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Cardiol Therapeutics releases positive study results of subcutaneously administered cannabidiol

Cardiol Therapeutics

Cardiol Therapeutics CEO David Elsley joined Steve Darling from Proactive with news the company has unveiled highly promising study results from international research, which showcased the remarkable potential of subcutaneously administered cannabidiol, the active pharmaceutical ingredient found in Cardiol's groundbreaking CRD-38 subcutaneous formulation. In this study, it was revealed that the application of subcutaneous cannabidiol effectively curtailed the upward trajectory of both body weight and heart weight, while also preventing undesirable increases in crucial cardiac inflammatory and remodelling markers. This research was conducted in a meticulously designed model of heart failure with preserved ejection fraction, noteworthy for its ability to accurately replicate the comorbidities commonly associated with this condition, such as hypertension, obesity, and metabolic dysfunction. Elsley emphasized the profound significance of these study findings, particularly focusing on the unique pre-clinical model employed. This model, meticulously crafted to mimic the conditions experienced by patients suffering from heart failure with preserved ejection fraction, serves as an essential tool in understanding the complex interplay of factors contributing to the disease. The results, which illuminated the multiple cardioprotective effects of subcutaneously administered cannabidiol, serve as a pivotal stepping stone towards the development and potential approval of CRD-38 as a groundbreaking treatment for heart failure. The collective body of evidence generated by this research provides strong support for the advancement of Cardiol Therapeutics' innovative therapeutic approach in combating this debilitating condition, offering hope and potential relief to countless individuals affected by heart failure with preserved ejection fraction. Contact Details Proactive Canada +1 604-688-8158 na-editorial@proactiveinvestors.com

October 11, 2023 01:05 PM Eastern Daylight Time

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Perimeter Medical Imaging AI shortlisted for grant funding under Biden Cancer Moonshot initiative

Perimeter Medical Imaging AI

Perimeter Medical Imaging AI CEO Adrian Mendes joined Proactive's Stephen Gunnion with news that the company has been shortlisted in a grant funding process sponsored by the Advanced Research Projects Agency for Health (ARPA-H) as part of its Precision Surgical Interventions (PSI) program. Mendes explained that the initiative aims to provide groundbreaking tools for surgeons to effectively remove cancer in a single operation. Perimeter's technology aligns perfectly with this goal, as they have been working on it for the past decade. Perimeter Medical Imaging AI utilizes a technology called OCT, which has been around for 30 years. However, it has developed wide-field OCT, enabling larger image capture crucial for examining excised tumors. The company's current S series device is already in use in several operating rooms, gathering user feedback. It is also conducting clinical trials for its next-gen B series device, integrating AI technology to enhance surgeon workflow. While the base OCT technology isn't new, the company's innovations and AI integration represent the latest advancements. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

October 11, 2023 01:02 PM Eastern Daylight Time

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Golden Rim says Kada has potential to be high-profit operation

Golden Rim Resources Ltd

Golden Rim Resources Ltd (ASX:GMR, OTC:GMRMF) MD Tim Strong speaks with Proactive after announcing an updated mineral resource estimate (MRE) of 30.3 million tonnes at 0.95 g/t for 923,000 ounces of contained gold across the Massan and Bereko prospects at the company’s Kada Gold Project in Guinea. The updated MRE for Kada contains a maiden resource for the Bereko prospect and an update for the Massan prospect. After the resource upgrade, a significant portion of Massan is now classified as indicated, which includes more than 40% of oxide material and 24% of Massan resources. Strong said: “The updated mineral resource estimate at Kada confirms the potential of this exciting deposit. “A comprehensive structural study using an orientated diamond core at Massan allowed us to refine our modelling and has resulted in a significant portion of the mineral resource being classified as Indicated, including over 40% of the oxide material. “For the new MRE, we have deliberately chosen to use a higher cut-off and a more conservative pit shell to increase confidence in the potential for Kada to be a high-profit operation. “Applying the same cut-off parameters as our maiden MRE (0.33 g/t gold cut-off for oxide/transitional material and 0.41 g/t for fresh material), we have added almost 200,000 ounces (20%) to the gold inventory." Contact Details Proactive Investors Jonathan Jackson +61 413 713 744 jonathan@proactiveinvestors.com

October 11, 2023 12:45 PM Eastern Daylight Time

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Pental has clear strategy to grow its e-Commerce business

Pental Ltd

Pental Ltd (ASX:PTL) managing director Charlie McLeish speaks with Proactive after entering a deal to sell its consumer products business and the Shepparton manufacturing facility to Selleys, a division of DuluxGroup, for $60 million on a debt and cash free basis. The Pental board believes this transaction represents significant value recognition for shareholders. Moving forward, Pental will transition into a dedicated e-commerce business underpinned by its e-commerce hamper and gifting business ‘Hampers with Bite’. Pental is a provider of household chemical and cleaning products. With an iconic portfolio of brands, Pental has been servicing Australians for generations with honest products that really work. Pental brands have a rich history. From White King, Australia’s iconic household cleaning brand since 1950, to Lux, whose soap flakes have been cleaning and freshening Australian and New Zealand clothes since 1903. Pental products our based on an ongoing commitment to values founded upon innovation, performance and a united team that propels our brand forward together. Brands include: White King, Janola, Sunlight, Softly, Country Life, Velvet, Martha’s, Huggie, Natural Selections, LUX, Little Lucifer and Jiffy set the benchmark for quality in supermarkets, and are also proudly Australian made and owned. Contact Details Proactive Investors Jonathan Jackson +61 413 713 744 jonathan@proactiveinvestors.com

October 11, 2023 12:40 PM Eastern Daylight Time

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VinFast to acquire VinES Energy Solutions to step up its integrated supply and production chain

Vingroup

HANOI, VIETNAM - Media OutReach - 11 October 2023 – Vingroup’s Chairman, Mr. Pham Nhat Vuong, announces that he will donate 99.8 percent of VinES Energy Solutions Joint Stock Company’s shares to VinFast. The merger is designed to enhance VinFast’s self-sufficiency in battery technology and its production chain, while increasing its competitive edge in the ever-growing electric vehicle market. Following the donation, VinES will be merged into VinFast to enhance its self-efficiency in battery technology and leverage resources to increase battery research and development for its vehicles. VinES is a member company of Vingroup with legal capital of VND6,500 billion ($270 million). The company specializes in researching, developing, and manufacturing advanced lithium-ion batteries for mobility and energy storage applications. VinES also cooperates with leading global battery technology partners and seeks to become a comprehensive energy solution provider. Under the terms of the merger, VinFast will acquire all VinES’ intellectual property related to battery cells, battery packs, manufacturing facilities, technology, partnerships, and supplier contracts. This comprehensive acquisition of VinES’ battery technology and modern manufacturing facilities is an important step in completing VinFast’s fully integrated production chain and creates an unparalleled competitive advantage for VinFast in the global electric vehicle market. Ms. Le Thi Thu Thuy, Vice Chairwoman of Vingroup and Global CEO of VinFast shared: “The acquisition of VinES will help VinFast control our battery technology and supply chain, thus optimizing operating expenses and enriching technology content in our electric vehicles. This is also an important step towards developing and controlling an integrated supply chain as well as comprehensive manufacturing system to further strengthen our competitiveness." In April 2023, Mr. Pham Nhat Vuong signed an agreement committing him to donate USD 1 billion from his personal assets to VinFast. Vingroup, together with Mr. Vuong, also announced the contribution of a further USD 500 million to VinFast in non-refundable grants as well as a guarantee for a loan of USD 1 billion carrying a maximum tenor of five years to support VinFast’s growth and global expansion plans. For more information, please visit: https://www.sec.gov/Archives/edgar/data/0001913510/000119312523253903/d535412d6k.htm Contact Details Media Contact +84 96 196 65 65 v.chidqd1@vingroup.net Company Website https://vinfastauto.com

October 11, 2023 11:34 AM Eastern Daylight Time

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The Open Network (TON) to Attempt World Record for the Fastest Blockchain

TON Foundation

Today, The Open Network Foundation ( TON Foundation ) announces their upcoming attempt to officially be named the world’s fastest blockchain, accredited by Guinness World Records. The public network performance test, which is scheduled for October 31, 2023, at 15:00 UTC, will demonstrate the reliability, scalability, and speed of The Open Network (TON) blockchain. TON Foundation will collaborate with Alibaba Cloud, amongst others, to set up 256 servers for validator nodes and start a separate TON blockchain network for performance tests. Since 2022, the TON blockchain has experienced exponential growth. The network has seen a staggering 20-fold increase in addresses, skyrocketing from 170,000 to a remarkable 3.5 million. The growth of TON’s user base has come alongside the expansion of TON validator nodes to 350, creating a more decentralized network, now spread over 25 separate nations. Throughout this rapid expansion, TON’s blockchain has upheld a notably reliable track record, with no documented major network disruptions. The collaboration between TON Foundation and Telegram, announced on September 13, underscores TON Foundation’s commitment to bringing decentralized technology to the mainstream. The upcoming performance test is a pivotal step in demonstrating the unique capabilities of the TON blockchain, now cemented as the trusted infrastructure layer for the Web3 ecosystem in Telegram. "We look forward to October 31, 2023 to confirm that the TON blockchain technically stands out among any other blockchain, especially in its ability to scale," says Anatoly Makosov, Core Development Lead at TON Foundation. "This is the first large-scale public performance testing of TON - we're just as excited as you are to see the results." Audiences worldwide are invited to witness the event in real-time by visiting live.ton.org. Viewers are encouraged to view the event for informational purposes only and should not make any investment decisions based on the outcome. About TON Foundation The Open Network Foundation (TON Foundation) is a non-profit organization founded in Switzerland in 2023. TON Foundation is 100% funded by the community, acting in the community's interests, and supports initiatives aligned with The Open Network’s mission. Learn more at https://ton.foundation. About The Open Network (TON) The Open Network (TON) is putting crypto in every pocket. By building a Web3 ecosystem in Telegram Messenger, TON is giving billions the opportunity to own their digital identity, data, and assets. See more at https://ton.org/. Contact Details TON Foundation TON Foundation Team ton@theagencypartnership.com Company Website https://ton.foundation/

October 11, 2023 11:12 AM Eastern Daylight Time

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OYO Rolls Out Contactless Anytime Check-In and Virtual Front Desk for its US Hotels

OYO

Global hospitality technology company OYO has announced the launch of a virtual front desk solution for its partner hotels in the US. Powered by GPT-4, the solution will eliminate waiting time for its customers offering anytime check in, help and guide international travellers who do not speak the local language and will also lead to faster response and resolution. The initiative is in line with OYO' s continuous efforts towards increasing operational efficiency of hotel partners by empowering them with latest technological tools. The self check-in technology is integrated with smart lock systems, allowing guests to enjoy keyless entry and exit without the need for physical key cards. Round-the-clock virtual front desk powered by ChatGPT4 will reduce front desk operations expenses by ~60%, saving an average OYO hotel ~$30,000 annually. The virtual front desk will support 80+ languages and will promptly assists guests in their preferred language, addressing queries and concerns in real-time. Additionally, the system automates payment collection, streamlining the entire process for a hassle-free experience. ChatGPT4 also analyses guest preferences to provide tailored recommendations for activities, dining, and local attractions. Talking about self-check in, Gautam Swaroop, CEO- OYO International said, “Guest facing tech such as the Contactless Self Check-in solution is not only important for enabling a seamless experience for guests, but also helps drive bookings and provides revenue-enhancing solutions for our hotel owners. The virtual front desk serves as a powerful tool that provides guests personalized hotel recommendations, exclusive offers, and seamless navigation. This also contributes to boosting bookings on OYO's own platforms, creating an additional revenue stream for hotel owners.” Nikhil Heda, Head of Business Development – OYO USA added, “There has been an increasing shift in consumer behaviour where they prefer digital-first interactions, convenience and personalization. This has steered the hospitality industry towards the adoption of guest-facing technology. At OYO, we have made a conscious effort to advance our tech stack to keep up with new customer demands and advanced technologies.” OYO offers hotels access to a large base of regular customers through its app and website, and lists hotels on multiple Online Travel Agents (OTAs) to boost booking demand and revenue. OYO’s best-in-class Artificial Intelligence-enabled pricing software automatically drives the best booking prices across all channels, based on room type, seasonality and other factors, therefore, enabling such an increase in online revenues. OYO has started offering hotels the flexibility of not having to invest heavily in redoing the hotel to join the OYO platform, something that other budget hotel chains insist on. Therefore, the initial investment to join OYO is minimal. It has been focusing instead on standardizing service led components such as customer support and booking experience. Nikhel Chand, the owner of OYO Woodland Hotel and Suites, who implemented the solution at his property said, "We implemented this solution to improve customer experience, help reduce costs, automate repetitive tasks and improve revenue. Our previous front desk setup had some gaps, both from a guest experience and operational perspective, including challenges with late-night check-ins and issues with keycard loss by customers. The biggest value this solution has brought to our property is the ability to manage hotel operations remotely from anywhere." The company helps ensure great experience for customers, with ease of search and a quick booking experience, highly competitive room prices as per market demand patterns, automated tools such as Artificial Intelligence powered chatbots to quickly resolve customer queries, loyalty programs and easy refund, if needed. OYO recently announced that it has partnered with Stripe to ease the payment experience for its customers and hotel owners in the US. The integration will provide hotel owners with a flexible and seamless solution for in-person payments with Stripe Terminal at their hotels. OYO hotels in the US will also be enabled with real-time payouts through Instant Payouts with Stripe, which will improve their cash flow. Earlier this year OYO said that it is planning to add over 100 hotels in the US. The company will focus on adding more hotels in the states of Oregon, Washington, Texas, Oklahoma, Georgia and Florida. Texas continues to be the largest and fastest growing market for OYO in the US, while it also has a sizable concentration of hotels in Oregon, South and North Carolina, Florida & Georgia. The company also achieved a 48% growth in revenue from bookings on its own platform, such as the app, website, mobile web and call centers in Q4 2022 vs same period in 2021. OYO’s app saw the highest growth with a 99% surge in revenue from bookings in Q4 2022 vs same period in 2021. The company had earlier disclosed that its app is the second most downloaded travel app with over 100 million downloads globally. OYO has presence in over 35 countries globally. It owns a vacations home business in Europe called OVH (OYO Vacation Homes) which operates legacy brands such as DanCenter and Belvilla. About OYO: OYO is a global platform that aims to empower entrepreneurs and small businesses with hotels and homes by providing full-stack technology products and services that aim to increase revenue and ease operations; bringing easy-to-book, affordable, and trusted accommodation to customers around the world. OYO offers 40+ integrated products and solutions to patrons who operate over 168,711 hotel and home storefronts in more than 35 countries including India, Europe and Southeast Asia, as of September 30, 2022. For more information, visit here Disclaimer: Oravel Stays Limited is proposing, subject to applicable statutory and regulatory requirements, receipt of requisite approvals, market conditions and other considerations, to make an initial public offering of its equity shares (the “Equity Shares”) and has filed the Draft Red Herring Prospectus (“DRHP”) with the Securities and Exchange Board of India (“SEBI”). The DRHP is available on the website of SEBI at www.sebi.gov.in, websites of the Stock Exchanges, i.e., BSE Limited and National Stock Exchange of India Limited at www.bseindia.com and www.nseindia.com, respectively, and is available on the websites of the Global Coordinators and Book Running Lead Managers, i.e., Kotak Mahindra Capital Company Limited, J.P. Morgan India Private Limited and Citigroup Global Markets India Private Limited at www.investmentbank.kotak.com, www.jpmipl.com and www.online.citibank.co.in/rhtm/citigroupglobalscreen1.htm; the websites of the Book Running Lead Managers, i.e., ICICI Securities Limited, Nomura Financial Advisory and Securities (India) Private Limited, JM Financial Limited and Deutsche Equities India Private Limited at www.icicisecurities.com, www.nomuraholdings.com/company/group/asia/india/index.html, www.jmfl.com and www.db.com/India, respectively. Investors should note that investment in equity shares involves a high degree of risk and for details relating to the same, refer to the Red Herring Prospectus which may be filed with the Registrar of Companies in the future, including the section titled “Risk Factors”. Potential investors should not rely on the DRHP filed with SEBI for making any investment decision. The Equity Shares offered in the Fresh Issue (as defined in the DRHP) and the Offer for Sale (as defined in the DRHP) have not been and will not be registered under the U.S. Securities Act of 1933, as amended (the “Securities Act”) and, may not be offered or sold within the United States except pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and applicable state securities laws. Accordingly, the Equity Shares are only being offered and sold (i) within the United States only to “qualified institutional buyers” (as defined in Rule 144A under the Securities Act) in transactions exempt from, or not subject to, the registration requirements under the Securities Act, and (ii) outside the United States in offshore transactions in reliance on Regulation S under the Securities Act and pursuant to the applicable laws of the jurisdictions where those offers and sales are made. There will be no public offering of the Equity Shares in the United States. Contact Details Anupriya +91 97911 63065 anupriya.d@oyorooms.com Company Website https://www.oyorooms.com/

October 11, 2023 10:00 AM Eastern Daylight Time

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PathAI Announces Research Presentations at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

PathAI

PathAI, a global leader in AI-powered pathology, today announced it will present research on advances in artificial intelligence (AI) approaches through three posters at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics on October 11-15 in Boston, Massachusetts, including one poster to be presented in partnership with Flare Therapeutics. The posters showcase how AI may improve the utility of complex and specialized modalities such as multiplexed immunohistochemistry and may enhance the utility of routine modalities, such as augmenting cellular resolution from H&E-stained images. The presentations underline the significant strides in AI that can enhance translational and clinical research applications. Spatially-resolved prediction of gene expression signatures in H&E whole slide images using additive multiple instance learning models (Poster B010) In this research, PathAI demonstrates the prediction of TGFβ-CAF gene expression signature levels in breast cancer from H&E images and links these levels to tumor microenvironment features using PathExplore, PathAI’s recently launched structured, standardized and scalable panel of human interpretable features (HIFs) offering unprecedented resolution of the tumor microenvironment (TME) from H&E whole-slide images. H&E staining is routine for cancer diagnosis but does not provide molecular information. This potentially limits its utility for molecular-targeted therapy development and selection. AI models augment the information that can be extracted from H&E staining, enhancing resolution of H&E data and increasing other applications such as associating spatial TME features with gene expression signatures. End-to-end additive multiple instance learning (aMIL) models developed and deployed by PathAI performed well at predicting TGFβ-CAF levels. Importantly, aMIL models link PathExplore HIFs to specific sub-regions within the TME, which allows for granular understanding of specific cellular contributions to various molecular predictions from H&E WSI. This poster adds to a series of PathAI achievements in predicting molecular phenotypes from digital pathology images, providing a means to harness complex biological signatures as clinical biomarkers for precision medicine. It will be presented by Chintan Parmar, manager of AI research at PathAI, on October 13 from 12:30-4 p.m. ET. Artificial intelligence (AI) analysis of histological images accurately identifies luminal subtype Urothelial Carcinomas characterized by high Peroxisome Proliferator-Activated Receptor Gamma (PPARG) expression (Poster B016) This research was completed in collaboration with Flare Therapeutics and highlights an AI-based model that identifies luminal subtype in Urothelial Carcinoma as a novel biomarker approach for its first-in-class clinical candidate FX-909. The poster will be presented by Stefan Kirov from Flare Therapeutics on October 13 from 12:30-4 p.m. ET. Machine-learning enabled quantification of colocalized multiplex IHC signals with spectral overlap (Poster B008) This poster demonstrates novel imaging and AI technology to accurately detect and quantify up to four co-localized antigens or stains from a single multiplex IHC slide. Multi-spectral imaging addresses the challenge of how to separate markers exhibiting both spectral and spatial overlap. Expression or staining of individual markers is identified in spectrally unmixed images and combined with information across all separate marker channels to create a “super annotation” co-expression map that is then used to train AI models. PathAI’s model utilizing super annotation demonstrated a significantly lower error rate in detecting co-expression of several markers such as ER, PR, and Ki67 compared to an commercially available method, which was consistent on two different scanners, Leica At2 and 3DHistech. These results may facilitate clinical utilization of higher-plex biomarkers, which could enable faster and more accurate co-expression measurement of various markers, promising cost and time savings by consolidating biomarker measurement to a single slide with automated scoring to assist pathologists. This poster will be presented by Waleed Tahir, pathology AI research scientist at PathAI, on October 13 from 12:30-4 p.m. ET. Learn More PathAI representatives will be on site at the conference for the poster presentations: Poster B008 October 13, 12:30-4:00 p.m. ET Presenter: Waleed Tahir, PathAI Poster B010 October 13, 12:30-4:00 p.m. ET Presenter: Chintan Parmar, PathAI Poster B016 (In partnership with Flare Therapeutics) October 13, 12:30-4:00 p.m. ET Presenter: Stefan Kirov, Flare Therapeutics If interested in meeting the PathAI team during or after the conference, contact the team via email at BD@pathai.com. About PathAI PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

October 11, 2023 10:00 AM Eastern Daylight Time

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Chipper Gives Student Loan Borrowers Relief with Lower Payment and Loan Forgiveness Options

Chipper

Chipper, the app that empowers student loan borrowers to better manage their debt, today announced that its full featured mobile app is now available to help borrowers lower their monthly payments and eliminate their debt. Chipper is a simple, easy to use app to help the 44-45 million Americans who have federal student loans manage their debt, find forgiveness, and lower monthly payments. The all-in-one student loan repayment app coincides with student loan payments restarting in October, following the pause that began in March 2020. Student loan debt is the second-biggest consumer debt category after mortgages, with the total amount of student debt now approaching $1.8 trillion and the average monthly payment being $400. Chipper has helped more than 140,000 customers conquer student debt up to four years faster with an average savings of $307 per month. Four out of five (82%) Chipper users find a better repayment plan through its app. "The restart of student loan payments has serious consequences on millions of Americans who are struggling financially and are already dealing with inflation and rising housing costs,” said Tony Aguilar, founder and CEO of Chipper. “Our app uses advanced technology to seamlessly connect student loans and automate enrollments into lower payment plans, improving outcomes for borrowers who are desperate for relief and forgiveness. We have already helped our members qualify for more than $250 million in student loan forgiveness. Chipper is on a mission to discover and take action on the different personalized options and programs that can eliminate their debt.” While more than four million people have enrolled in the SAVE plan, Chipper’s analysis shows that millions more borrowers are eligible for relief and forgiveness programs and their debt can be eliminated in one day if these borrowers take the proper action. Under the Public Service Loan Forgiveness (PSLF) program, Chipper’s research shows: Ninety percent of First Responders could have their debt forgiven. More than half of Educators could see their debt eliminated. One-third of Health Care workers’ debt could disappear. “Borrowers do not have to struggle under mountains of student debt, especially those who work in public service,” added Aguilar. “We know how to successfully apply for lower payments and forgiveness programs. Chipper makes the process easy and more effective so borrowers can successfully tackle their debt, putting them on a path towards savings and long-term wealth creation.” Since its inception in 2018, Chipper has been revolutionizing the way student loan borrowers manage and reduce their debt. By offering clear, actionable insights and strategies, Chipper empowers users to take charge of their financial futures, providing an authentic pathway to success and financial wellness. About Chipper Chipper, based in Austin, Texas, is the all-in-one student loan app that helps borrowers optimize and pay off their student debt faster. Chipper centralizes users' student loans while its algorithm identifies options for repayment management and loan forgiveness tailored to individual users. Chipper makes it possible for users to take further action on student loan repayments and chip away at debt even faster with Chipper Round-Ups and Chipper Rewards features. For more information, please visit chipper.app. Contact Details Joe LoBello Joe@LoBelloCommunications.com Company Website https://www.chipper.app/

October 11, 2023 10:00 AM Eastern Daylight Time

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