Kadimastem Earns FDA Approval of its IND Application For its US Multi-Site Phase IIa Clinical Trial of AstroRx® to Treat ALS | News Direct

Kadimastem Earns FDA Approval of its IND Application For its US Multi-Site Phase IIa Clinical Trial of AstroRx® to Treat ALS IND Approval Allows Commencement of the Multi-Site Clinical Trial and Recruitment of Eligible ALS Patients for Repeated Dosing of AstroRx® in Three-Month Intervals

News release by Kadimastem Ltd.

facebook icon linkedin icon twitter icon pinterest icon email icon Ness Ziona, Israel | March 20, 2023 07:00 AM Eastern Daylight Time

 

 Kadimastem Ltd. (TASE: KDST), a clinical stage cell therapy company, developing and manufacturing "off-the-shelf" allogeneic cell products using its platform technology to develop treatments for different neurodegenerative diseases and a potential cure for diabetes, has received FDA clearance to commence a phase IIa clinical trial in the US according to the Investigational New Drug (IND) application that was submitted in February 2023. The trial will test its lead neurological cell therapy product AstroRx® in repeated dosing of three-month intervals for the treatment of patients with ALS.

The planned clinical trial follows a first in human phase I/IIa clinical trial previously conducted by the company in Israel, in which AstroRx® was injected into the spinal cord fluid using a standard lumbar puncture procedure. In this phase I/IIa clinical trial Kadimastem demonstrated a good safety profile and clinically meaningful decline in the disease progression during the first 3-months follow-up period.

AstroRx® contains functional, healthy astrocytes (nervous system supporting cells) differentiated from human Embryonic Stem Cells (hESC) that aim to support the survival of diseased motor neurons through several mechanisms of action. The treatment’s goal is to nourish and support the malfunctioning motor neurons in the brain and spinal cord of patients suffering from Amyotrophic Lateral Sclerosis (ALS), to significantly slow the progression of the disease and improve the quality of life and life expectancy of the treated patients.

Kadimastem CEO Asaf Shiloni said, “The FDA approval for this multi-site clinical trial is a major achievement for us and is a recognition of our professional, clinical and scientific abilities. I’d like to congratulate our dedicated team on this extremely important landmark, which is an enormous milestone that brings great hope for the future of the ALS patients as well as our supporters and investors.”

Kadimastem Founder and Chief Scientific Officer Professor Michel Revel said, “The approval of submission of the IND to the FDA is a major achievement and moment of pride for me in the company that I have founded years ago, with an amazing team. It is very exciting, and we eagerly await to start this trial and wish to help ALS patients as soon as possible.”

  About AstroRx® & ALS 

Kadimastem’s flagship product, AstroRx®, is a breakthrough technology that is comprised of a unique and large cell population of astrocytes derived from human pluripotent stem cells. The cells are intended to support the survival of motoneurons (neurons the control the motor-capability) in the central nervous system (CNS, brain and spinal cord). AstroRx® enables the transplantation of healthy astrocytes into the CNS of the ALS patient and an improvement in the protection of the motoneurons.

In December 2020, Kadimastem announced the results 

Kadimastem (TASE:KDST) is a clinical stage biotechnology company, with a unique platform for cell therapy that enables the production of off-the-shelf cell-based products for the treatment of unmet medical needs.

of the first of its kind, Phase I/IIa clinical trial, in which healthy and functioning astrocyte cells (AstroRx®) were injected into the spinal fluid of 10 ALS patients. Data showed that AstroRx® has the potential to slow the progression of ALS, as indicated by a clinical score called ALSFRS-R. Kadimastem plans to test repeated doses every three months of AstroRx® to achieve a continuous delay of the disease.

 

This document may include forward-looking information as defined in the Securities Law, 5728 – 1968. Forward-looking information is uncertain and mostly is not under the Company's control and the realization or non-realization of forward-looking information will be affected, among other things, by the risk factors characterizing the Company's activity, as well as developments in the general environment and external factors affecting the Company's activity. The Company's results and achievements in the future may differ materially from any presented herein and the Company makes no undertaking to update or revise such projection or estimate and does not undertake to update this document. This document does not constitute a proposal to purchase the Company's securities or an invitation to receive such offers. Investment in securities in general and in the Company in particular bears risks. One should consider that past performance does not necessarily indicate performance in the future.

 

Contact Details

 

Kadimastem

 

Sarah Bazak

 

+972 73-797-1601

 

s.bazak@kadimastem.com

 

 

GOTLIVE Media Group

 

Lior Gottlieb

 

+972 50-920-0194

 

lior@gotlive-ir.co.il

 

Company Website

 

https://www.kadimastem.com/

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FDAapprovedFDAINDapporvalINDFDAINDALSALStreatmentcelltherapycelltechnologybiotechnologyisraelbiotechisraelinnovationstartupnation