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James McDevitt, Head of Equity Sales & Trading at Roberts & Ryan, Inc., is selected by Irish America Magazine for its 26th Annual Wall Street 50

Roberts & Ryan, Inc.

Roberts & Ryan, Inc., America’s first Service-Disabled Veteran-Owned Broker Dealer, is proud to recognize James McDevitt for his selection to Irish America Magazine’s 26th Annual Wall Street 50. The magazine’s Wall Street 50 recognizes the outstanding accomplishments and success of the best and the brightest Irish American and Irish-born leaders of the financial industry. Mr. McDevitt will be honored at the magazine’s gala dinner on Monday, October 30, 2023, at The New York Yacht Club. Jim’s Irish heritage can be traced back to both sets of Grandparents who emigrated to the United States in the late 1920’s. The McDevitt side from County Derry, and the maternal side from County Clare. Ireland and all things Irish have always been highlighted at family events, the history, and the luck that found the family in NYC. Mr. McDevitt is head of Equities Sales & Trading, Capital Markets at Roberts & Ryan, Inc., with an expertise in equity trading. He is a graduate of Oneota State College in New York, where he received his Bachelor of Arts degree, with a focus on American History. He also studied Technical Analysis at the New York Institute of Finance. Jim was a specialist on the floor of the New York Stock Exchange (NYSE) for 25 years, rising to become a partner at MJ Meehan & Co, and then as a Senior Vice President with Bank of America Specialists. During his career, Jim managed the trading post for marquee NYSE listed securities including Citibank, Walmart, Colgate, Sprint, McDonald’s, and JP Morgan. Jim spent three years at Academy Securities as a Managing Director selling fixed income and equity services to Corporate Treasurers. Jim has been involved in a number of charities and is a Board Member of Roberts & Ryan, Inc. He resides in Long Branch, NJ with his wife Nancy. They have three children, Patrick, Jennifer, and Colin. About Roberts and Ryan, Inc. Roberts & Ryan, Inc. is a Service-Disabled Veteran Owned (SDVO) broker dealer providing services in debt and equity capital markets, equity and fixed-income secondary trading, as well as corporate access events. The firm was founded in 1987 by a United States Marine Corps Vietnam combat veteran and Purple Heart recipient. With over $1.8 million in committed donations since 2018, Roberts & Ryan is active in donating to charitable foundations that make significant positive impacts in the lives of veterans and their families, focusing on general wellness, mental health, and career transition. To learn more about Roberts & Ryan, please visit www.roberts-ryan.com. Contact Details Michael C. Del Priore +1 646-859-4061 mdelpriore@roberts-ryan.com Company Website https://www.roberts-ryan.com

October 27, 2023 09:00 AM Eastern Daylight Time

BBVA Spark backs Twinco Capital with new €50 million debt facility to serve growing demand for sustainable supply chain finance

Twinco Capital

There is a staggering $2.5 trillion global trade finance gap that mainly affects SMEs in emerging countries, limiting their ability to access new business opportunities. Helping businesses to bridge this finance gap, supply chain fintech Twinco Capital announced on Tuesday, in the sixth edition of the Valencia Digital Summit (VDS), it has secured an additional €50 million facility with BBVA Spark to accelerate growth. Twinco, one of the few European high-growth fintechs led by women, offers the first sustainable supply chain finance solution in the market that covers purchase order funding and has provided over $250 million in funding to suppliers in emerging markets. "We are very pleased to support Sandra and Carmen, two entrepreneurs who have reinvented, with Twinco, the way supply chains are financed on a global scale by incorporating innovative environmental and social criteria into their supplier financing model" explains Roberto Albaladejo, head of BBVA Spark, an initiative that has more than 800 clients and facilitated €250 million in financing in just one year of operation. Twinco is a venture-backed business, with investors such as Quona Capital, Working Capital Fund, Mundi Ventures, Finch Capital. On the debt side, BBVA Spark will become one of Twinco’s key financial partners and joins EBN Banco de Negocios who has been supporting the Company from its inception, and Zubi Capital. Sandra Nolasco, CEO of Twinco Capital commented: We are thrilled to partner with BBVA Spark to help customers build truly sustainable and competitive global supply chains. It is only by partnering with this caliber of like-minded, financial institutions, that we will be able to address large-scale challenges like the one Twinco has set out to solve: closing the trade finance gap. This facility will support the company’s portfolio growth, expanding both the number of customers and geographies.” Twinco Capital engages with large corporations—mostly in the retail and apparel sectors—and offers funding to their suppliers worldwide, advancing up to 60% of the purchase order value upfront and paying the remainder upon delivery. The process is designed to be a fully transparent, no-hassle experience that provides the suppliers with funding for its purchase orders within 48 hours. The key to its success is its unique risk model, which complements the traditional view of financial risk with business performance and ESG data. In other words, it uses machine learning to assess the quality and strength of the commercial relationships between these large buyers and their suppliers. The company is growing rapidly and has already incorporated more than 150 suppliers, located in 13 different countries. Since launching in December 2019, Twinco Capital has grown by multiples of 3, supporting global trade during the pandemic and funding millions of purchase orders. Carmen Marin, COO of Twinco Capital added: “The value added Twinco is providing to customers stems from the combination of its unique funding solution with business intelligence that provides a holistic overview of supply chain risk. Technology and machine learning provide invaluable data insights on commercial, financial and ESG suppliers’ performance, giving our customers a state-of-the-art supply chain risk management tool.” The Amsterdam and Madrid-based fintech was founded in 2019 by Sandra Nolasco (CEO), an experienced banker and specialist in trade finance with an international career spanning over 20 years in major European commercial banks, and Carmen Marín (COO), who has over 16 years of management experience in both equity investing and project finance at Banco Santander. About Twinco Capital Twinco Capital, cofounded by Sandra Nolasco (CEO) and Carmen Marín (COO), is one of the few European high-growth fintechs led by women. Twinco offers the first sustainable supply chain finance solution in the market that covers purchase order funding.Twinco engages with large corporate partners to reduce financing costs and improve supply chain reliability by offering their suppliers access to affordable funding. Through its data analytics-powered platform, Twinco is able to provide suppliers across the globe with competitive liquidity from purchase order to final invoice. Twinco’s unique model benefits both suppliers and buyers, contributing to the construction of competitive and socially responsible supply chains. Learn more: www.twincocapital.com About BBVA Spark BBVA Spark was created in July 2022 with a banking offer aiming to meet the financial needs of startups. Its backing for innovative, high-growth companies includes short and long-term financing, with products ranging from credit cards to venture debt and access to a team of experts who understand their business model together with international support via its presence in Spain, Mexico, and Colombia. BBVA Spark has raised over €200 million in financing in Spain and Mexico and has just landed in Colombia. It offers its products and services to almost 500 customers. About BBVA BBVA is a customer-centric global financial services group founded in 1857. The Group has a strong leadership position in the Spanish market, is the largest financial institution in Mexico, it has leading franchises in South America and the Sunbelt Region of the United States. It is also the leading shareholder in Turkey's Garanti BBVA. Its purpose is to bring the age of opportunities to everyone, based on our customers' real needs: provide the best solutions, helping them make the best financial decisions, through an easy and convenient experience. The institution rests in solid values: Customer comes first, we think big and we are one team. Its responsible banking model aspires to achieve a more inclusive and sustainable society. Contact Details Twinco Capital Leticia Lopez-Perea communications@twincocapital.com Company Website https://www.twincocapital.com/

October 27, 2023 07:00 AM Eastern Daylight Time

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Procure Holdings CEO discusses space technology's role in modern warfare and beyond

HANetf Holdings Limited

Procure Holdings CEO Andrew Chanin, who works with HANetf on the Procure Space UCITS ETF (LON:YODA), delves into the rising significance of space technology in military operations in an interview with Proactive's Stephen Gunnion. Amid the conflicts in Ukraine and the Middle East, Chanin emphasized the pivotal role of satellite companies in monitoring border activities and military movements. Satellite imagery not only serves warfare and defense strategies but extends its importance to humanitarian efforts and climate change monitoring. Chanin highlighted the transformation of warfare due to advancements like GPS, with techniques such as GPS spoofing now emerging. As cyber threats loom large, the security of satellite technologies becomes imperative. Companies like SpaceX are making strides in launching capabilities, with countries like Israel striving for space independence. However, the space domain isn't devoid of challenges. The UK government recently faced a standoff with Russia over satellite control during the Ukrainian conflict, underlining space's evolving importance as the "new high ground for Modern Warfare." As the future unfolds, Chanin predicted enhanced security measures, increased satellite redundancy, and potentially even space-to-space or space-to-Earth combat. On a positive note, he envisioned space technology harnessing solar energy for Earth, signifying potential sustainable solutions benefiting global society. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 27, 2023 04:00 AM Eastern Daylight Time

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News Release

Borroe Finance Unveils AI-Powered Revenue Conversion Model For Businesses and Content Creators

Blockchain Digest

Borroe Finance ($ROE) ushers in a new medium for income generation in the Web3 landscape through artificial intelligence technology. This innovative approach sets it toward revolutionizing how businesses make money in the Web3 sector. Hence, many consider BorroeFinance a top DeFi project in the digital asset industry. Let’s put this claim to the test. Does BorroeFinance really hold such potential? Why or why not? >>BUY $ROE TOKENS NOW<< BorroeFinance: The AI-Powered Money Making Tool BorroeFinance ($ROE) is a platform that connects investors with businesses and content creators that need funding. It uses artificial intelligence (AI) to assess the risk of each business and to connect investors with businesses that match their interests. BorroeFinance is especially useful for content creators and other Web3 participants, as it allows them to sell their future earnings in exchange for upfront cash. Content creators can create non-fungible tokens representing their future revenue streams and sell them on the BorroeFinance marketplace for a discounted price using $ROE. This allows businesses to generate cash flow by selling their future earnings upfront. Also, buyers and sellers can exchange products without any form of disparity in terms of value sharing. BorroeFinance ($ROE) provides helpful solutions to people and businesses within Web3. Among these people include content creators, social media influencers, and others who create content services such as podcasts, blogs, and videos based on subscriptions. BorroeFinance adopts the fundamental aspects of Web3, such as inclusivity, transparency, and decentralization. Moreover, blockchain technology guarantees that all network transactions are untampered and traceable. Additionally, more investors can partake and invest in prospectively the best cryptocurrency investment available today. >>BUY $ROE TOKENS NOW<< $ROE Paves The Way To Financial Freedom Furthermore, investors are actively seeking projects that can unlock the door to financial independence. The BorroeFinance ($ROE) token presale is the key to achieving this feat in the cryptocurrency industry today. It has the potential to impact the market in the coming months and years significantly. It comes to a new DeFi project that is still in its early stages of development, but it is already rippling the crypto market. $ROE is the native token of BorroeFinance, and it is used to access all of the features and services the platform has to offer. It operates on the Polygon blockchain as a deflationary token. BorroeFinance’s contract address is accessible via the Polygon scan interface. Therefore, users can monitor activities within the blockchain. Also, to guarantee the safety of users, blockchain auditing platform BlockAudit certified BorroeFinance as a secure marketplace. The BorroeFinance ($ROE) presale is currently in its second stage, and it has been very successful so far. This progress shows that investors are interested in the project and believe that it has the potential to succeed. Investors who joined the presale at the beta stage have realized 50% of their initial capital. Priced at $0.015 in the second stage, $ROE investors may be glaring at a 167% rally in the coming term. This surge will see the token rise from $0.015 to the final stage price of $0.040. Hence, $ROE is a suitable option for investors searching for which crypto to buy in 2023. Learn more about BorroeFinance ($ROE) here: Visit BorroeFinance Presale | Join The Telegram Group | Follow BorroeFinance on Twitter Keywords: top DeFi project, new DeFi project, which crypto to buy Contact Details Borroe Finance media@borroefinance.ai

October 26, 2023 03:26 PM Eastern Daylight Time

News Release

Can Borroe Finance Over Take Meme Coins With its Real Life Utility?

Blockchain Digest

Recently, Binance announced that it would remove Dogecoin ($DOGE) and Shiba Inu ($SHIB) liquid swap from its liquidity pool on October 27, 2023. On the other hand, one of the best cryptocurrency exchanges in Japan recently listed these meme coins on its platform. Let’s delve in to find out if BorroeFinance ($ROE ) can overtake these meme coins in Q4 2023, according to experts’ forecasts. >>BUY $ROE TOKENS NOW<< BorroeFinance: Providing Short-term Liquidity to Web3 Participants BorroeFinance ($ROE) is an AI-powered fundraising marketplace that allows web3 businesses to generate instant cash by selling their future digital earnings to supportive communities at discounted prices. Experts believe BorroeFinance ($ROE) will eventually outperform Dogecoin ($DOGE) and Shiba Inu ($SHIB) because the platform offers real-life utility to DeFi companies as opposed to meme coins fueled by community interest only. BorroeFinance ($ROE) is selling for $0.015 in its second presale stage. According to analysts, BorroeFinance ($ROE) will hit the mainstream crypto market in the next few weeks and trade for $0.040. As a result, early BorroeFinance investors will see a massive 167% surge in the value of their $ROE tokens. >>BUY $ROE TOKENS NOW<< Dogecoin ($DOGE) Goes Live on Japanese Exchange On October 16, 2023, BitTrade, a leading Japanese exchange for top crypto coins, listed Dogecoin ($DOGE) on its platform. According to experts, this move will create more Dogecoin investors in Asia’s trillion-dollar economy. In addition, BitTrade also listed Shiba Inu ($SHIB) on the same day to satisfy the market’s demand for meme coins. Despite this development, Dogecoin ($DOGE) recorded no significant price surge. On October 14, $DOGE traded at $0.05931. A week later, $DOGE surged 3.19% to trade at $0.06123. According to analysts, Dogecoin ($DOGE) may trade below $0.05800 in Q4 2023 due to Binance delisting Dogecoin’s liquidity pool. Binance Delists Shiba Inu Liquidity Pool Recently, Binance announced that it will delist 17 liquidity pools from its liquid swap program to ‘reduce slippage and provide users with better transaction prices.’ According to the announcement, the $SHIB/$BUSD pair and $DOGE/$BUSD pairs were among the 17 liquidity pools to be delisted on October 27. Thankfully, Shiba Inu ($SHIB) investors remained calm after this announcement, and there was no subsequent selling pressure. On October 14, $SHIB traded at $0.000007003. By October 21, Shiba Inu ($SHIB) traded at $0.000007105. Analysts believe Shiba Inu ($SHIB) will surge to $0.000007860 in Q4 2023 due to a recent whale accumulation of 22.3 billion Shiba Inu ($SHIB) tokens on October 19. Learn more about BorroeFinance ($ROE) here: Visit BorroeFinance Presale | Join The Telegram Group | Follow BorroeFinance on Twitter Contact Details Borroe Finance media@borroefinance.ai

October 26, 2023 02:31 PM Eastern Daylight Time

Justin Sun and TRON DAO Celebrated at Dubai's Prestigious 2023 Blockchain Life Awards

TRON DAO

Geneva, Switzerland / October 26, 2023 / - TRON, a leading name in the blockchain space, is proud to attend the Blockchain Life Awards 2023. The event, held on October 25th in Dubai, saw TRON’s founder, Justin Sun, being awarded the prestigious title of “Crypto Entrepreneur of the Year”, and the TRON network itself securing the coveted “Layer-1 Solution of the Year” award. TRON's Advancements in the Blockchain Sector Under the guidance of various contributors including Justin Sun, TRON has demonstrated steady progress in the blockchain industry. As a Layer-1 solution, TRON has held its own amidst formidable platforms while continuing to enhance their ecosystem. The TRON network has reached impressive metrics: a robust user base of over 190 million total user accounts, a total value locked (TVL) of more than $17.90 billion, over 6.61 billion transactions conducted, and nearly 1.8 million average daily active users in the past month. These milestones are a testament to the collective efforts of the TRON community and their commitment to enhancing decentralized solutions. The continued growth and recognition are not just achievements but also an inspiration to innovate and serve the broader crypto community. About the Blockchain Life Conference Dubai’s Blockchain Life Conference stands as a global confluence for crypto aficionados. Attracting over 7,000 delegates from 120 countries, the event has become a cornerstone for sharing ideas, knowledge, and the future of blockchain technology. With more than 80 industry luminaries sharing invaluable insights on upcoming market trends and global strategies, the conference facilitates a deep dive into the crypto world. Additionally, the event showcased an impressive expo with over 100 of the world’s leading blockchain and crypto companies. One of its major highlights was the Startup Pitch session, where innovative projects got a chance to present their ideas before an elite audience and the gathered attendees. Quick networking sessions and other formats were available to ensure attendees could maximize their experience. The day was wrapped up with a legendary afterparty at Sky 2.0, Dubai’s iconic club, creating an unforgettable experience for attendees. Sergei Khitrov, Founder of the Blockchain Life Forum in Dubai, commented “Justin Sun and TRON’s victories underscore its undoubted prowess and potential in the blockchain space. The awards serve as a testament to the network’s resilience, innovation, and promise.” The Blockchain Life Awards 2023 heralds a new era for Justin Sun and TRON, one of continued dominance, innovation, and service to the global crypto community. About TRON DAO TRON DAO is a community-governed DAO dedicated to accelerating the decentralization of the internet via blockchain technology and dApps. Founded in September 2017 by H.E. Justin Sun, the TRON network has continued to deliver impressive achievements since MainNet launch in May 2018. July 2018 also marked the ecosystem integration of BitTorrent, a pioneer in decentralized Web3 services boasting over 100 million monthly active users. The TRON network has gained incredible traction in recent years. As of October 2023, it has over 192.00 million total user accounts on the blockchain, more than 6.61 billion total transactions, and over $17.90 billion in total value locked (TVL), as reported on TRONSCAN. In addition, TRON hosts the largest circulating supply of USD Tether (USDT) stablecoin across the globe, overtaking USDT on Ethereum since April 2021. The TRON network completed full decentralization in December 2021 and is now a community-governed DAO. Most recently in October 2022, TRON was designated as the national blockchain for the Commonwealth of Dominica, which marks the first time a major public blockchain partnered with a sovereign nation to develop its national blockchain infrastructure. On top of the government’s endorsement to issue Dominica Coin (“DMC”), a blockchain-based fan token to help promote Dominica’s global fanfare, seven existing TRON-based tokens - TRX, BTT, NFT, JST, USDD, USDT, TUSD, have been granted statutory status as authorized digital currency and medium of exchange in the country. TRONNetwork | TRONDAO | Twitter | YouTube | Telegram | Discord | Reddit | GitHub | Medium | Forum Contact Details Hayward Wong press@tron.network Company Website https://trondao.org/

October 26, 2023 01:15 PM Eastern Daylight Time

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OpenSense AI Transforms Content Creation with the Launch of Innovative NSFW Image Generator Powered by AI

Hotimage.AI

OpenSense AI has recently launched their platform hotimage.ai, which allows users to generate images with the help of AI, including NSFW (Not Safe For Work) images. This new development marks a significant milestone in the evolution of creative expression, offering users unparalleled customization options and a seamless interface for generating lifelike and immersive NSFW imagery. The newly introduced AI NSFW Image Generator hotimage.ai represents a significant leap forward in the world of digital content creation, empowering users to craft and customize content with unparalleled precision and sophistication. By harnessing the power of advanced deep learning algorithms, hotimage.ai seamlessly integrates user preferences, enabling the creation of high-fidelity, realistic, and visually striking imagery that caters to a diverse array of artistic and entertainment needs. The company is eager to delve into the potential of content creation using artificial intelligence and aims to offer an interactive and accessible platform that enables creators, artists, and digital enthusiasts to realize their creative ideas. In addition, they aspire to foster a community where users can anonymously create, share, and modify their own content, along with that of others. The NSFW AI Generator from OpenSense AI offers an extensive array of customization options, enabling users to select from a diverse range of body types, poses, and scenarios to create content tailored to their specific preferences and artistic visions. With a user-friendly interface and seamless navigation, the platform ensures a streamlined and intuitive experience, allowing users to effortlessly bring their creative ideas to fruition in a virtual environment that prioritizes both quality and user control. This innovative offering has garnered significant attention within the industry, positioning the company at the forefront of technological innovation and creative exploration. By fostering a culture of responsible and ethical content creation, hotimage.ai remains committed to implementing robust content moderation mechanisms, ensuring that the platform is used in a manner that upholds the highest standards of integrity, respect, and digital ethics. As the digital landscape continues to evolve, OpenSense AI is dedicated to spearheading the responsible integration of AI-driven technologies, fostering a culture of digital literacy, and promoting ethical standards within the realm of content creation. By prioritizing the well-being of online communities and advocating for responsible digital engagement, OpenSense AI aims to empower creators and users alike to harness the full potential of the NSFW Image Generator for artistic expression and creative innovation, thereby redefining the standards of excellence within the digital content creation sphere. About OpenSense AI: OpenSense AI is a leading technology company specializing in the development of innovative AI-driven solutions for the digital content creation industry. With a strong commitment to technological advancement and ethical innovation. Contact Details OPENSENSEAI TECHNOLOGY LIMITED Adam Scott +1 346-428-8364 support@hotimage.ai

October 26, 2023 10:00 AM Eastern Daylight Time

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Elizabeth Lukas Appointed CEO, Americas of AutogenAI

AutogenAI

AutogenAI, an enterprise-level artificial intelligence company, has announced the appointment of Elizabeth Lukas as CEO, Americas. This appointment marks an important milestone for AutogenAI’s expansion in the U.S. market, providing businesses with the power of generative artificial intelligence to streamline bid and proposal creation and increase win rates. Lukas brings decades of experience as an entrepreneurial leader with a proven track record of driving growth and success for some of the world's top companies. Prior to joining AutogenAI, Lukas was CEO, Americas at Decoded Ltd. where she launched the UK startup into the U.S. market and drove 30%+ YOY growth. In her current role, Lukas will be responsible for propelling growth and the adoption of generative AI in business. “We are living in a time of unprecedented technological advancement and generative artificial intelligence is at the forefront of this revolution,” said Lukas. “Businesses everywhere are recognizing the potential of AI to solve their most pressing growth challenges, and it is thrilling to be able to provide them with the solutions they need. We have already seen exceptional results in the UK and I’m excited to continue driving traction in the U.S.” AutogenAI has experienced rapid growth since its inception in 2022. In one year, the company drove 100x revenue, closed a $22.3M Series A from Blossom Capital, and was awarded the AI Grant – a prestigious accelerator for AI startups. With 100 global employees, and success in the UK and Australian markets, AutogenAI has supported international businesses to win over $50M of additional work. Companies implementing AutogenAI’s bespoke AI tool are reporting up to 85% cost savings and a 30% uplift in win rates. “Elizabeth arrives at an important time for AutogenAI and will be instrumental to the development and growth of a primary market,” said AutogenAI founder and CEO, Sean Williams. “Following a year of rapid growth and customer feedback, we found our unique AI tool can increase the productivity of bid teams by eightfold, allowing businesses to focus on more strategic aspects of bidding. The US is the biggest procurement market in the world and we want to help organizations here benefit from the efficiencies and increased win rates that our software delivers.” About AutogenAI AutogenAI is an enterprise-level artificial intelligence technology with cutting-edge natural language processing solutions that are focused on assisting in the process of procurement and bid writing. Its AI empowers people to improve the quality of bids, tenders, and proposals, while greatly increasing efficiency. The AutogenAI team includes specialists in procurement, bid writing and machine learning. Founded by serial entrepreneur, Sean Williams, who started his career as a bid writer, AutogenAI has become the fastest-growing generative artificial intelligence company in the UK and is now being deployed across three continents. For more information, visit https://autogenai.com. Contact Details Kite Hill PR Kite Hill PR for AutogenAI +1 973-722-7881 autogenai@kitehillpr.com

October 26, 2023 09:30 AM Eastern Daylight Time

How Elicio Therapeutics Is Taking A Different Approach To Treating Cancers Like Colon Cancer, Expected To Be The Leading Killer Cancer By 2030

Benzinga

By Jeremy Golden, Benzinga Founded in 2011, Elicio Therapeutics Inc. (NASDAQ: ELTX) strives to use precision vaccines, immunomodulators and cell-based therapies to assemble cancer-killing immune responses against both blood and solid tumors. Elicio’s proprietary Amphiphile or “AMP” platform differentiates the company through the development of cancer immunotherapies for patients with limited treatment options and often poor outcomes. As the foundation for the various vaccine candidates in the biotech company’s pipeline, the AMP platform will help Elicio combat cancer and other diseases. Groundbreaking Platform Therapeutic vaccines are designed to train the immune system to recognize and destroy cancer cells by targeting tumor-specific antigens. These molecules are present on the surface of cancer cells, allowing the immune response to differentiate them from healthy cells. Tumor biology is complex, and it is difficult to identify effective target antigens. This is, in part, because the tumor microenvironment suppresses immune activity. Differentiating itself from competitors, Elicio Therapeutics is attacking this challenge head-on by re-engineering the body’s immune response to defeat cancer with potent lymph node-targeted immunotherapies and vaccines. Elicio’s AMP platform combines expertise in materials science and immunology to develop novel immunotherapies, including cell therapy activators, immunomodulators, adjuvants and vaccines to treat many aggressive cancers. The platform was first developed in the lab of Darrell Irvine, Ph.D., whose work as a Howard Hughes Medical Institute investigator and professor at the Koch Institute for Integrative Cancer Research at MIT has put him at the forefront of the field. A clinical-stage biotechnology company, Elicio Therapeutics has developed multiple cancer vaccine candidates, including: ELI-002 for KRAS-driven cancers caused by a mutation of the KRAS gene; ELI-007 for cancers involving mutant BRAF gene; and ELI-008 for cancers involving p53 hotspot mutations. “Looking to the future, our focus is on developing ELI-002 as a treatment for mutant KRAS (mKRAS)-driven cancers,” Chief Executive Officer Robert Connelly said in June after a reverse merger with Angion Biomedica Corp. “We are conducting clinical studies evaluating the 2-peptide and 7-peptide formulations of ELI-002 and are encouraged by the interim data that will be presented at ASCO, supporting ELI-002’s potential clinical utility in patients with high relapse risk pancreatic and colorectal cancers.” Vaccinating Against Cancer The Pancreatic Cancer Action Network estimates that about 95% of pancreatic cancer patients have the KRAS mutation, an error in a protein in normal cells that has the potential to cause cancer. By specifically targeting the KRAS mutation, prominent in patients with pancreatic and colon cancer, Elicio Therapeutics’ lead asset, ELI-002, is more promising than others in the clinical trial phase. Though further studies are needed to confirm its efficacy, the shot could improve survival for colon cancer, expected to be the number one cause of cancer deaths for people between 20-49 years of age by 2030, and pancreatic cancer, which has just a 12% survival rate after five years. Unlike other experimental cancer vaccines in development, the shot won't have to be customized to each patient, making it more affordable and readily available. Preclinical trials have shown that Amphiphiles target and concentrate an array of different immunogens in the lymph nodes, resulting in tumor or pathogen-targeted immunity. In one trial, an Elicio Therapeutics vaccine was given to patients with pancreatic and colorectal cancers. The results were promising, with 77% of patients experiencing a reduction in biomarkers that show the persistence of tumors. 32% of patients completely cleared those biomarkers. Elicio Therapeutics seems to be leading the charge toward vaccination against cancer. By combining expertise in immunology and immunotherapy, Elicio is precisely targeting and fully engaging the lymph nodes, the site in our bodies where the immune response to cancer is orchestrated. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

October 26, 2023 09:25 AM Eastern Daylight Time

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