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Cardiol Therapeutics releases positive study results of subcutaneously administered cannabidiol

Cardiol Therapeutics

Cardiol Therapeutics CEO David Elsley joined Steve Darling from Proactive with news the company has unveiled highly promising study results from international research, which showcased the remarkable potential of subcutaneously administered cannabidiol, the active pharmaceutical ingredient found in Cardiol's groundbreaking CRD-38 subcutaneous formulation. In this study, it was revealed that the application of subcutaneous cannabidiol effectively curtailed the upward trajectory of both body weight and heart weight, while also preventing undesirable increases in crucial cardiac inflammatory and remodelling markers. This research was conducted in a meticulously designed model of heart failure with preserved ejection fraction, noteworthy for its ability to accurately replicate the comorbidities commonly associated with this condition, such as hypertension, obesity, and metabolic dysfunction. Elsley emphasized the profound significance of these study findings, particularly focusing on the unique pre-clinical model employed. This model, meticulously crafted to mimic the conditions experienced by patients suffering from heart failure with preserved ejection fraction, serves as an essential tool in understanding the complex interplay of factors contributing to the disease. The results, which illuminated the multiple cardioprotective effects of subcutaneously administered cannabidiol, serve as a pivotal stepping stone towards the development and potential approval of CRD-38 as a groundbreaking treatment for heart failure. The collective body of evidence generated by this research provides strong support for the advancement of Cardiol Therapeutics' innovative therapeutic approach in combating this debilitating condition, offering hope and potential relief to countless individuals affected by heart failure with preserved ejection fraction. Contact Details Proactive Canada +1 604-688-8158 na-editorial@proactiveinvestors.com

October 11, 2023 01:05 PM Eastern Daylight Time

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Perimeter Medical Imaging AI shortlisted for grant funding under Biden Cancer Moonshot initiative

Perimeter Medical Imaging AI

Perimeter Medical Imaging AI CEO Adrian Mendes joined Proactive's Stephen Gunnion with news that the company has been shortlisted in a grant funding process sponsored by the Advanced Research Projects Agency for Health (ARPA-H) as part of its Precision Surgical Interventions (PSI) program. Mendes explained that the initiative aims to provide groundbreaking tools for surgeons to effectively remove cancer in a single operation. Perimeter's technology aligns perfectly with this goal, as they have been working on it for the past decade. Perimeter Medical Imaging AI utilizes a technology called OCT, which has been around for 30 years. However, it has developed wide-field OCT, enabling larger image capture crucial for examining excised tumors. The company's current S series device is already in use in several operating rooms, gathering user feedback. It is also conducting clinical trials for its next-gen B series device, integrating AI technology to enhance surgeon workflow. While the base OCT technology isn't new, the company's innovations and AI integration represent the latest advancements. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

October 11, 2023 01:02 PM Eastern Daylight Time

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PathAI Announces Research Presentations at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

PathAI

PathAI, a global leader in AI-powered pathology, today announced it will present research on advances in artificial intelligence (AI) approaches through three posters at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics on October 11-15 in Boston, Massachusetts, including one poster to be presented in partnership with Flare Therapeutics. The posters showcase how AI may improve the utility of complex and specialized modalities such as multiplexed immunohistochemistry and may enhance the utility of routine modalities, such as augmenting cellular resolution from H&E-stained images. The presentations underline the significant strides in AI that can enhance translational and clinical research applications. Spatially-resolved prediction of gene expression signatures in H&E whole slide images using additive multiple instance learning models (Poster B010) In this research, PathAI demonstrates the prediction of TGFβ-CAF gene expression signature levels in breast cancer from H&E images and links these levels to tumor microenvironment features using PathExplore, PathAI’s recently launched structured, standardized and scalable panel of human interpretable features (HIFs) offering unprecedented resolution of the tumor microenvironment (TME) from H&E whole-slide images. H&E staining is routine for cancer diagnosis but does not provide molecular information. This potentially limits its utility for molecular-targeted therapy development and selection. AI models augment the information that can be extracted from H&E staining, enhancing resolution of H&E data and increasing other applications such as associating spatial TME features with gene expression signatures. End-to-end additive multiple instance learning (aMIL) models developed and deployed by PathAI performed well at predicting TGFβ-CAF levels. Importantly, aMIL models link PathExplore HIFs to specific sub-regions within the TME, which allows for granular understanding of specific cellular contributions to various molecular predictions from H&E WSI. This poster adds to a series of PathAI achievements in predicting molecular phenotypes from digital pathology images, providing a means to harness complex biological signatures as clinical biomarkers for precision medicine. It will be presented by Chintan Parmar, manager of AI research at PathAI, on October 13 from 12:30-4 p.m. ET. Artificial intelligence (AI) analysis of histological images accurately identifies luminal subtype Urothelial Carcinomas characterized by high Peroxisome Proliferator-Activated Receptor Gamma (PPARG) expression (Poster B016) This research was completed in collaboration with Flare Therapeutics and highlights an AI-based model that identifies luminal subtype in Urothelial Carcinoma as a novel biomarker approach for its first-in-class clinical candidate FX-909. The poster will be presented by Stefan Kirov from Flare Therapeutics on October 13 from 12:30-4 p.m. ET. Machine-learning enabled quantification of colocalized multiplex IHC signals with spectral overlap (Poster B008) This poster demonstrates novel imaging and AI technology to accurately detect and quantify up to four co-localized antigens or stains from a single multiplex IHC slide. Multi-spectral imaging addresses the challenge of how to separate markers exhibiting both spectral and spatial overlap. Expression or staining of individual markers is identified in spectrally unmixed images and combined with information across all separate marker channels to create a “super annotation” co-expression map that is then used to train AI models. PathAI’s model utilizing super annotation demonstrated a significantly lower error rate in detecting co-expression of several markers such as ER, PR, and Ki67 compared to an commercially available method, which was consistent on two different scanners, Leica At2 and 3DHistech. These results may facilitate clinical utilization of higher-plex biomarkers, which could enable faster and more accurate co-expression measurement of various markers, promising cost and time savings by consolidating biomarker measurement to a single slide with automated scoring to assist pathologists. This poster will be presented by Waleed Tahir, pathology AI research scientist at PathAI, on October 13 from 12:30-4 p.m. ET. Learn More PathAI representatives will be on site at the conference for the poster presentations: Poster B008 October 13, 12:30-4:00 p.m. ET Presenter: Waleed Tahir, PathAI Poster B010 October 13, 12:30-4:00 p.m. ET Presenter: Chintan Parmar, PathAI Poster B016 (In partnership with Flare Therapeutics) October 13, 12:30-4:00 p.m. ET Presenter: Stefan Kirov, Flare Therapeutics If interested in meeting the PathAI team during or after the conference, contact the team via email at BD@pathai.com. About PathAI PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

October 11, 2023 10:00 AM Eastern Daylight Time

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Immunic "super excited" about latest PMS trial data

Immunic Inc

Immunic Inc (NASDAQ:IMUX) President and CEO Dr Daniel Vitt speaks to Thomas Warner from Proactive after the biotechnology company announced encouraging interim data from its phase II CALLIPER trial assessing the potential of its treatment for progressive multiple sclerosis (PMS). Dr. Vitt expresses says he's "super excited" about the data, which he believes exceeded expectations. He adds that given the limited treatment options available for progressive MS, the company's findings are particularly significant. Immunic has observed a 22.4% reduction in the neurofilament light chain (NFL) biomarker, which correlates with better outcomes in preventing disability worsening in MS patients. This result was achieved with patients treated with 45 milligrams of their drug. The company has enrolled 467 patients in this 120-week phase two study, with final data expected around April 2025. Dr. Vitt also hints at upcoming updates from other programs as well as more news to come on a phase three clinical study. Contact Details Proactive United States +1 347-449-0879 action@proactiveinvestors.com

October 11, 2023 05:15 AM Eastern Daylight Time

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Trainee Human Rights Lawyer from Watford Launches Global Mental Health Campaign

Renske Technologies

This World Mental Health Day, a British human rights lawyer is launching an ambitious campaign to reshape attitudes, policies, and access to mental healthcare across the globe. Mohammed Sbahuddin Rafiuddin, a 32-year-old trainee human rights lawyer from Watford, UK, is unveiling "Mohammed's Mental Health Campaign" - a pioneering initiative to have sound mental health universally recognized as a fundamental human right worldwide. Mohammed, who has battled severe mental illness for a decade and draws from his own harrowing experiences, aims to completely transform the narrative and policies surrounding mental health through this bold campaign. "My mission is to ensure no one battling mental illness ever feels alone or has to surrender their fight for a fulfilling life of sound mental health," Mohammed said. "Together, we can create a world where mental health is no longer stigmatized but treated with the same urgency as physical health." The World Health Organization estimates 1 in 8 people globally live with a mental disorder - nearly 1 billion worldwide. Mental illness is a leading cause of disability and lost economic opportunities. However, mental health remains chronically underfunded. Stigma prevents many from seeking help. Access to quality, affordable treatment remains out of reach for too many. Mohammed's solution is a massive cultural and policy shift: enshrining the right to mental health as a protected Human Right across the globe. The campaign's central goal is incorporating the right to sound mental health into legislation such as the UK's Human Rights Act and seeing it recognized internationally through groups like the United Nations. "If we can secure the right to mental health as we have done for rights like fair trials or freedom of speech, it will transform how governments approach funding mental health services and force real change in access to care," Mohammed explained. Increased Investment in Research and Treatment A key pillar is advocating for urgently increased investment in mental health research and treatment worldwide. "The lack of funding for mental health research and resources is unacceptable given the scale of this crisis," said Mohammed. "We need a massive injection of funding to develop better treatments and make high-quality care available to all." Greater Focus on Prevention and Early Intervention The campaign also calls for a greater focus on prevention and early intervention worldwide. This includes broader public awareness campaigns, more proactive screening, and expanding free and low-cost community mental health programs. "We know so much more about how to prevent mental illness and intervene early. We desperately need greater investment in public mental health initiatives to give people the education, tools and support they need before reaching crisis," Mohammed stated. Tackling Stigma and Normalizing Conversations Around Mental Health Mohammed also aims to tackle head-on the stigma that prevents so many from seeking help - especially in minority communities. "Within many Asian communities, mental illness is simply not discussed," Mohammed shared. "I want to normalize these conversations, break taboos, and allow people to get treatment without shame." Drawing from Personal Struggles to Inspire Others As part of launching the campaign, Mohammed is courageously sharing his own story of overcoming severe mental illness after being bedridden for 7 years, in hopes it will inspire others worldwide facing similar challenges. Mohammed's mental health crisis began while finishing his law degree, when he developed severe depression and anxiety that later spiraled into psychosis. He spent his 30th birthday in a mental health ward. At his worst, he was on 4 medications just to stay alive. After finally receiving appropriate treatment and support, Mohammed has recovered and completed his law qualifications. He now wants to help millions of others get their lives back too. "My own journey has given me the strength and passion to fight for a future where no one has to suffer in silence or feel hopeless," said Mohammed. "I want to help empower people worldwide to live mentally healthy, fulfilling lives." Ambitious Worldwide Campaign Gaining Support Mohammed has spent years raising awareness on mental health issues and working with organizations like Mind, Rethink Mental Illness, and the NHS as an Expert by Experience. Now his ambitious global campaign is gaining backing from mental health professionals, community leaders, and policymakers across sectors. "Mohammed's courageous work will open minds, save lives, and bring us closer to treating mental health as a basic human right for all," said Dr. Malik, a psychiatrist who treated Mohammed. "I fully support this campaign and hope it inspires global action." A Collective Mission for Mental Health This World Mental Health Day, Mohammed is calling on people worldwide to join him in this urgent mission. "I believe together we can reshape the global narrative around mental health and create real, positive change in access to care," Mohammed said. "We have a collective responsibility to speak up and make sure mental health is no longer ignored." Mohammed hopes this bold campaign will spark a movement, driving real policy changes that secure mental health rights and transform millions of lives. "We have come too far to allow those with mental illness to keep suffering in silence," he said. "The time for action is now." Contact Details Mohammed Sbahuddin Rafiuddin Mohammed +44 7746 698754 mohammed@msrofficial.com Company Website https://www.msrofficial.com/

October 10, 2023 02:12 PM Eastern Daylight Time

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Over-the-Counter Hearing Aids are Breaking the Hearing Barrier and Revolutionizing Accessibility

YourUpdateTV

October marks the beginning of Audiology Awareness Month, a crucial period to highlight the importance of hearing health. Recently, Shannon Pope, Head of Diversity & Sustainability at Sony Electronics, conducted a satellite media tour to help raise awareness about hearing health and to highlight the latest advancements in hearing solutions and over-the-counter hearing aids. A video accompanying this announcement is available at: https://youtu.be/auiXuwy0Olo According to the U.S. Centers for Disease Control and Prevention, about 1 in 4 U.S. adults ages 20 to 69 who report excellent to good hearing already shows signs of hearing loss due to noise overexposure. Even though hearing loss is widespread, for many people, hearing health isn’t a consideration until they find they have noticeable hearing loss, such as missing part of a conversation. Sony’s Over-the-Counter Hearing Aids were created for the purpose of breaking down current barriers faced by those with hearing loss and provide an easy, do-it-yourself hearing solution for adults 18 and older with signs of mild to moderate hearing loss all without a doctor’s prescription. To learn more about your hearing, and how you could benefit from over-the-counter hearing aids, try this online at home hearing evaluation: electronics.sony.com/hearingtest. iv The CRE-C10 and the CRE-E10 self-fitting over-the-counter hearing aids were designed with the understanding that one size does not fit all, and that people deserve options that best fit their unique needs, situations, and lives. Utilizing the Sony Hearing Control app, users can set up and customize the devices. The CRE-C10 and CRE-E10 intuitively adapt to each user’s speech and surroundings, blending the latest technology with comfort to meet each individual’s hearing goals. i Created for daily use each device features an easy-to-navigate app interface with customizable options for the wearer’s specific hearing needs and preferences. Sony’s two models provide more choice when it comes to the look and capabilities of high-end hearing devices. i As one of the smallest over-the-counter hearing aids on the market, the CRE-C10 has a sleek, discreet design that delivers exceptional sound quality, yet is virtually invisible when worn and has a long battery life of up to 70 hours of continuous use. ii The CRE-E10 has an earbud-like design combining excellent sound quality and comfort, and offers the wearer both confidence and convenience. In addition, CRE-E10 has a rechargeable battery for wireless charging that delivers up to 26 hours of continuous use ii and is also Bluetooth compatible letting the user easily connect to streaming audio or music (iOS only). iii Regardless of which device the user selects, both models deliver outstanding automatic noise reduction and speech in noise features, for better understanding in challenging listening environments like restaurants. The user also has the ability to adjust and customize both volume and sound quality in the moment to ensure the best personalized listening experience in a variety of settings. As Sony works to fill the world with emotion, through the power of creativity and technology, these hearing devices hope to help to destigmatize the wearing of hearing aids and make the conversation more accessible while offering a premium over-the-counter hearing experience at a more affordable price point than current prescription devices. The Sony CRE-E10 and CRE-C10 i over-the-counter hearing aids are available directly from Sony and through third-party retailers including Amazon, Best Buy, and select hearing-care professionals. Now through Oct. 29, the CRE-C10 model is $100 off. Take Sony’s online hearing evaluation to find out if Sony’s over-the-counter hearing aids may be right for you. Go to electronics.sony.com/hearingtest. iv About Shannon Pope Shannon Pope is the Head of Diversity & Sustainability at Sony Electronics North America. She oversees Diversity, Equity, Inclusion & Belonging (DEI&B), which includes talent acquisition and the employee experience. In her role, Shannon is responsible for ensuring DEI&B is reflected at every stage in the employee journey. In addition, she works closely with leaders of our Accessibility and Environmental Impact pillars to support Sony’s global corporate social responsibility goals. About Sony Electronics Inc. Sony Electronics is a subsidiary of Sony Corporation of America and an affiliate of Sony Group Corporation, one of the most comprehensive entertainment companies in the world, with a portfolio that encompasses electronics, music, motion pictures, mobile, gaming, robotics and financial services. Headquartered in San Diego, California, Sony Electronics is a leader in electronics for the consumer and professional markets. Operations include research and development, engineering, sales, marketing, distribution and customer service. Sony Electronics creates products that innovate and inspire generations, such as the award-winning Alpha Interchangeable Lens Cameras and revolutionary high-resolution audio products. Sony is also a leading manufacturer of end-to-end solutions from 4K professional broadcast and A/V equipment to industry leading 4K and 8K Ultra HD TVs. Visit http://www.sony.com/news. for more information. i Sony | Hearing control app – Use app on smartphone to personalize settings. Download app at Google Play and the App Store at the time of the launch. Network services, content, operating system and software subject to terms and conditions and may be changed, interrupted or discontinued at any time and may require registration. ii Actual performance varies based on settings, environmental conditions, and usage. Batteries are consumable products and their capacity degrades over time as they age. Sony does not guarantee the life span of the battery. iii Interoperability and compatibility among Bluetooth® devices vary. iv This is not a diagnostic hearing test or medical assessment. It is designed to give you general information about your hearing. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

October 10, 2023 01:37 PM Eastern Daylight Time

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Big Pharma’s Billion-Dollar Bets on Advanced Cancer Therapies

MarketJar

Big Pharma is continuing its oncology buying spree, with a flurry of multi-billion-dollar deals, partnerships, and investments creating a buzz in the cancer treatment space. American pharmaceutical giant Eli Lilly is the latest company to jump on the bandwagon, acquiring cancer therapy firm Point Biopharma Global for a staggering $1.4 billion, an almost 90% premium. This acquisition includes a cash offer of $12.50 per share, significantly above Point's previous closing price.[1] Point Biopharma Global specializes in radioligand therapies, an advanced approach delivering radiation directly to cancer cells, minimizing damage to healthy tissue. Their project, PNT2002, targets advanced-stage prostate cancer patients unresponsive to hormonal treatments. Pfizer, another pharmaceutical giant, made waves with its $43 billion acquisition of biotech company Seagen. This strategic move follows Pfizer's success in the COVID-19 vaccine market. The acquisition adds four approved cancer therapies to Pfizer's portfolio, with combined 2022 sales nearing $2 billion. Seagen specializes in antibody drug conjugate (ADC) technology, precisely targeting cancer cells while sparing healthy tissue.[2] Cancer treatments are a top priority for Pfizer, generating $12 billion in revenue last year. This acquisition enhances Pfizer's position in oncology, enabling a broader range of treatments and innovative therapies for patients. These multi-billion dollar deals along with increasing government initiatives for cancer awareness and rising prevalence of cancer worldwide sent the global cancer therapy market soaring to US$158 billion in 2020. By 2026, the market is expected to grow at a compound annual growth rate (CAGR) of 9.15% to reach US$268 billion.[3] In alignment with this dedication is Defence Therapeutics Inc. (CSE:DTC) (OTC:DTCFF) (FSE:DTC), a Canadian biopharmaceutical company that specializes in cancer vaccines and drug delivery technologies. Partnering with the academic laboratory of world-renowned expert in immuno-oncology Dr. Moutih Rafei, Defence Therapeutics is focused on advancing the development of next-generation vaccines and ADC (Antibody-Drug Conjugate) products. Advancing Cancer Treatments With Upcoming Phase 1 Trials At the heart of Defence Therapeutics is its proprietary and US patented Accum® drug delivery platform, a first-of-its-kind solution solving previous cancer treatment challenges. This proven breakthrough technology has the ability to deliver treatments at 10 times the rate of other approved solutions. Utilizing its proprietary Accum® technology, Defence Therapeutics Inc. (CSE:DTC) (OTC:DTCFF) (FSE:DTC) has significantly improved the efficacy of ADCs by up to 100 times. While enhancing established ADCs like Enhertu, Defence is also forging ahead with two novel in-house ADCs. These developments target specific tumor cells, and in a strategic move, Defence has joined forces with the multinational giant, Orano, to pioneer radio-immunoconjugates, setting a new standard for ADC therapies. On October 10, Defence Therapeutics announced the publication of a pivotal peer-reviewed study in the prestigious journal of Cancer Science, spotlighting the anticancer potential of unconjugated Accum® for T-cell lymphoma treatment. The study showed that Accum® not only triggers the death of various cancer cells but also activates the immune system to combat the cancer. The research highlights the significant role of immune T cells, CD4 and CD8, in enhancing the product's efficiency, providing a promising approach to tumor control. Defence Therapeutics has been making strides in the realm of cancer research with its novel ARM vaccine. This innovative vaccine, created using the company's Accum technology, transforms certain cells into agents that can actively target and combat tumors. In animal models, it showed remarkable success against conditions like solid T-cell lymphoma and melanoma, boasting cure rates between 80-100%. In June, Defence announced a partnership with Transbiotech Biotechnology Research and Transfer Center to further test the vaccine's potency against pancreatic cancer, a notoriously challenging disease to treat. Defence's CEO, Mr. Plouffe, emphasized the potential implications of a successful pancreatic cancer treatment, suggesting it could revolutionize the broader battle against difficult-to-treat cancers. Defence Therapeutics has also made significant progress with its AccuTOX™ program, which is nearing the final stages required for the start of a Phase I clinical trial aimed at melanoma patients at City of Hope in California. AccuTOX has displayed its potent ability to halt tumor growth across several animal studies, targeting conditions like T-cell lymphoma, breast cancer, and notably, melanoma. To ensure quality production for the trial, Defence partnered with Bi opeptek Pharmaceuticals, a renowned US-based Contract Development and Manufacturing Organization (CDMO). Leveraging Biopeptek's expertise, the company is finalizing the AccuTOX™ drug product to meet FDA's rigorous standards. With manufacturing completed, a Phase I trial at the City of Hope National Medical Center and Beckman Research Institute is on the horizon for late 2023. For more information about Defence Therapeutics Inc. (CSE:DTC) (OTC:DTCFF) and its Accum® technology, visit this link or their website. References: [1] https://www.forbes.com/sites/anafaguy/2023/10/03/eli-lilly-acquiring-cancer-therapy-developer-for-14-billion-a-nearly-90-premium/ [2] https://www.aljazeera.com/news/2023/3/13/pfizer-buys-seagen-for-43bn-boosts-access-to-cancer-drugs [3] https://www.mordorintelligence.com/industry-reports/cancer-therapy-market Disclosure: 1) The author of the Article, or members of the author’s immediate household or family, do not own any securities of the companies set forth in this Article. The author determined which companies would be included in this article based on research and understanding of the sector. 2) The Article was issued on behalf of and sponsored by, Defence Therapeutics Inc. Market Jar Media Inc. has or expects to receive from Defence Therapeutics Inc.’s Digital Marketing Agency of Record (Native Ads Inc.) ninety six thousand five hundred US dollars for 30 days (21 business days). 3) Statements and opinions expressed are the opinions of the author and not Market Jar Media Inc., its directors or officers. The author is wholly responsible for the validity of the statements. The author was not paid by Market Jar Media Inc. for this Article. Market Jar Media Inc. was not paid by the author to publish or syndicate this Article. Market Jar has not independently verified or otherwise investigated all such information. None of Market Jar or any of their respective affiliates, guarantee the accuracy or completeness of any such information. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security. Market Jar Media Inc. requires contributing authors to disclose any shareholdings in, or economic relationships with, companies that they write about. Market Jar Media Inc. relies upon the authors to accurately provide this information and Market Jar Media Inc. has no means of verifying its accuracy. 4) The Article does not constitute investment advice. All investments carry risk and each reader is encouraged to consult with his or her individual financial professional. Any action a reader takes as a result of the information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Market Jar Media Inc.'s terms of use and full legal disclaimer as set forth here. This Article is not a solicitation for investment. Market Jar Media Inc. does not render general or specific investment advice and the information on PressReach.com should not be considered a recommendation to buy or sell any security. Market Jar Media Inc. does not endorse or recommend the business, products, services or securities of any company mentioned on PressReach.com. 5) Market Jar Media Inc. and its respective directors, officers and employees hold no shares for any company mentioned in the Article. 6) This document contains forward-looking information and forward-looking statements, within the meaning of applicable Canadian securities legislation, (collectively, “forward-looking statements”), which reflect management's expectations regarding Defence Therapeutics Inc.’s future growth, future business plans and opportunities, expected activities, and other statements about future events, results or performance. Wherever possible, words such as “predicts”, “projects”, “targets”, “plans”, “expects”, “does not expect”, “budget”, “scheduled”, “estimates”, “forecasts”, “anticipate” or “does not anticipate”, “believe”, “intend” and similar expressions or statements that certain actions, events or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved, or the negative or grammatical variation thereof or other variations thereof, or comparable terminology have been used to identify forward-looking statements. These forward-looking statements include, among other things, statements relating to: (a) revenue generating potential with respect to Defence Therapeutics Inc.’s industry; (b) market opportunity; (c) Defence Therapeutics Inc.’s business plans and strategies; (d) services that Defence Therapeutics Inc. intends to offer; (e) Defence Therapeutics Inc.’s milestone projections and targets; (f) Defence Therapeutics Inc.’s expectations regarding receipt of approval for regulatory applications; (g) Defence Therapeutics Inc.’s intentions to expand into other jurisdictions including the timeline expectations relating to those expansion plans; and (h) Defence Therapeutics Inc.’s expectations with regarding its ability to deliver shareholder value. Forward-looking statements are not a guarantee of future performance and are based upon a number of estimates and assumptions of management in light of management’s experience and perception of trends, current conditions and expected developments, as well as other factors that management believes to be relevant and reasonable in the circumstances, as of the date of this document including, without limitation, assumptions about: (a) the ability to raise any necessary additional capital on reasonable terms to execute Defence Therapeutics Inc.’s business plan; (b) that general business and economic conditions will not change in a material adverse manner; (c) Defence Therapeutics Inc.’s ability to procure equipment and operating supplies in sufficient quantities and on a timely basis; (d) the accuracy of budgeted costs and expenditures; (e) Defence Therapeutics Inc.’s ability to attract and retain skilled personnel; (f) political and regulatory stability; (g) the receipt of governmental, regulatory and third-party approvals, licenses and permits on favorable terms; (h) changes in applicable legislation; (i) stability in financial and capital markets; and (j) expectations regarding the level of disruption to as a result of CV-19. Such forward-looking information involves a variety of known and unknown risks, uncertainties and other factors which may cause the actual plans, intentions, activities, results, performance or achievements of Defence Therapeutics Inc. to be materially different from any future plans, intentions, activities, results, performance or achievements expressed or implied by such forward-looking statements. Such risks include, without limitation: (a) Defence Therapeutics Inc.’s operations could be adversely affected by possible future government legislation, policies and controls or by changes in applicable laws and regulations; (b) public health crises such as CV-19 may adversely impact Defence Therapeutics Inc.’s business; (c) the volatility of global capital markets; (d) political instability and changes to the regulations governing Defence Therapeutics Inc.’s business operations (e) Defence Therapeutics Inc. may be unable to implement its growth strategy; and (f) increased competition.Except as required by law, Defence Therapeutics Inc. undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future event or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. Neither does Defence Therapeutics Inc. nor any of its representatives make any representation or warranty, express or implied, as to the accuracy, sufficiency or completeness of the information in this document. Neither Defence Therapeutics Inc. nor any of its representatives shall have any liability whatsoever, under contract, tort, trust or otherwise, to you or any person resulting from the use of the information in this document by you or any of your representatives or for omissions from the information in this document. 7) Any graphs, tables or other information demonstrating the historical performance or current or historical attributes of Defence Therapeutics Inc. or any other entity contained in this document are intended only to illustrate historical performance or current or historical attributes of Defence Therapeutics Inc. or such entities and are not necessarily indicative of future performance of Defence Therapeutics Inc. or such entities. 8) Investing is risky. The information provided in this article should not be considered as a substitute for professional financial consultation. Users should be aware that investing in any form carries inherent risks, and as such, there is a possibility of losing some or all of their investment. The value of investments can fluctuate significantly within a short period, and investors must understand that past performance is not indicative of future results. Additionally, users should exercise caution as transactions involving investments may be irreversible, even in cases of fraud or accidental actions. It is crucial to acknowledge that rapidly evolving laws and technical issues can have adverse effects on the usability, transferability, exchangeability, and value of investments. Furthermore, users must be cognizant of potential security risks associated with their investment activities. Individuals are strongly encouraged to conduct thorough research, seek professional advice, and carefully evaluate their risk tolerance before engaging in any investment endeavors. Market Jar Media Inc. is neither an investment adviser nor a broker-dealer. The information presented on the website is provided for informative purposes only and is not to be treated as a recommendation to make any specific investment. No such information on PressReach.com constitutes advice or a recommendation. Contact Details James Young +1 800-340-9767 campaigns@pressreach.com Company Website https://pressreach.com

October 10, 2023 12:00 PM Eastern Daylight Time

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Oxford Cannabinoid Technologies CEO says objective "absolutely met" in lead asset trial

Oxford Cannabinoid Technologies Holdings PLC

Oxford Cannabinoid Technologies Holdings PLC (LSE:OCTP, OTCQB:OCTHF) chief executive Clarissa Sowemimo-Coker speaks to Thomas Warner from Proactive London after the pharmaceutical group announced phase 1 clinical trial results for its lead drug candidate OCT461201. Sowemimo-Coker explains that OCT461201 is the most advanced of the company's four programmes. The trial, conducted in collaboration with Simbec-Orion, tested the compound on healthy volunteers, with the final dose administered on September 20th. She says "since then we've been crunching the numbers and just processing those healthy volunteers to make sure we are in good shape and I'm very pleased to report [that we're] absolutely fine, no adverse events and all looking good from a safety and tolerability point of view - so that objective absolutely met." Sowemimo-Coker emphasises that while the compound binds to a cannabinoid receptor, it's technically not a cannabinoid but a new chemical entity. The company aims to treat chemotherapy-induced peripheral neuropathy (CIPN) with this compound, a condition affecting 60% of chemotherapy patients. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 10, 2023 04:36 AM Eastern Daylight Time

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Chill Brands Group makes major breakthrough with WHSmith agreement

Chill Brands Group PLC

Chill Brands Group PLC (LSE:CHLL, OTCQB:CHBRF) CEO Callum Sommerton speaks to Thomas Warner from Proactive after the wellness and recreational products company announced it has secured a deal with major UK retailer WHSmith to stock Chill Brands' nicotine-free Chill Zero vape products. The products will be available in 150 of WH Smith's travel stores, including airport and train station locations. These hubs offer high exposure, reaching thousands of daily travellers. Sommerton emphasises that the nicotine-free vape products target individuals aged 18-35, offering a healthier alternative to nicotine products. Despite a 10-12% bump in share price following the announcement, Sommerton acknowledges challenges in the market, including geopolitical issues and concerns around vaping. However, he remains optimistic about the industry's adaptability to regulations and reaffirms Chill Brands' commitment to ethical retailing. Additionally, he hinted at expanding the chill.com platform, introducing new brands and product categories, including wellness items and hemp products. He says that "as we continue to grow the channel and add additional retailers off the back of this announcement, I think people will understand that we are here to stay." Contact Details UK Editorial +44 20 7989 0813 uk@proactiveinvestors.com

October 10, 2023 04:27 AM Eastern Daylight Time

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