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CK Life Sciences Presenting Preclinical Data for Its Investigational Dual-Antigen Cancer Vaccines, Co-targeting PRAME and PD-L1, at the 2023 Society for Immunotherapy of Cancer (SITC) Annual Meeting

CK Life Sciences Int'l., (Holdings) Inc.

HONG KONG SAR - Media OutReach - 1 November 2023 - CK Life Sciences Int'l., (Holdings) Inc. is presenting preclinical data for its investigational dual-antigen cancer vaccines, co-targeting PRAME (preferentially expressed antigen in melanoma) and PD-L1 (programmed death-ligand 1), on November 4 at the 2023 Society for Immunotherapy of Cancer (SITC) Annual Meeting in San Diego, California, USA. The investigational cancer vaccines evaluated in the preclinical study contain antigenic sequences of PRAME and PD-L1 intended to induce anti-cancer immune responses. PRAME is a cancer antigen highly expressed in many different types of cancers and has been associated with different oncogenic processes. PD-L1 represents one of the most important immune checkpoint antigens highly expressed on cancer cells to limit T-cell activation in the tumour microenvironment. "CK Life Sciences has a growing pipeline of cancer vaccines in various stages of development. The preclinical efficacy results of our dual-targeting PRAME/ PD-L1 cancer vaccines in liver cancer are promising and we hope to start clinical trials in the coming years," said Melvin Toh, Vice President & Chief Scientific Officer at CK Life Sciences. "Liver cancer is the second most common cause of cancer death in Asia and remains a major unmet medical need. We plan to investigate the PRAME/ PD-L1 dual-targeting cancer vaccines further in liver cancer and other cancer types known to over-express PRAME and PD-L1." DETAILS ON POSTER PRESENTATION: Abstract 1336: Authors: Session Date and Time In this preclinical study, we investigated whether dual-antigen cancer vaccines co-targeting PRAME and PD-L1 could suppress tumour growth in both prophylactic and therapeutic syngeneic mouse hepatocellular carcinoma (HCC) models. Two recombinant fusion protein vaccines comprised of PD-L1 and PRAME with or without GM-CSF were synthesised and formulated with a Toll-like receptor 9 agonist CpG oligodeoxynucleotide and aluminum hydroxide for vaccination. In the prophylactic tumour model study, the vaccines were administrated subcutaneously twice at a two-week interval before implantation of mouse HCC cells expressing PRAME, followed by weekly vaccination. In the therapeutic model study, the vaccines were administrated weekly into the animals after tumour cell implantation. Body weight and tumour volume were measured three times a week. All mice experienced a recoverable body weight loss without any abnormal behavior or reduction of activity after vaccination. In the prophylactic model (n=10 mice), both fusion protein vaccines significantly inhibited tumour growth, with 76.4% ( P<0.01 ) and 59.5% ( P<0.05 ) tumour growth inhibition (TGI) compared to control group, respectively. Importantly, there were some vaccinated mice without palpable tumour mass at the end of the study. These results were consistent with that found in the therapeutic model study (n = 10 mice), in which both vaccines significantly inhibited tumour growth, with 43.4% ( P<0.01 ) and 40.7% ( P<0.05 ) TGI, respectively, and prolonged animal survival compared to the control group (P<0.01). The results of this preclinical study clearly highlight the potential of simultaneously targeting PRAME and PD-L1 by fusion protein vaccination in cancer immunotherapy. DISCLAIMER This press release may contain forward-looking statements regarding the Group's research and development projects which may involve risks and uncertainties. Actual results may differ materially from expectations discussed in such forward-looking statements. All information in this press release is for general reference only and is not intended as investment advice or medical advice. CK Life Sciences Int'l., (Holdings) Inc. does not warrant or represent, express or implied, as to the accuracy, completeness or updated status of such information. No liability will be accepted for any loss or damage howsoever arising from or in reliance upon such information. REFERENCES [1] Gradecki S, Slingluff C, Gru A. J Cutan Pathol. PRAME expression in 155 cases of metastatic melanoma. Accessed at https://onlinelibrary.wiley.com/doi/10.1111/cup.13876. [2] Oyama K, Kanki K, Shimizu H, Kono Y, Azumi J, Toriguchi K, Hatano E, Shiota G. Gastrointest Tumors. Impact of preferentially expressed antigen of melanoma on the prognosis of hepatocellular carcinoma. Accessed at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465675/. [3] Thongprasert S, Yang PC, Lee J, Soo R, Gruselle O, Myo A, Louahed J, Lehmann F, Brichard V, Coche T. Lung Cancer. The prevalence of expression of MAGE-A3 and PRAME tumor antigens in East and South East Asian non-small cell lung cancer patients. Accessed at https://pubmed.ncbi.nlm.nih.gov/27794402/. [4] Epping M, Hart A, Glas A, Krijgsman O, Bernards R. Br J Cancer. PRAME expression and clinical outcome of breast cancer. Accessed at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527791/. [5] Ahmad S, Borch T, Hansen M, Andersen M. Cancer Immunol Immunother. PD-L1-specific T cells. Accessed at https://pubmed.ncbi.nlm.nih.gov/26724936/. CK Life Sciences Int'l., (Holdings) Inc. CK Life Sciences Int'l., (Holdings) Inc. (stock code: 0775) is listed on the Stock Exchange of Hong Kong. Bearing the mission of improving the quality of life, CK Life Sciences is engaged in the business of research and development, manufacturing, commercialisation, marketing, sale of, and investment in, products and assets which fall into three core categories - nutraceuticals, pharmaceuticals and agriculture-related. CK Life Sciences is a member of the CK Hutchison Group. For additional information, please visit www.ck-lifesciences.com. About PRAME PRAME is a protein commonly expressed by cancer cells, including melanoma (1), liver cancer (2), lung cancer (3) and breast cancer (4). PRAME contributes to the development and spread of cancer cells, and studies have shown that high levels of PRAME are associated with poor outcomes in cancer patients (2,4). In recent years, researchers have been exploring ways to target PRAME using immunotherapy, such as T-cell therapy and cancer vaccines, as a potential treatment for cancer. About PD-L1 PD-L1 is a protein expressed by certain immune cells and cancer cells. It plays a role in suppressing anti-cancer immune responses by binding to a receptor called programmed death-1 (PD-1) on T-cells, limiting the activation of T-cells, thereby helping cancer cells evade the immune system. Antibodies that can block the interaction of PD-L1 and PD-1 have been approved for the treatment of certain types of cancer. Recent studies have shown the presence of PD-L1-specific T-cells in both healthy individuals and cancer patients, which suggests that targeting PD-L1 with T-cell therapy or cancer vaccines could be a promising approach for cancer treatment (5). Contact Details CK Life Sciences Int'l., (Holdings) Inc. Wendy Tong Barnes +852 2122 2150 wendytb@ckah.com

November 01, 2023 09:06 PM Eastern Daylight Time

MGC Pharmaceuticals secures funding through to the end of 2024

MGC Pharmaceuticals Ltd

MGC Pharmaceuticals Ltd (LSE:MXC, OTC:MGCLF, ASX:MXC) CEO and Managing Director Roby Zomer speaks to Thomas Warner from Proactive London about the recent securing of the single largest injection of funding in the company's history. Following a difficult period of restructuring for the business, the investment provides the company with financial stability through to the end of 2024. MGC aims to progress its leading drugs, CannEpil and CimetrA, toward FDA approval and expand its medicinal footprint via early patient access schemes in the UK, Ireland, and other regions. Crucially, the recent funding influx originated primarily from Israel and the United States, indicating a shift in MGC's financial grounding. While historically reliant on Australian and UK capital, the company now sees American investors recognizing its potential, especially in FDA registrations in the lucrative US pharmaceutical market. Furthermore, MGC's European operations continue to strengthen, with production facilities in Slovenia and Malta and headquarters in Slovenia and the UK. For existing shareholders, Zomer assures that the restructuring and new investment ensure that the company remains on track to meet its goals. Reflecting on the company's challenging journey, Zomer emphasises the importance of persistence and belief in the company's mission. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

November 01, 2023 11:08 AM Eastern Daylight Time

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Brain Injury Association of America honors Centre for Neuro Skills’ Dr. Mark Ashley with Sheldon Berrol MD Clinical Service Award

Centre for Neuro Skills

The Brain Injury Association of America (BIAA) recognized Dr. Mark J. Ashley, CEO and founder of Centre for Neuro Skills (CNS), at the American Congress of Rehabilitation Medicine’s (ACRM) Centennial Conference as the recipient of the 2023 Sheldon Berrol MD Clinical Service Award on October 31, 2023. The award honors the person who has made “outstanding contributions to improving the quality of care, professional training, and/or education in the field of brain injury” in their career. “As someone who knew and worked with Dr. Sheldon Berrol, “Shelly,” witnessing his unwavering commitment to improving patient care and independence first-hand, I’m truly honored to receive this award,” says Dr. Mark Ashley. Dr. Ashley founded CNS in 1980 after his brother, Steve, experienced a life-changing event, leaving him cognitively intact, but dependent on a ventilator. Conventional medicine and available rehabilitative therapies gave his brother little hope for significant recovery or regaining an independent life, but Dr. Ashley believed that Steve could overcome the odds and that rehabilitation was possible through an intense therapy program. His brother became one of CNS’ first patients, and his recovery became the model for the brain injury rehabilitation provider’s philosophy. Steve’s recovery galvanized a belief that people with brain injuries should have a place to heal, and Dr. Ashley and his family could provide this essential service. Dr. Ashley’s dedication to understanding brain injury through personal experience, treating patients and research has helped countless patients over his 40 years of developing clinical therapies. He established the Clinical Research and Education Foundation, a nonprofit research organization that advances public and clinical understanding of brain injury causes and treatment in 2011. He has served on numerous committees and boards for organizations focused on brain injury treatment, research and outcomes. A published author on brain injury rehabilitation, Dr. Ashley has not only written books but also had his work and research published in peer-reviewed journals and research publications. Dr. Ashley received a Master of Science degree in Speech Pathology and holds a Doctor of Science degree from Southern Illinois University in Carbondale, Ill. He received a Doctor of Science degree from State University of New York at Geneseo. He is a licensed Speech Language Pathologist in California and Texas and is both a Certified Case Manager and Certified Brain Injury Specialist Trainer. *** About Centre for Neuro Skills Centre for Neuro Skills is an experienced and respected world leader in providing intensive rehabilitation and medical programs for those recovering from all types of brain injury. CNS covers a full spectrum of advanced care from residential and assisted living to outpatient/day treatment. Founded by Dr. Mark Ashley in 1980, CNS has seven locations in California and Texas. For more information about Centre for Neuro Skills, visit: www.neuroskills.com, Facebook, Twitter, LinkedIn, YouTube. Media, please note: Visual assets, including photos, are available. To request an interview with CNS leadership or clinical staff, please contact Robin Carr at 415.766.0927 or CNS@landispr.com. # # # Contact Details Landis Communications Inc. Robin Carr +1 415-971-3991 cns@landispr.com Company Website https://www.neuroskills.com/

November 01, 2023 08:01 AM Pacific Daylight Time

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RHIZOME AND PAUL G. ALLEN FAMILY FOUNDATION ANNOUNCE PARTNERSHIP TO ADVANCE CIVIC EDUCATION IN WASHINGTON SCHOOLS

Paul G. Allen Family Foundation

Seattle, WA — Today, Rhizome and the Paul G. Allen Family Foundation announced a $620,000 initiative aimed at creating a new Civic Service Fellowship program in Washington high schools. This three-year initiative will establish over 100 teams of Fellows in hyperlocal Chapters across the state of Washington. Rhizome’s Civic Service Fellowship prioritizes rural communities, under-resourced areas, and communities of color. The Civic Service Fellowship will empower high school students to lead year-round initiatives designed to boost civic engagement within their schools and communities. This will include organizing community events, educating younger students about democracy, and assisting their eligible peers with voter registration or pre-registration. Students have the opportunity to mend divisions, combat disengagement, and address the mental health crisis by creating civic communities. By inviting students to gain leadership experience and build healthy habits based on who they want to become, Rhizome inspires responsibility and produces pathways for lifelong leadership and public engagement. Civic participation can be an important factor for young people’s social and mental well-being. Recent research from Gallup has found that less than half of Gen Z members feel as though they are “thriving” and only 44% feel prepared for their future. While 76% of young people across the country believe their age group has the power to enact change, only 40% of all youth—and only 34% of youth of color—report feeling well-qualified to participate in politics. In an era marked by diminishing public trust and worsening mental health outcomes among young people, this initiative will equip students with the tools to engage their communities in building a healthier world for all. “After 90 of us came together as Co-Founders of Rhizome just two years ago, we are thrilled to announce this multi-year partnership with the Paul G. Allen Family Foundation, addressing the need for sustainable systems that empower emerging leaders to shape change,” said Jacob Merkle, Rhizome’s CEO. “In an era of unmet challenges to our civic and mental health, this collaboration allows Rhizome to scale our grassroots system, deepen our impact, and build collective power for young people. We’re grateful for the Foundation's recognition that young people are the future. We hope this early commitment will spur philanthropy to provide more scale-enabling, no-strings-attached funding for young people to create the safer, happier, and healthier world they deserve.” “Witnessing the growth of Rhizome from day one has been one of the most fulfilling experiences in my life. Not simply the growth of the organization, but the tangible difference that has been made in the confidence of countless students. As an organizer in Washington, my proudest moment is seeing the transformation in students as they gain their voice to fearlessly advocate for their own beliefs,” said Hiba Siddiqui, a Rhizome Regional Organizer who works in Eastern Washington. “Having the support of partners like the Paul G. Allen Family Foundation reaffirms our mission and gives us the resources to expand our reach. I am excited to see the indelible impact that will be made as Rhizome brings our community of trust, friendship, and belonging to other areas in Washington.” “Civic education is necessary now more than ever. Our civic landscape has shifted and testifies to the urgency to actively involve youth in bettering their communities and solving societal issues. As a committed civic educator for over two decades, I cannot emphasize enough how important it is to have partners in this mission,” said Jen Reidel, a Social Studies and English teacher at Bellingham High School. “I can provide classroom experiences, but I need like - minded civic organizations like Rhizome to help students find their civic identities and mission outside the classroom.” According to Ms. Reidel, Rhizome removes the responsibility of supporting a student club outside of class from the teacher and places it on the students and their Rhizome mentor. It honors student agency and diversity by equipping students to promote civic engagement within their school and identify issues they would like to address at a local level and authentically work toward their solution. Funds from the partnership will directly support student-led efforts by paying a dedicated team of Rhizome’s student organizers in Washington, who will work to implement the Civic Service Fellowship in local schools in their communities. By funding this important work, Rhizome and the Paul G. Allen Family Foundation are investing deeply in the next generation of lifelong civic leaders. About Rhizome Founded in 2021, Rhizome is a national network of student leaders organizing to empower young people to build stronger communities. Rhizome was co-founded by 90 young people to help students become more civically active while training the next generation of organizers and emerging leaders. Learn more at www.werhize.org. About the Paul G. Allen Family Foundation Founded in 1988 by philanthropists Jody Allen and the late Paul G. Allen, co-founder of Microsoft, the foundation invests in communities across the Pacific Northwest to enhance the human experience of arts & culture, center under-served populations, and mobilize young people to make impact. In addition, the foundation supports a global portfolio of nonprofit partners working across science and technology solutions to protect wildlife, preserve ocean health, and create lasting change. The foundation also funds the Paul G. Allen Frontiers Group, which works to advance cutting-edge research in all areas of bioscience. Contact Details Rhizome Maya Rodriguez, Communications Director +1 415-488-7692 mayar@werhize.org Company Website https://www.werhize.org

November 01, 2023 08:00 AM Pacific Daylight Time

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Living with Acromegaly: Spreading Awareness and Highlighting Treatment Options on Acromegaly Awareness Day

YourUpdateTV

A video accompanying this announcement is available at: https://youtu.be/y696riLIIKs For more information, visit MYCAPSSA.COM Acromegaly is a rare condition that affects about 25,000 people living in the U.S. It is caused by a benign tumor in the pituitary gland which is located just beneath the brain. This benign tumor makes too much growth hormone, and this can cause various issues such as fatigue, headaches, and increased growth of hands and feet and pretty much every part of the body. If not treated, acromegaly can cause high blood sugar as in Diabetes and high blood pressure, and sometimes cause serious damage to the heart which can be life-threatening. The good news is that there are some very good treatments available to help control the problem. A nationwide media tour was conducted on October 23rd to discuss the drug MYCAPSSA as well as to hear about the experiences of someone living with acromegaly. The media tour featured Dr. Anthony P. Heaney, Professor at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA) and Becky Bierman, a person living with acromegaly. Mycapssa, is a twice-daily oral medication that reduces the production of growth hormone and is designed for people who have previously been on an injectable version of octreotide therapy for the long-term maintenance of acromegaly. During the media tour Dr. Heaney and Becky discussed: · What acromegaly is and how many people it affects. · What it is like living with acromegaly. · Treatment options available for someone living with this disease. People diagnosed with acromegaly considering a new treatment option should talk to their doctors first. For more information, you can visit www.Mycapssa.com Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

November 01, 2023 09:57 AM Eastern Daylight Time

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HKBU studies show over half of COVID-19 patients have post-disease syndrome

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 1 November 2023 - The School of Chinese Medicine at Hong Kong Baptist University (HKBU) found that 55% of the patients who sought medical treatment from the "HKBU Chinese Medicine Telemedicine Centre Against COVID-19" during the fifth wave of the COVID-19 pandemic continued to experience at least one long COVID symptom for six months to a year after diagnosed with an infection. The most common symptoms are fatigue, brain fog and cough. Professor Bian Zhaoxiang, Director of the Clinical Division at HKBU’s School of Chinese Medicine (middle), together with his research team members Mr Cheung Chun-hoi, Associate Director of the Clinical Division (2nd left); Dr Zhang Jialing, Postdoctoral Fellow of the Centre for Chinese Herbal Medicine Drug Development (1st left); Mr Luo Jingyuan and Wong Hoi-ki, PhD students (2nd and 1st right) of SCM at HKBU, analyse patient statistics to deepen the medical community’s understanding of the symptoms during the early and middle stages of COVID-19 infection as well as the post-COVID syndrome. The study also revealed that patients who took Chinese medicine after COVID-19 infection took a shorter time to test negative in rapid tests, and experienced significant symptom relief compared to patients who did not take Chinese medicine. The research findings have been published in a number of papers in international academic journals including the Journal of Medical Virology and The American Journal of Chinese Medicine. HKBU established the "HKBU Chinese Medicine Telemedicine Centre Against COVID-19" in 2021 during the fifth wave of the COVID-19 pandemic in Hong Kong to provide free telemedical services for COVID-19 patients. Making reference to the treatment protocols and clinical experiences in Mainland China, the expert team of HKBU's School of Chinese Medicine formulated the "Chinese Medicine Clinical Guidelines for COVID-19 in Hong Kong" as the University's clinical diagnosis and treatment standards for COVID-19. The Telemedicine Centre follows the guidelines to provide diagnosis, treatment, and prevention services to COVID-19 patients, close contacts, and caregivers. Coughing is the most common early symptom of infection The HKBU research team led by Professor Bian Zhaoxiang, Director of the Clinical Division at the School of Chinese Medicine, conducted a retrospective study using patient statistics collected by the Telemedicine Centre during the fifth wave of the pandemic. The team analysed the symptoms in the first four weeks of about 13,000 patients who were infected with COVID-19 from mid-March to early May in 2022 and underwent home isolation. The results showed that 93% of patients experienced at least one symptom. The most common symptoms during the first week of infection were cough (91%), sputum (75%), dry throat (50%) and sore throat (44%). 17% of patients still had these symptoms four weeks after infection. Although the symptoms gradually subsided over time, the prevalence of fatigue increased. Chinese medicine accelerates viral clearance Among this batch of patients, the research team selected 311 patients who had taken Chinese medicine for five days within 10 days after diagnosis, and another 311 patients who had not taken any Chine medicine during the same period to evaluate the efficacy of Chinese medicine. The results showed that patients who took Chinese medicine within 10 days after COVID-19 infection needed an average of seven days to test negative in rapid tests, and experienced an average of four symptoms, which were significantly milder compared to patients who didn't take Chinese medicine. The average time to test negative for patients who did not take Chinese medicine was eight days, and they experienced an average of 11 symptoms. The results show that Chinese medicine is an effective treatment for COVID-19 infection. Over half of the patients experience long COVID after six months The research team conducted a follow-up telephone survey from November 2022 to January 2023 with 6,242 COVID-19 patients who sought medical consultation at the Telemedicine Centre between December 2021 and May 2022 to understand their symptoms and risk factors after six months to a year of infection. The study found that 55% of patients still experienced at least one long-term symptom, i.e. "long COVID" or "post-COVID syndrome". The most common symptoms were fatigue (36%), brain fog (34%) and cough (31%). Furthermore, females, middle-aged persons, obese people, those with comorbidities such as ophthalmology or otorhinolaryngology diseases, digestive system diseases, respiratory diseases, hyperlipidemia and cardiovascular diseases, and patients with more initial symptoms were more likely to develop long COVID. However, there was no significant correlation between taking three or more doses of vaccine and the occurrence of long COVID. Professor Bian said: "HKBU established the Telemedicine Centre during the COVID-19 outbreak to provide free treatments for COVID-19 patients. We analysed the Centre's data to deepen the medical community's understanding of the symptoms during the early and middle stages of COVID-19 infection as well as the post-COVID syndrome. It allows the public to understand the effectiveness of Chinese medicine in treating COVID-19. The study also shows that the tele-services of Chinese medicine can be an important component of Hong Kong's healthcare and disease prevention system." To address the issues of long COVID, Professor Bian's team has initiated a series of clinical and basic research, including a survey of COVID-19 patients with diabetes and a clinical trial conducted in collaboration with other partners to investigate the efficacy, safety and action mechanism of senlingcao oral liquid in treating long COVID fatigue. These projects aim to further explore the impact of COVID-19 and its treatment options. Contact Details Christina Wu christinawu@hkbu.edu.hk

November 01, 2023 09:00 AM Eastern Daylight Time

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Elsevier Partners with the Korean Society for Molecular and Cellular Biology to Publish Molecules and Cells

Elsevier

The Korean Society for Molecular and Cellular Biology (KSMCB), one of the largest and most prominent academic societies in the field of life sciences in Korea, and Elsevier, a leader in information and analytics for customers across the global research and health ecosystems, are pleased to announce a new partnership to publish Molecules and Cells, the flagship journal of KSMCB. This English-language publication will be hosted on Elsevier’s industry-leading online platform of peer-reviewed literature, ScienceDirect, beginning January 1, 2024. Continuing as a Gold Open Access, online-only publication, all articles will be immediately and permanently free to read and download. Junho Lee, PhD, Professor, Department of Biological Sciences, Seoul National University and President of KSMCB, commented, “It is with great pleasure that I would like to announce that KSMCB has entered into a co-publishing agreement with Elsevier. The rationale behind this decision is to meet the challenges of an ever-changing publishing environment and the growing needs of society members and scientific colleagues. We will be able to take advantage of the global network and professionalism that Elsevier brings, which will result in the recognition that our journal strives to achieve on the global stage. We envision that Molecules and Cells will make a giant leap forward in the near future to becoming a premier international scientific journal of which we can all be proud.” Launched in 1990 and now in its 46th volume, Molecules and Cells has continually solidified its position as a leading journal in the fields of molecular and cellular biology. It has published articles in English from more than 30 countries on its way to becoming a globally recognized journal. Since 1995, the journal has been indexed in Web of Science/Science Citation Index-Expanded, the first Korean journal in the biological sciences to be accepted for inclusion in this service. Molecules and Cells continues its tradition of publishing excellence under the expert leadership of Editor-in-Chief Jae Bum Kim, PhD, supported by an eminent editorial board. After earning his doctoral degree in the Department of Microbiology & Molecular Genetics, Harvard University, Prof. Kim has held a number of prestigious academic appointments in Korea and the United States. He is currently Professor in the Department of Biological Sciences and serves as the Director of the Center for Adipose Tissue Remodeling, Creative Research Initiatives, Center for Studies on Structure-Function in Adipocyte at Seoul National University. Prof. Kim noted, “The editorial team, editorial board, KSMCB leadership, and I remain passionate and committed to timely publication of the highest quality scholarly work. We anticipate that Elsevier’s exceptional level of publishing expertise and professionalism will help bring the journal to a wider worldwide audience of authors and readers more efficiently and effectively, providing greater opportunities for collaboration and knowledge sharing.” The journal will expand its impact and outreach through availability via ScienceDirect, which will host 33 years of Molecules and Cells back volumes (from 1990 onwards). ScienceDirect has 1 billion annual visits and over 17,000 licenses worldwide. Manuscripts may be submitted via Editorial Manager. Accepted manuscripts, on average, will be available online within 48 hours in a pre-release format. Molecules and Cells is covered in important abstracting and indexing services including Science Citation Index-Expanded (current Journal Impact Factor 3.8), Scopus (current CiteScore 6.9), PubMed, Current Contents®/Life Sciences, and Chemical Abstract Service. Louise Curtis, Elsevier Senior Vice President, Life Sciences, Social Sciences, Economics, remarked, “We are delighted that KSMCB has selected Elsevier as its partner, and we are proud to publish this well-established, well-run open access journal. It is an excellent complement to the Elsevier molecular and cell biology journal portfolio, expanding our author base into the Korean scientific community. We are committed to providing the best possible support for KSMCB’s mission and community and fostering an international exchange of cutting-edge research.” Notes for editors About Molecules and Cells Molecules and Cells is an international online open access journal devoted to the advancement and dissemination of fundamental knowledge and ground-breaking research in all areas of cellular and molecular biology. Publications cover a broad range of topics of general interest but should be within relevant fields of biology. It is the official journal of the Korean Society for Molecular and Cellular Biology. www.sciencedirect.com/journal/molecules-and-cells About the Korean Society for Molecular and Cellular Biology (KSMCB) The Korean Society of Molecular and Cellular Biology (KSMCB) was founded in 1989. During the last 30 years, KSMCB has grown into one of the largest and most prominent academic societies in the life sciences in Korea. KSMCB serves as a platform for molecular and cellular biologists outside Korea as well, providing them with the opportunity of collaboration and knowledge of cutting-edge research trends. The Society publishes Molecules and Cells, a molecular biology journal with a broad subject coverage and readership, and hosts an annual international conference, a forum for cutting-edge research in all areas of molecular and cellular biology. www.ksmcb.or.kr/eng About Elsevier and society partnerships Elsevier has long-standing partnerships with over 600 learned societies worldwide, helping them to realize their missions and inspire and support their communities. We pride ourselves on consistently delivering outstanding publishing outcomes through strategic insight, reliable finances, global dissemination, embracing open science and open access, and championing the needs of the communities we jointly serve. www.elsevier.com/societies About Elsevier As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems. In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, academic leaders, funders, R&D-intensive corporations, doctors, and nurses. Elsevier employs 9,000 people worldwide, including over 2,500 technologists. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on over 2,800 journals, including The Lancet and Cell; 46,000+ eBook titles; and iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. Contact Details Carolien van der Zanden Senior Marketing Communications Manager, Elsevier c.zanden@elsevier.com Jae Bum Kim Editor-in-Chief, Molecules and Cells jaebkim@snu.ac.kr Company Website https://www.elsevier.com/

November 01, 2023 09:00 AM Eastern Daylight Time

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DPH Biologicals, University of Illinois Team Up to Improve Crop Residue Management

DPH Biologicals

• Trials focus on benefits of biologicals for post-harvest stubble control • First-year results unveiled October 30 at international agronomy sciences meeting DPH Biologicals and the University of Illinois Urbana-Champaign (UIUC) announced today a research collaboration validating the impact biologicals make to accelerate decomposition of crop residue, thereby unlocking the adoption of more sustainable and profitable farming practices for United States high-yield, broadacre growers. Starting in spring of 2023, the UIUC Crop Physiology Lab run by Fred Below, Ph.D. and Connor Sible, Ph.D., began researching the impact of microbial solutions in crop residue management including the use of TerraTrove® Residuce®, technology developed by DPH Bio. Residuce is a biodigester, a biological specifically formulated to accelerate the process of plant tissue degradation. “Supporting Dr. Below’s lab is an opportunity to ground-truth the benefits of biodigesters, understand how technologies like Residuce can enable more sustainable and profitable cropping practices and to develop best practice use recommendations supporting our retail and channel partners with high-value, science-verified cropping solutions,” said Alex Cochran, Ph.D., DPH Bio’s Chief Technology Officer. A subset of biofertilizers, biodigester sales are exploding as part of the expanding global biofertility market, projected to reach $3.75 billion USD in sales by 2030, a CAGR of 12.80%, underpinned by market demand for more sustainably-grown food with farmers’ need to offset increasing costs and shrinking profit margins. Residuce, available in a liquid and dry formulation, is currently used on 1.5 million North American acres, a 50% growth rate in the past year. Already, early UIUC trial results indicate improved yields when biodigesters were used with cover crop plantings. Cover crops are typically associated with lower yields, a correlation that has discouraged grower adoption despite the well-known soil health benefits of cover cropping. Using Residuce on an unmanaged cereal rye cover crop partially eliminated the nearly nine-bushel yield penalty average experienced when a cover crop is planted between no-till corn and soybean rotations, according to research presented Monday by UIUC graduate student Darby Danzl at the 2023 ASA, CSSA, SSSA International Annual Meeting, held jointly by the American Society of Agronomy, the Crop Science Society of America and the Soil Science Society of America. The yield penalty was nearly fully eliminated when a fertilizer source was combined with Residuce. Research Focuses on Value-Creation of Biodigesters for Corn, Soybean and Wheat Production With UIUC already a research leader in residue management strategies in broadacre cropping systems, the ongoing field trial collaborations with DPH Bio will focus on further defining the value biodigesters bring to unlocking the value of residue for sustainable agriculture. DPH Bio recently published “ Rethinking Crop Residue Management with Biodigesters,” an analysis of research into crop residue management, includes work already completed by the UIUC crop physiology lab as well as DPH Bio’s field trial results. The UIUC-DPH partnership will expand upon the research and benefits of biodigesters presented in the white paper. Large volumes of crop residue create problems, Sible said, with high-yielding cultivars and practices like no-till, double-cropping and cover cropping generating more residue than growers’ have ever experienced. Today’s average 180-bushel corn crop yields 3.9 tons per acre of corn stover and every additional bushel in yield contributes another 43.7 pounds of stover, according to UIUC research. Growers complain of delayed germination, poor plant stands, nutrients locked up in the decomposing process, increased disease and pest outbreaks from pathogens that overwinter in thick residue layers and yield penalties associated with residue accumulation. Yet, once broken down, residue is an untapped source of nutrients and better soil and crop health. Strategies for accelerating residue degradation are key, Below said. “Residue is nature’s biological. It’s so good for the soil and the plant, and there's a lot of nutrition there. But residue can be your best friend or your worst nightmare,” Below said. “The quicker you can degrade residue, the easier you can plant, the more uniform your crop is going to emerge and the more likely you’re going to get the benefits of that residue.” The next round of joint UIUC-DPH Bio trials will focus on: ● The benefits of biodigesters for cover crop management in no-till corn and soybean. ● Fall versus spring residue management with biodigesters to benefit continuous corn yield. ● Biodigesters value to residue management in a wheat-soybean double crop rotation. Studies conducted in 2023 will be available this winter. The second round of trial results will be available before the 2025 planting season. About DPH Biologicals DPH Biologicals aims to be the industry’s most trusted biologicals provider. We attract, develop and scale technologies improving broad market access and simplifying the grower experience with biologicals. With more than three decades invested into scientific research, field-testing, partner relationships and product development, we’ve built three proven product platforms – BellaTrove® for biocontrols; TerraTrove® for biofertility and biodigesters; and RegenAphex™, a regenerative, plant-based humus extract that serves as a foundation for our flagship biofertilizer SP-1 Classic and a platform for third-party technological development. For more information, visit www.dphbio.com. Contact Details AgTech PR for DPH Bio Georgie Smith georgie@agtechpr.com Company Website http://www.dphbio.com

November 01, 2023 08:30 AM Eastern Daylight Time

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CURE ALZHEIMER’S FUND RECEIVES $50,000 GRANT FROM GREATER TOLEDO COMMUNITY FOUNDATION

Alzheimer’s Disease Research Foundation

Cure Alzheimer’s Fund (CureAlz), a non-profit dedicated to funding the most promising research to end Alzheimer’s disease, received a $50,000 grant from the Robert A. Stranahan, Jr. Charitable Advised Fund of the Greater Toledo Community Foundation. This grant represents their largest gift to Cure Alzheimer’s Fund since the Robert A. Stranahan, Jr. Charitable Advised Fund made its first grant to the non-profit in 2016. Through eight years of consecutive giving, the fund has provided $235,000 to CureAlz scientists working to find a cure. “Year after year, we are more encouraged by the progress Cure Alzheimer’s Fund is making to understand Alzheimer’s disease,” said Keith Burwell, President of Greater Toledo Community Foundation. “Our continued philanthropic support provides necessary funding for research that accelerates the discoveries that will eventually tackle Alzheimer’s disease and find a cure.” “The Greater Toledo Community Foundation recognizes the physical, emotional and financial impact this disease has on so many families in its community and around the world and has been a wonderful partner to CureAlz in our mission to find a cure,” said Meg Smith, CEO of Cure Alzheimer’s Fund. “Alzheimer’s devastates not just individual patients but their family and community as well. Developing effective, accessible therapies requires deep understanding of the complex causes and pathologies of Alzheimer’s. The scientists CureAlz supports are pursuing vital high-risk, high-reward research to accelerate progress. We are deeply grateful to the Greater Toledo Community Foundation for sharing our goal to end the burden of Alzheimer’s.” It is estimated that more than 6.5 million Americans are currently living with Alzheimer’s disease, a number that is expected to increase rapidly as the Baby Boomer generation continues to age. It is projected that the share of adults 65 and older in the US population will rise to 22 percent by 2050. With age as the biggest risk factor, Alzheimer’s disease is poised to place an unmanageable financial burden on the US healthcare system, caregivers, and loved ones. With the philanthropic support of the Robert A. Stranahan, Jr. Charitable Advised Fund of the Greater Toledo Community Foundation and tens of thousands of other donors, CureAlz has been able to direct more than $180 million to Alzheimer’s disease research since its inception in 2004 and has delivered critical breakthroughs for the research community. About Greater Toledo Community Foundation Greater Toledo Community Foundation is a public charitable organization created by citizens of our community to enrich the quality of life for individuals and families in our area. In existence since 1973, the Foundation has more than 970 individual current funds with assets of approximately $406 million. The Foundation provides philanthropic services for individuals, families, businesses and corporations to meet their charitable giving needs. For more information on the Foundation, visit the organization’s website at www.toledocf.org or follow them on Facebook or LinkedIn. About Cure Alzheimer’s Fund Cure Alzheimer’s Fund is a non-profit dedicated to funding the most promising research to prevent, slow, or reverse Alzheimer’s disease. Since its founding in 2004, Cure Alzheimer’s Fund has provided grants to the world’s leading researchers and contributed more than $180 million to research. Its funded initiatives have been responsible for many key breakthroughs in understanding the causes and pathology of Alzheimer’s disease. Cure Alzheimer’s Fund has received a 4-star rating for more than 12 consecutive years from Charity Navigator. With 100 percent of funds raised going to support research, Cure Alzheimer’s Fund has been able to provide grants to many of the best scientific minds in the field of Alzheimer’s research. For more information, please visit https://www.curealz.org/. Contact Details Barbara Chambers +1 978-417-9890 bchambers@curealz.org

November 01, 2023 05:51 AM Eastern Daylight Time

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