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HTX Research:DePIN: Current State and Prospects

HTX Ventures

Introduction: DePIN - Current State and Prospects Singapore / April 30, 2024 – Decentralized Physical Infrastructure Networks (DePIN) are reshaping the blockchain landscape with their innovative use of existing infrastructure and data-centric business models. Moving beyond traditional IoT frameworks, DePIN stands out for its decentralized efficiency and cost-effectiveness. This report explores the burgeoning DePIN sector, particularly within the Solana network, noted for its robust infrastructure and innovative applications. DePIN projects prioritize tangible profitability over speculative financials and are pivotal in integrating technologies like privacy enhancements, zero-knowledge proofs, and artificial intelligence. The strategic composability with other ecosystems positions DePIN to transform economic systems through data integrity and scalable solutions. As the leading platform for DePIN, Solana exemplifies the integration of high-performance blockchain technology with physical networks, promising significant economic returns and pioneering new ways to merge technology with practical applications. HTX Ventures, the global investment arm of HTX, leverages an integrated approach that combines investment, incubation, and research to identify the most exceptional and promising teams around the world. To date, HTX Ventures has supported over 200 projects spanning multiple blockchain tracks, with some high-quality projects already listed on HTX for trading. Key Takeaways · While DePIN projects are decentralized physical infrastructure networks, their core business models focus on effectively utilizing data, whether for storage, transmission, sharing, or use. · There is no need to compare DePINs to traditional IOT projects or categorize them as Web2 or Web3. What matters most is their ability to utilize data efficiently and distribute economic resources effectively. · DePIN's development will combine blockchain technology to enhance data credibility and establish extensive protocols along with the Internet of Things, creating an infinite network connecting people to people, people to machines, and machines to machines. · When assessing DePIN projects, it's crucial to disregard speculative or financial aspects, which are more applicable to sectors like DeFi, meme, and BRC20. Instead, the focus should be on a project's profit potential. · In the near term, attention should be paid to the composability of DePIN with other ecosystems, such as DePIN x Privacy, DePIN x Gaming, DePIN x ZK, and DePIN x AI. In the long term, DePIN's future involves gig economy, sharing economy, and data credibility. · The Solana network has emerged as the preferred blockchain for deploying DePIN projects. Solana DePIN projects boast an FDV exceeding $10 billion and a market capitalization of over $4 billion. · Advantages of Solana for DePIN include: o Superior performance and technological advancements o Robust token standards and a thriving ecosystem o Low cost o Concentrated liquidity, composable ecosystem, and unified community o An active developer community driving innovative projects and new concepts What Is DePIN? DePIN, short for Decentralized Physical Infrastructure Networks, was first introduced in early 2023 in Messari's research report titled "The DePIN Sector Map." It was defined as leveraging cryptographic economic protocols for the deployment of real-world physical infrastructure and hardware networks. Essentially, DePIN employs a blockchain-driven, token-incentivized approach to encourage collective efforts in building physical infrastructure networks. While the term "DePIN" is new, projects deploying real-world physical infrastructure and hardware networks via cryptographic economic protocols have been in existence for some time. Notable examples include Helium, a decentralized network created in 2013, and Storj, a decentralized storage solution launched in 2014. These projects explored decentralized ways to build physical infrastructure networks in fields such as communications and storage. Subsequently, sectors like the internet, AI, energy, and data collection followed suit. Despite their differences, these projects share a common underlying mechanism, contributing to the flourishing landscape of DePIN today. Current State of DePIN Overview As of 2023, data from Messari and DePIN.Ninjia revealed that the DePIN ecosystem comprised 650 projects with a total market capitalization of $35 billion. These projects span various sectors, with 250 in computing, 200 in AI, 100 in wireless, 50 in sensors, 50 in energy, and 25 in services. The DePIN landscape's potential market size is estimated at approximately $2.2 trillion, projected to reach $3.5 trillion by 2028, according to Messari. According to CoinMarketCap (CMC) data, 60 DePIN projects have issued tokens, collectively amounting to a market cap of $1.33 billion. Among the top 100 projects by market cap are FIL, RNDR, HNT, THETA, BTT, AKT, and AR. Other notable examples include IOTX and ANKR, along with AI-related projects like TAO. The majority of the top 10 projects focus on AI, storage, and computing. However, DePIN currently occupies a small share of the crypto market, falling behind sectors like Meme, DeFi, and NFTs. Compared to the traditional IoT sector, DePIN has only 21 projects with a market cap exceeding $100 million and only 4 surpassing $1 billion. Based on these figures, the potential profitability of the DePIN sector is expected to be 243 times in the near-to-medium term and over 400 times in the mid-to-long term. Breakdown of DePINs Similar to IoTeX, DePINs can be categorized into software and hardware projects. Hardware encompasses sensors and wireless networks, while software includes computing, storage, network distribution, and AI. Although DePIN projects are decentralized physical infrastructure networks, their core business models focus on extracting value from data. · Sensors are responsible for data collection. · Wireless networks and network distribution are responsible for data transmission. · Computing is responsible for data processing. · Storage is responsible for data storage. · AI is responsible for data application. While hardware serves as the foundation, the evolution of DePIN projects lies in their ability to effectively utilize data. This echoes the growth model seen in traditional internet economies. Therefore, evaluating a DePIN project's potential requires a data-focused approach. Projects that utilize and control data well are more likely to succeed. It's essential to remove the speculative elements of crypto and focus on tangible value. DePIN Investors As mentioned earlier, investment institutions and entrepreneurs have shown significant interest in the DePIN sector. The limited number of new DePINs in early 2023 was primarily due to unfavorable market conditions and the sector's nascent stage. By the end of 2023, improving market conditions and accumulated experience led to the emergence of tangible prototypes, prompting their introduction to the market. These developments garnered attention, establishing DePINs as a noteworthy presence in a landscape hungry for technological innovation. Venture capital firms like Multicoin, Borderless, A16Z, and HTX Ventures have made substantial investments in the DePIN sector, focusing on projects with robust utility and minimal speculative elements. That said, DePINs still represent a small portion of their portfolios. The following image shows the capital raised by top DePIN projects.Top DePINs by Capital Raised. Solana DePIN Projects Solana: The Preferred Choice for DePIN Project Deployment · Solana DePIN projects boast a Fully Diluted Valuation (FDV) exceeding $10 billion and a market capitalization of over $4 billion. According to CMC data, the top 500 Solana DePIN projects by market capitalization feature Render Network (RNDR), Helium Network (HNT), and Helium Mobile (MOBILE). Other notable DePINs include Helium IOT (IOT) and Hivemapper (HONEY). Recent trending projects include MOBILE and IOT, as well as getgrass, a bandwidth network market project set to issue tokens. · DePIN and Solana: A Synergistic Partnership Solana's recovery is attributed in part to the irreplaceability of Mass Adaption, especially DePIN and Web2 applications. Solana successfully met the needs of STEPN, a project that made Web3 stand out. Solana's cNFTs provide DePIN/PoPW nodes with more cost-effective authorization certificates, which is a common practice. The migration of RNDR and Helium to Solana has empowered these projects with enhanced capabilities. For instance, Render's transition enabled new features such as real-time streaming, dynamic NFTs, and state compression. This has significantly improved the network's performance and scalability while unlocking its range of use cases. Unlike high-value DeFi applications, DePIN projects are closely aligned with traditional edge computing and IoT concepts. They prioritize stability and affordability, while Solana excels in synchronization. Helium, with over 300,000 IoT devices and 3,000-some 5G devices, underscores the huge demand for hardware coordination, which can only be satisfied by Solana. · DePIN Brings High Value to Solana Projects like Helium have remarkably increased the number of active wallets within the Solana ecosystem. Helium alone reports over 60,000 active wallets monthly, engaged in activities like reward collection, staking, delegation, or token burning. Additionally, over 30,000 wallets are using other SPL programs, highlighting Helium's impact on the Solana ecosystem. From the perspectives of regulators and policymakers, DePIN showcases Solana's practical application, enhancing its legitimacy and brand recognition. Solana's Advantages · Superior Performance and Technological Advancements Solana boasts remarkable throughput capability, handling over 65,000 transactions per second (TPS) at peak times and between 2,500 to 3,000 TPS during regular periods. Notable performance features include rapid transaction confirmations, scalability, and block size. After the Firedancer upgrade, theoretical TPS could surpass 1 million, with routine TPS potentially exceeding 100,000. This is a primary reason why both Visa and DePIN have selected Solana. · Robust Token Standards and a Thriving Ecosystem Solana is a dynamic ecosystem with well-tested DEXs and established standards such as compressed NFTs (cNFTs), programmable NFTs (pNFTs), and Token Extensions. These provide fundamental components for DePIN projects to develop and launch their on-chain products. · Low Cost Even after the Cancun upgrade, Solana remains a low gas fee L1 solution. Some leading L2s, including ZK Rollup-based ZkSync and Starknet, as well as Optimistic Rollup-based Optimism and Base, have switched their DA layers to Ethereum mainnet Blob. This has reduced gas fees significantly, but not to the lowest level, as they didn't switch to Celestia. · Concentrated Liquidity, Composable Ecosystem, and Unified Community Significant ideological differences between Ethereum and other L2s have led to liquidity competition. This has been particularly pronounced in the current bull market, where minimal differentiation in technologies and ecosystems has resulted in limited wealth opportunities. General L2s pose no threat to competitive chains like Solana. Driven by the recent momentum of meme coins, Solana's DeFi ecosystem has experienced rapid growth, with TVL reaching $3.3 billion. This suggests the launch of more attractive yield products and speculative products on Solana. Coupled with RWA, AI, and DePIN projects, DeFi products are poised for greater composability. · An Active Developer Community Driving Innovative Projects and New Concepts Solana has nurtured an active developer community through hackathons and various incentives, driving the expansion of its ecosystem. Prominent projects like Magic Eden, Stepn, and jito have emerged. Solana maintains its developer ecosystem and community activities even during bear markets. Through consistent incentive measures and hackathons, Solana has improved its infrastructure and stimulated greater development of innovative applications, further fueling its ecosystem's growth. · Wealth Creation as the Best Marketing Tool Saga's massive airdrops lead the way for crypto phone strategies, fostering the unity within Solana's communities. Projects like Solend, Helius, Chads, and Solcial have announced airdrops, benefits, and giveaways for Saga 2 owners. In the recent bull market, meme coin $BOME achieved the feat of being listed on Binance within just three days. Ecosystem Developments Below is a summary of DePIN projects on Solana Summary of the Solana DePIN Ecosystem: Leading Projects: RNDR and Helium RNDR is a decentralized rendering platform. Helium Network is a wireless network project. Since its inception in 2014, Helium has raised over $350 million from renowned investors such as a16z, Deutsche Telekom, Google, and Tiger Global. It migrated to the Solana blockchain in April 2024. Its current ranking on CMC is 64. Second-tier Projects: Helium series (MOBILE and IOT), io.net, and Nosana MOBILE and IOT are projects within the Helium ecosystem. · IOT: The protocol token for the Helium IoT network, mined by LoRaWAN Hotspots through data transmission revenue and coverage proof. · MOBILE: The protocol token for the Helium 5G network, awarded to those who provide 5G wireless coverage and Helium network validation. MOBILE is currently ranked 166th on CMC. io.net is a "GPU Aggregator" that integrates GPU networks from data centers, crypto miners, and projects like Render, utilizing computing power for machine learning applications. Yet to issue tokens, it has 426,000 followers on Twitter. Its Serie A financing totaled $30 million, led by Hack VC, with participation from Multicoin Capital, 6th Man Ventures, M13, Delphi Digital, Solana Labs, and Aptos Labs. Its GUP miners have exceeded 50,000. Nosana is a consumer marketplace connecting user-provided GPU networks and aiming to develop AI products. Potential Projects: ALEPH, HONEY, and Shadow ALEPH is a storage solution and interchain database. Hivemapper (HONEY), launched in November 2022, is a decentralized global mapping network, rewarding contributors who collect 4K street images using dash cams through the Drive-to-Earn model. In April 2022, the project completed $18 million in financing, led by Multicoin Capital, with participation from industry professionals such as Solana's founder, former Apple Maps executives, and Helium's CEO. Hivemapper is currently ranked 513th on CMC. Shadow, a rival to Filecoin, employs Shdw Drive to reduce the cost of corporate data center storage by utilizing efficient traditional and action computing – a technology called DAGGER. Prospects of DePINs · As DePIN projects demand infrastructure with high throughput, they are likely to be established on high-performance L1 networks, or even on L2 or L3 solutions. · DePIN projects may explore various possibilities, including clean energy infrastructure and virtual power plants, exemplified by projects like Daylight and Etheos. · The transition of DePIN projects to larger platforms, as observed with Helium and Render, enables smaller projects to harness their capabilities for further development. · Dedicated DePIN chains have emerged, such as Peaq and IoTeX, two EVM/substrate chains specifically designed for DePINs. Additionally, some blue-chip DePIN projects, like Dimo, are using Polygon CDK to build their chains, indicating the demand for application chains. · The composability of DePIN with other ecosystems is particularly evident on Solana, exemplified by the wealth opportunities resulting from Bonk's airdrops to Saga holders. In the future, we can anticipate further integration between DePIN and DeFi for enhanced returns and speculative activities, as well as the fusion of DePIN with RWA, providing financing solutions for projects or data for the real world. Let's look at some examples. · DePIN x ZK As technology continues to advance, solutions like ZK TLS can prove the authenticity of Web2 or Web3 data, bridging the gap between the two. Combining DePIN with ZK technology will give rise to a flurry of Web3 projects capable of "vampire attacking" their Web2 counterparts, a development worth noting. Take Space and Time as an example. Space and Time is a verifiable compute layer that extends zero-knowledge proofs on decentralized data warehouses, providing trustless data processing for smart contracts, LLM, and enterprises. It connects indexed blockchain data with off-chain datasets and adopts Proof of SQL to prevent computations from being tampered and to validate the integrity of query results. Proof of SQL, a new ZK-proof develped by Space and Time, allows the data warehouse to generate a SNARK cryptographic proof of SQL query execution, proving that query computation was done accurately and that both the query and the data are verifiably tamperpoof. Through the project, developers can connect indexed on-chain and off-chain data, and perform low-latency cached queries and large-scale analytical tasks using SQL transformations. Additionally, they can customize data into business-specific patterns, deploy queries to APIs, and build dashboards. Meanwhile, zero-knowledge technology ensures that tamperproof query results are sent to smart contracts in a trustless manner or directly published on-chain. Currently, Space and Time has indexed Ethereum, Polygon, Sui, Sei, and Avalanche. It is supporting more chains while integrating with Chainlink. · DePIN x AI The development of decentralized physical infrastructure networks could revolutionize data utilization, including decentralized machine learning, exemplified by projects like Bittensor. Bittensor is an open-source protocol that powers a decentralized, blockchain-based machine-learning network. Machine learning models engage in collaboration training in TAO and receive rewards based on the value of information they contribute. TAO also facilitates external access, empowering users to extract information from the network and customize network activities to suit their requirements. · DePIN x Privacy As mentioned earlier, while DePINs are decentralized physical networks, their business models focus on data utilization. Protecting data privacy is paramount for large decentralized networks. Consequently, integrating privacy protection measures is imperative for the growth of DePIN. Therefore, it's crucial to keep an eye on the sector's integration with privacy-enhancing technologies. · DePIN x Gaming The integration of DePIN and gaming can be analyzed from multiple angles: 1. Large decentralized hardware networks may enhance gaming experiences to some extent. 2. The combined concept of real-world wearable devices, gaming, and metaverse could become popular again. 3. DePIN hardware infrastructure may reshape incentive mechanism and gaming experiences. References 1. https://www.panewslab.com/zh_hk/articledetails/8vy12wz3Ft.html 2. https://mp.weixin.qq.com/s/DE28WI5hE7OE5s2D-TFLxw 3. https://foresightnews.pro/article/detail/53218 4. https://DePIN.ninja/leader-board 5. https://DePINhub.io/rankings/investors About Us This article is a product of diligent work by the HTX Research Team that is currently under HTX Ventures. HTX Ventures, the global investment division of HTX, integrates investment, incubation, and research to identify the best and brightest teams worldwide. With a decade-long history as an industry pioneer, HTX Ventures excels at identifying cutting-edge technologies and emerging business models within the sector. To foster growth within the blockchain ecosystem, we provide comprehensive support to projects, including financing, resources, and strategic advice. HTX Ventures presently backs over 200 projects spanning multiple blockchain sectors, with select high-quality initiatives already trading on the HTX exchange. Furthermore, as one of the most vigorous Fund of Funds (FOF) investors, HTX Ventures collaboratively forges the blockchain ecosystem alongside premier global blockchain funds, including IVC, Shima, and Animoca. Contact Details Michael Wang glo-media@htx-inc.com Company Website https://www.htx.com/en-us/ventures Disclaimer 1. The author of this report and his organization do not have any relationship that affects the objectivity, independence, and fairness of the report with other third parties involved in this report. 2. The information and data cited in this report are from compliance channels. The sources of the information and data are considered reliable by the author, and necessary verifications have been made for their authenticity, accuracy and completeness, but the author makes no guarantee for their authenticity, accuracy or completeness. 3. The content of the report is for reference only, and the facts and opinions in the report do not constitute business, investment and other related recommendations. The author does not assume any responsibility for the losses caused by the use of the contents of this report, unless clearly stipulated by laws and regulations. Readers should not only make business and investment decisions based on this report, nor should they lose their ability to make independent judgments based on this report. 4. The information, opinions and inferences contained in this report only reflect the judgments of the researchers on the date of finalizing this report. In the future, based on industry changes and data and information updates, there is the possibility of updates of opinions and judgments. 5. The copyright of this report is only owned by HTX Ventures. If you need to quote the content of this report, please indicate the source. If you need a large amount of references, please inform in advance (see “About HTX Ventures” for contact information) and use it within the allowed scope. Under no circumstances shall this report be quoted, deleted or modified contrary to the original intent. About HTX Ventures HTX Ventures, the global investment division of HTX, integrates investment, incubation, and research to identify the best and brightest teams worldwide. With a decade-long history as an industry pioneer, HTX Ventures excels at identifying cutting-edge technologies and emerging business models within the sector. To foster growth within the blockchain ecosystem, we provide comprehensive support to projects, including financing, resources, and strategic advice. HTX Ventures presently backs over 200 projects spanning multiple blockchain sectors, with select high-quality initiatives already trading on the HTX exchange. Furthermore, as one of the most vigorous Fund of Funds (FOF) investors, HTX Ventures collaboratively forges the blockchain ecosystem alongside premier global blockchain funds, including IVC, Shima, and Animoca. Contact Details Michael Wang glo-media@htx-inc.com Company Website https://www.htx.com/en-us/ventures

May 03, 2024 10:17 AM Eastern Daylight Time

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How Can Small Investors Access Private Deals With Big Potential?

OurCrowd

By MATTHEW KALMAN OurCrowd allows investors to stake a claim in promising startups for as little as $10,000 “Stripe, a payments startup, is one of the most successful companies to emerge from Silicon Valley in a generation. Last year, it hit a valuation of $65 billion. But in the 15 years since it was founded, there has not been a way for most individuals to invest in it,” Erin Griffith reported in The New York Times in April. “It is a problem that has vexed retail investors for years, as startups like Stripe, SpaceX and OpenAI soar to enormous valuations in the private market,” Griffith says. “By the time the companies go public a decade or more after they started, their growth has often slowed and their valuations are high.” Even if you can access such deals, the minimum investment is “often very high,” James Seyffart, a research analyst at Bloomberg Intelligence, tells Griffith. One rare access point for such private deals is OurCrowd, a global investment platform that has introduced its worldwide community of over 235,000 accredited investors to opportunities in more than 460 portfolio companies, attracting over $2.3 billion in commitments to date. The minimum investment in a single startup deal through OurCrowd can be as little as $10,000. <iframe width="560" height="315" src= https://www.youtube.com/embed/MOoAs0m2JRE?si=qS2U_CDdsArdnTip title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe> The definition of “accredited investor” varies, depending on your jurisdiction. In the U.S., the SEC sets the bar at someone with an annual income of at least $200,000, or a net worth of $1 million or more. That’s because investing in startups is a high-return, high-risk business and investors must be wealthy and sophisticated enough to realize what they are getting into. Startup companies seeking private investment generally prefer to attract VCs, institutions, pension funds and high net worth individuals who can commit at least six-figure sums. This keeps the company’s cap table clean, allowing its executives to concentrate on building their business instead of fielding phone calls from dozens of retail investors. The result: thousands of would-be investors are locked out of opportunities where startups can sometimes grow by 50x or 100x. Extending Access The OurCrowd model blows open this exclusive club, extending access to these potential blockbuster deals to thousands of investors for whom a $100,000 investment in a single company is too high, but $10,000 is attractive. “OurCrowd is enabling hundreds of thousands of investors around the world to access the exciting venture capital asset class,” says Jon Medved, OurCrowd’s founder and CEO. “It turns out that if you want to make real money today, you have to invest in startup companies before they go public. In the good old days, you could have invested in something like Amazon or Microsoft, held it from an IPO and made thousands of times your money. But today that's not possible because the private companies are going public much later.” “The smart money, the smart investor, wants to find a way to get into these exciting dynamic growth stories while they're still private,” Medved says. While SpaceX did not appear on the OurCrowd platform, members have invested in Axiom Space, selected by NASA to build the successor to the International Space Station and NASA’s new generation of space suits; Stoke Space, which is developing reusable rockets for daily launch missions; ICON, which is creating 3D-printed housing for use on the Moon; and Ursa Major, America’s only independent provider of aerospace propulsion engines for the commercial space, hypersonic and defense launch markets. Likewise, OpenAI is not available via OurCrowd, but other promising AI companies have recently attracted millions of dollars of investment and, for investors wishing to further diversify, OurCrowd also offers a dedicated AI Fund. “It’s traditionally very hard for accredited investors and even family offices to invest in individual startup investment opportunities,” says Lisa Graston, OurCrowd’s associate director for Investor Relations. “You can invest via a VC fund, but then you’re relinquishing control and you’re dependent on the fund managers.” “Historically, the VC asset class has outperformed the public markets and it’s an asset class that’s really difficult to access. We are really democratizing the space,” Graston adds. To give investors added comfort, OurCrowd vets every opportunity offered on its platform and selects only a small number, invests its own money in every deal, and co-investors often include many of the world’s leading VCs and institutions. By participating through OurCrowd, smaller investors can secure access to some of the best classes of shares, anti-dilution protection and other privileges usually reserved for major shareholders. “It can be difficult to get a clear picture of the current valuation of a private company when you are investing through secondary marketplaces. When you invest with OurCrowd you are joining a funding round alongside other very experienced dealmakers, reducing the risk of investing at an outsized price compared to the current company value,” Graston says. OurCrowd is not a passive investor. It takes an active role in helping the companies added to its portfolio to succeed, often taking a seat on the board and introducing them to potential partners, customers and future investors. Recently, OurCrowd extended its offering beyond VC funds to additional private market alternatives, including venture debt, private credit and private equity funds where the entry ticket can start at half a million dollars or more. OurCrowd makes funds from top-tier managers available to investors at much lower minimums, enabling many more people to participate in these opportunities. “The innovation wave, which is changing all of our lives – whether telemedicine or e-commerce or climate change – is going to be led by entrepreneurs who are backed by smart money and smart investors,” Medved says. “OurCrowd is where those entrepreneurs meet the smart money on a global basis, where they can work together to benefit everyone.” For more information about investing in startups with OurCrowd, click HERE. Featured photo courtesy of OurCrowd. OurCrowd was started in 2013, driven by the idea that the business of building startups grows bigger and better when the global ‘crowd’ gains access to VC-level investment opportunities.Today, OurCrowd is a global venture and alternative investing platform that empowers institutions and individuals to invest and engage in emerging companies. OurCrowd vets and selects companies, invests its capital, and provides its global network with unparalleled access to co-invest and contribute connections, talent and deal flow. OurCrowd builds value for its portfolio companies throughout their lifecycles, providing mentorship, recruiting industry advisors, navigating follow-on rounds and creating growth opportunities through its network of multinational partnerships. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Lisa Graston lisa.graston@ourcrowd.com Company Website http://www.ourcrowd.com

May 03, 2024 09:00 AM Eastern Daylight Time

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AI In Orthopedic Surgery: How Leveraging AI Could Improve Surgical Outcomes

Benzinga

By Meg Flippin, Benzinga Artificial intelligence isn’t reserved only for chatbots and autonomous vehicles; it's also increasingly important in various other fields, like orthopedics, particularly for knee and hip replacement surgeries. Of the nearly 800,000 total knee replacement surgeries performed annually in the U.S., 88% are still performed manually – putting patients at risk from potential human errors and potentially longer recovery times. Then there are the implants. Many implants used today are “one-size-fits-none,” which don’t fit all patients perfectly. Today's major problems in joint replacement include mechanical loosening, bone loss, dislocation, ease of revision and fracture. About 100,000 hip and knee replacements fail every year, and 36% of patients regret their procedure altogether. How AI Is Transforming Surgery AI is helping address these challenges, speeding up surgeries and potentially improving patient outcomes. By analyzing patient data – including patient records and medical images – AI can assist surgeons in providing patients with precise and accurate diagnoses, identifying patterns or abnormalities that would be difficult to spot with the human eye. In the planning stage, in the future AI could help give surgeons valuable insights regarding where to place the implants and how to better predict surgical outcomes. Artificial intelligence can also help surgeons in the operating room with robots leveraging AI-powered preoperative planning that provides real-time guidance to efficiently cut bone for precise and accurate implant placement. Let’s not forget the recovery stage – even there, AI could prove useful in the future to potentially help surgeons develop customized treatments by analyzing the range of motion, muscle strength and gait of the patient. Monogram’s Mission Monogram Orthopedics Inc. (NASDAQ: MGRM) will be using AI (machine learning) and robotics to deliver the next generation of patient care and improve implants to improve fit and capital efficiency. The Austin, Texas-based medical device company is at the cutting edge, betting that customizing implants to the unique needs of patients will go a long way in improving outcomes for the countless people who need hip and knee replacements each year – with machine learning algorithms that could identify the critical anatomical landmarks to help inform the implant design. These technologies are not yet commercial or FDA-cleared. “Our mission is to make orthopedics personal. The current standard of care is highly impersonal,” says Monogram CEO Benjamin Sexson. “In crude terms, patients are permanently and irreversibly amputating arthritic bone to have it replaced with an off-the-shelf generic implant that, in non-clinical terms, gets ‘hammered’ into place. Simplistically our goal is to replace joints with implants that are designed for a more personalized fit and placed with advanced robotics. We are working to mitigate the risks of arthroplasty with technology that drives personalization.” Monogram is aiming to revolutionize orthopedics with the launch of its robotic technology mBôs, which links 3D printing and robotics with advanced pre-operative imaging. The robots aim to help surgeons plan where to place the implant to achieve target laxity values under stress. Accompanying the robot are “best fit” implants that the company believes could improve the personalization of what is available today. Better Outcomes With AI The idea is to get to a point where surgeons use 3D-printed implants that are designed based on the patient’s unique characteristics. The custom implants could reduce the need to carry excess inventory and would be press-fit (they wouldn’t need cement to hold them in place). Monogram’s robots are designed to precisely cut the bone to help surgeons place the custom implants on the patient. With more of the patient's bone preserved, this could result in a more bone-sparing design. Using the Monogram software platform and product solution architecture powered by AI and machine learning, the vision is for surgeons to be able to design optimized implants that they anticipate could improve stability and physiological loading. The company is researching the potential benefits of its designs and has not conducted clinical trials. Quick-build 3D printing could also enable maximum logistical and clinical efficiency, enabling clinical representatives to process patient image data using industry-leading machine learning algorithms and automated processes, says Monogram. This could reduce case processing time, lowering the cost of surgery. “Bone is a composite. It consists of compact bone at the periphery, spongy bone and bone marrow. Our implants are designed to maximize contact with the inner cortical wall (inner surface of the compacted bone at the periphery) to improve initial stability,” says Sexson. “The primary purpose of the machine learning algorithms is to segment bone (inner and outer cortex) from the CT scans as well as to identify the critical anatomical landmarks that inform the implant design algorithms.” Monogram is leaning heavily into AI. With Monogram’s technology, surgeons could get efficient case planning, fast registration and efficient cutting. Monogram has indicated it will be largely complete with its verification and validation in the first half of 2024, with a planned 510(k) application submission for FDA clearance in the second half of 2024. Technological advancements like AI are transforming healthcare, particularly when it comes to joint replacement surgeries, and for good reason. Today’s approaches are antiquated, generic, and can be ineffective ( 20% of patients aren’t satisfied with their knee replacement ). Monogram hopes it can change that, leveraging technology to personalize what has been a non-personalized procedure to date. Featured photo courtesy of Monogram Orthopedics. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

May 03, 2024 08:35 AM Eastern Daylight Time

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5thScape to list its first game “MMA Cage Conquest” on Meta Store: Ultimate Virtual MMA Experience

Spark Metro PR

Mixed Martial Arts fans and enthusiasts, your virtual fighting dreams have arrived! 5th Scape delivers a transformative experience with "MMA Cage Conquest," stepping far beyond traditional fighting games into true sensory immersion. Step into the iconic MMA cage, feel the roar of the crowd and become the champion you always envisioned. The 5thScape Project is an ambitious venture that aims to create a comprehensive Virtual Reality ecosystem. In this VR ecosystem many developers, gamers and experts from various industries can collaborate. This is a VR gaming studio startup in which they focus on developing games, movies, animations etc. Apart from this, they are also planning to launch a special VR headset and a VR Chair which is an ergonomically perfect chair for long gaming sessions. Now, coming back to the game, - "MMA Cage Conquest" redefines virtual combat. Its skill-based system demands true martial arts strategy along with honed reflexes. Learn and master strikes like a real-life wrestling professional. It includes (not limited to) powerful grappling throws and the intricacies of ground control to secure your victories. Feel the impact of every blow, the thrill of a perfectly executed submission, and the tension of a match fought on the razor's edge. Training lies at the heart of "MMA Cage Conquest." This journey transcends button-mashing and enters the realm of personal development. Start as an eager underdog, mastering the fundamentals through rigorous simulations. Refine your striking, defense, and ground game, tracking your progression and building unshakeable confidence. With each session, you don't just play the game – you live the fight. MMA Cage Conquest is all set to make gaming experiences more vigorous and a powerhouse for the senses. Feel the rush in your bones as you climb the leaderboards, and establish yourself as the ultimate MMA cage conqueror. Ready to unleash your inner champion? " MMA Cage Conquest " will be available on the Meta platform. Submitted for listing on May 2, 2024, the developers await approval from Meta. Visit 5thscape.com for trailers, release updates, and the latest news on your journey to become the undisputed MMA Cage Conqueror. Contact Details 5th Scape 5thScape Team +1 302-597-6768 Team@5thscape.com Company Website https://5thscape.com

May 03, 2024 06:51 AM Eastern Daylight Time

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ARway.ai Strikes Two Major Deals with ImmersLabs and Riyad Bank for Immersive AR Experiences

ARway.ai

ARway.ai Chief Executive Officer Evan Gappelberg joined Steve Darling from Proactive to unveil two significant partnerships with ImmersLabs and Riyad Bank, marking a significant leap forward in immersive augmented reality (AR) experiences. The collaboration with ImmersLabs entails ARway.ai joining as an ARway Developer to pilot AR maps across three floors of a prestigious museum located in the heart of Washington, D.C. This innovative installation aims to revolutionize navigation within the museum, offering visitors an immersive journey enriched with educational content about the museum's exhibits and architectural updates. Through AR technology, visitors can interact directly with various elements of the exhibits, enhancing their overall museum experience. Additionally, ARway.ai has partnered with Riyad Bank to prototype a cutting-edge navigation experience at their new corporate campus complex in Riyadh, Saudi Arabia. This initiative is designed to deploy across all buildings within the property, providing employees with seamless navigation from parking lots to offices and other facilities within the campus. By leveraging AR technology, Riyad Bank aims to enhance employee productivity and streamline movement within their corporate environment. These partnerships underscore ARway.ai's commitment to leveraging advanced AR solutions to transform navigation experiences across diverse environments, from cultural institutions to corporate campuses. By harnessing the power of AR technology, ARway.ai is pioneering new standards in immersive navigation and user engagement, empowering organizations to unlock the full potential of spatial computing for enhanced experiences and operational efficiency. Contact Details Proactive United States +1 347-449-0879 action@proactiveinvestors.com

May 02, 2024 02:12 PM Eastern Daylight Time

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Nextech3D.ai Achieves 80% Gross Profit Milestone, Propelled by AI and Strategic Shift to Hyderabad

Nextech3D.AI

Nextech3D.ai CEO Evan Gappelberg joined Steve Darling from Proactive to announce the company has reached a significant milestone by achieving an 80% gross profit in Q2, 2024. This remarkable accomplishment marks a 166% increase from the 30% gross profit reported in 2023, showcasing the company's strong growth trajectory. Evan Gappelberg, CEO of Nextech3D.ai, attributes this milestone to the company's strategic investment in AI and its pivot to Hyderabad, India, in Q3, 2023. He expressed confidence in the company's ability to achieve profitability in 2024 by scaling revenue with impressive 80% profit margins while concurrently reducing operating expenses. This reduction in expenses is attributed to the continued investment in the company's patented AI technology, which enhances efficiency and productivity across operations. The strategic shift to Hyderabad, India, aligns perfectly with Nextech3D.ai's commitment to delivering top-tier 3D modeling and augmented reality solutions while maintaining a sharp focus on profitability and fiscal responsibility for its valued shareholders. This move underscores the company's dedication to maximizing shareholder value while capitalizing on emerging market opportunities in the eCommerce and technology sectors. Contact Details Proactive United States +1 347-449-0879 action@proactiveinvestors.com

May 02, 2024 02:10 PM Eastern Daylight Time

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Toggle3D.ai Welcomes Hareesh Achi as New CEO, Transitioning from Evan Gappelberg

Toggle3D.ai Inc

Toggle3D.ai Chief Executive Officer Hareesh Achi and Nextech3D.ai CEO Evan Gappelberg joined Steve Darling from Proactive to announce Toggle3D.ai's latest move involves appointing Hareesh Achi as the new Chief Executive Officer, succeeding Evan Gappelberg, who remains the CEO of parent company NextTech3D.ai. Achi, with a rich background at tech giants like Microsoft and Meta, brings a wealth of experience in large-scale operations, a crucial asset for Toggle3D's ambitions in 3D technologies and AI. Gappelberg expressed confidence in Achi's ability to steer growth and innovation at Toggle3D, citing his deep understanding of the company's operations and technological framework. Achi, in turn, reiterated his dedication to leveraging his expertise to elevate Toggle3D's offerings in the 3D space. He recognized the vast potential for expansion and innovation across industries such as e-commerce and manufacturing. Under Achi's leadership, Toggle3D aims to harness its advanced AI capabilities and user-friendly technologies to secure a prominent position in the market. Gappelberg emphasized the strategic timing of this leadership transition, aimed at enhancing shareholder value during a pivotal growth phase for Toggle3D. Contact Details Proactive Canada +1 604-688-8158 action@proactiveinvestors.com

May 02, 2024 02:02 PM Eastern Daylight Time

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AI Sports Odds Intelligence Firm Bettormetrics Finds US Sportsbooks Leave Billions in Handle on the Table Due to Poor Suspension Strategies

Bettormetrics

Bettormetrics, an innovative company providing competitive sports odds intelligence and insight to the sports betting industry, reported today through its latest data analysis, that the leading US sportsbooks are potentially losing tens of millions of dollars in revenue due to length of suspension times during live sport contests. According to the findings, FanDuel led the top three sportsbooks in potential revenue lost, leaving an estimated $1.45 billion in handle on the table with an average suspension rate of 15.8% (84.2% uptime) per fixture. DraftKings, although best in class, leaves a potential $249 million in handle with an industry leading suspension rate of 4.8% (95.2% uptime) The analysis was done leveraging NBA betting data for the 2023-2024 season. “While suspension is an inevitable occurrence in sports betting as traders necessarily evaluate the risks surrounding new situations within games, some sportsbooks are more systematically cautious than others. It’s this situational nuance that leads to more sportsbooks looking at risk instead of the potential rewards around improving its average uptime” said Robert Urwin, CEO and co-founder of Bettormetrics. “In looking at our NBA data of the top three US sportsbooks, it’s clear to see the suspension strategies and the risk management perspectives of each book’s trading desks. While FanDuel is potentially losing out on the most revenue, based on its incredible volume, with a few optimizations it can dramatically increase its margins and create distance between itself and DraftKings as the definitive leader in US sportsbook operations.” Suspension is when a sportsbook periodically shuts down betting lines in a sporting event to readjust the odds based on activity within the event (a basket, touchdown, goal, penalty, key injury, etc.). Each sportsbook handles suspension differently and for different periods of time. Depending on the length of time the odds are suspended, sportsbooks are losing the opportunity to accept new bets and can potentially lose active users to other sportsbooks, should odds be shut down for extended periods of time. “Every operator is looking for ways to grow their margins, increase wagering and reduce customer attrition. While many sportsbooks externalize their focus on the cost of user acquisition, suspension can help a sportsbook find new revenue from within by becoming more efficient than their competitors,” said Sabin Brooks, Commercial Director of Bettormetrics. “In the US, market share is gained in very slim percentage points. By understanding and addressing these crucial trading efficiencies, sportsbooks can gain potentially billions in lost revenue. A poor suspension strategy is very bad business for customers and shareholders alike.” Suspension is just one element of overall sportsbook performance. Bettormetrics monitors and analyzes thousands of live in-play sports betting events traded every single week. Observed performance and competitive analysis by Bettormetrics has already helped traders and analysts discover and ameliorate deficiencies that directly impact sportsbook revenues and profitability. About Bettormetrics Bettormetrics is an innovative company providing competitive sports odds intelligence and insight to the sports betting industry. Bettormetrics’s Trading Analytics Platform is a SAAS product supporting sportsbook trading desks with cutting edge insight and analysis on the entire event life cycle, helping sportsbooks, data suppliers and B2B platforms gain an edge on competitors and ensure no profits are left on the table. For more information, please email info@bettormetrics.com or visit Bettormetrics.com. Contact Details Digital Sport by Hot Paper Lantern Bailey Irelan birelan@hotpaperlantern.com Square In The Air Ben Cleminson ben@squareintheair.com Company Website https://bettormetrics.com/

May 02, 2024 12:50 PM Eastern Daylight Time

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Tokens.com Expands into AI and Robotics with Acquisition of Simulacra Corporation

Tokens.com

Tokens.com CEO Andrew Kiguel joined Steve Darling from Proactive to unveil the company's strategic pivot towards AI and robotics, marking a significant step to position itself as a pioneer in technological innovation. Tokens.com recently completed the acquisition of Simulacra Corporation, a leading specialist in AI for companionship and ultra-realistic humanoid robots. These cutting-edge technologies are not only designed for interactive companionship but also find applications across entertainment, healthcare, and education sectors. Kiguel emphasized the transformative potential of humanoid robots in various domains, including classrooms for interactive teaching experiences and healthcare settings for providing companionship and assistance to patients. Tokens.com has already demonstrated the practical utility of its technologies through successful projects with prominent entities like the US military and Johns Hopkins Hospital. Moreover, Tokens.com is exploring novel governance applications by considering the integration of AI-enabled robots as advisors on its board. This strategic move underscores the company's commitment to leveraging AI to enhance decision-making processes while ensuring impartiality and efficiency. With over $20 million in revenue, Tokens.com has solidified its position as a leader in the field of humanoid robotics, distinguishing itself from competitors such as Boston Dynamics and Tesla. The acquisition of Simulacra Corporation marks a significant milestone in Tokens.com's journey towards innovation and technological advancement. Contact Details Proactive North America +1 604-688-8158 na-editorial@proactiveinvestors.com

May 02, 2024 12:03 PM Eastern Daylight Time

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