy Mazon speaks to Thomas Warner from Proactive London following the release of audited final results for the year ended 31 March 2023. Mazon gives his highlights from the news release, saying that "all in all we are very pleased with the year", which was the company's first as a listed entity. Group revenues for the year ending 31 March 2023, grew by 53% to £5.6mln, with basic earnings per share closing at 2.4p compared to losses of 7.1p in 2022. Mazon says that strong demand from international markets played a significant role in the results and aligning with the company's growth strategy. Looking ahead, Mazon says 4GLOBAL PLC is focusing on capitalising on the strong demand, particularly in the North American market, where they have established key relationships and commercial partnerships. He explains that commercial partnerships, like the recent one with Jonas Fitness in the US, provide a valuable route to market and complement their product offerings and client onboarding capabilities. As the market shifts towards valuing data and insights, 4GLOBAL PLC aims to leverage its extensive database and technology for cleansing and transforming data into actionable insights. They also have plans to explore AI integration with a view to providing more valuable insights to their customers. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 10:43 AM Eastern Daylight Time

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Oxford Cannabinoid Technologies "officially on the way" after first dosing

Oxford Cannabinoid Technologies Holdings PLC

Oxford Cannabinoid Technologies Holdings PLC (LSE:OCTP, OTCQB:OCTHF) Clarissa Sowemimo-Coker speaks to Thomas Warner from Proactive London after announcing that the company has commenced its phase I clinical trial for the lead drug candidate, OCT461201, marking the administration of the first human dose. Researchers will assess the pain relief treatment's safety, tolerability, and pharmacokinetic profile (how it interacts with the body). Sowemimo-Coker says its "so important to have that significant milestone of finally getting that first dose into a healthy volunteer, so we can officially say we're on the way and looking forward to getting those results over time." The trial holds promise for patients suffering from chemotherapy-induced peripheral neuropathy (CIPN), a condition affecting 60% of chemotherapy recipients, causing severe pain and sensitivity in extremities. Sowemimo-Coker also highlights the recent addition to the team of Dr. Farquhar Smith, who runs the only CIPN clinic in the UK at the Royal Marsden. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 10:39 AM Eastern Daylight Time

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Oxford Cannabinoid Technologies first dosing a "major achievement" - Proactive Research Analyst

Oxford Cannabinoid Technologies Holdings PLC

Proactive Research Analyst Daniel Appiah speaks to Thomas Warner at the London Studio after publishing a new research note on Oxford Cannabinoid Technology Holdings PLC. The pharmaceutical group announced on 27 July that it has commenced its phase I clinical trial for lead drug candidate, OCT461201, marking the administration of the first human dose. Appiah describes the news as a "major achievement" for Oxford Cannabinoid Technologies, highlighting its transformation from a development company into being a clinical company He also gives an overview of other recent news from the business. For more details, read Daniel's full report by clicking the link provided. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 10:38 AM Eastern Daylight Time

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PathAI Launches its AI-Powered PathExplore Data Access Program for Academic Researchers

PathAI

PathAI, a global leader in AI-powered pathology, today announced it has applied its PathExplore panel of human interpretable features (HIFs) on publicly available samples from The Cancer Genome Atlas (TCGA), a comprehensive resource of oncology data containing genomic and outcomes data, along with associated H&E whole-slide images (WSIs). PathAI will make the HIFs from eight TCGA cancer types available for free as a data access program for academic researchers to perform independent research to support their own investigations. Earlier this year, PathAI launched PathExplore, an AI-powered panel of HIFs offering unprecedented resolution of the tumor microenvironment (TME) from digitized H&E slides. Powered by artificial intelligence, PathExplore spatially characterizes the TME with single-cell resolution, giving researchers the ability to unlock insights on patient response, drug pathways, and potential novel biomarkers. The ability to characterize and quantify histopathological features of the TME will enable new avenues of disease research, and may lead to promising new therapies. With this PathExplore HIF research data set, oncology researchers can analyze tissue compositions, cell populations, and how their quantities and spatial relationships correlate with molecular signatures, treatment response or prognostic outcomes. This data set is the first of its kind: no other widely available quantitative, structured data set based on histopathology exists. The features are standardized across indications, so researchers can glean new insights into the common or distinct TME characteristics of each tumor type or patient subset. Adding structured and standardized pathology data to TCGA enables a new set of multi-model investigations for researchers to pursue, all while lowering the barrier to integrating pathology image data into biomedical research that previously had been restricted to labs that had access to manual pathology analysis. “The TME has been a challenge to fully investigate due to the sheer amount of spatially distributed information contained within it,” said Mike Montalto, PathAI’s chief scientific officer. “Pathologists can assess the specimens and try to estimate how certain cell or tissue growth patterns are present in each patient, but they cannot exhaustively enumerate each and every relevant cell type under the microscope. That is what our PathExplore products provide - they not only accurately identify where each cell is located, but they provide structured and standardized feature tables that can enable next generation pathology research to be performed.” To learn more about PathAI’s PathExplore HIF research data set and apply for access, please reach out to pathexplore.hifs@pathai.com. If approved, there is no cost to academic researchers to access and use these data sets. PathExplore HIFs are for research use only and not for use in diagnostic procedures. Biopharma industry partners interested in purchasing a license to access PathExplore TCGA HIFs may reach out to bd@pathai.com for more information. PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and diagnostic use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of patient samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

July 27, 2023 10:00 AM Eastern Daylight Time

Preventable Emergency Dental Visits Cost Americans $2 Billion Every Year — Here’s What You Can Do To Better Manage The High Costs of Dental Care

DentalPlans.com

By Rachael Green, Benzinga The end of the COVID-19 public health emergency has triggered many state Medicaid programs to review recipient eligibility for the first time since the pandemic first began — and an estimated 14.2 million people are expected to lose what little dental coverage they have. While the move to disenroll millions of Americans who no longer qualify for benefits might result in temporary cost savings for states, the long-term costs of reducing access to affordable preventative dental care will likely end up far outpacing any initial savings. Dental emergencies can be a very expensive issue that Americans face, costing approximately $2 billion per year, according to a systematic review of emergency department data. It’s also one of the most preventable. The average Medicaid enrollee with five continuous years of preventive care prior to 2019 experienced 43% lower costs than an individual who received no preventive dental care at all. Dental Care Still Costs Americans Billions Even With Insurance The 14 million Americans at risk of losing dental coverage this year are just part of the affordable dental care problem. According to the American Dental Association, the total amount spent on dental expenditures in the United States reached $162 billion in 2021. Less than half of that was covered by insurers, meaning patients had to pay $63 billion in out-of-pocket costs with the remaining $25 billion paid by publicly-funded supplemental programs. Due to budget concerns, more than half of Americans experiencing an oral health problem opt to just delay dental care which can lead to serious health problems. Dental Savings Plans Are An Affordable Alternative To Insurance That Could Put Dental Care Back In Reach For The Uninsured Or Underinsured Dental savings plans are a flexible insurance alternative that allows plan members to access preventive, restorative and even cosmetic dental services at reduced rates. Plan members report an average savings of 50%*. Anyone can sign up at any time and begin using their plan as soon as it activates, typically within 72 hours – though some plans activate in as little as 24 hours – even on large procedures. Unlike dental insurance, which typically caps coverage at $1,000-$1,500 annually, dental savings plans have no annual limits or restrictions based on current health conditions. With the cost of a root canal and crown costing roughly $1,200, it’s easy for traditional dental insurance to be maxed out after just one treatment plan. With dental savings plans, there is no limit to worry about. To use your plan, you simply show your membership card to one of the thousands of participating dentists and specialists nationwide, and you’ll be billed at the special reduced rate offered by your plan. For those who don’t have dental insurance, dental savings plans can help you afford expensive restorative care like root canals, crowns, bridges and dentures. They also include savings on procedures like dental implants, teeth whitening and veneers that are often not covered by insurance – as well as preventative care. Find your perfect plan today at DentalPlans.com, the largest dental plan marketplace with more than 25 plans from the most trusted brands in healthcare. DentalPlans.com makes it easy to find the plan that fits your specific needs. Visit DentalPlans.com and use their guided online plan finder today to get a personalized plan recommendation in minutes. *Discount Health Program consumer and provider surveys indicate average savings of 50%. Savings may vary by provider, location, and plan. All cost averages obtained from DentalPlans.com procedure search tool, and independent research. DentalPlans.com, founded in 1999, is a leading online marketplace for dental savings plans in the U.S., helping more than a million people to affordably access quality healthcare services. Our mission is to empower consumers with the tools, information, and services that they need to live happier, healthier lives. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Matthew Wong matthew.wong@wpromote.com Company Website https://www.dentalplans.com/

July 27, 2023 09:00 AM Eastern Daylight Time

hVIVO CEO reports on "very strong" H1 2023

hVIVO PLC

hVIVO PLC (AIM:HVO) chief executive Mo Khan speaks to Thomas Warner from Proactive after the specialist contract research organisation released a trading update for first half of 2023 - a period he describes as a "very strong six months." Khan gives his highlights from the update, highlighting a 52% year-on-year increase in revenues to £27.3mln. He attributes the growth to improved operational efficiencies and the increasing frequency of large concurrent trials. The company reports cash reserves of £31.3 million, even after paying out a special dividend of £3 million, with an order book of £78 million. Addressing a technical detail, Khan mentioned that the company would now report revenue exclusive of other income to align with industry practice. Despite delays at the Medicines and Healthcare Products Regulatory Agency impacting some UK clinical trials, Khan says that hVIVO has successfully managed the situation through its risk mitigation strategy. For the next six months, hVIVO plans to maintain its growth momentum, with full-year guidance of £53 million in revenue and an ever-expanding order book. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 08:36 AM Eastern Daylight Time

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Eco Animal Health Group diversifying its product portfolio

Eco Animal Health Group PLC

ECO Animal Health Group PLC (AIM: EAH) CEO David Hallas speaks to Thomas Warner from Proactive about the company's recent performance and his hopes for its future, during his first interview on the platform. Hallas starts by giving an overview of the business, which specialises in developing, registering and marketing pharmaceutical products for global animal health markets and particularly for pigs and chickens. The company's flagship product Aivlosin is a proprietary, patented medication which is effective against both respiratory and enteric diseases in pigs and poultry is an anti-infective treatment for respiratory and enteric diseases in animals. Over the past year, the company achieved 4% revenue growth, surpassing market expectations. Hallas highlighted strong growth in Latin America and South and Southeast Asia, driven by increasing demand for high-quality white meat. Looking ahead, Eco Animal Health plans to diversify into preventative disease solutions, such as vaccines and monoclonal antibodies, targeting the US market by the end of next year. Hallas also addressed misconceptions, emphasising that the company's growth is not solely reliant on the Chinese market and that a balanced approach of prevention and treatment is essential for success. Contact Details Proactive UK Ltd Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 08:23 AM Eastern Daylight Time

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Communications, Video, and Technology Accessibility Act Bill (CVTA) Announced before the 33rd Anniversary of the Americans with Disabilities Act (ADA)

Communication Service for the Deaf

Senator Edward J. Markey of Massachusetts announced the Communications, Video, and Technology Accessibility Act Bill (CVTA) this morning before the 33rd anniversary of the Americans with Disabilities Act. Accessibility standards and requirements have not kept pace with advances in communication technology since the 21 st Century Communications and Video Accessibility Act (CVAA) was passed over a decade ago. As such, individuals who rely on closed captioning, audio descriptions, and a wide range of other accessibility features do not have full access to a range of products and services that are integral to our daily lives. The passage of the CVTA Bill will ensure that Deaf and disabled communities have full access to technology in their personal and professional lives by addressing the following: Requiring closed captioning for online video programming, mirroring current televised video programming requirements; Requiring audio description for both online and televised video programming; Directing the FCC to create and update quality standards for video programming accessibility; Requiring video conferencing services to have built-in accessibility features, such as automatic captioning functions, and the ability to connect sign language interpreters and assistive technologies that are designed to increase access for people with disabilities (e.g., refreshable braille displays); Establishing standards for American Sign Language interpretation when provided during video programming; Ensuring Deaf people who use sign language have equitable access to 9-1-1 emergency services through the use of direct video calling or telecommunications relay services; Requiring manufacturers of devices that display video programming, such as televisions and computers, to include features that allow easy activation and customization of closed captioning and audio description preferences; Expanding the contribution base for the Telecommunications Relay Services Interstate Fund to ensure its sustainability; and Empowering the FCC to ensure accessibility regulations keep pace with emerging technologies, such as artificial intelligence and virtual reality platforms. The team at Communication Service for the Deaf (CSD) encourages you to get in touch with your congressional leaders and express your support for the CVTA Bill. Let Your Representatives Know You Support the CVTA You can download one of our letter templates to get started and use the links below to find your Congressional representative(s). Download the template that applies to you Find your representative Learn more about the 21st Century Communications and Video Accessibility Act (CVAA) Learn more about the CVTA Bill “We are committed as an organization to clearly identifying barriers to accessibility wherever they reside and delivering solutions to ensure full inclusion for all as technology evolves and advancements are made,” Chris Soukup, CEO of CSD, shared. “The CVTA Bill supports this important work and advances equitable access to information, communication, and opportunities for deaf and disability communities.” With this legislation in place accessibility standards will catch up with the rapid advancements in communication technology, ensuring that closed captioning, audio descriptions, and other essential features are seamlessly integrated into television programming and online video streaming platforms. Viewers with disabilities will have the power to easily activate and customize their preferred settings, whether on televisions, smartphones, laptops, or tablets, empowering them to engage fully with the content they love. Together, we can secure a brighter future for the Deaf and hard of hearing community, where technology is a tool for empowerment, not exclusion. Support the CVTA Bill and be a part of this inspiring journey toward equality. About Communication Service for the Deaf Communication Service for the Deaf (CSD) is the largest Deaf-led social impact organization in the world. For more than four decades, CSD has been a leader in creating and providing accessible and innovative solutions for the Deaf community. Today, CSD continues its work to create opportunities for personal and economic growth within the Deaf community, specifically addressing leadership and employment. For more information, please visit CSD and follow us on Facebook, Twitter, Instagram, and LinkedIn. Contact Details Communication Service for the Deaf Molly Miller +1 315-679-8948 mmiller@csd.org Company Website https://www.csd.org/

July 25, 2023 02:05 PM Eastern Daylight Time

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