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Obesity And Back Pain: BioRestorative Therapies Inc. Is Working To Address 2 Common Ailments That Plague Americans with a Major Near Term Data Catalyst

BioRestorative Therapies, Inc.

In 2016, Americans spent roughly $380 billion on lower back and neck pain. In the same year, medical costs for adult obesity in the United States were $260.6 billion. That’s why BioRestorative Therapies Inc. (NASDAQ: BRTX) is working to develop treatments for these 2 indications, laser-focusing on obesity and lower back pain. Lower back pain and obesity are major health crises. Lower back pain is the leading cause of disability worldwide, and obesity has been identified as a national security threat by the Department of Defense. With the escalation of both lower back pain and obesity in recent years, companies have realized the market potential for finding ways to improve the lives of those suffering from these conditions. Companies such as Pfizer Inc. (NYSE: PFE), Novo Nordisk (NYSE: NVO) and Vertex Inc.. (NASDAQ: VRTX) seem to have recognized the market potential for potential obesity treatments and are actively looking for the next breakthrough in obesity therapies. FDA Authorizes BioRestorative to Begin Phase 2 Clinical Trials For Chronic Lower Back Pain Indication; Development For Brown Fat Indication Underway BioRestorative Therapies is looking into the viability of BRTX-100 as an alternative to current treatments for chronic lower back pain that manages the pain rather than attacking the root cause such as pain relievers, steroid injections and opioids. The Food and Drug Administration (FDA) has authorized BioRestorative to begin a Phase 2 clinical trial using BRTX-100 to treat persistent lower back pain resulting from pain-causing degenerative discs. Currently, BioRestorative Therapies is actively recruiting patients to participate in the Phase 2 study. More information can be found here https://clinicaltrials.gov/ct2/show/NCT04042844?term=brtx&draw=2&rank=1. Another treatment BioRestorative is developing is ThermoStem, which targets obesity and metabolic disorders through the use of brown adipose-derived stem cells to generate new brown fat tissue. This brown fat tissue has been shown to increase metabolic activity and potentially regulate metabolic dysfunction in mice. New Developments Might Promise Better Health BioRestorative Therapies’ leadership is excited about the company’s ability to continue developing its two major technologies that could potentially provide access to multibillion-dollar markets. The company raised $23 million last November 2021 and is funded to prosecute its phase 2 clinical trial targeting chronic lumbar disc disease. Major Catalyst Near Term BioRestorative plans to unveil major safety data for its new therapies within the first quarter of 2023. Company leadership believes this will be a major catalyst for driving growth because positive safety data would provide acceleration to enrollment in and provide major validation for BRTX-100’s Phase 2 clinical trial for lower back pain. BioRestorative also reports that top key opinion leaders (KOLS) are highly engaged in the company’s research and development and are having their clinical sites participate in BioRestorative’s clinical trial. The Company also reports they are oversubscribed in terms of high-quality clinical site selection. With the company’s recent developments, upcoming safety data reveals and involvement of KOLS, BioRestorative is confident that it is heading in a positive direction and is hopeful it will positively impact the lives of millions. BioRestorative Therapies was founded by scientists and researchers committed to developing stem cell therapies to address unmet needs in patients with highly prevalent conditions.Our advances in stem cell biology and delivery protocols harbor great promise in conditioning our bodies’ own regenerative potential to treat major diseases more effectively than current interventions.Today, BioRestorative is actively developing programs that aim to dramatically increase quality of care for both (i) chronic back pain caused by disc degeneration, as well as (ii) metabolic disorders including obesity and diabetes. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Investor Relations ir@biorestorative.com Company Website https://www.biorestorative.com/

September 01, 2022 09:00 AM Eastern Daylight Time

SHATTERPROOF TO BRING CHICAGO COMMUNITY TOGETHER FOR RISE UP AGAINST ADDICTION EVENT ON SATURDAY, SEPTEMBER 10

Shatterproof

WHAT: Shatterproof, a national nonprofit focused on reversing the course of the addiction crisis in America, will host an event on Saturday, Saturday 10 for the Chicago community to rise up against addiction and support family, friends, neighbors and colleagues impacted by the disease. The third Rise Up Against Addiction Walk will give the community the opportunity to bring the disease of addiction into the light and share inspiring stories of hope and recovery. Participants will unite to engage in several activities geared toward ending the stigma associated with substance use disorder, including a 5K walk. Other highlights include: • The Shatterproof Community Resource Village, showcasing substance use disorder resources from local organizations • The Memorial Gallery, featuring an area dedicated to photos and stories of lost loved ones • Celebrate Recovery Wall, an interactive space to unite and celebrate with hundreds of others in recovery • An opening ceremony profiling local walkers touched by addiction and recognition of top teams, fundraisers and leading event sponsors Revenues raised from the Rise Up Against Addiction event supports Shatterproof’s work in advocating for changes in federal and state policy as well as programming focused on saving lives and changing the conversation about addiction. **For more information or to register for the Rise Up Against Addiction 5K Walk event, visit: https://fundraise.shatterproof.org/index.cfm?fuseaction=donorDrive.event&eventID=623 WHO: Local families touched by addiction and leading event sponsors. Shatterproof executives: L. Patrick Reedy, CFRE, Chief Development Officer and Kirsten Suto Seckler, Chief Marketing and Communications Officer – Speaking and available for interviews Caitlin Strebing, Shatterproof Ambassador and Chicago Walk Captain who lost her brother to a fentanyl overdose a year ago. – Available for interviews WHEN: Saturday, September 10, 2022 8:00 a.m. Site opens 9:00 a.m. Opening Ceremony begins 9:30 a.m. Walk begins WHERE: Soldier Field 1410 Special Olympics Drive Chicago, IL 60605 About Shatterproof: Shatterproof is a national nonprofit organization dedicated to reversing the addiction crisis in the U.S. Shatterproof harnesses the models of business, the rigor of science and the power of a national movement to create change and save lives through three pillars of work: revolutionizing the addiction treatment system, breaking down addiction-related stigmas and supporting and empowering our communities. Find Shatterproof on Facebook, Twitter and YouTube: @ShatterproofHQ or follow them on Instagram at @weareshatterproof. To learn more, visit www.Shatterproof.org. Contact Details Shatterproof Lauren Lawson-Zilai +1 240-910-5483 press@shatterproof.org Company Website https://www.shatterproof.org/

August 29, 2022 12:32 PM Eastern Daylight Time

The Chicago School of Professional Psychology Awarded $260K For Students

The Chicago School of Professional Psychology

The Chicago School of Professional Psychology announced it has been awarded $260,000 as part of the Ronald E. McNair Postbaccalaureate Achievement Program, a federal government initiative for colleges and universities to assist low-income, first-generation college students and individuals with disabilities. The U.S. Department of Education earlier this month set aside $51.7 million in 189 new grant awards to institutions of higher education such as The Chicago School to provide disadvantaged college students effective preparation for doctoral studies. “We are excited to implement new programs that will further set up our students for success in school and in their chosen professions,” said Dr. Michele Nealon, President of The Chicago School of Professional Psychology. “We are deeply invested in enlarging the pipeline of mental health professionals who will go on to work in underserved communities where they are needed most.” Through McNair grant funding, The Chicago School will offer research or other scholarly activities, such as summer internships and seminars to students. McNair-funded initiatives also prepare students for doctoral study through tutoring, academic counseling, and assistance with securing admission to and financial assistance for enrollment in graduate programs. McNair projects may also fund financial and economic literacy of students, mentoring programs, and exposure to cultural events and academic programs not usually available to disadvantaged students. The Chicago School is a majority minority-serving institution serving more than 6,000 students, maintains campuses in six major metro areas and an online program. Two-thirds of its students identify as people of color. About The Chicago School of Professional Psychology Integrating theory with hands-on experience, The Chicago School of Professional Psychology provides education rooted in a commitment to innovation, service, and community for thousands of diverse students across the United States and globally. Founded in 1979, the nonprofit, regionally accredited university now features campuses in iconic locations across the country (Chicago, Southern California, Washington, D.C., New Orleans, Dallas) and online. To spark positive change in the world where it matters most, The Chicago School has continued to expand its educational offerings beyond the field of psychology to offer more than 30 degrees and certificates in the professional fields of health services, education, counseling, business, and more. Through its engaged professional model of education, commitment to diversity and inclusion, and an extensive network of domestic and international professional partnerships, The Chicago School’s students receive real-world training opportunities that reflect their future careers. The Chicago School is proud to be a part of TCS Education System, a nonprofit, integrated system of colleges and universities that work collaboratively to advance student success and community impact. To learn more, visit www.thechicagoschool.edu. Contact Details The Chicago School of Professional Psychology Vivien Hao +1 323-893-4743 vhao@thechicagoschool.edu The Chicago School of Professional Psychology Victor Abalos +1 818-321-5371 vabalos@thechicagoschool.edu

August 26, 2022 06:00 AM Pacific Daylight Time

Hong Kong Baptist University scientists develop versatile compound for treating Alzheimer’s disease

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 24 August 2022 - A study led by researchers from Hong Kong Baptist University (HKBU) has demonstrated that a multifunctional organic compound named F-SLOH has the potential to treat Alzheimer’s disease (AD) at an early stage. The team found that it can inhibit the aggregation of amyloid-beta (Aβ), and reduce the hyperphosphorylation of tau proteins and neuroinflammation in the brain to improve the pathological features of AD. The findings have been published in the international academic journal Redox Biology. The study conducted by Professor Li Min (left), Professor Ricky Wong Man-shing (right) and Dr Iyaswamy Ashok (middle) provides the first in vivo evidence that F-SLOH is an effective agent that can target and treat multiple neurodegenerative changes in an AD mouse model. AD is the most common cause of dementia. It accounts for nearly 65% of dementia cases in elderly Hong Kong Chinese. It is pathologically characterised by the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerve cells in the brain, which cause progressive neuronal loss and cognitive impairment. Currently there is no cure for AD, and the available medicines can only relieve its symptoms. Inhibiting the abnormal aggregation of Aβ and the hyperphosphorylation of tau proteins is considered the primary and a promising therapeutic approach to treat AD. F-SLOH as theragnostic agent for AD In the search for novel therapeutic and diagnostic methods for AD, a research team comprising Professor Li Min, Professor of the Teaching and Research Division and Associate Dean of the School of Chinese Medicine; Professor Ricky Wong Man-shing, Professor of the Department of Chemistry of the Faculty of Science; and Dr Iyaswamy Ashok, Research Assistant Professor of the Teaching and Research Division of the School of Chinese Medicine at HKBU, demonstrated the in vivo therapeutic efficacy of a compound called F-SLOH in reducing the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerves cells in the brain, thereby improving the learning and memory functions of mice with AD. F-SLOH is a multi-functional cyanine probe synthesised by a team led by Professor Ricky Wong Man-shing for the detection of biological materials such as proteins and peptides. Its features include real-time visualisation of Aβ aggregation in brains, excellent permeability across the blood-brain barrier and low bio-toxicity. Previous studies showed that F-SLOH could inhibit the abnormal aggregation of Aβ species and provide neuroprotection against neurotoxicity induced by the abnormal aggregation of Aβ in vitro at the cellular level. F-SLOH improves pathological features in AD mice To determine the therapeutic efficacy of F-SLOH for AD, the researchers injected or fed F-SLOH to a group of transgenic AD mice. Histopathology and biochemical analyses showed that in mice treated with F-SLOH, Aβ oligomers (one of the Aβ species) and Aβ plaque deposits (the clumps of Aβ) were dramatically reduced in their hippocampus and their brains when compared with the AD mice in the control group who had not been fed F-SLOH. The researchers also found that F-SLOH can reduce the levels of an amyloid precursor protein that generates Aβ and tau protein hyperphosphorylation. In an immunoblot analysis of the transgenic AD mice brian, the F-SLOH treatment group showed a significant reduction in the levels of the amyloid precursor protein and its metabolites compared to the control group. In other experiments on the transgenic AD mice after F-SLOH treatment, the researchers separated the soluble and insoluble tau proteins in their brain tissue samples. The results showed that F-SLOH treatment significantly reduced the levels of insoluble tau protein in the brains of AD mice, which forms neurofibrillary tangles, one of the pathological features of AD. F-SLOH improves memory and cognitive functions in AD mice Aggregation of Aβ is closely related to the dysfunction of the links between nerve cells and memory decline. The researchers conducted two experiments to test the memory functions of AD mice. In the first experiment, mice were trained to swim in a water maze, reach a platform and remember its position. After the platform was removed, researchers observed whether the mice were able to recall and approach the original position of the platform. Compared to the control group, transgenic AD mice treated with F-SLOH spent more time swimming around the platform’s original position, showing that they can better memorise the platform’s location. In the second experiment, mice were placed in a chamber and exposed to an audio tone followed by an instant small electric shock to their feet from the floor of the chamber. On the following day, they were put back in the chamber but without any electric shock. When the mice were exposed to the same audio tone, they “froze” their body movements due to the fear of an electric shock. The transgenic AD mice treated with F-SLOH exhibited a longer freezing time than that of the control group. The results of the two experiments showed that AD mice treated with F-SLOH have better memories compared to the control group, suggesting that F-SLOH improved AD mice’s memory and cognitive functions. F-SLOH shows early potential for treating AD The researchers also revealed that F-SLOH degraded the abnormal aggregation of Aβ and reduced the levels of tau protein hyperphosphorylation, the amyloid precursor protein and its metabolites through the activation of the transcription factor EB. Transcription factor EB is the main regulator of the autophagy-lysosomal pathway, a major mechanism for degrading ageing intracellular macromolecular proteins, including the intracellular metabolites such as Aβ aggregates. Professor Li Min said: “AD patients lose their self-management abilities and require long-term care as the disease progresses. As the population is ageing in Hong Kong, the prevalence of AD is likely to increase. There is an urgent need to develop new drugs that can treat or slow down the progression of AD. The current study suggests that the compound F-SLOH has promising theragnostic potential for treating AD at an early stage.” Professor Ricky Wong Man-shing said: “The study provides the first in vivo evidence that F-SLOH is an effective agent that can target and treat multiple neurodegenerative changes in an AD mouse model. The research findings can drive advancements in AD diagnosis and treatment in humans.” Contact Details Communication and Public Relations Office at HKBU Christina Wu christinawu@hkbu.edu.hk

August 25, 2022 10:52 PM Eastern Daylight Time

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Giving Metabolism A Boost? BioRestorative Uses Science Surrounding Brown Fat Cells To Provide A Possible Breakthrough In Metabolic Disorders

BioRestorative Therapies, Inc.

In 2017, 41.9% of Americans experienced some level of obesity. Adults experiencing obesity in 2019 spent an average of $1,861 more on medical expenses than people with a healthy weight. For people who experience obesity, the presence of excess fat is a legitimate concern that can cost money, cause additional health problems and be associated with psychological problems such as anxiety, depression and low self-esteem. Some of the health concerns associated with obesity include high blood pressure, high bad cholesterol and low good cholesterol, type 2 diabetes, coronary heart disease, stroke, gallbladder disease and osteoarthritis. Research has found that extreme obesity is associated with suicidal behavior and suicide attempts in adults. With growing data on the impacts of obesity, researchers at organizations like the National Institute of Health and Harvard Medical School have devoted resources to understanding new methods for combatting metabolic disorders such as obesity and type 2 diabetes. Both the National Institute of Health and Harvard Medical School reportedly made an exciting discovery. While fat has often been villainized, what many people may not know is that there are two types of fat cells — brown fat cells and white fat cells. Excessive amounts of white fat can be concerning and may lead to an increased risk for health issues such as heart disease, diabetes and numerous other metabolic diseases. On the other hand, brown fat cells have been found to potentially be an important tool for combating different metabolic diseases. When people with high brown fat activity are exposed to a relatively cold temperature, a protein (SLC25A44) is produced and used as energy in cells to generate heat, which results in burned calories and increased metabolism. When researchers blocked the production of this protein in mice, it was found to increase levels of obesity and signs of diabetes. Researchers found that boosting SLC25A44 activity is a promising strategy for potentially treating conditions such as obesity and diabetes. Companies such as Ember Therapeutics Inc. (NASDAQ: EMBT), Adipo Therapeutics LLC and BioRestorative Therapies Inc. (NASDAQ: BRTX) are actively working to use these scientific studies to combat metabolic diseases. Promising New Treatments One of the treatments developed by BioRestorative Therapies designed to potentially target obesity, diabetes and other metabolic disorders is ThermoStem. BioRestorative says that the ThermoStem program uses brown adipose-derived (otherwise known as brown fat) stem cells to help increase metabolic activity. Previously published studies by BioRestorative have demonstrated that transplanting brown fat can increase metabolic activity and regulate metabolic dysfunction in diet-induced obese mice. BioRestorative Therapies reports it is working on Investigational New Drug Application (IND)-enabling studies to enter into first-in-man clinical studies. Using a cell-based approach to target metabolic disorders may potentially provide a disruptive solution to address a multi-billion market opportunity. While the fight against metabolic disorders such as obesity is far from over, it is hopeful that therapies based on the findings surrounding brown fat, such as ThermoStem may provide relief for many currently struggling. BioRestorative Therapies was founded by scientists and researchers committed to developing stem cell therapies to address unmet needs in patients with highly prevalent conditions.Our advances in stem cell biology and delivery protocols harbor great promise in conditioning our bodies’ own regenerative potential to treat major diseases more effectively than current interventions.Today, BioRestorative is actively developing programs that aim to dramatically increase quality of care for both (i) chronic back pain caused by disc degeneration, as well as (ii) metabolic disorders including obesity and diabetes. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Investor Relations ir@biorestorative.com Company Website https://www.biorestorative.com/

August 25, 2022 03:49 PM Eastern Daylight Time

This Company Reports Its Consumer Therapeutics Could Be A Game Changer For People With Skin Problems

Jupiter Wellness, Inc.

From allergies and insect bites to sunburns and irritations, the human skin can succumb to several conditions, including acne, psoriasis, blisters, hives, actinic keratosis, rosacea, and carbuncle. Skin diseases are more prevalent than many think; they currently make up 1.79% of the global disease burden. Zooming in on the U.S., the American Academy of Dermatology (AAD) reports that 84.5 million Americans — 1 in 4 — are impacted by skin diseases. In addition to the debilitating physical and emotional impact, skin diseases can have on people, they can also be a financial strain. Skin diseases cost the U.S. healthcare system $75 billion in medical, preventative and prescription, and nonprescription drug costs. For every three Americans with skin disease, the AAD reports that a dermatologist saw only one. To make matters worse, the dermatology association also observed that acne has become a significant problem among teenagers — more than 85% of young people suffer from at least one form of acne. Demand for effective therapies is growing as cases continue to soar. Luckily, a large number of drugs from companies like AbbVie Inc. (NYSE: ABBV), GSK plc (LON: GSK), Eli Lilly and Co. (NYSE: LLY), and Viatris Inc. (NASDAQ: VTRS) have been approved to treat various dermatologic conditions. These drugs are contributing to the growth of the global dermatology treatment market. The market size was $36.82 billion in 2019 and is projected to reach $63.99 billion by 2027, exhibiting a compound annual growth rate (CAGR) of 12.9% during the forecast period. For a company like Jupiter Wellness Inc. (NASDAQ: JUPW), which is ramping up research, development, and trial of new therapies, the market's growth, and need could present opportunities. The company’s clinical pipeline of prescription skin-care therapeutics addresses health conditions such as eczema, burns, herpes, cold sores, and skin cancer. Founded in 2018, Jupiter Wellness is engaged in early-stage manufacturing, distribution, and marketing of consumer products. A Look At Jupiter Wellness’s Consumer Products The Jupiter, Florida-based company’s clinical pipeline includes JW-100, a novel topical formulation containing CBD and aspartame for treating eczema, dermatitis, and actinic keratosis. Also in the pipeline is JW-300, a prescription product for treating burns, and JW-400, a nonprescription lotion/lip balm for treating symptoms of cold sores. Eczema (JW-100): Topical treatment for atopic dermatitis (eczema) According to Jupiter Wellness, studies showed that JW-100 cleared or reduced eczema symptoms after two weeks of use. Results suggest that JW-100 may potentially prove superior to existing prescription drugs. A Phase 3, double-blind, placebo-controlled multicenter trial is underway to evaluate the superiority of JW-100 to Eucrisa a Food and Drug Administration (FDA)-approved topical drug) in mild to moderate eczema. Female sexual wellness (RJ-101): Topical treatment for female libido loss The company’s studies showed that RJ-100 increased nipple erection, sensitivity, and genital lubrication in clinical trials conducted on normal patients and those with nipple neuropathy. Jupiter Wellness hopes to launch RJ-101 in 2023 and anticipates it will be sold as an over-the-counter (OTC) treatment for female sexual dysfunction and as a consumer product for general sexual wellness and pleasure. Hair Loss (Minoxidil Booster): Topical treatment designed to improve Minoxidil efficacy The company reports minoxidil is the only FDA-approved topical drug for treating common hair loss (androgenetic alopecia). The company says clinical studies of Minoxidil Booster have shown it increases the enzymes needed for minoxidil to work, sulfotransferase enzymes, by up to seven times over a two-week period. Minoxidil Booster has been licensed to Taisho Pharmaceutical Holdings, a $2.6 billion company and Japan’s leading seller of minoxidil products. It expects to launch the product commercially in 2023. It has also been licensed to India-based Cosmofix Technology and Sanpellegrino Cosmetics and is expected to be launched soon. Psoriasis and vitiligo (Photocil): Topical treatment for psoriasis and vitiligo Jupiter Wellness says Photocil safely and effectively permits phototherapy treatments at home by blocking harmful radiation and allowing the passage of therapeutic ultraviolet (UV) radiation. It is anticipated that Photocil will be available online in the U.S. in the fourth quarter of 2022 as an FDA-approved over-the-counter product under a United States Pharmacopeia (USP) monograph for psoriasis and vitiligo. The company reports that clinical trial results showed that Photocil cream acts as a barrier to nontherapeutic radiation from the sun when skin is exposed to direct daylight. Burns (JW-300): Topical treatment of first-degree burns and sun exposure Jupiter Wellness reports that JW-300 was shown to significantly lower the incidence of burns in patients exposed to UV radiation. JW-300 is being evaluated for sale as an after-sun consumer product to complement the company’s NoStingz sunscreen — topical protection from jellyfish, sea lice, and ultraviolet A (UVA)/ultraviolet B (UVB) rays — and legacy sun care product lines. Cold sores (JW-400): Topical treatment for herpes labialis (cold sores) Jupiter Wellness revealed that phase 1, a double-blind placebo-controlled investigational study in Europe and Asia with FDA-similar protocols initiated in preparation for FDA Investigational New Drug (IND) filing. We support health and wellness through the research and development of over-the-counter (OTC) products and intellectual property. Our product pipeline addresses a range of conditions, including hair loss, eczema, burns, and sexual wellness. Revenue is generated through the sales of OTC and consumer products, contract research agreements, and licensing royalties. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details TraDigital IR- Camille Baptiste camille@tradigitalir.com Company Website https://jupiterwellness.com/

August 25, 2022 03:03 PM Eastern Daylight Time

Nutramax Laboratories Files Lawsuit Against Zesty Paws Alleging E. coli Contamination, Undetectable Active Ingredients in Pet Products

Nutramax Laboratories

Nutramax Laboratories (“Nutramax”) recently brought legal action against Zesty Paws LLC (“Zesty Paws”) and its Hong Kong-based owner, H&H Group (1). The action is for false advertising regarding the ingredients, quality, third-party rankings and recommendations, and market performance of their products, as well as for making false or misleading comparisons to Nutramax’s DASUQUIN® products. Third-party testing of Zesty Paws’ products indicates that at least some of their products contain inconsistent, and sometimes undetectable, amounts of key active ingredients, and in some instances contaminants, including E. coli and high aerobic microbial counts. For more than 30 years, Nutramax has placed its valued customers first. We are committed to providing innovative products that are backed by science and held to the highest quality standards. Our dedication to science and quality has been recognized by customers and earned us the distinction as the #1 veterinarian-recommended supplement company. We take the responsibility as the industry leader seriously and prioritize protecting customers and their pets from low-quality pet supplements and protecting the overall reputation of the industry. We believe that pets deserve supplements of the absolute highest quality and pet parents should feel confident that what they give their pets meets label claims and is contaminant free. We invite you to learn more about our dedication to quality at nutramaxlabs.com/our-quality or by contacting our knowledgeable customer service team at (888) 886-6442. Nutramax Laboratories Veterinary Sciences, Inc. develops, and markets supplements backed by research for companion animals to help support their quality of life. Small animal products include Cosequin®, the #1 Veterinarian Recommended Retail Joint Health Supplement Brand*,**; Dasuquin®, the #1 veterinarian-recommended joint health supplement brand*; the #1 veterinarian-recommended liver support brand Denamarin®***; and products supporting urinary tract health, digestive health, and skin/coat health plus overall wellness. To learn more, call (888) 886-6442 or visit nutramaxlabs.com. *Source: Among retail brands. Survey conducted among small animal veterinarians who recommend oral joint health supplements. **Source: Among veterinary brands. Survey conducted among small animal veterinarians who recommended oral joint health supplements. ***Source: Survey conducted among small animal veterinarians who recommended liver support brands. (1) Nutramax Laboratories Inc. et al. v. Zesty Paws LLC et al., Civil Action No. 6:22-cv-00626-CEM-LHP (U.S. District Court for the Middle District of Florida) Contact Details Erika Dyer +1 703-906-6368 erika@curleycompany.com Company Website https://www.nutramaxlabs.com/

August 22, 2022 07:30 AM Pacific Daylight Time

Millions Suffering From Diabetes May Soon See Relief From Some Of The Pain And Expenses Associated

Know Labs, Inc.

Americans with diabetes have been relying on insulin injections to manage their illness for decades. Those injections can be painful, expensive and inconvenient. The daily invasive testing regimen adds to that pain and inconvenience. But new developments from companies such as Novo Nordisk A/S (NYSE: NVO), Rockley Photonics Holdings Ltd (NYSE: RKLY), Movano Inc (NASDAQ: MOVE) and Know Labs Inc. (OTCQB: KNWN) are reportedly on the verge of changing the game for those dealing with diabetes. The U.S. Food and Drug Administration (FDA) recently approved Rybelsus, also known as oral semaglutide, which controls blood sugar in Type 2 diabetes patients. Novo, which developed Rybelsus, has not revealed what the pill will cost. Still, the company claims it is committed to working with health insurance providers and pharmacy benefit managers to increase patient access. Novo is not yet done and is awaiting more guidance from the FDA on a second Rybelsus indication — reducing the risk of cardiovascular issues in Type 2 diabetes patients. The price of insulin products has been soaring with Novo, Eli Lilly and Co. (NYSE: LLY) and Sanofi SA (NASDAQ: SNY) controlling most of the world’s nearly $30 billion insulin market. Ninety percent of commercially insured patients with Type 2 diabetes are prescribed newer versions of insulin that are more effective and more accessible to administer than the costlier versions. Insulin prices have risen more than 15% across the board in the last 10 years. Newer versions of insulin retail for between $175 and $300 per vial, but several moves have been made in the commercial sector to address affordability. This includes insurance company Cigna Corp. ’s (NYSE: CI) pharmacy benefit Express Scripts division announcing a new program that caps out-of-pocket costs for patients with diabetes at $25 per month. Beyond the cost and availability of insulin is the issue of invasive or minimally invasive blood glucose diagnostics, which is also seemingly on the verge of change due to companies like Seattle-based Know Labs. The company says its Bio-RFID™ technology uses radio-frequency spectroscopy to direct electromagnetic energy through a substance or material to capture a unique molecular signature. The technology can be integrated into various wearable, mobile or bench-top form factors. That would make it possible to effectively identify and monitor biomarkers that could only previously be performed by invasive, expensive and time-consuming lab-based tests. Know Labs recently announced it was granted two new foundational patents for its proprietary Bio-RFID™ technology. The patents allow the company to protect its ability to create and use any database built with data captured through its noninvasive sensors. The Company believes this widens their technological gap to others pursuing non-invasive diagnostics, such as Movano and Rockley. Know Labs believes it could become the first company to bring an FDA-cleared noninvasive glucose monitoring device to market. It is conducting a 200-person internal clinical trial of Bio-RFID, which will help refine its algorithm and confirm its Bio-RFID accuracy. This could be a significant milestone towards regulatory clearance and ultimately product commercialization, potentially changing the lives of millions worldwide. For more information on Know Labs, Inc., visit www.knowlabs.co. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Know Labs Know Labs info@visualant.net Company Website http://www.knowlabs.co

August 18, 2022 07:01 PM Eastern Daylight Time

GROUNDWORK BIOAG RAISES $18 MILLION TO ACCELERATE DECARBONIZATION OF MAINSTREAM AGRICULTURE

Groundwork BioAg

Groundwork BioAg, a leading producer of mycorrhizal inoculants with broad benefits for mainstream agriculture, has completed an $18 million Series B raise. The round was led by Climate Innovation Capital (ClimateIC) with participation from HSBC Global Asset Management (HSBC), BASF Venture Capital, and Edaphon (a climate-focused fund), as well as individual investor John Abele, Co-Founder and former CEO of Boston Scientific. All previous investors, including MoreVC, Middleland Capital, and Ibex Investors also participated in the round. This new round, which follows rapid global market expansion after Groundwork BioAg’s $11 million raise in 2021, underscores the demand for biologicals that increase yield while providing carbon mitigation, sequestration, and regenerative solutions. “Building upon our proven science and trusted network of distributors, Groundwork BioAg’s Mycorrhizal BioPlatform, which delivers ROI to both conventional and regenerative farmers while permanently sequestering carbon in their fields, is uniquely positioned to help farmers around the world manage mounting economic and environmental pressures,” said Dr. Yossi Kofman, Co-Founder and CEO of Groundwork BioAg. The company has established commercial operations across the world’s major breadbaskets, including the United States, Brazil, China, India, Canada, Ukraine, and other countries in Europe, Asia and Africa, to improve the efficiency of major crop production, including corn, soybean, grains, fruits and vegetables. “We search for commercial solutions that can deliver the greatest amount of decarbonization in the shortest period of time, and Groundwork BioAg fits that profile squarely,” said Nelson Switzer, Co-Founder and Managing Partner of ClimateIC. “Groundwork BioAg has the technology, team, expertise, and network to help farmers leverage a cost-effective solution to reduce fertilizer use, increase crop yield and restore soil health while mitigating and sequestering an extraordinary measure of carbon.” Based on naturally robust strains of mycorrhizal fungi that are symbiotic with 90% of plant species, Groundwork BioAg ’s Mycorrhizal BioPlatform can easily integrate into local planting regimes and fertility programs. “As demand for nature-based, climate solutions accelerates, investing in businesses with a strong potential climate impact is aligned with HSBC sustainability goals,” said Idan Mor, Investment Director, Climate Technology Ventures for HSBC. “Groundwork BioAg offers a compelling net-zero alternative to a critical area of the global economy – our food supply.” "AgTech is one of our key global investment priorities. Groundwork BioAg's founders have developed a highly effective product for widespread use in agriculture that can substantially reduce fertilizer dependency by making phosphorus available to the plant roots. Furthermore, it has the potential to convert and store CO2,” said Markus Solibieda, Managing Director of BASF Venture Capital GmbH. About Groundwork BioAg Groundwork BioAg, a global bioagriculture company, leverages the natural power of mycorrhizal fungi to improve the productivity, sustainability and profitability of commercial agriculture and expand regenerative agriculture practices. Groundwork BioAg is the first to use innovative techniques to solve challenges inherent in high-volume mycorrhizal inoculant production. We will not rest until every hectare of arable land is protected by mycorrhizae and every farmer benefits from higher crop yields while preserving our soils and permanently sequestering carbon. For more information, visit www.groundworkbioag.com. About Climate Innovation Capital Climate Innovation Capital (ClimateIC) is a growth fund investing in technology and service businesses focused on climate change. We find, fund and grow climate innovations with the highest projected financial returns and the greatest decarbonization potential – delivered in the shortest period of time. We leverage our strong network and our extensive experience as operators, climate advisors and investment professionals to source attractive opportunities and enhance the growth prospects of our investments. Visit https://climateic.com/ Contact Details AgTech PR for Groundwork BioAg Jennifer Goldston +1 816-260-0040 jennifer@agtechpr.com Company Website https://www.groundworkbioag.com

August 18, 2022 08:00 AM Eastern Daylight Time

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