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UNOS applauds passage of FAA reauthorization bill

United Network for Organ Sharing

Today, the United Network for Organ Sharing (UNOS) issued its support of Congress’ passage of the bipartisan, bicameral Federal Aviation Administration (FAA) reauthorization bill, which includes a provision to improve the safety and efficiency of the transportation of donor organs through the nation’s commercial aviation system. The bill now heads to the president’s desk for signature. The Securing Growth and Robust Leadership in American Aviation Act requires the Department of Transportation (DOT), in consultation with the FAA, to convene a working group to develop best practices for transporting organs in the cabin of a commercial aircraft. The working group will include organ procurement organizations, transplant hospitals, commercial airlines, flight attendants and other federal agencies. DOT is required to convene the working group no later than 90 days after the bill is enacted. No later than one year after convening, the working group must present recommendations to the secretary of DOT. Before the September 11 attacks, organs – primarily kidneys – were transported within a commercial flight’s main cabin under supervision of the aircrew. The attacks prompted significant changes to airport protocols, including removing transplant professionals’ ability to accompany an organ through security without an airplane ticket. As a result, organs currently travel in the cargo hold and are subject to cargo business hours, which vary between airlines and are impacted by staffing shortages. Organs arriving when a cargo office is closed sit on ice for prolonged periods, increasing the potential for an organ not to be used. “Ensuring a donated organ gets to a patient on time and safely is absolutely critical, which is why UNOS has been working with the donation and transplant community and Congress to create a process to bring organs out of the cargo hold and back into the cabin of an airplane,” said Maureen McBride, Ph.D., CEO of UNOS. “Thank you to those working with us to advocate for change and include this provision in the FAA reauthorization package, namely Senators Ron Wyden, Maria Cantwell, Ted Cruz, and John Thune, and Reps. Bruce Westerman, Greg Stanton, Beth Van Duyne, Sam Graves, and Rick Larsen. The bill’s passage highlights the bipartisan consensus and understanding of the lifesaving importance of this issue. I appreciate the commitment to honor the gift of life and do right by patients on the waitlist, generous donors, and their families. I look forward to working with the Department of Transportation to bring organs back into the cabin of an aircraft.” Transportation is a cornerstone of the UNOS Action Agenda, a series of recommendations to strengthen the U.S. donation and transplant system. To further reduce the risk of delaying or damaging organs in transport, UNOS also recommends the next contracts for the Organ Procurement and Transplantation Network (OPTN) should require the use of physical trackers for unaccompanied donor organs recovered for transplant, and the establishment of a centralized organ tracking system. “Donations and transplants are going up across the country, and so are the number of organs traveling every hour of every day,” said McBride. “This community owes it to patients and donor families to ensure that organs travel as safely and efficiently as possible. Every viable organ ultimately not transplanted represents a profound loss.” The provision included in the FAA reauthorization bill is the result of ongoing advocacy by UNOS and other members of the nation’s organ donation and transplant community. Since 2022, UNOS has engaged with FAA leadership, the Transportation Security Administration and the House and Senate to pursue this reform. Actions to move organs back to the airplane cabin and out of cargo are widely endorsed by the donation and transplant community, including the American Association of Kidney Patients, American Foundation for Donation & Transplantation, American Kidney Fund, American Society of Histocompatibility and Immunogenetics, American Society of Nephrology, American Society of Transplantation, American Society of Transplant Surgeons, Association of Organ Procurement Organizations, Donate Life America, Donate Life Virginia, Kidney Care Partners, Kidney Transplant Collaborative, National Kidney Foundation, Nationwide Organ Recovery Transport Alliance, North American Transplant Coordinators Organization, Organ Donation Advocacy Group, Renal Physicians Association, Transplant Recipients International Organization, Transplant Families, Transplant Unwrapped, and Waitlist Zero. About UNOS United Network for Organ Sharing (UNOS) is the mission-driven non-profit serving as the nation’s transplant system under contract with the federal government. We lead the network of transplant hospitals, organ procurement organizations, and thousands of volunteers who are dedicated to honoring the gifts of life entrusted to us and to making lifesaving transplants possible for patients in need. Working together, we leverage data and advances in science and technology to continuously strengthen the system, increase the number of organs recovered and the number of transplants performed, and ensure patients across the nation have equitable access to transplant. Contact Details United Network for Organ Sharing Anne Paschke +1 804-782-4730 anne.paschke@unos.org Company Website https://unos.org

May 15, 2024 02:53 PM Eastern Daylight Time

FOR IMMEDIATE RELEASE

Apple Rush Company, Inc.

Apple Rush Company, Inc. (Otcpink:APRU), a leading player in the functional beverage industry, proudly announces it has cleared up final details of brand ownership with Bob Corr and Corr Brands, Inc. Tony Torgerud, CEO of Apple Rush, has negotiated a historical closing on the rights and trademarks of Corr Brands, Inc. In the transaction, Bob Corr has agreed to transfer the rights of the Corr Brands, Inc. trademarks and to forgo any royalties from previous agreements to give Tony and Apple Rush the best opportunity to succeed moving forward. Tony Torgerud said, “I have been negotiating for a year with Bob and he finally felt it was time to work out an agreement that would benefit everyone. Over the next couple months, all the required paperwork will be filed for transference and updates on all intellectual property held by Corr Brands, Inc. Not having to pay royalties will add thousands to the bottom line.” This agreement solidifies the future of the “Rush” family of brands that have been in the market since 1972. Bob Corr stated, “I want to see Apple Rush succeed and I feel the timing is right to get this deal done. I retired a long time ago and it is now time to write the next chapters of this story and with Apple Rush having its own production capabilities and its own tunnel pasteurizer, it is an opportunity that shouldn’t be wasted. I have given up hundreds of thousands of dollars in royalties, licensing fees and shares to enhance shareholder value.” With our pilot production abilities, we hope to do some reformulations to introduce a 2024 version of Ginseng Rush and the relaunch of the original Apple Rush flavor line. Apple Rush has held a license for 13 states and International distribution for the last 8 years and now owns the IP without paying the $5,000 per state license, another bottom line gain for all of our stockholders. About The Apple Rush Company, Inc. The Apple Rush Company, Inc., through its subsidiary APRU, LLC, is a distributor of CPG products under the trademarked Apple Rush brand, Element brand and other labels. The Apple Rush brand has more than 50 years of existence in the natural beverage industry. As a historical leader in the organic and natural beverage sector our goal is to now become a leader in the distribution of anhydrous hemp oil products nationwide. For more information, please go to www.aprubrands.com, www.element-brands.com, elementk.kratomwave.store www.alkhemicalroots.com with our expanded product portfolio. Safe Harbor Act: Forward-Looking Statements are included within the meaning of Section 27A of the Securities Act of 1933, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements regarding our expected future financial position, results of operations, cash flows, financing plans, business strategy, products and services, competitive positions, growth opportunities, plans and objectives of management for future operations including words such as "anticipate," "if," "believe," "plan," "estimate," "expect," "intend," "may," "could," "should," "will," and similar expressions are forward-looking statements and involve risks, uncertainties and contingencies, many of which are beyond our control, which may cause actual results, performance, or achievements to differ materially from anticipated results, performance, or achievements. We are under no obligation to (and expressly disclaim any such obligation to) update or alter forward-looking statements, whether as a result of new information, future events or otherwise. Contact Details Apple Rush Company, Inc. Tony Torgerud +1 888-741-3777 dtorgerud@aprullc.com Company Website http://www.aprubrands.com

May 14, 2024 10:00 AM Eastern Daylight Time

PathAI Announces PLUTO: a State-of-the-art Foundation Model to Enhance AI-powered Pathology Tools

PathAI

PathAI, a global leader in AI-powered pathology, today announced the launch of Pathology Universal Transformer (PLUTO), a pathology-centric foundation model, to further differentiate their portfolio of products geared towards biopharma and pathology laboratory customers. In machine learning, a foundation model 1 (FM) is a model trained using self-supervised learning on a large scale of unlabeled data to mathematically capture salient information from inputs to the model. Once trained, the FM can be adapted to enable specific tasks in new contexts, especially including previously unforeseen contexts and tasks. The process of adapting a high-quality FM yields better downstream pathology tools, with lower development time and cost, than building bespoke tools from scratch. For example, a pathology FM may be adapted variously to perform cell and nucleus segmentation at microscopic scale on immunohistochemistry (IHC) slides, or to perform histological subtyping at macro-scale for H&E slides. Developing high-quality FMs is particularly important and complex in pathology where there are many different kinds of tasks at different scales of the whole slide image (WSI) data including cell, tissue, and (whole) slide levels. PathAI’s PLUTO was developed to enable this wide diversity of pathology tasks, and was trained using hundreds of millions of unlabeled image patches from about 160,000 WSIs across 30+ disease areas, numerous indications, stains, scanner types and magnification, and over 50 sources of data. To learn high-quality representations of the unlabeled training data, PathAI researchers designed a pathology-focused self-supervised training process using multi-scale, flexible deep vision transformer architectures with novel training objectives. Researchers then evaluated the quality of the resulting FM by adapting it to a wide diversity of pathology-specific tasks, and found that PathAI’s FM outperforms current state-of-the-art models on (whole) slide, cellular and subcellular tasks. Additionally, PathAI’s FM enables building AI-powered pathology tools at multiple scales and resolutions, and is significantly more compact than previously published models, driving massive reductions in training and inference costs, and enabling highly scalable data generation and product development. PLUTO and its adaptations are set to power PathAI’s best-in-class suite of AI products 2 for diagnostic pathology labs and biopharma use. PLUTO will be adapted to develop the next generation of PathAI’s best-in-class products. PLUTO’s embeddings will enable prediction of underlying molecular alterations driving cancer and disease phenotypes–including those previously hidden to AI–as well as the discovery of new biomarkers and therapeutic targets. “PLUTO is meticulously designed to fuel research efforts for better diagnostic and prognostic tools across multiple disease areas. This technology will enable users to compress their pathology workflows using an exceptionally diverse, multi-resolution foundation model at significantly greater speed and a much broader scale than before,” said Harsha Pokalla, Head of Machine Learning at PathAI. “Our aim is to deploy this single, robust model to address a diverse range of applications and use cases within pathology and to continue developing new high performance AI tools that serve our mission to improve patient outcomes.” Footnotes Foundation Models are for research use only. Not for use in diagnostic procedures. PathAI’s AI products are for research use only. Not for use in diagnostic procedures. About PathAI PathAI is the leading precision pathology company providing software and AI-enabled solutions to all pathologist stakeholders including laboratories, research institutions, and the biopharma industry. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

May 14, 2024 10:00 AM Eastern Daylight Time

College of American Pathologists: Cancer Rates Soaring in Younger Adults

YourUpdateTV

A video accompanying this announcement is available at: https://youtu.be/rq8XcHBnPw0 Cancer doesn’t discriminate by age today. Consider celebrities like Chadwick Boseman, who died from colon cancer; Olivia Munn, who recently underwent a double mastectomy; Ninja, a popular streamer on Twitch diagnosed with skin cancer; and Catherine, the Princess of Wales, who is currently being treated for the disease. All of them were diagnosed before the age of 50. Why is this happening and what can we do to catch it early? There are several reasons: diet, lifestyle, and environmental factors. The College of American Pathologists is emphasizing the importance of early detection, screening, and being vigilant regarding symptoms. A nationwide media tour was conducted to discuss this important issue featuring Dr. Donald Karcher, president of the College of American Pathologists. Topics that Dr. Karcher discussed included: · What is behind the soaring trend of younger adults being diagnosed with cancer? · What symptoms to look for to improve cancer outcomes. · What cancers can and should be screened for? · What if you don’t meet the minimum age requirements for screening but are having symptoms? · Discussing the importance of early detection. FOR MORE INFORMATION VISIT: YOURPATHOLOGIST.ORG Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

May 14, 2024 09:30 AM Eastern Daylight Time

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Lisata Therapeutics gets 2024 off to a strong start as it prepares for crucial ASCEND trial results

Lisata Therapeutics Inc

Lisata Therapeutics Inc (NASDAQ:LSTA) CEO David Mazzo tells Proactive's Stephen Gunnion that 2024 is a pivotal year for the oncology company, with Phase 2b ASCEND trial top-line data expected in the fourth quarter. Discussing the company's first-quarter milestones, Mazzo said the results are anticipated to be foundational for the company's future, potentially leading to provisional approval applications in Australia and subsequent discussions with the FDA and EMA. Mazzo highlighted Lisata's effective cash management, with over $43 million in funds ensuring operations into 2026. The company has achieved several regulatory milestones, including orphan designations for pancreatic cancer and glioma in the EU and US, and a rare pediatric disease designation for osteosarcoma in the US. Additionally, Mazzo discussed the rapid progress of the BOLSTER trial in cholangiocarcinoma, expected to provide early data points in 2025. The company plans to expand its trials and anticipates potential partnership announcements by year-end, driven by these developments. Contact Details Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

May 13, 2024 10:45 AM Eastern Daylight Time

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Triomics automates oncology workflows with GenAI powered platform, raises $15M

Triomics

Currently, oncology staff must manually search thousands of patient health records to find the right trials or care pathways for their patients. Triomics is today announcing it has raised $15M to help cancer centers streamline these workflows and process oncology data at scale by applying their framework to build, institution-tuned large language models (OncoLLM™) and use case-specific software. The company has raised from several Silicon Valley firms making pioneering investments in generative AI and healthcare, including Lightspeed, Nexus Venture Partners, General Catalyst and Y Combinator. Manual chart review can take hours per patient, and many health systems face significant backlogs in completing key oncology-related workflows for thousands of patients. This workload leads to clinical delays, such as patients missing out on clinical trials or biomarker-driven treatments, lagging quality reporting, and provider dissatisfaction and turnover. Triomics co-founders Sarim Khan (CEO) and Hrituraj Singh (CTO) were college friends who later worked as an MIT biotech researcher and Adobe AI researcher, respectively. They knew software existed to quickly analyze the ~20% of medical data that is stored in a uniform, structured manner, like a patient’s demographics or laboratory values. However, they realized recent advances in generative AI created the possibility of similarly analyzing the ~80% of medical data that exists in an unstructured format, like a doctor’s free-text note. “Hrituraj and I decided to partner to build solutions leveraging the advances in the field of generative AI and LLMs to help hospital staff,” said Sarim Khan, CEO of Triomicss. “We want our solutions to reason and sound like experts in oncology.” After developing an OncoLLM™ with Medical College of Wisconsin researchers, Triomics found that, in just minutes, it found 90% of eligible patients for clinical trials, which would have taken days or weeks for qualified nurses. It also extracted structured data points from unstructured notes at similar or higher accuracy to proprietary models like GPT4 or Claude while being 40 times cheaper. Triomics recently also published the results of its information retrieval engine for oncology, which they found to be 1.5-2 times better than other state-of-the-art retrieval models. “Most of the solutions on the market today claim they use GenAI, but many lack published evidence. Triomics is setting themselves apart by taking a truly collaborative approach to co-developing these models,” said Bradley Taylor, Chief Research Informatics Officer at the Medical College of Wisconsin and Director of the CTSI Center for Biomedical Informatics. Anai Kothari, a surgical oncologist at the Medical College of Wisconsin Cancer Center added: “The ability to quickly and accurately convert complex cancer data into a format that can be used to improve patient care is crucial. Triomics has been a great partner in integrating our suggestions and rigorously studying their approach to ensure safety.” OncoLLM™ powers proprietary Triomics software that integrates with health system EHRs to complete specific clinical and administrative tasks. For example, Triomics Prism aids in patient-trial matching by prescreening oncology patients with upcoming appointments to find relevant clinical trials. Triomics Harmony curates EHR data to support quality reporting, cohort analysis and precision oncology. Hrituraj Singh, CTO at Triomics, commented: “Our investments in our core areas of focus have been deliberate. We have successfully merged expertise in two complex functional areas: our AI researchers, who are specialized in customizing language models to specific domains, and our clinical staff, who have decades of oncology-specific experience. As a result, our software can complement the strengths of these advanced models while also proactively addressing potential flaws, all with the intricacies of cancer research and care in mind.” Given the heightened importance of accuracy for oncology data, Triomics partners with leading academic cancer centers and researchers to develop generative AI performance and safety benchmarks and best practices. Partners include the Collaboration for Oncology-focused LLM Training (COLT), a consortium of leaders from a dozen NCI-designated cancer centers, and the Cancer Informatics for Cancer Centers (CI4CC) Society. “We differentiate ourselves by building tailored models specifically for oncology and pairing them with GenAI native workflows,” said Sarim Khan. “While other solutions address some of the use cases we’re working on, like patient-trial matching, they are broad based solutions that use or modify legacy technologies that have proven not to have the scalability or ROI the industry is requesting.” Triomics next plans to publish additional data on OncoLLM efficacy across a diversity of settings and patient populations, and develop software that powers additional use cases. “Triomics is leveraging existing healthcare datasets and Generative AI to empower hospital staff to automate clinical trials and streamline cancer center workflows,” said Dev Khare, partner at Lightspeed. “We are excited to back Triomics in this important mission.” “With robust early results for their proprietary oncology specific LLMs and partnerships with leading cancer care and research centers, Triomics is well poised to deliver significant value to cancer care providers and patients in the U.S. and globally,” said Jishnu Bhattacharjee, managing director at Nexus Venture Partners. “We are thrilled to partner with Sarim and Hrituraj to help build a remarkably impactful company!" About Triomics Triomics uses generative AI to streamline workflows for cancer centers. Its oncology specialized generative AI model (OncoLLMTM) and use case-specific software help cancer providers process free-text health record data at scale, match patients to clinical trials, improve quality of care operations, deliver precision oncology and more. Based in San Francisco, the company has raised $15 million from leading VC investors. About Lightspeed Lightspeed is a global multi-stage venture capital firm focused on accelerating disruptive innovations and trends in the Enterprise, Consumer, Health, and Fintech sectors. Over the past two decades, the Lightspeed team has backed hundreds of entrepreneurs and helped build more than 500 companies globally including Affirm, Acceldata, Carta, Cato Networks, Darwinbox Epic Games, Faire, Innovaccer, Guardant Health, Mulesoft, Navan, Netskope, Nutanix, Rubrik, Sharechat, Snap, OYO Ultima Genomics and more. Lightspeed and its global team currently manage $25B in AUM across the Lightspeed platform, with investment professionals and advisors in the U.S., Europe, India, Israel, and Southeast Asia. About Nexus Venture Partners Nexus Venture Partners is a leading early-stage venture capital firm partnering with extraordinary entrepreneurs to build product-first companies. With $2.6 billion under management, Nexus operates as one team across the US and India. Nexus portfolio includes Apollo.io, Aryaka, Clover Health, Delhivery, Druva, FingerprintJS, Hasura, H2O.ai, Infra Market, Kaltura, Mezi, MinIO, Observe.ai, Postman, Pubmatic, Quizizz, Rancher, Sibros, Snapdeal, TileDB, Turtlemint, Unacademy, and Zomato. Contact Details Triomics Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://www.triomics.com/

May 09, 2024 01:16 PM Eastern Daylight Time

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Texas’ Leading Hormone Provider Expands Cutting-Edge Preventative Screening Tool to All Clinics

Forum Health

Hormones by Design, a Forum Health provider and leader in hormone replacement therapy, has acquired DITI Imaging – a pioneer in digital infrared thermal imaging. This strategic move combines the expertise of both companies to offer comprehensive and preventative health care to two of its five renown Texas locations. Learn more about Hormones by Design. Digital infrared thermal imaging (DITI) is a non-invasive, radiation-free screening tool to detect early signs of inflammation and abnormal blood flow patterns, which may be precursors to various health conditions. By identifying these indicators early, patients can proactively address potential issues before they develop into more serious conditions. Phil Hagerman, Forum Health CEO: “ With 1 in 8 women diagnosed with breast cancer and chronic inflammatory diseases on the rise, early detection is paramount. This acquisition underscores our commitment to advancing personalized, integrative healthcare and providing the latest, top-of-the-line technology to help our patients achieve optimal health.” DITI is the only screening tool capable of detecting inflammation and associated heat patterns unlike X-rays, mammograms, MRIs and ultrasound tests. Some of the many health conditions DITI can screen for are: Breast cancer Early indications of asymptomatic and systemic inflammatory and degenerative processes Systemic, artery, dental, and sinus inflammation Unexplained and referred pain, including arthritis and nerve damage Fibromyalgia and digestive disorders Overactive and underactive thyroid conditions Dr. Melissa Miskell, Hormones by Design founder: "We’re thrilled to welcome DITI Imaging into the Hormones by Design family. It allows us to expand our preventative healthcare offerings, better monitor the effects of hormone therapy, more comprehensively treat patients with thyroid conditions, and help people maintain optimal health as they age.” Patients will have access to advanced screening services, including breast, full-body, and region-specific imaging, in addition to personalized BHRT options. Schedule an appointment or find a Hormones by Design location near you. About Forum Health, LLC Forum Health, LLC is a nationwide provider of personalized healthcare steeped in the powerful principles of functional and integrative medicine. Our providers take a root-cause approach to care exploring lifestyle, environment, and genetics to help each patient achieve their ultimate health goals. Members have access to advanced medical treatments and technology, with care plans informed by data analytics and collaborative relationships. For more, visit www.forumhealth.com. Contact Details Forum Health Britt Wittelsberger +1 410-852-0738 bwittelsberger@forumhealth.com Company Website https://forumhealth.com

May 09, 2024 08:50 AM Eastern Daylight Time

6.7 Million Americans Live With Alzheimer’s – IGC Pharma Believes They Deserve Treatment Options Without Black Box Warnings

IGC Pharma, Inc. (IGC)

By Faith Ashmore, Benzinga Over 6.7 million Americans aged 65 and older are living with Alzheimer’s disease (AD) and this number is predicted to grow to 13.8 million by 2060. AD is the sixth leading cause of death in the U.S. and in 2023, it was projected to cost the U.S. $345 billion. Alzheimer's disease is characterized by a gradual decline in memory, thinking, behavior and social skills; however, a lesser-known subsection of Alzheimer’s patients – despite a prevalence of 40%-80% in the patient population – suffer from Agitation in Alzheimer’s Disease (AAD). AAD is associated with higher admission rates to assisted living facilities, higher use of medications, higher rates of long-term hospitalizations and higher mortality rates for Alzheimer’s patients. This brings a significant emotional and financial cost to patients and caregivers. Currently, there is no perfect treatment for AD or ADD. Otsuka’s (OTC: OSUKF) Rexulti is one of the major medications currently being explored as a potential treatment for Alzheimer's disease. It was originally developed as an atypical antipsychotic to help treat mental health illnesses, and it is believed to work by affecting the activity of certain neurotransmitters in the brain. Due to this, ongoing research is investigating its potential to address the behavioral and psychological symptoms often associated with the condition, such as agitation and aggression, but some concerns are yet to be addressed. One of the major criticisms of Rexulti is that it carries a black box warning regarding the increased risk of death in elderly patients with dementia-related psychosis. Patients have reported adverse events associated with the drug like restlessness, weight gain and sleepiness. IGC Pharma (AMEX: IGC) is looking to an alternative to existing drugs with its drug, IGC-AD1, which has been specifically designed to target the underlying causes of AAD and aims to fill the gap for a safe and effective therapy. IGC Pharma began developing IGC-AD1 in 2017, and it was approved by the FDA as an investigational new drug in 2019. IGC-AD1 is designed to target neuroinflammation and dysfunction of the CB1 receptor. This investigational drug contains THC as one of two active pharmaceutical agents. THC is the primary psychoactive compound found in the cannabis plant. IGC-AD1 is undergoing extensive clinical trials to evaluate its effectiveness and safety in treating Alzheimer's disease. After a successful phase 1 clinical trial that resulted in patent protection in the U.S., the company has moved on to phase 2 trials. The phase 2 clinical trial, begun in 2023, encompasses 20 sites across the United States and Canada. With a target of 146 participants, this trial focuses on determining the efficacy of IGC-AD1 in alleviating agitation in Alzheimer's patients. The company has just announced the results of an interim analysis of its ongoing phase 2 trial. The main objective of the study is to evaluate the change in AAD over six weeks, utilizing the Cohen Mansfield Agitation Inventory (CMAI). According to IGC Pharma, the study showed that patients who were given IGC-AD1 had a more significant reduction in agitation levels compared to those who were given a placebo, with positive effects being observed as early as week two of the trial. At the six-week mark, the difference in agitation levels between the IGC-AD1 group and the placebo group was quite noticeable, with an effect size of 0.66 according to Cohen's d measure. The mean difference in the CMAI scores between the active treatment and placebo was -10.45, which indicates a meaningful contrast. Additionally, at the two-week mark, a secondary evaluation showed a positive effect size of 0.79 for IGC-AD1 compared to the placebo. If IGC-AD1 continues to perform well in clinical trials, it could be an effective, simpler and faster treatment option for patients – and importantly, the company is aiming to deliver a product with full approval from the FDA without major black box warnings. The formula as an oral liquid solution also caters to the older population. For millions of Americans who have family members with AD or are worried about developing AD later in life, this drug could provide hope. Featured photo by Cristina Gottardi on Unsplash. IGC Pharma Inc. (IGC) is at the forefront of the fight against Alzheimer's disease, developing innovative solutions to address this devastating illness. The company's mission is to transform the landscape of Alzheimer's treatment with a robust pipeline of five promising drug candidates. IGC-AD1 and LMP target the hallmarks of Alzheimer's disease, including neuroinflammation, Aβ plaques, and neurofibrillary tangles. IGC-AD1 is currently undergoing a Phase 2b clinical trial for agitation in dementia associated with Alzheimer's (clinicaltrials.gov, CT05543681). TGR-63 disrupts the progression of Alzheimer's by targeting Aβ plaques. IGC-M3, currently in preclinical development, aims to inhibit the aggregation of Aβ plaques, potentially impacting early-stage Alzheimer's. IGC-1C, also in preclinical stages, targets tau protein and neurofibrillary tangles, representing a forward-thinking approach to Alzheimer's therapy. In addition to its drug development pipeline, IGC Pharma is actively leveraging Artificial Intelligence (AI) for Alzheimer's research. Their AI projects encompass various areas, including clinical trial optimization and early detection of Alzheimer's. These forward-looking statements are based largely on IGC Pharma’s expectations and are subject to several risks and uncertainties, certain of which are beyond IGC Pharma’s control. Actual results could differ materially from these forward-looking statements as a result of, among other factors, the Company’s failure or inability to commercialize one or more of the Company’s products or technologies, including the products or formulations described in this release, or failure to obtain regulatory approval for the products or formulations, where required, or government regulations affecting AI or the AI algorithms not working as intended or producing accurate predictions; general economic conditions that are less favorable than expected; the FDA’s general position regarding cannabis- and hemp-based products; and other factors, many of which are discussed in IGC Pharma’s U.S. Securities and Exchange Commission ("SEC") filings. IGC Pharma incorporates by reference the human trial disclosures and Risk Factors identified in its Annual Report on Form 10-K filed with the SEC on July 7, 2023, and Quarterly Report on Form 10-Q filed with the SEC on February 14, 2024, as if fully incorporated and restated herein. Considering these risks and uncertainties, there can be no assurance that the forward-looking information contained in this release will occur. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Rosalyn Christian rchristian@imsinvestorrelations.com Company Website https://igcpharma.com/

May 09, 2024 08:45 AM Eastern Daylight Time

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Genflow Biosciences advances three major programs in fight against ageing diseases

Genflow Biosciences PLC

Genflow Biosciences PLC CE Dr Eric Leire tells Proactive's Stephen Gunnion the company had a successful year in 2023, allowing it to expand its research and development pipeline. Leire highlighted three main programs during an interview. The first focuses on MASH (Metabolic Dysfunction-Associated Steatohepatitis), soon progressing to clinical trials, indicating a strong move towards addressing liver diseases. The second program deals with Werner Syndrome, a progeria-related condition, where Genflow is innovating with synthetic organoids to mimic human organ function for better clinical trial predictions. The third program targets sarcopenia in collaboration with Revatis SA, aiming to combat muscle loss associated with ageing. The company has also engaged with regulatory agencies in Europe and the US, receiving positive feedback on its approach, particularly with its MASH program. It is awaiting further feedback from the FDA to decide the trial's location. In addition to a recent £715,000 fundraise, Genflow's financial strategy relies heavily on grants, with recent significant funding from the Wallonia Region in Belgium, which Leire believes positions it well to continue its work without heavy reliance on venture capital. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

May 09, 2024 07:37 AM Eastern Daylight Time

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