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Vascudyne Announces Presentation of First Clinical Results of TRUE AVC™ in Hemodialysis Access at the VASA Conference

Vascudyne, Inc.

Vascudyne, Inc., a biotechnology trailblazer in regenerative medicine, announced today that the first clinical results of TRUE AVC™ acellular vascular conduit in hemodialysis access will be presented at the Vascular Access Society of the Americas (VASA) conference in Charleston, South Carolina at 11:20 am EDT on June 10, 2022. The presentation, titled “First in Human Evaluation of a Novel Biologic Regenerative Vascular Conduit for Hemodialysis Access”, will be made by Vascudyne’s medical advisor Monnie Wasse, MD, MPH, FASN, Professor of Medicine in the Division of Nephrology and Department of Internal Medicine at Rush University Medical Center. Dr. Wasse serves as Vice-Chairperson for Clinical Operations for the Department of Medicine and is also the Director of Interventional Nephrology, focused on the planning and maintenance of dialysis vascular access for patients with kidney diseases. Dr. Wasse will present 6-month results and preliminary evidence of the safety and effectiveness of the device as a conduit for hemodialysis vascular access. Vascudyne’s TRUE™ Tissue products are unique, 100% biological, and become the patient’s own living and functional tissue. Nothing synthetic or artificial is ever used in the manufacturing process, in contrast to other regenerative medicine cardiovascular devices with synthetic polymer-based scaffolds that slowly degrade in the body and may lead to adverse immune response. “Dr. Wasse brings extensive experience and clinical expertise to our medical advisory board, and we are excited she is presenting the promising initial results from the TRUE AVC studies,” said Mark Stenoien, Vascudyne’s Chief Regulatory and Clinical Science Officer. Vascudyne announced in February its relocation to a high capacity GMP manufacturing facility to support TRUE AVC manufacturing through commercialization. “We are excited to share our first clinical results with our TRUE Tissue technology in hemodialysis access and have been working on developing our platform technology to address additional cardiovascular diseases” said Dr. Zeeshan Syedain, Vascudyne’s Chief Scientific Officer. “Our move to the new facility dramatically increased our GMP manufacturing space and added a dedicated cleanroom that is poised to support our ongoing TRUE AVC clinical studies all the way to commercialization,” added Dr. Syedain. TRUE AVC is not available for commercial sale. Dr. Monnie Wasse, MD, MPH, FASN Vascudyne’s Clinical Collaborators at Sanatorio Italiano in Asuncion, Paraguay Vascudyne’s TRUE AVC TM for Hemodialysis Access About Vascudyne Headquartered in the heart of Medical Alley in Minnesota, Vascudyne is on a mission to improve patient care with regenerative biomaterials that are inspired by nature. Vascudyne, a privately held company founded in 2014, uses the TRUE™ Tissue technology to develop TRUE to Nature™ biomaterials for soft tissue repair and replacement. For more information, please visit https://www.vascudyne.com/. About TRUE Tissue Technology TRUE™ Tissue is developed from cells isolated from donor tissue and is 100% biological. There are no synthetic materials or chemical fixation used, and implanted tissues are completely cell-derived and acellular. The TRUE Tissue technology can be readily shaped into tubes, sheets, and other geometries making it suitable for many soft tissue applications, is mechanically comparable to native tissues, and is a ready to use, off-the-shelf allograft. Forward Looking Statements This announcement contains forward-looking statements. Such statements may include, without limitation, statements identified by words such as "projects," "may," "will," "could," "would," "should," "believes," "expects," "anticipates," "estimates," "intends," "plans," "potential" or similar expressions. These statements relate to future events or Vascudyne’s clinical development programs, reflect management’s current beliefs and expectations and involve known and unknown risks, uncertainties and other factors that may cause Vascudyne’s actual results, performance or achievements to be materially different. Vascudyne undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future presentations or otherwise, except as required by applicable law. Contact Details Sandy Williams, Marketing Director swilliams@vascudyne.com

June 07, 2022 09:23 AM Eastern Daylight Time

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Freight Rate Transparency gains traction in Freight Forwarding – SHIFEX by Shifl

Shifl

Digital forwarding and supply chain platform Shifl has announced the launch of SHIFEX, an Ocean Spot Freight Rate Index for container shipments which is now available on their website ( https://shifl.com/index ). The recent and continuing unprecedented chaos in the freight markets has brought the dire need for transparency and visibility into actual ocean freight rates. Shabsie Levy, CEO and Founder of Shifl, said he often found thousands of dollars of disparities between reported and actual freight rates on the market. “In the current market condition, just about no one can afford to pay hundreds and sometimes thousands of dollars more for moving a single container,” said Levy. SHIFEX provides live insights into ocean freight rates. It tracks and displays the average ocean spot freight rates for 40'containers (FEU) on main Transpacific routes at any given period. Freight rate transparency and accuracy have always been touted as core business values. They improve customer engagement, build trust, and increase productivity in an industry that has been opaque. “By leveraging our existing technology, we are helping shippers benchmark the freight rates they should be paying for their shipments and help them better plan their order placements and inventory” said Levy. By analyzing its own data of actual bookings and shipments, Shifl was able to alert the market in advance of the drastic changes in the ocean spot freight rates across the volatile periods in 2021 and 2022. Eli Gelbman of The New York Doll Collection a company that manufacturers and sells childrens dolls and accessories says, "I am pleased that Shifl is launching SHIFEX. As a regular importer, we have been following Shifl's rate data in their market reports which has helped us tremendously in managing the volatility in the freight market. Having the same info now on-demand, will allow us to make better supply chain decisions, and improve efficiency in costing and in planning our orders." More about SHIFEX SHIFEX, the first ocean spot freight rate index by a US freight forwarder, provides live insights into ocean spot freight rates as it tracks and displays rates that are applicable on the Trans-Pacific route. SHIFEX is based on the actual spot freight rates quoted and/or paid for moving shipments on the Trans-Pacific route and is therefore a true reflection of the prevailing market conditions in the freight forwarding spot market. SHIFEX is offered as a free service by Shifl and covers Port to Port container spot freight rates. SHIFEX includes all commonly applicable surcharges, —including but not limited to BAF (Bunker and/or Emergency Bunker Adjustment Factor), CAF (Currency Adjustment Factor) ISPS (International Security Port Surcharge), PCS (Port congestion surcharge). The index provides past and current freight rates with the option of tracking rates on a 3, 5, 12 and 18 month basis from the base ports of China to both Los Angeles and New York. In addition to freight rates, Shifl is also planning to include its highly popular vessel transit and container dwell data and add spot freight rates of other trade lanes to SHIFEX so customers can track the past and current performance of these metrics as well. SHIFEX complements digital offerings that include Shifl.com, the digital forwarding and supply chain platform, and Shifl.capital, the cutting-edge FinTech solution designed to make business transactions easier for supply chain companies. About Shifl Shifl is leading the supply chain industry into the future with technology and innovation that brings a huge array of real-life benefits to its users. If you are a shipper looking to bring your business into today's digital age, be more in control, and pay less overall - Shifl is for you. Shifl is headquartered in New York and maintains a presence in China, India, Vietnam, Malaysia, Bangladesh, Georgia, DR, and The Philippines. To learn more, visit https://shifl.com. Contact Details CHARLIE PESTI Priyanka Ann Saini +91 98332 68264 priyanka@pesti.io

June 06, 2022 12:00 AM Eastern Daylight Time

Clear Cannabis Inc. Launches Legacy Brand The Clear™ In Montana Through Bloom MT Partnership

Clear Cannabis Inc.

Clear Cannabis Inc. (CCI), national licensor of legacy cannabis brand The Clear™ announces an exclusive partnership with licensed Cannabis provider Bloom Montana. “We are ecstatic to establish this partnership and be one of the first nationwide cannabis brands in the great state of Montana, ” said Seth Wiggins, President of CCI. “With a newly legalized adult-use market, we know there’s a growing demand for high quality, consistent cannabis products from a reputable brand. As pillars of brand value, The Clear will certainly deliver for the cannabis consumer in Montana.” The Clear was one of the original cannabis brands and was the first to bring molecular distillation to the legal cannabis market in 2013. Since then, they have won multiple cannabis industry awards for their products and all-natural flavors, including awards in the High Times Cannabis Cup in Michigan, Las Vegas Cannabis Awards, and THC Classics in Colorado. The Clear products will be available to purchase in Montana dispensaries starting in July 2022 and includes The Clear Elite distillate 1000mg and 500mg cartridges. They will also offer their Elite All-In-One 350mg disposable vape pen in their award-winning botanically derived flavors. The flavors include Blue Raz, Golden Goat, Grapevine, Lime Sorbet, Orange Cream, and OG. “As a reliable, well-established brand providing high-quality, consistent products, The Clear is an ideal brand for Big Sky Country,” said John Hoofman Jr., Principal Owner of Bloom MT. Consumers who are waiting to try The Clear products in Montana can find them starting in July primarily in the following regions – Billings, Bozeman, Missoula, Helena, Butte, Kalispell, Sidney, and Havre. The initial product launches will be at Bloom, Sweetgrass, and Fat Hippie dispensaries. Products will be made available to all Montana licensed distribution partners in the upcoming months. Contact The Clear directly to inquire at info@clearconcentrate.com. Following the launch of its flagship Elite Line this summer, The Clear is planning to bring both their ENDO live resin cartridges and TWAX Infused Pre-rolls to Montana in the latter half of 2022. About Clear Cannabis, Inc. The Clear™ is one of the original cannabis brands. The brand was founded in 2013 by a team of scientists who introduced molecular distillation to the legal cannabis market and in the process reinvented the cannabis industry. As a national cannabis brand and licensor of The Clear™, Clear Cannabis, Inc. products are available in multiple cannabis markets in the U.S. The company is focused on product consistency regardless of state, proprietary formulations, product safety, consumer experience, and expanding product lines. Contact Details Clear Cannabis Inc. Rebecca Maestas Sincere, Executive Director of Marketing +1 720-330-5000 r.sincere@clrcan.com

June 02, 2022 09:00 AM Mountain Daylight Time

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AllerVie Health Presents AllerVie Clinical Research & Expands Clinical Research Division Nationwide

AllerVie Health

Today, AllerVie Health announced the milestone accomplishment and unveiling of the new brand for their affiliate, AllerVie Clinical Research. Formerly known as Clinical Research Center of Alabama, AllerVie Clinical Research brings cutting-edge treatments and medical advancements to patients who need them most by contributing to the development of innovative, new therapies that connect patients and physicians to the future of medicine. Championing innovative clinical research built to scale for pharmaceutical sponsorship partners, Contract Research Organizations, and patients across the United States, AllerVie Clinical Research offers more clinical research studies in asthma, allergy, and related immunological conditions than any other organization in the nation through our network of national clinical research sites. In collaborative partnership with sponsors and AllerVie board-certified allergists, AllerVie Clinical Research is pioneering new therapies based on years of experience in clinical research and the field of allergy and immunology. This rebranding positions AllerVie Clinical Research for increased nationwide expansion, mirroring the dynamic growth of AllerVie Health’s allergy clinic footprint over the last 15 months. Together, the two organizations are poised for continued growth with eyes on the future. “We firmly believe that best practice is derived from the best clinical research,” said Chief Research Officer, Dr. John Anderson. “As we expand our clinical research footprint in tandem with our allergy clinic footprint, we have complete confidence in our ability to pursue life-changing clinical trials in diverse populations across the country. We believe that hope is having options, and the work that we are doing has life-transforming impact on patients today and into the future.” National Director of Research, Christopher Ingraham, Ph.D., agrees, “We are unique and transformative in this space in our approach to combining best clinical practice across the country with a network of clinical research sites. We are taking care of the administrative aspects of clinical research so that our allergists and immunologists can still see patients, operate productive and thriving practices, and contribute to the future of medicine through clinical research. In this model, everyone wins.” Learn more about how AllerVie Clinical Research is changing lives every day for participating patients, our clinical research studies, and our past sponsorship partners by visiting www.allervieclinicalresearch.com. About AllerVie Health AllerVie Health is a national network of board-certified allergists and immunologists partnering together for the advancement of patient care, currently serving patients across 12 states in over 75 clinic locations. Our providers are committed to establishing the allergy and immunology gold standard, expanding access to best-in-class care, and bringing relief and renewed vitality to the millions of Americans affected annually, many of whom live in underserved communities today. AllerVie is relentlessly dedicated to clinical excellence, creating an improved patient experience, and supporting the development of advanced allergy and immunology-focused therapeutics and treatment options. With AllerVie Health, our patients can feel their best, reclaim their lives, and live in freedom! To learn more about our practices, our approach, and our vision, visit www.allervie.com. About AllerVie Clinical Research AllerVie Clinical Research, an affiliate of AllerVie Health, conducts clinical studies in adult and pediatric patients, contributing to the advancement of new therapies for asthma, allergies, and other related immunological conditions. We provide access to otherwise unavailable treatments to patients suffering from these conditions. As the fastest growing national network of clinical research sites specializing in allergy and asthma-related studies, AllerVie Clinical Research provides comprehensive care to patients nationwide employing the most efficacious and up-to-date treatments—including biologics. Highly regarded for their standards of excellence, our providers have been conducting clinical trials for pharmaceutical companies and Contract Research Organizations since 1998, giving us more than 20 years of successful clinical research experience in this area of immunological diseases. To learn more, visit www.allervieclinicalresearch.com. Contact Details AllerVie Health/AllerVie Clinical Research Rachel Russell, Chief Marketing Officer rrussell@allervie.com

June 01, 2022 04:00 PM Central Daylight Time

New Cannabis Testing to Help Growers Manage, Prevent Microbial Outbreaks

MCR Labs

Local cannabis testing laboratory MCR Labs has released a new testing suite designed to diagnose microbial issues and determine the best path forward for successful remediative measures. This new service can prevent future outbreaks by allowing cultivators to monitor their grow environment closely for any potential contamination sources, avoiding a full-on outbreak altogether. “It’s really a game changer for growers, as microbial outbreaks are not an ‘if’ but a ‘when’ issue,” said Jonathan Wani, MCR’s director of Business Development. “The biggest value for them is identifying the specific species behind the outbreak. Once you know what species you’re working with, you can develop a targeted remediation plan that’s going to be much more effective than a generic remediative method.” Environmental Monitoring is the latest addition to MCR’s arsenal of plant health services, following the release of Speciation and Plant Nutrition. These tools are meant to provide cultivators with actionable data on their grow to aid in the production of happy, healthy plants. “What we don’t want to do is just fail producers on these mandatory microbiological screens and leave them hanging,” said Michael Kahn, CEO & Founder of MCR Labs. “We’re here to assist cultivating a healthy plant, and therefore a safe product for the consumer.” MCR Labs is licensed as an independent testing laboratory in both the Medical and Adult Use Marijuana programs, which are overseen by the Massachusetts Cannabis Control Commission (CCC). The lab also offers their services to home growers, patients, researchers, or curious consumers. About MCR Labs: MCR Labs is one of the longest operational cannabis testing laboratories on the East coast with facilities operating in several legal cannabis markets. We are ISO/IEC 17025:2017 accredited providers of analytical cannabis product testing and R&D services committed to assisting licensed marijuana establishments, patients, researchers, entrepreneurs, and advocates. Our team of chemists and pharmaceutical scientists are dedicated to advancing public health and safety through leading-edge chemical analysis of cannabis products and offering unparalleled guidance and support for partners, regulators, and the communities we serve. For more information visit http://mcrlabs.com. Contact Details MCR Labs Alexandra Gomes +1 508-782-9772 alexandra@mcrlabs.com Company Website http://mcrlabs.com

May 31, 2022 12:19 PM Eastern Daylight Time

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North Texas Municipal Water District Completes One of Nation’s Largest Environmental Restoration Projects

North Texas Municipal Water District

North Texas Municipal Water District (NTMWD), in collaboration with Resource Environmental Solutions (RES), is celebrating the completion of one of the largest environmental restoration projects of its kind in the U.S. After four years of dedicated efforts, North Texas is now home to a new and growing forest of 6.3 million trees, thousands of acres of enhanced wetlands and grasslands and 70 miles of improved streams. This thriving, renewed ecosystem was completed as part of the Bois d’Arc Lake project, the first major reservoir built in Texas in 30 years. NTMWD provides drinking water to more than 2 million people, and the new lake is necessary to meet needs for one of the fastest growing regions in the country. The lake is currently filling with water delivery scheduled for Spring 2023. In addition to providing this critical water supply, the lake will offer recreation and economic benefits. The environmental improvements help offset, or mitigate, the loss of local natural habitat associated with construction of Bois d’Arc Lake. They cover approximately 17,000 acres and will have a legacy that extends for generations to come. NTMWD purchased the Upper Bois d’Arc Creek Mitigation Site and approximately 15,000 acres located along the Red River north of Monkstown, Texas, formerly known as Riverby Ranch. The U.S. Army Corps of Engineers Permit requires the size of mitigated areas to be similar to those inundated by a reservoir. Bois d’Arc Lake has a surface area of 16,641 acres. NTMWD’s goal was to go beyond meeting the regulatory permit requirements: The District chose to restore the land to its pre-agricultural condition. The Riverby area was entirely forested before it was converted to a working cattle ranch. The four-year mitigation efforts included planting 6.3 million trees, restoring and enhancing over 8,500 acres of wetlands, restoring 70 miles of existing streams, including sections of Willow Branch Creek, and planting approximately 3,200 acres of native grassland. This is the final year of active planting and restoration activities. Trees function as the pillar of thriving North Texas ecosystems. Earlier this year, the last several million native saplings were planted at the ranch and neighboring Upper Bois d’Arc Lake Mitigation Area. The trees were added in one to two million increments over the previous four years, with crews filling in areas as needed to establish resilient, mature forests. To better support streambanks, crews also planted live stakes, which are branches cut from black willows, cottonwoods and sycamores that grow into new trees. “Trees support complex ecosystems for wildlife, help control erosion and flooding and improve air quality,” explained RES Project Manager Matt Stahman. “All the work—stream restoration, tree planting and grass establishment—was done concurrently to create thriving ecosystems. The trees help keep sediment out of the streams, and in turn they benefit from water provided by the restored streams.” Less erosion in the lake’s watershed and waterways will decrease sedimentation and nutrient loads into Bois d’Arc Creek, the Red River and surrounding topography and improve the lake’s overall water quality. More than a million more trees were planted than originally planned, due to the need for categorizing and replanting some habitat areas. “It takes time to learn which habitats work best in each area,” said RES Project Ecologist Brandon Hall. “We came up with a plan, but our job is to work with what nature wants to do. There were some areas that we labeled in the plan as grasslands, but they ended up being better restored as forest, and vice versa. So we replanted more trees accordingly.” “The main lesson we learned was to work with and not against nature,” agreed Daniel Kampfer, RES Project Superintendent for the mitigation process. “Now we will take everything we’ve learned here—the successes as well as the setbacks—and work even more effectively and efficiently on the next large-scale restoration project.” The restoration team initially sectioned the restoration areas into 300 larger habitat sections, with trees selected for planting in some of these areas. Ultimately, over 670 habitat areas were identified and individually restored. The result of these careful designations and restoration of trees, rivers and other habitats is a highly resilient landscape that supports a diverse set of inhabitants, including pollinators, predators and birds of prey. According to Jim Bednarz, Senior Lecturer at the University of North Texas, the first signs of successful restoration is a diverse community of birds and animals, especially those at the top of the food chain—the predators. “Our preliminary data has already shown a huge number of birds of prey,” Bednarz said. Master’s degree students from the university have been onsite analyzing avian life and identified over a hundred bird species, including many that are threatened or protected in the state of Texas. RES highlighted this important research project which is available to watch online. Now that active restoration efforts are concluding, NTMWD and RES will transition to monitoring and maintenance for decades to ensure that the entire site continues to thrive. While all the new habitats must be monitored, “a lot of our ongoing efforts will be forestry, to develop those saplings and live stakes into the tree stands,” Stahman said. Teams will track the number of stands and types of trees per acre, including those that didn’t make it. Watch this video produced by RES for a stunning overview of the project and its transition to maintenance. “Think of it like a garden,” Hall explained. “The construction phase of a garden includes planting and tilling, but then it requires weeding and possibly planting a trellis and so forth to maintain. Our work is similar, just on a much larger, 17,000-acre scale.” For more information on Bois d’Arc Lake and its extensive environmental improvements, visit BoisdArcLake.org. About Bois d’Arc Lake Bois d’Arc Lake is the first major reservoir to be built in Texas in over 30 years. Located in Fannin County, the lake is owned and operated by the North Texas Municipal Water District. While the lake’s primary purpose is to provide drinking water to one of the fastest growing regions in the country, it will also offer future water recreation and outdoor activities. About NTMWD The North Texas Municipal Water District (NTMWD) was created in 1951 as a special district of the state. Today, NTMWD is a regional wholesale provider of water, wastewater, and solid waste disposal services for approximately two million residents across 10 counties – a service territory covering 2,200 square miles. With an annual operations budget of $570 million and 900 employees, NTMWD serves up to 80 communities with drinking water, more than 1.4 million people with wastewater collection and treatment, about 930,000 people with waste management services, and operates one of the largest advanced water treatment plants with a capacity of 876 million gallons per day. About RES Resource Environmental Solutions serves as the nation’s only fully scaled operating company, providing comprehensive ecological restoration and water resource solutions that build and sustain natural resiliency in local ecosystems. Contact Details North Texas Municipal Water District Wayne Larson, Director of Communications +1 214-449-8092 wlarson@ntmwd.com Company Website https://www.ntmwd.com/

May 31, 2022 09:10 AM Central Daylight Time

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SleepX approved by the Helsinki Committee to conduct clinical trial with the SleepX PRO smartphone application

Appyea

SleepX, a subsidiary of AppYea (OTC: APYP) focusing on the development of accurate wearable monitoring solutions to treat sleep apnea and snoring, announces it received approval from the Helsinki Committee to begin its planned clinical trial on the SleepX PRO application. This follows the company’s recent update that it intends to test the SleepX Pro application at a hospital sleep lab. The trial is the first step towards applying for an FDA approval under the first-of-its-kind medical device category for contactless detection of sleep apnea to be performed through the Artificial Intelligence (AI) analysis of breathing during sleep. SleepX Pro, which is designed to diagnose sleep apnea using only a smartphone, requires no physical contact with the subject. Global Smart Sleep Tracking Products Market to Garner a Revenue of USD 11,234.55 Million by 2028 and Grow with a CAGR of 17.50% during 2020-2028; Surge in Concern for Sleep-Related Disorders to Drive the Market Growth, according to Kenneth Research (May 16, 2022). “Poor sleep is associated with the compromised immune system, heart problems, reduce physical and mental performance, mood problems, obesity and many other health problems”, said Neil Kline, Founder & former CEO of the American Sleep Association, and a AppYea Board Member. “Unfortunately, most people with sleep disorder breathing problems, like sleep apnea, are undiagnosed and untreated. Our goal in this unique technology is to raise the awareness to the problem and to improve people’s they can live healthier and more fulfilling lives.” “SleepX PRO makes for a unique, quick and friendly diagnosis tool that will prevent subjects from having to spend nights at sleep labs while saving the healthcare system and insurance companies hundreds of millions of dollars”, said Boris (Bary) Molchadsky, President and CEO of SleepX, and Chair at AppYea. “We plan to make our diagnosis solution highly accessible so people get tested easily. SleepX is an Israeli research and development company recently acquired by AppYea. The company had developed a unique product for monitoring and treating sleep apnea and snoring. The technology is protected by several international patents and the company plans to start serial production in 2022. The company currently focuses its activities on the development and commercialization of its flagship product DreamIT. Legal Notice Regarding Forward-Looking Statements This release includes forward-looking statements. Such statements involve risks and uncertainties which could cause actual results to differ materially from those set forth herein. No statement herein should be considered an offer or a solicitation of an offer for the purchase or sale of any securities. Although APYP believes that the expectations reflected in the forward-looking statements and the assumptions upon which they are based are reasonable, it can give no assurance that such expectations and assumptions will prove to have been correct. Forward-looking statements, which involve assumptions and describe our future plans, strategies, and expectations, are generally identifiable by use of the words "may," "will," "should," "could," "expect," "anticipate," "estimate," "believe," "intend," or "project" or the negative of these words or other variations on these words or comparable terminology. The reader is cautioned not to put undue reliance on these forward-looking statements, as these statements are subject to numerous factors and uncertainties, including but not limited to adverse economic conditions, intense competition, entry of new competitors and products, adverse federal, state and local government regulation, inadequate capital, unexpected costs and operating deficits, increases in general and administrative costs, unanticipated losses, financial condition and stock price, inability to carry out research, development and commercialization plans and other specific risks. APYP does not undertake any obligation to publicly update any forward-looking statement. Neither APYP nor SLEEPX are subject to the reporting requirements of the Securities and Exchange Commission under the Securities and Exchange Act of 1934 as amended. Contact Details Asaf Porat +1 800-674-3561 info@appyea.com Company Website http://www.appyea.com

May 31, 2022 08:30 AM Eastern Daylight Time

Kadimastem Awarded Patent in Japan for AstroRx® For ALS and Drug Screening

Kadimastem

Kadimastem Ltd. (TASE: KDST), a clinical stage cell therapy company developing a treatment for ALS, exploring one for multiple sclerosis and developing a potential cure for diabetes, has received a patent from the Japan Patent Office for AstroRx ® for the treatment of ALS and drug screening. The patent also protects AstroRx® for the treatment of multiple sclerosis. AstroRx® is comprised of a differentiated cell population of human astrocytes derived from human pluripotent stem cells. The cells are intended to support the central nervous system (brain and spinal cord), impaired by neurological diseases such as ALS and multiple sclerosis, which disrupt voluntary muscle movement. In a first of its kind Phase I/IIa clinical trial, healthy and functioning astrocyte cells (AstroRx®) were injected into the spinal cord fluid of 10 ALS patients in a standard lumbar puncture. Data showed that AstroRx® delayed the progression of ALS by three months in ALSFRS-R measurement in both tested AstroRx doses. In the next clinical trial of AstroRx®, the plan is to test if this three-month effect can be prolonged with repeated doses every three months of the off-shelf product of AstroRx®. Kadimastem remains on track to submit an IND to the FDA before the end of 2022 to begin a multicenter clinical trial of AstroRx® for ALS in 2023 in the U.S. Kadimastem CEO Asaf Shiloni said, “The Japanese patent strengthens our intellectual property and gives our cell therapy products top priority in the very important and large Southeast Asian region of the world. In addition, we are exploring the possibilities of business partnerships with the pharmaceutical industry in Japan, both for AstroRx® for ALS and IsletRx for diabetes.” Kadimastem Chief Scientist Professor Michel Revel said, "Japan is a prominent territory. This patent protects a significant and highly unique technology and provides a solid IP advantage for Kadimastem." The Japanese market is one of the most significant for stem cell-derived cell therapies. Japan has strategic importance in this field, as it is at the forefront of the international community supporting innovation and the development of products in the field of cell therapy. In November 2014, the Japanese Parliament approved a special law 1 to facilitate clinical trials in the field of cellular medicine, with the aim of expediting approvals of intracellular therapies and quickly bringing them to market. Japan has more than 12,000 ALS patients and this number continues to increase as the population ages. The treatment of these patients is currently estimated at an annual $ 1 billion 2. [1] Azuma K. Regulatory Landscape of Regenerative Medicine in Japan. Curr Stem Cell Reports. 2015; 1: 118–128. doi:10.1007/s40778-015-0012-6 [2] Doi et al., J Epidemiol. 2014; 24(6): 494–499. doi: 10.2188/jea.JE20140059. Prevalence of ~0.01 of Japanese population of 125 M (https://worldpopulationreview.com/countries/japan-population) =12,500 About Kadimastem: Kadimastem is a clinical stage cell therapy company, developing and manufacturing "off-the-shelf", allogeneic, proprietary cell products based on its technology platform for the expansion and differentiation of Human Embryonic Stem Cells (hESCs) into functional cells. AstroRx®, the Company's lead product, is an astrocyte cell therapy in clinical development as a treatment for ALS. IsletRx is the Company's second product in development. IsletRx is comprised of functional pancreatic islet cells intended to treat patients with insulin dependent diabetes. IsletRx demonstrated safety and efficacy in a proof-of-concept preclinical study. Kadimastem was founded by Professor Michel Revel, CSO of the Company and Professor Emeritus of Molecular Genetics at the Weizmann Institute of Science. Professor Revel received the Israel Prize for the invention and development of Rebif®, a multiple sclerosis blockbuster drug sold worldwide. Kadimastem is traded on the Tel Aviv Stock Exchange (TASE: KDST). Forward Looking Statement: This document may include forward-looking information as defined in the Securities Law, 5728 – 1968. Forward-looking information is uncertain and mostly is not under the Company's control and the realization or non-realization of forward-looking information will be affected, among other things, by the risk factors characterizing the Company's activity, as well as developments in the general environment and external factors affecting the Company's activity. The Company's results and achievements in the future may differ materially from any presented herein and the Company makes no undertaking to update or revise such projection or estimate and does not undertake to update this document. This document does not constitute a proposal to purchase the Company's securities or an invitation to receive such offers. Investment in securities in general and in the Company in particular bears risks. One should consider that past performance does not necessarily indicate performance in the future. Contact Details Kadimastem Asaf Shiloni +972 73-797-1613 s.bazak@kadimastem.com Must Have Communications Marjie Hadad +1 917-790-1178 marjie@mhc-pr.com Company Website https://www.kadimastem.com/

May 30, 2022 09:10 AM Eastern Daylight Time

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Hong Kong Baptist University-led research identifies new regulatory mechanism of satiety and therapeutic target for obesity

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 30 May 2022 - A research team led by Hong Kong Baptist University (HKBU) has found that a proteolytic enzyme called membrane-type 1 matrix metalloproteinase ( MT1-MMP) plays an important role in the regulatory mechanism of fullness, or satiety, and it could serve as a promising potential drug target for the management of obesity. Dr Xavier Wong Hoi-leong, Assistant Professor of the Teaching and Research Division of the School of Chinese Medicine (left), and Professor Bian Zhaoxiang, Director of the Clinical Division of the School of Chinese Medicine and Tsang Shiu Tim Endowed Chair of Chinese Medicine Clinical Studies at HKBU (right), identified a proteolytic enzyme called MT1-MMP which could serve as a promising potential drug target for the management of obesity. The research findings were published in the internationally-renowned scientific journal Nature Metabolism. The study has also been featured as a research highlight in multiple high-impact journals, including Nature Reviews Endocrinology, Nature Metabolism and Science Signaling. Half of Hong Kong’s population obese or overweight Being overweight, especially to the extent of obesity, exposes people to a higher risk of life-threatening diseases such as cardiovascular diseases, diabetes, and cancer. According to the Population Health Survey conducted in 2014/15 by the Department of Health, about 30% of people in Hong Kong aged 15 to 84 were obese, and another 20% were overweight. The most effective way to tackle obesity is to reduce food consumption, but obese people often encounter difficulties in regulating their dietary habits as they lose their sense of satiety. Identifying a factor that specifically controls body weight, and investigating how it regulates our sense of satiety, is crucial for the development of therapeutic approaches for obesity. Identification of new regulator of satiety signals A research team led by Dr Xavier Wong Hoi-leong, Assistant Professor of the Teaching and Research Division of the School of Chinese Medicine (SCM), and Professor Bian Zhaoxiang, Director of the Clinical Division of SCM and Tsang Shiu Tim Endowed Chair of Chinese Medicine Clinical Studies at HKBU, identified a proteolytic enzyme called MT1-MMP which regulates the mechanism of issuing satiety signals in the human brain. Growth and differentiation factor 15 (GDF15) is a hormone that sends out satiety signals by binding with the neuron receptor in the hindbrain called GDNF-family receptor α-like (GFRAL). Mediation of GFRAL can therefore affect the ability of GDF15 to send satiety signals, and thus help regulate food intake. From this starting point, the research team conducted a series of experiments to investigate the mediation effects of MT1-MMP on GFRAL. Depletion of MT1-MMP reduces obesity The research team generated an obesity mouse model by feeding a fat-rich diet to a group of transgenic mice with a depletion of MT1-MMP in their satiety neurons, as well as a control group of ordinary mice. After 16 weeks, the mice with depleted MT1-MMP ate 10% less food, gained 50% less weight, and exhibited reduced glucose and plasma insulin levels compared to the control group. The results show that depletion of MT1-MMP protects mice from obesity induced by a high-fat diet. Following analysis with western blots, a widely used analytical technique that can detect specific proteins, the research team also found that the obese mice displayed an increased activity of MT1-MMP in the Area Postrema and Nucleus of the Solitary Tract, the brain regions involved in appetite and weight regulation. The finding suggests that increased MT1-MMP activity in the brain of obese mice could be a risk factor causing sustained weight gain. To understand the mechanism by which MT1-MMP suppresses GDF15 satiety signalling, the research team conducted a series of molecular biology experiments involving animal models and cell culture. The results show that in cells with active MT1-MMP, a significant reduction of GFRAL and thus GDF15 signalling were observed. It could be explained by MT1-MMP clipping GFRAL from the surface of the brain neurons, which blocks GDF15 from binding to GFRAL and thus reduces the number of satiety signals. This in turn keeps the neurons from transmitting the satiety signals sent by GDF15. MT1-MMP as a therapeutic target for obesity The researchers also explored the therapeutic potential of targeting MT1-MMP for obesity management, in particular through pharmacological inhibition of its activity in vivo. With the application of a specific neutralising antibody that inhibits MT1-MMP, significant improvements in metabolic parameters including food intake, glucose tolerance and body weight in obese mice were observed. The results suggest that MT1-MMP is a potential therapeutic target that could be used in the development of innovative drug treatments for obesity. Dr Wong said: “The research findings have established the role played by MT1-MMP in regulating satiety, and they have provided preliminary indications that the proteolytic enzyme is a promising target for the treatment of obesity. Pharmacological inhibition of MT1-MMP could be a viable strategy for the development of effective pharmacotherapy for the treatment of obesity.” Apart from researchers from HKBU, the research team included scientists from The University of Hong Kong, The Chinese University of Hong Kong, the University of Texas Health Science Center at Houston, and the University of Helsinki. #HongKongBaptistUniversity #HKBU Contact Details Christina Wu from the Communication and Public Relations Office +852 3411 7828 christinawu@hkbu.edu.hk Company Website https://www.hkbu.edu.hk/

May 30, 2022 04:26 AM Eastern Daylight Time

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