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Arecor Therapeutics announces collaboration on oral GLP-1 drug for diabetes and obesity treatment

Arecor Therapeutics PLC

Arecor Therapeutics PLC (AIM:AREC) CEO Sarah Howell joined Proactive's Stephen Gunnion with details of a collaboration with TRX Biosciences to develop an oral GLP-1 product for treating type 2 diabetes and obesity. GLP-1s are therapeutic peptides known for improving blood sugar levels and promoting weight loss. The market for GLP-1 products is expected to reach $100 billion by 2030. Currently, GLP-1 treatment options are predominantly injectable, which limits patient compliance and adoption. Arecor aims to develop an oral GLP-1 with enhanced bioavailability, making it a once-daily pill. This development could significantly increase access to effective treatments for these conditions. Howell told Proactive that Arecor is well-positioned for this development due to its successful track record with its Arestat technology platform, which enhances the profiles of existing therapeutics. The collaboration aims to overcome challenges faced by the only available oral GLP-1, such as low bioavailability and the need for dosing on an empty stomach, by leveraging Arecor's technology in conjunction with TRX Biosciences' Lipper core technology. She said the collaboration complements Arecor's existing diabetes portfolio, which includes two leading insulin products and Gluco, a product for severe hypoglycemia in diabetes patients. The focus is on reducing the daily burden of disease management and improving patient outcomes. TRX Biosciences was chosen for their complementary technology and expertise in oral peptide delivery. The initial development phase will last up to 18 months, aiming to demonstrate the feasibility of a stable, orally delivered GLP-1 with improved bioavailability. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 14, 2024 08:13 AM Eastern Daylight Time

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The Cultivated B Introduces n!Biomachines: Fit-For-Purpose Bioreactors Designed to Easily and Affordably Scale Cellular Agriculture

The Cultivated B

The Cultivated B (TCB) today announced the name change of its Canadian subsidiary, now embracing a broader mission. Formerly called The Cultivated B Canada and located in Burlington, Ontario, n!Biomachines (pronounced “n factorial biomachines”) is dedicated to fulfilling the commercial scalability and viability potential of industrial cellular agriculture technologies across a number of product categories. Unlike over-engineered bioreactors that were designed predominantly for pharmaceutical use, n!Biomachines delivers affordable, easy-to-operate systems for the food, dietary supplement and cosmetics industries, offering sustainable solutions that consume remarkably low amounts of electricity, in some cases as low as 150 watts. The company’s AUXO V fit-for-purpose bioreactors are engineered to focus on single applications, such as animal cells or yeast. This streamlines complex processes and eliminates the operational clutter that multifunctionality typically brings to bioprocessing. The AUXO V’s revolutionary design benefits large-scale manufacturing by improving process efficiency and drastically reducing the level of expertise needed to operate a bioreactor. “The mathematical term, 'n!', or n factorial, acknowledges the core of our mission: scalability and multiplication, with respect to our bioreactor capacity as well as bioprocessing opportunities for our customers,” said Dr. Hamid Noori, CEO of n!Biomachines and The Cultivated B. “'Biomachines' refers to the revolutionary redesign of bioreactors to be useful across all industry sectors that want to step away from overengineered, overly complex equipment. The name n!Biomachines signifies our ambition to expand the applications of bioprocessing through affordable, sustainable and purpose-driven bioreactor design.” Unparalleled usability, increased automation and optimized operational and equipment costs define this new generation of bioreactors for benchtop-, pilot- and industrial-scale bioprocessing without compromising production quality, safety or efficiency. With an emphasis on rapid delivery and cost-effective design, n!Biomachines unlocks bioprocessing for new industries while accelerating growth and innovation for established sectors. “It became clear to us that cellular agriculture industry is at an inflection point where benchtop processes are quite well-proven, but scalability and commercial viability have yet to be sufficiently addressed,” continued Dr. Noori. “Our new bioreactor designs enable efficient processes and the faster delivery times needed to accelerate and integrate cellular agriculture as an additional pillar of our food production system. n!Biomachines is the answer to removing the bioreactor bottlenecks that currently prevent this emerging industry from scaling.” About n!Biomachines n!Biomachines, a subsidiary of The Cultivated B, specializes in developing and manufacturing fit-for-purpose bioreactors for the next generation of bioprocessing. It targets benchtop, pilot- and industrial-scale bioprocessing, ensuring high-quality, safe and efficient operations. Unlike traditional bioreactors that were designed primarily for the pharmaceutical industry, n!Biomachines provides affordable, user-friendly systems for various bioprocesses and organisms, improving commercial viability and scalability for the food, supplement and cosmetics industries. By overcoming industry growth barriers, n!Biomachines aims to revolutionize manufacturing and facilitate the adoption of cellular agriculture technologies sustainably and efficiently. For more information, visit https://www.n-factorial.com/ and follow the company on LinkedIn. About The Cultivated B (TCB) The Cultivated B is a multinational company dedicated to the development and application of breakthrough technologies in cellular agriculture, precision fermentation and bioreactor engineering to enable scalable commercialization of the cellular-agriculture industry. TCB serves startups, corporations and academic research institutions within the food, pharma, cosmetics and personal care industries with its outstanding capabilities. The company’s fundamental commitment to minimizing the natural resources used paves the way towards a sustainable future, locally, regionally and globally. TCB’s research and development team is based in Germany. PreFer Industries and n!Biomachines, based in Canada, are subsidiaries of TCB. For more information, visit https://www.thecultivatedb.com and follow the company on LinkedIn. Contact Details Jenna Beaucage +1 508-340-6851 tcb@rainerco.com Company Website https://www.thecultivatedb.com

March 13, 2024 06:03 AM Eastern Daylight Time

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atai Life Sciences advances VLS-01 for treatment-resistant depression

atai Life Sciences

atai Life Sciences chief scientific officer Dr Srinivas Rao discusses the company's development candidate VLS-01, aimed at treating treatment-resistant depression, with Proactive's Stephen Gunnion. Rao explained that VLS-01 is a formulation of DMT, the active component in ayahuasca, known for its short-duration psychedelic effects. The innovation lies in its delivery method, an oral transmucosal film, resembling a Listerine strip, which dissolves inside the mouth over 20 minutes, providing a patient-friendly alternative to intravenous administration. Rao said this approach is designed to enhance the patient and healthcare provider experience, especially in settings not equipped for IV treatments. The ongoing Phase 1B trial seeks to confirm VLS-01's safety, tolerability, pharmacokinetics (PK), and pharmacodynamics, aiming for a psychoactive effect lasting 30-45 minutes with patients returning to baseline within two hours post-administration. Rao said this trial format follows the US treatment paradigm established by Spravato (esketamine) for depression. The trial will involve 16 healthy volunteers to assess the drug's impact, setting a baseline with intravenous DMT before testing up to three oral doses of VLSI-01. Initial results are expected in the second half of the year, with plans to proceed to Phase 2 trials involving patients with treatment-resistant depression to evaluate the compound's efficacy further. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

March 12, 2024 12:35 PM Eastern Daylight Time

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Hemogenyx Pharmaceuticals discusses successful £3.5M capital raise as it advances HEMO-CAR-T program

HemoGenyx Pharmaceuticals

Hemogenyx Pharmaceuticals PLC (LSE:HEMO, OTC:HOPHF) Dr Vladislav Sandler joins Proactive's Stephen Gunnion after the pre-clinical stage biopharmaceutical group raised £3.5 million, which will be utilized to progress its lead product candidate, Chimeric Antigen Receptor T-cells (HEMO-CAR-T), into human trials following the lifting of a clinical hold. The HEMO-CAR-T therapy is focused on treating relapsed and refractory acute myeloid leukaemia. Despite the challenging market conditions, particularly for biotech firms, Sandler said HemoGenyx successfully secured the necessary funds. He highlighted the company's efficiency and ability to progress with minimal funds, contrasting the struggles faced by other micro-cap companies in raising capital. Looking forward, Sandler said the company plans to advance its clinical trials and continue development on its CBR platform and CDX bispecific antibody, albeit at a potentially slower pace due to funding limitations. As a development-stage company, HemoGenyx anticipates further funding needs but remains committed to efficient and fast-paced progress, seeking various funding sources. Sandler expresses long-term aspirations for HemoGenyx to save lives and generate significant returns for investors. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 12, 2024 12:23 PM Eastern Daylight Time

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MHTN Launches: The First 24/7 Mental Health Streaming Network

Mental Health Television Network

The Mental Health Television Network (MHTN) officially launches today, marking a groundbreaking moment as the world's first 24/7 streaming platform dedicated exclusively to mental health news, education, and resources. MHTN aims to revolutionize the conversation around mental well-being, providing reliable information from medical experts, reducing stigma, and empowering individuals seeking support. "The need for greater awareness and accessible mental health resources has never been more urgent," states Kieran Clarke, Co-Founder and CEO of MHTN. "With MHTN, we're creating a comprehensive, trustworthy hub where viewers can find accurate information, inspiring stories, and tools to enhance their mental health journeys." "MHTN isn't just about watching; it's about engaging viewers to connect, learn, and find pathways to support," says Troy McGuire, Founder & President. "This platform gives a voice to the millions whose experiences with mental health often remain in the shadows." The network's leadership includes Co-Founder and Chief Medical Officer Dr. Daniel Bober, a distinguished psychiatrist dedicated to responsible, medically informed approaches to mental health content. "MHTN provides a vital opportunity to combat misinformation and harmful stereotypes around mental health," says Dr. Bober. "We will always prioritize evidence-based perspectives and empowering those dealing with mental health challenges." MHTN's diverse programming will feature documentaries, in-depth interviews with experts, news coverage of mental health developments, spotlights on community initiatives, wellness workshops, and more. It boasts a unique partnership structure with leading mental health organizations, ensuring content aligns with the latest research and best practices. Key Features of MHTN: Live & On-Demand Programs: News roundups, documentaries, expert panels. Interactive Resource Hub: National hotline directory, support group finders, therapist locators. Social Media Integration: Live Q&A sessions and hashtag campaigns promoting dialogue. Partnerships: Collaborations with leading mental health advocacy groups for greater impact. How to Watch: MHTN will soon be available through major streaming services and apps and as a direct subscription offering. Visit www.mhtn.org for more information. ### About Mental Health Television Network (MHTN): MHTN is a groundbreaking media platform dedicated to transforming how we understand and address mental health. Utilizing the power of media, MHTN's mission is to increase awareness, provide information, and cultivate open conversations about mental well-being. Contact Details Mental Health Television Network Kieran Clarke +1 971-226-1749 kieran@mhtn.org Company Website https://www.mhtn.org

March 12, 2024 10:00 AM Eastern Daylight Time

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Blind Review and PathPresenter Partner to Eliminate Expert Witness Bias in Pathology Malpractice Cases

PathPresenter

Blind Review, LLC, the secure digital platform for eliminating expert witness bias, and PathPresenter, the global image sharing platform for pathology, today announced a strategic partnership ushering digital pathology into the medical malpractice space. This alliance will revolutionize how pathology expert reviews are conducted in malpractice cases, transforming it from the old-school, glass-slide model to a cutting-edge, digital model that increases efficiency, streamlines access, and simplifies the traditional pathology review. Blind Review specializes in removing hindsight, financial, and party-identity bias from expert witnesses through a proprietary digital platform and customized process. Once onboarded to the platform, experts are digitally placed into the shoes of the treating physician. As the care-story unfolds, the expert’s opinion is captured at each critical point of care, all while shielding the identity of the attorney, client, and care outcome. Importantly, the process prevents the expert from knowing what comes next without first committing to an opinion based only on the records available at that point in the care – eliminating hindsight bias. PathPresenter is a secure and scalable multi-tenant enterprise pathology workflow platform that has been developed by pathologists with deep domain knowledge and experience. Trusted by over 45 tier-one medical institutions, PathPresenter is the most comprehensive image management/viewing suite available for clinical care, remote consultations, education, and research. Pathologists play a critical role in reviewing medical malpractice cases for disease diagnosis or when timing of an injury or cause of death is in question. PathPresenter has taken the desktop microscope and transformed it into a state-of-the-art digital viewer that pathologists can access anytime, anywhere to review microscopic evidence in a legal case. Utilizing PathPresenter’s cloud-based, clinical consultation platform, Blind Review’s proprietary process is far more efficient and eliminates the risks and limitations that come with glass slides. “Juror’s trust in experts has fallen to levels below where they were before the pandemic, and we continue to see very large, unexpected verdicts,” says Blind Review’s CEO and attorney-founder, Stephanie Franckewitz. “Independent research supports that a blinded expert doubles the chances of a favorable verdict because jurors perceive them as significantly more credible. We are proud to partner with PathPresenter, and we are in good company, as many of the world’s elite medical institutions use PathPresenter on a day-to-day basis in their pathology departments.” “PathPresenter’s partnership with Blind Review brings the practice of expert pathology review within the medical malpractice space into the 21st century,” adds Patrick Myles CEO of PathPresenter. “Whether in the courtroom or in the pathology lab, expert opinion is all about trust. By partnering with Blind Review, we’re enabling a never-before-seen way to restore jurors’ trust in experts.” About Blind Review, LLC Blind Review is the digital platform that provides the infrastructure to eliminate expert witness bias in medical malpractice cases. We deliver a strong competitive advantage to the trial teams who share our vision: Unbiased, reliable, and trustworthy expert opinions. Blind Review digitally places the expert into the shoes of the treating healthcare provider. As the care-story unfolds, the expert’s opinion is captured at each critical point of care, all while shielding the identity of the attorney, client, and care outcome. Simple and intuitive, our cloud-based interface allows robust customization, with the ability to deliver our unique Blind Review process across multiple specialties within a single case. Blind Review’s platform includes seamless integration with a secure cloud-based Radiology PACS system and Digital Pathology system, with state-of-the-art viewers. About PathPresenter PathPresenter is the global image sharing platform for pathology. We are on a mission to help democratize access to the world’s pathology knowledge by connecting pathologists to the vast expertise of their colleagues globally and providing a practical platform to access and use best-in-class AI models. Founded by dermatopathologist and digital pathology pioneer, Dr. Rajendra Singh, PathPresenter has been adopted by 45+ tier one medical institutions for clinical care, education, and research, and has built a thriving community of 50,000+ users in 172 countries to easily view and share digital pathology images and knowledge. ### Media Inquiries: Michelle Rupp 501-658-9277 or michelle@memorableresultsmedia.com PathPresenter is the global image sharing platform for pathology. We are on a mission to democratize access to the world’s pathology knowledge by connecting pathologists to the vast expertise of their colleagues globally and providing a practical platform to access and use best-in-class AI models. Founded by dermatopathologist and digital pathology pioneer, Dr. Rajendra Singh, PathPresenter has been adopted by 45+ tier one medical institutions for clinical care, education, and research, and has built a thriving community of 50,000+ users in 172 countries to easily view and share digital pathology images and knowledge. For more information visit www.pathpresenter.com. Contact Details Cory Batenchuk +1 873-355-9913 cory@pathpresenter.com Company Website https://pathpresenter.com

March 11, 2024 01:00 PM Eastern Daylight Time

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Centre for Neuro Skills Promotes Dr. Stefanie Howell to Director of Research Integration

Centre for Neuro Skills

Centre for Neuro Skills (CNS), a leader in traumatic brain injury and stroke rehabilitation services, today announced the promotion of Stefanie N. Howell, Ph.D., CBIS, to director of research integration. “Stefanie has been integral to Centre for Neuro Skills’ research program, looking closely at how we can not only improve the lives of our patients but people with brain injuries everywhere,” said David Harrington, president and CEO of Centre for Neuro Skills. “I’m excited to see the outcomes of our research efforts and how this can give us new insight into improving patient care. Since joining CNS in 2016, Howell has coordinated and designed clinical research studies, written manuscripts and provided education focused on methods for facilitating recovery and maximizing patient outcomes. Howell was promoted to Senior Neuroscientist in 2022 and now oversees the integration of CNS’ original research to expand understanding of brain injury, its causes and best treatment practices in the clinical setting. CNS’ ongoing research includes: Effects of Rehabilitation Following Traumatic Brain Injury (TBI) and Stroke CNS researchers evaluate the durability of outcomes obtained during post-acute rehabilitation following stroke and TBI. This will also determine if rehabilitation outcome is associated with future occupational status, life quality, cognitive function, and overall health, including rehospitalization. Traumatic Brain Injury and the Gut Microbiome Years after a brain injury, some individuals develop a complex set of conditions that prevent them from absorbing essential amino acids. The purpose of this study is to determine if altering the diet in these individuals can change their amino acid absorption and reduce symptoms and markers of neuroinflammation. Effects Of Aerobic Exercise and Rehabilitation After Traumatic Brain Injury Exercise contributes to overall health and protects and heals the brain, but the response to exercise may change after a brain injury. Through examining exercise and how it facilitates recovery, CNS hopes to determine the individual response to exercise (and how it has changed), in order to better tailor therapy to each person. Outcome Biomarkers After Brain Injury Patients consent to providing biological samples to help identify biomarkers in blood, saliva, and other tissues that will help CNS increase diagnostic and prognostic capabilities, tailor patient care and determine how much treatment is necessary. This study will allow clinicians to foresee potential risks that may inhibit recovery and aid intervention effectiveness, allowing CNS to better evaluate current and novel therapeutic interventions. Sleep Alterations After Traumatic Brain Injury and Stroke Sleep-wake disturbances have been identified in up to 80% of those with brain injuries. Sleep problems are linked to impaired attention, decreased cognitive functioning (including memory and attention) and overall diminished response to rehabilitation. This study will determine the nature of sleep-wake disturbances post injury. Researchers may then identify whether disturbances are related to the type, location, or time since the injury, as well as the impact sleep has on outcome and responsiveness to rehabilitation. Transcranial Direct Current Stimulation (tDCS) Following Traumatic Brain Injury This is a noninvasive technique of neurostimulation, which uses low amplitude direct current to alter brain cell firing. Studies suggest that tDCS is a painless technique for electrically stimulating the brain with almost no risk of harm. This form of therapy has been studied as a treatment modality for stroke patients but there is less evidence in literature for effectiveness in treating traumatic brain injury. This project will analyze the effects of a three-week program of tDCS on motor recovery and attention/concentration in individuals following a traumatic brain injury. To learn more about CNS and its research, visit www.neuroskills.com. *** About Centre for Neuro Skills Centre for Neuro Skills is an experienced and respected world leader in providing intensive rehabilitation and medical programs for those recovering from all types of brain injury. CNS covers a full spectrum of advanced care from residential and assisted living to outpatient/day treatment. Founded by Dr. Mark Ashley in 1980, CNS has seven locations in California and Texas. For more information about Centre for Neuro Skills, visit: www.neuroskills.com, Facebook, Twitter, LinkedIn, YouTube. Media, please note: Visual assets, including photos, are available. To request an interview with CNS leadership or clinical staff, please contact Robin Carr at 415.766.0927 or CNS@landispr.com. # # # Contact Details Landis Communications Inc. Robin Carr +1 415-766-0927 cns@landispr.com Company Website https://www.neuroskills.com/

March 11, 2024 08:00 AM Pacific Daylight Time

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BenevolentAI CEO Dr Joerg Moeller discusses AI's impact on drug discovery

BenevolentAI

BenevolentAI CEO Dr Joerg Moeller tells Proactive's Stephen Gunnion how the company is positioning itself as a pioneer in AI-augmented drug discovery, aiming to enhance the success rates of drug development by identifying optimal targets early in the process. The company operates on three strategic pillars: advancing its proprietary pipeline of molecules for high medical need indications with limited treatment options, offering comprehensive drug discovery services through collaborations with notable industry partners such as AstraZeneca and Merck KGaA, and providing a Software as a Service (SaaS) platform for knowledge exploration. This multi-faceted approach not only drives BenevolentAI's scientific endeavours but also underpins its business model, which generates revenue through pipeline progression, collaboration milestones, and the innovative SaaS offering. A key example of the platform's validation is the repurposing of baricitinib, an Eli Lilly drug, for COVID-19 treatment based on BenevolentAI's insights. Dr Moeller's belief in AI's transformative potential in R&D is reinforced by the company's capabilities and the dedication of its team. Near-term milestones include anticipated results from a Phase 1a study of their lead program in ulcerative colitis, with strategic goals focusing on pipeline advancement, forging more partnerships, and exploring the viability of their SaaS model for sustainable growth. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

March 08, 2024 11:01 AM Eastern Standard Time

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ImmuPharma CEO Tim McCarthy discusses financial stability and promising drug developments

ImmuPharma PLC

ImmuPharma PLC (AIM:IMM) chief executive Tim McCarthy provides an extensive update during an interview with Proactive's Stephen Gunnion, focusing on the financial, business, and portfolio developments of the company. McCarthy clarified that the company is in a strong financial position, dismissing rumours of needing a highly dilutive fundraising. He emphasized that ImmuPharma has sufficient funding for its needs, supported by a business model reliant on developing drugs to a stage attractive to larger pharmaceutical companies for further development and market introduction. This strategy, according to McCarthy, is expected to generate non-dilutive upfront payments and royalties from licensing agreements, particularly for their P140 platform focused on autoimmune diseases like lupus and CIDP (Chronic Idiopathic Demyelinating Polyneuropathy). McCarthy detailed progress on the lupus program, including changes to their clinical study approach and discussions with the FDA, highlighting the uniqueness of their molecule's mechanism of action. This uniqueness, McCarthy pointed out, has garnered interest from big pharma, distinguishing their lupus treatment from others that failed due to efficacy or side effects issues. Moreover, he announced advancements in the CIDP program and the company's intention to achieve orphan drug designation for it, promising significant market potential despite its smaller patient population compared to lupus. The CEO also touched on an early-stage anti-infective program, underscoring the evolution of ImmuPharma's drug portfolio over the last two and a half years under his leadership. This transformation involved corporate restructuring, significant cost reductions, and strategic focus on developing a diversified drug portfolio. McCarthy concluded by affirming the company's position as substantially undervalued based on its developmental and financial assets, particularly highlighting a major interest in the oncology company Incanthera, which recently secured a substantial commercial deal with AS Watson. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 08, 2024 09:48 AM Eastern Standard Time

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